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| 1 | 师生互动的实证研究:中芬法澳四国中学数学课堂中的师生互动显示文摘师生互动是中学数学课堂中的关键教学行为。通过选取中国、芬兰、法国和澳大利亚四个国家中学数学课堂录像进行实证研究,探寻出中芬法澳课堂中师生互动模式的可能形态:整体态势上中国课堂中的师生互动较为静态,并表现出教师主导性;而芬法澳三国的师生互动更为动态。互动模式1:教师提问-学生回答是各国主导的师生互动模式,中国尤甚;中国的互动模式1与芬法澳迥异,主要表现在互动对象上;互动模式2:学生提问-教师回答在中国课堂几乎缺失;互动模式3:教师讲解-学生听讲是各国课堂知识传输的主要媒介,中国课堂中尤甚;互动模式4:学生做题-教师辅导中的教师辅导,在中国主要表现为全班集中讲解,体现出集体主义色彩,在芬法澳课堂中主要是个性化、针对性的小组或个别辅导;互动模式5:课堂管理在芬法澳课堂是重要的师生互动形式,中国课堂缺失。 | 于国文 曹一鸣 David Clarke Man Ching Esther Chan | 2019 | 全球教育展望2019，48，1： | 27 |
| 2 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 3 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 4 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 5 | Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong显示文摘氨基酸,器官的酸和丰满的酸氧化的新陈代谢(IEM ) 的古典先天的错误的背景数据大部分正在缺乏香港,在集体基于 spectrometry 的扩展新生儿为 IEM 屏蔽没被开始的地方。瞄准在香港评估近似发生,光谱和古典 IEM 的另外的特征的当前的学习,将在开发为实验室血浆氨基酸记录的本地 area.Methods 屏蔽节目的一个扩展新生儿重要,血浆 acylcarnitines 和尿从年 2005~2009 的器官的酸分析在为 IEM 提供生物化学、基因的诊断服务的三个地区性的化学病理实验室包括回顾地 reviewed.Resu 在香港的古典 IEM 的发生粗略地被估计每 1000live 出生每 4122 生活出生,或 0.243 个盒子是至少 1 个盒子。这发生类似于全球报导的那些,包括中国的大陆。hyperphenylalaninemia 的估计的发生在 29 542 实时 births.Conclusions 是 1 我们的数据显示它为在香港的扩展新生的屏蔽节目的介绍是无可争辩的。因为香港是一个大城市的城市,一个全面扩展新生的屏蔽程序和工作分派系统应该是可得到的服务在区域出生的出生不满一月的婴儿。 | Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 6 | 冲突与支持影响情侣依恋的文化差异显示文摘采用香港和美国的被试,运用亲密关系经历量表、冲突量表和社会支持量表,考察了冲突和支持对于情侣依恋影响的文化差异。结果发现,当以依恋焦虑为因变量时,冲突、支持和文化×冲突×支持都是显著的预测变量;当以依恋逃避为因变量时,仅文化和文化×支持是显著的预测变量。由此可见,文化影响冲突×支持与依恋焦虑的关系:在香港,情侣之间的冲突和支持各自对于依恋焦虑的作用在很大程度上相互抵消;在美国,情侣之间冲突的负面影响比支持的积极影响要强,冲突×支持越高,依恋焦虑越高。对于依恋逃避,文化差异仅调节支持与依恋逃避的关系:在香港,支持对依恋逃避的影响要比美国强。整个研究表明,对不同类型的情侣依恋,文化的调节作用不同。 | 陆爱桃 张积家 Michael Harris Bond 张学新 Michael Friedman Chan Ching | 2009 | 心理学报2009，41，6： | 9 |
| 7 | Enabling Industrial Internet of Things(IIoT) towards an emerging smart energy system显示文摘The increasing penetration of renewable energy on the transmission and distribution power network is driving the adoption of two-way power flow control, data and communications needed to meet the dependency of balancing generation and load. Thus, creating an environment where power and information flow seamlessly in real time to enable reliable and economically viable energy delivery, the advent of Internet of Energy(IoE) as well as the rising of Internet of Things(IoT) based smart systems.The evolution of IT to Io T has shown that an information network can be connected in an autonomous way via routers from operating system(OS) based computers and devices to build a highly intelligent eco-system. Conceptually, we are applying the same methodology to the Io E concept so that Energy Operating System(EOS) based assets and devices can be developed into a distributed energy network via energy gateway and self-organized into a smart energy eco-system.This paper introduces a laboratory based IIo T driven software and controls platform developed on the NICE Nano-grid as part of a NICE smart system Initiative for Shenhua group. The goal of this effort is to develop an open architecture based Industrial Smart Energy Consortium(ISEC) to attract industrial partners, academic universities, module supplies, equipment vendors and related stakeholder to explore and contribute into a test-bed centric open laboratory template and platform for next generation energy-oriented smart industry applications.In the meanwhile, ISEC will play an important role to drive interoperability standards for the mining industry so that the era of un-manned underground mining operation can become the reality as well as increasing safety regulation enforcement. | Ding Zhang Ching Chuen Chan George You Zhou | 2018 | Global Energy Interconnection2018，1，1： | 9 |
| 8 | Whole-system thinking, development control, key barriers and promotion mechanism for EV development显示文摘Electric vehicles(EVs)have received significant attention because of the potential energy savings and emission reductions they enable.However,current studies and demonstrations have focused mainly on specific technologies and equipment types,which cannot in themselves solve the predicaments facing EVs.This study points out that EVs will form a large,complex system that needs to be optimized over different aspects to compete with traditional vehicles.Therefore,wholesystem thinking is needed to support the development control of EVs,with a broader scope than operational control,and the core issue is the interaction between EVs and power grid,including their coordinated development and operational management.For development control of EVs,a target system and a step-wise optimization method are presented,as well as the basic principles for designing the target system.There are two key barriers in EVs’development:the research and mass production of highperformance power batteries,and the formulation of a favorable mechanism to capture benefits and encourage development.To address the problems of EV development,a promotion method that combines franchising with moderate competition is proposed.The concepts and methods developed in this study can facilitate the research and development of EVs. | Chunlin GUO Ching Chuen CHAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 9 |
| 9 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 10 | Recent Developments of Genomic Research in Soybean显示文摘大豆是有象高种子蛋白质那样的唯一、重要的特点的重要现金庄稼并且给执行共生的氮固定的内容,和能力上油。栽培大豆的一个参考染色体在 2010 被建立,列在后面由整个染色体野、栽培的大豆就职重新定序。这些努力揭示了大豆染色体的唯一的特征并且帮助理解它的进化。在野、栽培的大豆染色体之间的变化印射被执行。这些 genomic 变化可能与驯服和人的选择的过程有关。野大豆 germplasms 展出了高 genomic 差异并且可以因此是新奇基因 / 等位基因的重要来源。genomic 数据的累积将帮助精制基因地图并且帮助功能的基因的鉴定。在这评论,我们从整个染色体的定序工程总结主要调查结果并且在大豆研究和繁殖节目上讨论可能的影响。象 transcriptomic 和 epigenomic 研究那样的一些新兴的区域将被介绍。另外,我们也公布了将帮助大豆 genomic 数据的采矿的一些有用生物信息学工具。 | Ching Chan Man-Wah Li Fuk-Ling Wong Hon-Ming Lam | 2012 | Journal of Genetics and Genomics2012，39，7： | 8 |
| 11 | Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly- developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON , one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73.CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. | Tan To Cheung See Ching Chan Kenneth SH Chok Albert CY Chan Wan Ching Yu Ronnie TP Poon Chung Mau Lo Sheung Tat Fan | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 8 |
| 12 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 13 | Acute pancreatitis induced by transarterial chemoembolization:a single-center experience of over 1500 cases显示文摘BACKGROUND: Acute pancreatitis is a relatively rare but potentially lethal complication after transarterial chemotherapy. This study aimed to review the complications such as acute pancreatitis after transarterial chemotherapy with or without embolization for hepatocellular carcinoma.METHODS: A total of 1632 patients with hepatocellular carcinoma who had undergone transarterial chemoembolization from January 2000 to February 2014 in a single-center were reviewed retrospectively. We investigated the potential complications of transarterial chemoembolization, such as acute pancreatitis and acute pancreatitis-related complications.RESULTS: Of the 1632 patients with hepatocellular carcinoma who had undergone 5434 transarterial chemoembolizations, 1328 were male and 304 female. The median age of these patients was 61 years. Most(79.6%) of the patients suffered from HBV-related hepatocellular carcinoma. The median tumor size was 5.2 cm. Of the 1632 patients, 145 patients underwent transarterial chemoembolization with doxorubicin eluting bead, making up a total of 538 episodes. The remaining patients underwent transarterial chemoembolization with cisplatin. Seven(0.4%) patients suffered from acute pancreatitis postchemoembolization. Six patients had chemoembolization with doxorubicin and one had chemoembolization with cisplatin. Patients who received doxorubicin eluting bead had a higher risk of acute pancreatitis [6/145(4.1%) vs 1/1487(0.1%), P<0.0001]. Two patients had anatomical arte-rial variations. Four patients developed acute pancreatitisrelated complications including necrotizing pancreatitis(n=3) and pseudocyst formation(n=1). All of the 4 patients resolved after the use of antibiotics and other conservative treatment. Three patients had further transarterial chemoembolization without any complication.CONCLUSIONS: Acute pancreatitis after transarterial chemoembolization could result in serious complications, especially after treatment with doxorubicin eluting bead. Continuation of current treatment with transarterial chemoembolization after acute pancreatitis is feasible providing the initial attack is completely resolved. | Wong Hoi She Albert CY Chan Tan To Cheung Kenneth SH Chok See Ching Chan Ronnie TP Poon Chung Mau Lo | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 6 |
| 14 | Modulation of graft vascular inflow guided by flowmetry and manometry in liver transplantation显示文摘BACKGROUND:Survival of the partial graft after living donor liver transplantation owes much to its tremendous regenerative ability.With excellent venous outflow capacity,a graft within a wide range of graft-to-standard-liver-volume ratios can cope with portal hypertension that is common in liver transplant recipients.However,when the ratio range is exceeded,modulation of graft vascular inflow becomes necessary for graft survival.The interplay between graft-to-standard-liver-volume ratio and portal pressure,in the presence of portosystemic shunt or otherwise,requires individualized modulation of graft portal and arterial inflows.Boosting of portal inflow by shunt ligation can be guided by transonic flowmetry,whereas muting of portal inflow by splenic artery ligation can be monitored by portal electronic manometry.METHOD:We describe four cases to illustrate the above.RESULTS:One patient had hepatic artery thrombosis resulting from splenic artery steal syndrome which was the sequela of small-for-size syndrome.Emergency splenic artery ligation and re-anastomosis of the hepatic artery successfully muted the portal inflow and boosted the hepatic arterial inflow.Another patient with portal vein thrombosis underwent thrombendvenectomy.Portal inflow was boosted with ligation of portosystemic shunt,which is often present in these patients with portal hypertension.The coexistence of splenic aneurysm and splenorenal shunt required ligation of both in the third patient.The fourth patient,with portal pressure and flow monitoring,avoided ligation of a coronary vein which became a main portal inflow after portal thrombendvenectomy.CONCLUSION:Management of graft inflow modulation guided selectively by transonic flowmetry or portal manometry was described. | See Ching Chan Chung Mau Lo Kenneth SH Chok William W Sharr Tan To Cheung Simon HY Tsang Albert CY Chan Sheung Tat Fan | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 5 |
| 15 | A case of laparoscopic hepatectomy for recurrent hepatocellular carcinoma显示文摘Conventional hepatectomy is an effective way to treat hepatocellular carcinoma.However,it is invasive and stressful.The use of laparoscopy in hepatectomy,while technically demanding,reduces surgical invasiveness and stressfulness but still achieves complete resection with adequate margins.Compared with conventional hepatectomy,laparoscopic hepatectomy provides a better chance and situation for further surgery in the case of recurrence of hepatocellular carcinoma.Even aged patients can successfully endure repeated hepatectomy using laparoscopy,as shown in the present report.This report presents a case of repeated laparoscopic hepatectomy treating hepatocellular carcinoma and its recurrence in an aged patient having cirrhosis,a disease causing extra difficulty for performing laparoscopic hepatectomy.The report also describes techniques of the operation and displays characteristic results of laparoscopic hepatectomy such as smaller wounds,less blood loss,less pain,less scars and adhesion,shorter postoperative hospital stay,and faster recovery. | Tan To Cheung Kelvin Kwok-chai Ng Ronnie Tung-ping Poon See Ching Chan Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，4： | 5 |
| 16 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 17 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 18 | Surgical Outcomes in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis显示文摘 | Kenneth S. H. Chok Tan To Cheung See Ching Chan Ronnie T. P. Poon Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Surgery2014，，2： | 4 |
| 19 | 社会支持在情侣依恋与生活满意度关系中的中介作用显示文摘目的:考察香港大学生情侣依恋和生活满意度的关系,及社会支持对情侣依恋与生活满意度的中介效应。方法:采用方便取样,选取香港某大学生153名。用亲密关系经历量表、生活满意度量表(SWLS)和社会支持量表(SSQ)测查。结果:女生SSQ得分高于男生,而亲密关系经历量表的依恋回避维度得分低于男生。依恋回避、依恋焦虑得分均与SSQ、SWLS得分呈负相关(r=-0.69,-0.22,-0.24,-0.29;P<0.05),SSQ得分与SWLS得分呈正相关(r=0.28;P<0.05)。社会支持对情侣依恋和生活满意度有部分中介效应(△R2=0.15,P<0.01)。结论:大学生的情侣依恋与其生活满意度直接相关,并通过所获得的社会支持间接与生活满意度相关。 | 赵思萌 王晓玲 陆爱桃 金淼 CHAN Ching 许艺青 黎焕枝 | 2011 | 中国心理卫生杂志2011，25，8： | 4 |
| 20 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
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