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| 1 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 2 | A Phase II Trial of Neoadjuvant Chemoradiation and Local Excision for T2N0 Rectal Cancer: Preliminary Results of the ACOSOG Z6041 Trial显示文摘 | Julio Garcia-Aguilar MD PhD Qian Shi PhD Charles R. Thomas MD Emily Chan MD PhD Peter Cataldo MD Jorge Marcet MD David Medich MD Alessio Pigazzi MD Samuel Oommen MD Mitchell C. Posner MD | 2012 | Annals of Surgical Oncology2012，，2： | 2 |
| 3 | Surgical Indication for Non-curative Endoscopic Resection in Early Gastric Cancer显示文摘 | Keun Won Ryu MD Il Ju Choi MD Young Woo Doh MD Myeong-Cherl Kook MD Chan Gyoo Kim MD Hyun-Jung Park RN Jun Ho Lee MD Jong-Seok Lee MD Jong Yeul Lee MD Young Woo Kim MD Jae-Moon Bae MD | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 4 | Risk Factors Associated with Complication Following Laparoscopy-Assisted Gastrectomy for Gastric Cancer: A Large-Scale Korean Multicenter Study显示文摘 | Min Chan Kim MD Wook Kim MD Hyung Ho Kim MD Seung Wan Ryu MD Seong Yeob Ryu MD Kyo Young Song MD Hyuk Joon Lee MD Gyu Seok Cho MD Sang Uk Han MD Woo Jin Hyung MD | 2008 | Annals of Surgical Oncology2008，，10： | 2 |
| 5 | Biochemical and immunologic mechanisms in atopic dermatitis:New targets for imerging therapies显示文摘 | Hanifin MD Chan S | 1999 | J Am Acad Dermatol1999，41，： | 1 |
| 6 | Prognostic Significance of Circumferential Resection Margin Following Total Mesorectal Excision and Adjuvant Chemoradiotherapy in Patients with Rectal Cancer显示文摘 | Seung Hyuk Baik MD Nam Kyu Kim MD Young Chan Lee MD Hoguen Kim MD Kang Young Lee MD Seung Kook Sohn MD Chang Hwan Cho MD | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 7 | Laparoscopy for appendicitis and cholelithiasis during pregnancy:a new standard of care显示文摘 | Rollins MD Chan K J Price RR | 2004 | Surg Endosc2004，18，2： | 1 |
| 8 | Diagnostics and epidemiology in ventilator-associated pneumonia显示文摘 | Shorr AF Chan CM Zilberberg MD | 2011 | Ther Adv Respir Dis2011，5，2： | 1 |
| 9 | Regulation of ocular inflammation-what experimental and human stmties have taught us 显示文摘 | de Smet MD Chan CC | 2001 | Progr Retin Eye Res2001，20，6： | 1 |
| 10 | Radiosurgical manage- ment of trigeminal neuralgia显示文摘 | Chan MD Shaw EG Tatter SB | 2013 | Neurosurg Clin N Am2013，24，4： | 1 |
| 11 | Deep venous thrombosis: detection by using indirect CT venography 显示文摘 | Chan MD Yankelevitz DF Shanham D | 2000 | Radiology2000，216，： | 1 |
| 12 | Cemented hemiarthroplasties for elderly patients with intertrochanteric fractures 显示文摘 | Chan K Casey MD Gill | 2000 | Clin Orthop2000，371，： | 1 |
| 13 | Repeat gamma knife radio- surgery for trigeminal neuralgia显示文摘 | Aubuchon AC Chan MD Lovato JF | 2011 | International Journal of Radiation Oncology Biology Physics2011，81，4： | 1 |
| 14 | Prognostic Significance of Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Angiogenin in Patients With Resectable Hepatocellular Carcinoma After Surgery显示文摘 | Yee Chao MD PhD Chung-Ping Li MD Gar-Yang Chau MD Chih-Ping Chen MD Kuang-Liang King MD Wing-Yiu Lui MD PhD Sang-Hue Yen MD Full-Young Chang MD Wing-Kai Chan MD Shou-Dong Lee MD | 2003 | Annals of Surgical Oncology2003，，4： | 1 |
| 15 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 16 | Calcium singnal in the ER, it's role in neuronal placity and neurodegerative disorders显示文摘 | Laferl FM Chan SL | 2000 | Trends Neurosci2000，23，5： | 1 |
| 17 | Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer显示文摘 | Harris S Chan MD Lovato JF | 2012 | Int J Radiat Oncol Biol Phys2012，83，： | 1 |
| 18 | Thyroid hormone and central nervous system development 显示文摘 | Chan S Kilby MD | 2000 | Journal of Endocrinology2000，165，： | 1 |
| 19 | Protcemic analysis of UVC irradiation-induced damage of plasma proteins:Serum amyloid P component as a major target of photolysis显示文摘 | Chan HL Gaffuey P R MD Waterfield | 2006 | JOUR2006，580，13： | 1 |
| 20 | Immunologicdiagnosis of tuberculo sis:areview显示文摘 | Chan ED Heifets L Iseman MD | 2000 | TuberLung Dis2000，80，3： | 1 |
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