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| 1 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 2 | GRP78 inhibits macrophage adhesion via SR-A显示文摘Class A scavenger receptor(SR-A)plays an important role in macrophage adhesion.However,the underlying mechanism remains unclear.We previously found that 78 kDa glucose-regulated protein(GRP78)inhibited SRA-mediated ligand internalization into macrophage by binding to SR-A.The aim of the study was to investigate whether GRP78 could regulate SR-A-mediated cell adhesion.We demonstrated that GRP78 bound directly to SR-A by fluorescence resonance energy transfer(FRET)assay.Overexpression of GRP78 inhibited macrophage adhesion via SR-A.These results suggest that GRP78 may act as an inhibitor of macrophage adhesion via SR-A. | Hui Bai Nan Li Xiaodan Zhou Chenchen Wang Yan Zhang Xudong Zhu Min Huang Yaoyu Chen Xiaoyu Li Qing Yang Chaojun Li Jingjing Ben Qi Chen | 2014 | The Journal of Biomedical Research2014，28，4： | 2 |
| 3 | A New Indicator for Global Food Security Assessment: Harvested Area Rather Than Cropland Area显示文摘Cropland area has long been used as a key indicator of food security.However,grain yield is not solely controlled by the area of the cropland.Therefore,we proposed a new indicator to assess food security.Results show that from 1992 to 2004,the global cropland area increased by 840200 km^(2)(99.4%),but the grain yield increased only by 310 million t(29.1%);and from 2004 to 2015,the cropland area decreased by 39000 km^(2)(4.64%),but the grain yield increased by 370 million t(70.84%).This result showed that grain yield was not linearly correlated with cropland area,and delimiting the threshold of cropland protection may not guarantee food security.Combined with further correlation analysis,we found that the increase in the global grain yield was more closely related to the harvested area(R^(2)=0.94),which indicated that the harvested area is a more scientific and accurate indicator than cropland area in terms of guaranteeing food security.Therefore,if governments want to ensure the food security,they should choose a new and more accurate indicator:harvested area rather than cropland area. | SONG Fengjiao WANG Shijie BAI Xiaoyong WU Luhua WANG Jinfeng LI Chaojun CHEN Huan LUO Xuling XI Huipeng ZHANG Sirui LUO Guofeng YAN Mengqi ZHEN Qingqing | 2022 | Chinese Geographical Science2022，32，2： | 2 |
| 4 | Ultralarge Rabi splitting and broadband strong coupling in a spherical hyperbolic metamaterial cavity显示文摘Strong coupling(SC) between two resonant plasmon modes can result in the formation of new hybrid modes exhibiting Rabi splitting with strong energy exchange at the nanoscale. However, normal Rabi splitting is often limited to ~50–320 me V due to the short lifetime of the plasmon mode. Here, we theoretically demonstrate a record Rabi splitting energy as large as 805 me V arising from the SC between the high-Q plasmonic whispering gallery mode and high-Q cavity plasmon resonance supported by a spherical hyperbolic metamaterial cavity,which consists of a dielectric nanosphere core wrapped in 7 alternating layers of silver/dielectric materials.In addition, the new hybrid modes formed by the SC are shown to exhibit an extralong lifetime of up to 71.9–81.6 fs, with the large electric field intensity enhancement at both the dielectric core and the dielectric layers. More importantly, the spectral ranges of SC can be tuned across an ultrabroad range from the visible to the near-IR by simply changing the dielectric core size. These findings may have potential applications in bright single-photon sources. | PING GU JING CHEN SIYU CHEN CHUN YANG ZUXING ZHANG WEI DU ZHENGDONG YAN CHAOJUN TANG ZHUO CHEN | 2021 | Photonics Research2021，9，5： | 2 |
| 5 | Application of a low pressure economizer for waste heat recovery from the exhaust flue gas in a 600 MW power plant显示文摘 | Chaojun Wang Boshu He Shaoyang Sun Ying Wu Na Yan Linbo Yan Xiaohui Pei | 2012 | Energy2012，，1： | 1 |
| 6 | Application of a low pressure economizer for waste heat recovery from the exhaust flue gas in a 600 MW power plant显示文摘 | Chaojun Wang Boshu He Shaoyang Sun Ying Wu Na Yan Linbo Yan Xiaohui Pei | 2012 | Energy2012，，1： | 1 |
| 7 | Thermodynamic analysis of a low-pressure economizer based waste heat recovery system for a coal-fired power plant显示文摘 | Chaojun Wang Boshu He Linbo Yan Xiaohui Pei Shinan Chen | 2013 | Energy2013，，： | 1 |
| 8 | Analysis of the Relationship between Soil pH and Clubroo of Mustard显示文摘[Objective]The paper was to study the severity of mustard clubtoot under different pH conditions and to clear the relationship between pH and mustard clubroot.[Method] Totally 288 soil samples were collected from the infected patches of clubroot in Fuling District,Chongqing City,and their pH were measured.Meanwhile,the germination rate of resting spores,the incidence rate of clubroot and vegetative growth of mustard was measured under different pH conditions,to figure out the relationship between pH and mustard clubroot.[Result] The pH of 288 pathogenic soil samples distributed from 4.0 to 7.0.The germination rates of resting spores were higher than 50% when the pH was 5.0-6.5,and the germination rates were low when the pH was 3.0,4.0,8.0,8.5,9.0 and 10.0.Greenhouse pot test showed that the incidence rate of mustard clubroot in acidic environment was higher than that in alkaline environment.The incidence of mustard clubroot was severe when the pH was 4.5-6.5; the incidence was the severest at the pH of 6.0,and the disease index reached 84.22; mustard was not attacked by clubroot at the pH of 8.0.Measurement results of various growth indicators of mustard under different pH conditions demonstrated that mustard had better growth at the pH of 5.0-7.5,and the growth was the best at the pH of 6.5,while the growth was suppressed at the pH of 4.0 and 8.0.[Conclusion]Clubroot of mustard is likely to happen under weak acidic condition.The suitable pH for the vegetative growth of mustard is 5.0-7.5. | Jiang Huan Peng Yumei Dong Daiwen Yan Yufang Wu Chaojun Liu Qin | 2017 | Plant Diseases and Pests2017，8，6： | 0 |
| 9 | The expression and function of miR-376a-3p/DLX axis in gastric cancer cells显示文摘Gastric cancer(GC)was referred to a malignant tumor of the digestive tract originating from the epithelium of gastric mucosa.Transcription factor DLX5 was verified as an oncogene in various types of tumors,while miR-376a-3p was speculated as a tumor suppressor.Based on the bioinformatics database,we hypothesized that miR-376a participated in the regulation of GC development by targeting DLX5.Compared with adjacent tissue,a significant increase of DLX5 expression was determined in GC tissues,but the expression level is significantly reduced in miR-376a.Similar expression signature of DLX5 and miR-376a was also determined between 4 GC cells(HGC,SGC,MGC,and AGS cell lines)and GES cell line.The level of DLX5 was notably reduced in HGC and MGC cell lines after miR-376a-3p overexpression,and increased after miR-376a-3p inhibition.Then,the inhibition role of miR-376a-3p on DLX5 was further proved by dualluciferase reporter assay.Gain-of-function experiments showed that upregulation of miR-376a-3p in GC cells could inhibit the ability of epithelial-mesenchymal transition,proliferation,and invasion,and enhance the GC cell apoptosis level.However,these roles of miR-376a-3p could be abolished by DLX5 overexpression.This study confirmed that reduction of miR-376a-3p expression level in GC cells would lead to the increase in cell growth and invasion,indicating that upregulation of miR-376a-3p might have a potential therapeutic role on GC. | YAN ZHANG CHAOJUN ZHANG ZHEN CAO ZHANWEI ZHAO LIN CHEN | 2022 | BIOCELL2022，46，9： | 0 |
| 10 | HIV/AIDS Knowledge, Attitudes and Behaviors among Undergraduate Students in China显示文摘 | Xiaodong Tan Jingju Pan Dong Zhou Chaojun Xie Xinglan Wen Yan Hong | 2006 | Journal of US-China Medical Science2006，3，5： | 0 |
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