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| 1 | Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules显示文摘AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related HCC.METHODS: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically analyzed.RESULTS: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic metastasis.CONCLUSION: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis. | Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park | 2005 | World Journal of Gastroenterology2005，11，14： | 62 |
| 2 | Gastric cancer patients at high-risk of having synchronous cancer显示文摘瞄准:识别病人与一在胃的癌症病人之中有同步癌症高风险。方法:我们回顾地在国家癌症中心分析了未来的胃的癌症数据库,从 2000 年 12 月的朝鲜到 2004 年 12 月。有没有同步癌症的病人的同步癌症和那些的病人的 clinicopathological 特征被比较。Multivariate 分析被执行在胃的癌症病人为同步癌症的存在识别风险因素。结果:在数据库登记的 3291 个胃的癌症病人(3.4%) 中的 111 个有同步癌症。在这 111 个病人之中, 109 有单个同步癌症, 2 个病人有二同步癌症。同步癌症的最普通的形式是颜色表面的癌症(42 个病人, 37.2%) 由肺癌症列在后面(21 个病人, 18.6%) 。Multivariate 分析表明有区分的早胃的癌症的老病人有同步癌症的更高的可能性。结论:在胃的癌症病人的同步癌症不是很少发生的。医生应该试着在胃的癌症病人发现同步癌症,在特别与区分的早胃的癌症老。 | Jun Ho Lee Ja Seong Bae Keun Won Ryu Jong Seok Lee Sook Ryun Park Chan Gyoo Kim Myoung Cheorl Kook Il Ju Choi Young Woo Kim Jae-Gahb Park Jae-Moon Bae | 2006 | World Journal of Gastroenterology2006，12，16： | 15 |
| 3 | Individual having a parent with early-onset gastric cancer may need screening at younger age显示文摘AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with GC.METHODS: A total of 4282 patients diagnosed with GC at National Cancer Center Hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by questionnaire.RESULTS: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P < 0.001). However, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(< 50 years old), mean age at diagnosis was 47.7 ± 10.3 years for those with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier. | Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-Jeong Cho Bang Wool Eom Hong Man Yoon Jungnam Joo Keun Won Ryu Young-Woo Kim | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 4 | Recent updates and current issues of sentinel node navigation surgery for early gastric cancer显示文摘With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard treatments.Sentinel node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with EGC.Although many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is debatable.Several issues regarding technical standardization and oncological safety need to be resolved.Recently several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future. | Sung Gon Kim Bang Wool Eom Hong Man Yoon Chan Gyoo Kim Myeong-Cherl Kook Young-Woo Kim Keun Won Ryu | 2021 | Chinese Journal of Cancer Research2021，33，2： | 7 |
| 5 | In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria,Streptococcus mutans and Streptococcus sobrinus显示文摘Objective:To evaluate the antibacterial activity of Cinnamomum verum(C.verum) from32 different essential oils against cariogenic bacteria,Streptococcus mutans(S.mutans)and Streptococcus sobrinus(S.sobrinus).Methods:The antibacterial activities of each essential oil were individually investigated against S.mutans and S.sobrinus.The essential oil of C.verum was selected for further evaluation against S.mutans and S.sobrinus.Gas chromatography mass spectrometry was used to determine the major constituents of C.verum essential oil.In addition,the minimum inhibitory concentration(MIC) and minimum bactericidal concentration of the most effective constituent was investigated.Results:The essential oil from C.verum exhibited the greatest antibacterial activity.Gas chromatography mass spectrometry analysis revealed that the major components of C.verum essential oil were cinnamaldehyde(56.3%),cinnamyl acetate(7.1%) and bphellandrene(6.3%).The MIC of cinnamaldehyde was measured using broth dilution assays.The MIC of cinnamaldehyde was 0.02%(v/v) against both bacterial strains tested.The minimum bactericidal concentration of cinnamaldehyde against S.mutans and S.sobrinus were 0.2% and 0.1%(v/v),respectively.Conclusions:The essential oil of C.verum and its major component cinnamaldehyde possessed considerable in vitro antibacterial activities against cariogenic bacteria,S.mutans and S.sobrinus strains.These results showed that the essential oil of C.verum and its bioactive component,cinnamaldehyde,have potential for application as natural agents for the prevention and treatment of dental caries. | Okhee Choi Su Kyung Cho Junheon Kim Chung Gyoo Park Jinwoo Kim | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，4： | 4 |
| 6 | 利用桑木人工栽培药用真菌灵芝(Phellinus linteus)的研究(英文)显示文摘比较了利用无菌短木接种法、钻孔接种法和端木夹心接种法等接种方法接种桑树段木后Phellinus linteus的菌丝生长和定殖状况。研究表明利用灭菌的短木接种P.linteus,生长和定殖良好,传统的钻孔接种法和端木夹心接种法菌丝生长定殖不好。P.linteus在20 cm长的桑木上生长和定殖所需的最适的含水量为42%,接种后12 h,P.linteus立即进入快速生长期。接种后的桑木埋入土壤中需要5~6个月产生担子果,在培养室内温度为31~35℃,相对湿度大于96%时有利于子实体的形成。 | Hong In Pyo Sung Gyoo Byung Nam Hack Woo | 2004 | 华中农业大学学报2004，23，1： | 3 |
| 7 | Endoscopic submucosal dissection for metachronous tumor in the remnant stomach after distal gastrectomy显示文摘 | Jong Yeul Lee Il Ju Choi Soo-Jeong Cho Chan Gyoo Kim Myeong-Cherl Kook Jun Ho Lee Keun Won Ryu Young-Woo Kim | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 8 | Estimation of vegetative mercury emissions in China显示文摘Vegetative mercury emissions were estimated within the framework of Biogenic Emission Inventory System (BEIS3 V3.11). In this estimation, the 19 categories of U.S. Geological Survey landcover data were incorporated to generate the vegetation-specific mercury emissions in a 81-km Lambert Conformal model grid covering the total Chinese continent. The surface temperature and cloud-corrected solar radiation from a Mesoscale Meteorological model (MM5) were retrieved and used for calculating the diurnal variation. The implemented emission factors were either evaluated from the measured mercury flux data for forest, agriculture and water, or assumed for other land fields without available flux data. Annual simulations using the MM5 data were performed to investigate the seasonal emission variation. From the sensitivity analysis using two sets of emission factors, the vegetative mercury emissions in China domain were estimated to range from a lower limit of 79 × 103 kg/year to an upper limit of 177 × 103 kg/year. The modeled vegetative emissions were mainly generated from the eastern and southern China. Using the estimated data, it is shown that mercury emissions from vegetation are comparable to that from anthropogenic sources during summer. However, the vegetative emissions decrease greatly during winter, leaving anthropogenic sources as the major sources of emission. | Shang Gyoo SHIM | 2008 | Journal of Environmental Sciences2008，20，9： | 3 |
| 9 | Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study显示文摘AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients. | Eun Kyung Lee So Young Kim You Jin Lee Mi Hyang Kwak Hak Jin Kim Il Ju Choi Soo-Jeong Cho Young Woo Kim Jong Yeul Lee Chan Gyoo Kim Hong Man Yoon Bang Wool Eom Sun-Young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 10 | Gene expression analysis of primary normal human hepatocytes infected with human hepatitis B virus显示文摘瞄准:由 cDNA 在感染的起始的状态期间发现在肝炎 B (HBV ) 和 hepatocytes 之间的关系微数组。方法:主要正常人的 hepatocytes (PNHH ) 被孤立并且与 HBV 感染了。从 PNHH, RNA 与为微数组分析标记 dUTP 的 Cy3- 或 Cy5- 被孤立并且转换进补充 DNA (cDNA ) 。标记的 cDNA 是有微数组薄片的 hybridized,包括 4224 cDNAs。从微数组的图象,表达式侧面被生产,他们中的一些被 RT-PCR,免疫污点分析,和 NF-kappaB 酶记者试金证实。结果:从 cDNA 微数组,我们获得了 98 差别调整基因。98 基因, 53 起来调整并且 45 下面调整。有趣地,在里面起来调整基因,我们发现了 TNF 表明小径相关的基因:LT-alpha, TRAF2,和 NIK。由使用 RT-PCR,我们在 HepG2, Huh7,和 Chang 肝细胞证实了这些基因的起来规定,它是有 pHBV1.2x 的 transfected,编码所有 HBV 的一个原生质标志发送消息。而且,这三基因参予了调停 HBV 的 NF-kappaB 激活。结论:在 HBV 感染的起始的状态期间, hepatocytes 直在 LT-alpha, TRAF2,和 NIK 的规定上面便于 NF-kappaB 的激活。 | Hyun Mi Ryu Sung Gyoo Park Sung Su Yea Won Hee Jang Young-Il Yang Guhung Jung | 2006 | World Journal of Gastroenterology2006，12，31： | 3 |
| 11 | Surgical Indication for Non-curative Endoscopic Resection in Early Gastric Cancer显示文摘 | Keun Won Ryu MD Il Ju Choi MD Young Woo Doh MD Myeong-Cherl Kook MD Chan Gyoo Kim MD Hyun-Jung Park RN Jun Ho Lee MD Jong-Seok Lee MD Jong Yeul Lee MD Young Woo Kim MD Jae-Moon Bae MD | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 12 | Analysis of rolls deflection of Sendzimir mill by 3D FEM显示文摘The deflection of rolls of Sendzimir mill with double AS-U-Roll was simulated by finite element method(FEM). The influences of rolling pressure, strip width and rolls-assignment on rolls deflection were analyzed. The results show that the work roll deflection increases with the increase of rolling pressure and the reduction of work roll radius, but the rigid displacement of work roll slightly changes; the work roll end might appear negative displacement for the narrow strip width and high rolling pressure that might cause the contact of work rolls. The research results are significant for guiding production and theoretical analysis of the rolls system of Sendzimir mill. | 喻海良 刘相华 LEE Gyoo Taek | 2007 | 中国有色金属学会会刊:英文版2007，17，3： | 2 |
| 13 | Covered versus uncovered self-expandable metallic stents for palliation of malignant pyloric obstruction in gastric cancer patients: a randomized, prospective study显示文摘 | Chan Gyoo Kim Il Ju Choi Jong Yeul Lee Soo-Jeong Cho Sook Ryun Park Jun Ho Lee Keun Won Ryu Young-Woo Kim Young Iee Park | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 14 | An evolutionary approach for time optimal trajectory planning of a robotic manipulator 显示文摘 | Lee Young Dae Lee Beom Hee Kim Han Gyoo | 1999 | Information Sciences1999，113，34： | 1 |
| 15 | High mechanical strengths of Mg-Ni-Y and Mg-Cu-Y amorphous alloys with significant supercooled liquid region 显示文摘 | Gyoo Kim S Inoue A Masumoto T | 1990 | Mater Trans JIM1990，31，11： | 1 |
| 16 | Numerical analysis of strip edge drop for Sendzimir mill显示文摘 | YU Hai-Liang LIU Xiang-Hua Gyoo Taek Lee | 2008 | Journal of materials processing technology2008，11，： | 1 |
| 17 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 18 | High mechanical strengths of Mg-Ni-Y and Mg-Cu-Y amorphous alloys with significant supercooled liquid region显示文摘 | Inoue A Masumoto T | 1990 | Mater Trans JIM1990，31，11： | 1 |
| 19 | 显示文摘 | Gyoo Kim S Inoue A Masumoto T | 1990 | MaterTrans JIM1990，31，： | 1 |
| 20 | Morphology, thermal, and mechanical properties of polyamide 66/clay nanocomposites with epoxy-modified organoclay显示文摘 | Gyoo P M Venkataramani S Kim S C | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
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