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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 3 | Neonatal chylothorax: aetinlogy, clini-cal course and efficacy of treatment显示文摘 | Capons Fernandez C Benifez Segura I Castillo Salinas F Salcedo Ahizanda S | 2008 | An Pediatr (Barc)2008，68，3： | 1 |
| 4 | Poultry slaughter wastewater treatment with an up-flow anaerobic sludge blanket(UASB)reactor显示文摘 | CHAVEZ P C CASTILLO L R DENDOOVEN L | 2005 | Bioresource Technology2005，96，： | 1 |
| 5 | In situ study of austenite formation by dilatometry in a low carbon microalloyed steel显示文摘 | Martin D S Rivera-Dlaz-del Castillo P E J Garcia de-Andres C | 2008 | Scripta Materialia2008，58，10： | 1 |
| 6 | Cystic neoplasms of the pancreas 显示文摘 | Fernandezdel Castillo C Warshaw AL | 2001 | Pancreatology2001，1，： | 1 |
| 7 | A blast of gas in the latest Paleocene: simulation first-order effects of massive dissociation of oceanic methane hydrate显示文摘 | Castillo M M Walker J G C | 1997 | Geology1997，25，： | 1 |
| 8 | Generalized anxiety after stroke显示文摘 | Castillo C S Strarkstein S E Fedorof F | 1993 | J Nerv Ment Dis1993，181，2： | 1 |
| 9 | A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cy- anobacteriochrome TIr0924 from Thermosynecho- coccus elongates 显示文摘 | Rockwell N C Njuguna S L Roberts L Castillo E Parson V L Dwojak S Lagarias J C Spiller S C | 2008 | Biochemistry2008，47，： | 1 |
| 10 | Advances in the recovering of spent lithium battery compounds 显示文摘 | CASTILLO S ANSART F LABERTY-ROBERT C | 2002 | J Power Source2002，112，1： | 1 |
| 11 | Query reformulation mining: Models, patterns, and applications 显示文摘 | Boldi B Bonchi F Castillo C | 2011 | Information Retrieval2011，14，3： | 1 |
| 12 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 13 | Shellfish hypersensitivity: clinical and immunological characteristics 显示文摘 | CASTILLO R CARRILO T BLANCO C | 1994 | Allergol Immunopathol (Madr)1994，22，2： | 1 |
| 14 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | J Arid Environ2003，53，2： | 1 |
| 15 | Polycyclic aromatic hydrocarbons in the South American environment 显示文摘 | Barra R Castillo C Torres JP | 2007 | Rev Environ Contam Toxicol2007，191，： | 1 |
| 16 | Oleic and doc- osahexaenoic acid differentially phase separate from lipid raft mole- cules: a comparative NMR, DSC, AFM, and detergent extraction study 显示文摘 | SHAIKH S R DUMAUAL A C CASTILLO A | 2004 | Biophysical Journal2004，87，3： | 1 |
| 17 | On the response of a terminated twisted-wire cable excited by a plane-wave electromagnetic field 显示文摘 | Taylor C D Castillo J P | 1980 | IEEE Transactions on Electromagnetic Compat- ibility1980，22，1： | 1 |
| 18 | Dynamical models of tuberculosis and their applications 显示文摘 | CASTILLO C C JUN S B | 2004 | Mathematical Bioscience and Engineering2004，1，2： | 1 |
| 19 | Anin vivo confocal masked study on corneal epithelium and suhbasal nerves in patients with dry eye显示文摘 | Benitez del Castillo JM Wasfy MA Fernandez C | 2004 | Invest Ophthalmol Vis Sei2004，45，9： | 1 |
| 20 | Genetic profile characterization and segregation analysis of 10 X-STRs in a sample from Santander,Colombia显示文摘 | Pico A Castillo A Vargas C | 2008 | Int J Legal Med2008，122，4： | 1 |
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