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| 1 | Herbicide resistant fertile transgenic wheat plant obtained by microprojectile bombardment of regenerable embryogenic callus显示文摘 | Vasil V Castillo A M Fromm M E Vasil I K | 1992 | Bio/Tech1992，10，： | 2 |
| 2 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 3 | New echoanatomical correlations in aortic dissection显示文摘 | Vilacosta I Castillo JA San Roman JA | 1995 | Eur Heart J1995，16，1： | 1 |
| 4 | Neonatal chylothorax: aetinlogy, clini-cal course and efficacy of treatment显示文摘 | Capons Fernandez C Benifez Segura I Castillo Salinas F Salcedo Ahizanda S | 2008 | An Pediatr (Barc)2008，68，3： | 1 |
| 5 | Correlation of Myoinositol Levels and Grading of Cerebral Astroeytomas显示文摘 | Castillo M Smith JK Kwoch I | 2000 | AJNR2000，21，11： | 1 |
| 6 | In-plant evaluation of a lactic acid treatment for reduction of bacteria on chilled beef carcasses显示文摘 | CASTILLO A LUCIA L M MERCADO I | 2001 | Food Protection2001，，64： | 1 |
| 7 | Upper u rinary tract transitional cell carcinoma: current treatment op tions and minimally invasive approaches显示文摘 | Vidal Mora I Castillo O Velasco Palma A | 2009 | Arch Esp Urol2009，62，5： | 1 |
| 8 | Predictors of the level of patient satisfaction in a university hospital显示文摘 | Castillo L Dougnac A Vicente I | | 0，，06： | 1 |
| 9 | Epidemiology of de- mentias and Alzheimer's disease 显示文摘 | Sosa - Ortiz AL Acosta - Castillo I Prince MJ | 2012 | Arch Med Res2012，43，8： | 1 |
| 10 | Thyroid hormone preconditioning:protection against ischemia-reperfusion liver injury in the rat 显示文摘 | Fernandez V Castillo I Tapia G | 2007 | Hepatology2007，45，1： | 1 |
| 11 | Timetabling opti- mization of a mixed double - and single - tracked railway network显示文摘 | Castillo E Gallego I Urena J M | 2011 | Applied Mathematical Modelling2011，35，2： | 1 |
| 12 | A deletion involving the Connexin 30 gene in nonsyndromic hearing impairment显示文摘 | del Castillo I Villamar M Moreno--Pelayo MA | 2002 | N Engl J Med2002，346，： | 1 |
| 13 | Enhanced duckweed detection using bootstrapped SVM classification on medium resolution RGB MODIS imagery显示文摘 | CASTILLO C CHOLLETI' I KLEIN E | 2008 | International Joumal of Remote Sensing2008，29，19： | 1 |
| 14 | Insulin resistance in critical illness 显示文摘 | Dhar A Castillo I | 2011 | curr Opin Pediatr2011，23，3： | 1 |
| 15 | Effect of a hygienized rennet paste and a defined strain starter on proteolysis, texture and sensory properties of semi-hard goat cheese显示文摘 | Calvo MV Castillo I Dfaz-Barcos V | 2007 | Food Chemistry2007，202，3： | 1 |
| 16 | Depressed mood in breast cancer survi- vors : Associations with physical activity, cancer - related fatigue, quality of life, and fitness level显示文摘 | GALIANO CASTILLO N ARIZA GARCIA A CANTARERO VILLANUEVA I | 2014 | Eur J Oncol Nurs2014，18，2： | 1 |
| 17 | Retroperitoneal laparoscopic lymph node dissection(RPLND) in testicular cancer显示文摘 | Vidal-Mora I Castillo OA | 2010 | Arch Esp Urol2010，63，5： | 1 |
| 18 | Molecular signature of brain injury after intracerebral hemorrhage显示文摘 | Castillo J Davalos A Alvarez-Sabin I | 2002 | Neurology2002，58，： | 1 |
| 19 | A study of the Candida albicans cell wall proteome 显示文摘 | Castillo L Calvo E Mart nez A I | 2008 | Proteomics2008，8，18： | 1 |
| 20 | Plasmamalonaldehyde ( MDA ) and total antioxidant status ( TAS )during lactation in dairy cows显示文摘 | Castillo C Hernandez J Valverde I | 2006 | Res Vet Sci2006，80，： | 1 |
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