|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 2 | Long-term changes of phytoplankton community in Xiagu waters of Xiamen,China显示文摘Long-term changes of phytoplankton community by water sampling method in Xiagu Sea waters of Xiamen,China,were investigated in this study.Species composition of the phytoplankton community in these waters changed greatly since the 1950s.The numbers of Dinophyta species increased significantly,although Bacillariophyta species are generally dominant.The succession of dominant species in phytoplankton community is obvious: large-size dominant species such as Biddulphia sinensis of the 1950s were gradually replaced by small-size ones such as Cyclotella striata and Nitzschia closterium,and species that still maintain dominant such as Skeletonema costatum are also small ones,leading the whole phytoplankton community of smaller size.Cell density of phytoplankton community increased greatly,among which cell density of the most dominant species Skeletonema costatum have been increasing in exponent function.Margalef index of phytoplankton community decreased,indicating decline of biodiversity of the community,and dominant character of Skeletonema costatum increased.Generally,the structure of the entire phytoplankton community is becoming more and more singular and unstable,which makes the occurrence of red tides more frequent.The succession in the phytoplankton community is related to the long-term changes in marine environment,influenced by human activities and global climate changes,especially the increases of nutrient content. | CHEN Baohong XU Zhuhua ZHOU Qiulin CHEN Changping GAO Yahui YANG Shengyun JI Weidong | 2010 | Acta Oceanologica Sinica2010，29，6： | 14 |
| 3 | Seasonal variations in the Sr-Nd isotopic compositions of suspended particulate matter in the lower Changjiang River:Provenance and erosion constraints显示文摘Suspended particulate matter samples were collected monthly for more than 2 years in Nanjing,China to examine seasonal changes in the Sr-Nd isotopic compositions of the lower Changjiang River(CR).The results indicate that the 87Sr/86Sr ratios of the samples ranges from 0.725352 to 0.738128,and the values ofεNd(0)ranges from-10.55 to-12.29.The Sr-Nd isotopic compositions show distinct seasonal variations.The samples had lower 87Sr/86Sr ratios and higherε Nd(0)values during the flood season than the dry seasons.The seasonal variations primarily reflect the controls of provenance rocks and erosion in different sub-catchments.The relative decrease in 87Sr/86Sr ratios and the increase inε Nd(0)values during the flood season may reflect an increasing in the mechanical erosion rate in the upper basin and the contribution of more sediment from the upper reaches.The end member values of 87Sr/86Sr andε Nd(0)of the samples were 0.728254 and?11.26,respectively. | MAO ChangPing CHEN Jun YUAN XuYin YANG ZhongFang JI JunFeng | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 4 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 5 | Conformation-activity studies on the interaction of berberine with acetylcholinesterase:Physical chemistry approach显示文摘Berberine has been reported as an acetylcholinesterase(AChE) inhibitor.With significantly low cytotoxicity,berberine will be developed for the clinical treatment of Alzheimer disease(AD) with higher efficacy and fewer side effects.This work investigated the structure change events of AChE that occur during the interaction with berberine by isothermal titration calorimetry(ITC),fluorescence titration, and circular dichroism(CD).The results show that the binding of berberine to AChE is mainly driven by a favorable entropy increase with a less weak affinity.Berberine causes a loss in enzymatic activity at a concentration much below the concentration which gradually exposed the tryptophan residues to a more hydrophilic environment and unfolded the protein,which indicates that the inhibition of AChE with berberine includes the main contributions of interaction and minor conformation change of the protein induced by the alkaloid. | Jin Xiang Changping Yu Fang Yang Ling Yang Hong Ding | 2009 | Progress in Natural Science:Materials International2009，19，12： | 4 |
| 6 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 7 | Unveiling the mechanical response and accommodation mechanism of pre-rolled AZ31 magnesium alloy under high-speed impact loading显示文摘Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage. | Xiao Liu Hui Yang Biwu Zhu Yuanzhi Wu Wenhui Liu Changping Tang | 2022 | Journal of Magnesium and Alloys2022，10，4： | 2 |
| 8 | Polyploidy events shaped the expansion of transcription factors in Cucurbitaceae and exploitation of genes for tendril development显示文摘Cucurbitaceae is one of the most important plant families distributed worldwide.Transcription factors(TFs)regulate plant growth at the transcription level.Here,we performed a systematic analysis of 42641 TFs from 63 families in 14 Cucurbitaceae and 10 non-cucurbit species.Whole-genome duplication(WGD)was the dominant event type in almost all Cucurbitaceae plants.The TF families were divided into 1210 orthogroups(OGs),of which,112 were unique to Cucurbitaceae.Although the loss of several gene families was detected in Cucurbitaceae,the gene families expanded in five species that experienced a WGD event comparing with grape.Our findings revealed that the recent WGD events that had occurred in Cucurbitaceae played important roles in the expansion of most TF families.The functional enrichment analysis of the genes that significantly expanded or contracted uncovered five gene families,AUX/IAA,NAC,NBS,HB,and NF-YB.Finally,we conducted a comprehensive analysis of the TCP gene family and identified 16 tendril-related(TEN)genes in 11 Cucurbitaceae species.Interestingly,the characteristic sequence changed from CNNFYFP to CNNFYLP in the TEN gene(Bhi06M000087)of Benincasa hispida.Furthermore,we identified a new characteristic sequence,YNN,which could be used for TEN gene exploitation in Cucurbitaceae.In conclusion,this study will serve as a reference for studying the relationship between gene family evolution and genome duplication.Moreover,it will provide rich genetic resources for functional Cucurbitaceae studies in the future. | Yu Zhang Yingchao Zhang Bing Li Xiao Tan Changping Zhu Tong Wu Shuyan Feng Qihang Yang Shaoqin Shen Tong Yu Zhuo Liu Xiaoming Song | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 9 | Effects of ternary compound additives on densification and microstructure of alumina 显示文摘 | CHEN Changping GAO Jingxia YANG Huizhi | 2008 | Mater Sci Eng A2008，477，12： | 1 |
| 10 | Effects of Si addition on microstructure and mechanical properties of Mg–8Gd–4Y–Nd–Zr alloy显示文摘 | Xinming Zhang Jilong Hu Lingying Ye Yunlai Deng Changping Tang Liu Yang Zhaoyang Liu | 2013 | Materials and Design2013，，： | 1 |
| 11 | Effect of terna- ry compound additives on densification and microstructure of altmaina显示文摘 | Chen Changping Gao J ingxia Yang Huizhi | 2008 | Mater Sci Eng2008，477，12： | 1 |
| 12 | Densification behavior and micro structural evolution of TiO2/CAS incor- porated alumina显示文摘 | Chen Changping Yang Huizhi Gao Jingxia | 2009 | Ceram Int2009，35，2： | 1 |
| 13 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 14 | S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery显示文摘Photocleavable hydrogels are of great importance in the field of controlled drug delivery,stem cell fate regulation,surface patterning,and intelligent devices.However,the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions.Herein,we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages.The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light,and the degradation kinetics could be significantly promoted by hydrogen peroxide.Correspondingly,the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment.This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and ondemand drug release properties. | Changping Wang Chongyi Liu Qiyao Wei Lei Yang Peng Yang Yiwen Li Yiyun Cheng | 2020 | Research2020，，1： | 1 |
| 15 | Gastrodin inhibits cell proliferation in vascular smooth muscle cellsand attenuates neointima formation in vivo显示文摘 | Lihua Zhu Hongjing Guan Changping Cui Song Tian Da Yang Xinan Wang Shuming Zhang Lang Wang Hong Jiang | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 16 | Influ- ence of heat - treatment schedule on crystallization and microstructure of bauxite tailing glass - ceramics coated on tiles 显示文摘 | Huizhi Yang Changping Chen Hongwei Sun | 2008 | Journal of Materials Processing Technology2008，197，13： | 1 |
| 17 | Preparation of double - layer glass - ceramic/ ceramic tile from bauxite tailings and red mud 显示文摘 | Huizhi Yang Changping Chen Lijun Pan | 2009 | Journal of the European Ceramic Society2009，29，10： | 1 |
| 18 | Resveratrol derivative BTM-0512 mitigates obesity by promoting beige remodeling of subcutaneous preadipocytes显示文摘 | Qingqing Li Kuansong Wang Yipeng Ma Chunxiang Qin Changsheng Dong Ping Jin Yan Wu Xiaoming Xiong Niansheng Li Changping Hu Jun Peng Zhichun Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 1 |
| 19 | Rpl10l通过补偿转录失活的Rpl10确保精子发生减数分裂的正常进行显示文摘文章简介课题组通过构建Rpl10l敲除小鼠,发现RPL10L在小鼠睾丸中特异表达且与精子发育相关。 | Long Jiang Tao Li Xingxia Zhang Beibei Zhang Changping Yu Yang Li Suixing Fan Xiaohua Jiang Teka Khan Qiaomei Hao Peng Xu Daita Nadano Mahmoud Huleihel Eitan Lunenfeld P.Jeremy Wang 张远伟 史庆华 | 2018 | 科学新闻2018，0，4： | 1 |
| 20 | Gastrodin inhibits cell proliferation in vascular smooth muscle cellsand attenuates neointima formation in vivo显示文摘 | Lihua Zhu Hongjing Guan Changping Cui Song Tian Da Yang Xinan Wang Shuming Zhang Lang Wang Hong Jiang | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员