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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods显示文摘 | José Manuel Silván Jürgen van de Lagemaat Agustín Olano Maria Dolores del Castillo | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，5： | 2 |
| 3 | In vitro glycation and antigenicity of soy proteins显示文摘 | Jürgen van de Lagemaat J. Manuel Silván F. Javier Moreno Agustín Olano M. Dolores del Castillo | 2006 | Food Research International2006，，1： | 2 |
| 4 | Metastases in small lymph nodes from colon cancer显示文摘 | Herrera OL Justiniano J Castillo N | 1987 | Arch Surg1987，122，11： | 1 |
| 5 | Decontamination of beef carcass surface tissue by steam vacuuming alone and combined wit h hot water and Iactic acid sprays显示文摘 | Castillo A L ucia L M Goodson K J | 1999 | J Food Prot1999，62，： | 1 |
| 6 | Levels of anti-Inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，3： | 1 |
| 7 | Body temperature and fi brinogen are related to early neurological deterioration in acute isehe mie stroke显示文摘 | Davalos A Castillo J Pumar JM | 1997 | Cerebrovasc Dis1997，7，： | 1 |
| 8 | Body iron stores and early neurologic deterioration in acute cerebral infarction显示文摘 | Davalos A Castillo J Marrugat J | 2000 | Neurology2000，54，8： | 1 |
| 9 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 10 | Nonlinear time series modeling and prediction using functional networks, extracting information masked by chaos 显示文摘 | Castillo E Gutierrez J | 1998 | Phys Lett A1998，244，： | 1 |
| 11 | The release of tumor necrosis factor-alpha is associated with ische mic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 12 | The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke显示文摘 | Castillo J Moro MA Blanco M | 2003 | Ann Neurol2003，54，6： | 1 |
| 13 | Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans 显示文摘 | Castillo U F Strobel G A Ford E J | 2002 | Microbiology2002，148，9： | 1 |
| 14 | Molecular signatures of brain injury after intracerebral hemorrhage显示文摘 | Castillo J Ddvalos A Alvarez-Sabfn J | 2002 | Neurology2002，58，4： | 1 |
| 15 | Munumbicins, wide spectrum antibiotics produced by Streptomyces endophytic on Kennedia nigriscans显示文摘 | CASTILLO U F STROBEL G A FORD E J | 2002 | Microbiology2002，148，： | 1 |
| 16 | Somatic embryogenesis and plant regenerarion from barley cuhivars grown in spain 显示文摘 | Castillo A Egana B Sanz J M | 1995 | Plant Cell Rep1995，17，： | 1 |
| 17 | HIV -associatedplasmablastic lymphoma: Lessons learned from 112 publishedcases显示文摘 | Castillo J Pantanowitz L Dezube BJ | 2008 | Am J Hematol2008，83，10： | 1 |
| 18 | Molecular siguatures of brain injury after intracerebral hemorrhage 显示文摘 | Castillo J Davalos A AIvarez -sabin J | 2002 | Neurology2002，58，4： | 1 |
| 19 | Proinflammatory cy-tokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 20 | Global kinetic evaluation during the reduction of C0WO4with methane for the production of hydrogen显示文摘 | De Los Rios Castillo T Salinas G J Lopez O A | 2013 | International Journal of Hydrogen Energy2013，38，12： | 1 |
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