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| 1 | New perspectives in occult hepatitis C virus infection显示文摘Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays, can be found in anti-HCV positive patients with normal serum levels of liver enzymes and in anti-HCV negative patients with persistently elevated liver enzymes of unknown etiology. Occult HCV infection is distributed worldwide and all HCV genotypes seem to be involved in this infection. Occult hepatitis C has been found not only in anti-HCV positive subjects with normal values of liver enzymes or in chronic hepatitis of unknown origin but also in several groups at risk for HCV infection such as hemodialysis patients or family members of patients with occult HCV. This occult infection has been reported also in healthy populations without evidence of liver disease. Occult HCV infection seems to be less aggressive than chronic hepatitis C although patients affected by occult HCV may develop liver cirrhosis and even hepatocellular carcinoma. Thus, anti-HCV negative patients with occult HCV may benefit from antiviral therapy with pegylated-interferon plus ribavirin. The persistence of very low levels of HCV RNA in serum and in PBMCs, along with the maintenance of specific T-cell responses against HCV-antigens observed during a long-term follow-up of patients with occult hepatitis C, indicate that occult HCV is a persistent infection that is not spontaneously eradicated. This is an updated report on diagnosis, epidemiology and clinical implications of occult HCV with special emphasis on anti-HCV negative cases. | Vicente Carreño Javier Bartolomé Inmaculada Castillo Juan Antonio Quiroga | 2012 | World Journal of Gastroenterology2012，18，23： | 5 |
| 2 | Systematic review of noninvasive treatments to arrest dentin non-cavitated caries lesions显示文摘AIM: To systematically review the literature on the efficacy of noninvasive methods of arresting the progression of non-cavitated occlusal carious lesions in dentin.METHODS: The Medline/Pub Med,LILACS,Sci ELO and Scopus databases were searched to identify relevant publications through to November 2013.Only clinical trials evaluating the ability of noninvasive methods to arrest the progression of occlusal non-cavitated carious lesions in dentin were included.Screening,data extraction and quality assessment were conducted independently and in duplicate.RESULTS: Of 167 citations identified,nine full text articles were screened and five were included in the analysis.All papers reported on occlusal fissure sealing using a self-curing glass ionomer(n = 1) or resin-based(n = 4) sealant.Only the use of resin-based sealant to obliterate occlusal fissures arrested the progression of non-cavitated occlusal carious lesions in dentin.CONCLUSION: Occlusal fissure sealing with a resin-based sealant may arrest the progression of non-cavitated occlusal dentinal caries.Further clinical trials with longer follow-up times should be performed to increase scientific evidence. | Isauremi Vieira de Assun??o Giovanna de Fátima Alves da Costa Boniek Castillo Dutra Borges | 2014 | World Journal of Clinical Cases2014，2，5： | 3 |
| 3 | Global kinetic evaluation during the reduction of C0WO4with methane for the production of hydrogen显示文摘 | De Los Rios Castillo T Salinas G J Lopez O A | 2013 | International Journal of Hydrogen Energy2013，38，12： | 1 |
| 4 | An improved method for cdgc detection based on interval type-2 fuzzy logic显示文摘 | MELIN P MENDOZA O CASTILLO O | 2010 | Expert Systems with Applications2010，37，12： | 1 |
| 5 | Beneficial Action of Citrus Flavonoids on Multiple Cancer- Related Biological Pathways显示文摘 | Ortuno A Benavente-Garcia O Castillo J | 2007 | Current Cancer Drug Targets2007，7，8： | 1 |
| 6 | Usefulness of free prostate specific antigen in the detection of prostate cancer显示文摘 | Axocar G Castillo O Van-Caawelacrt R | 1999 | Reu Med Chil1999，127，2： | 1 |
| 7 | Laparoscopic resection of adrenal teratoma显示文摘 | CASTILLO O A VITAGLIANO G VILLETA M | 2006 | JSLS2006，10，： | 1 |
| 8 | Laparoscopic surgery in the treatment of adrenal pathology: experience with 200 cases显示文摘 | CASTILLO O CORTIS O KERKEBE M | 2006 | Actas Urol Esp2006，30，9： | 1 |
| 9 | Upper u rinary tract transitional cell carcinoma: current treatment op tions and minimally invasive approaches显示文摘 | Vidal Mora I Castillo O Velasco Palma A | 2009 | Arch Esp Urol2009，62，5： | 1 |
| 10 | Methylenetet- rahyd - Rofolate reductase polymorphism( 677C > T)predicts long time to pro - gression in metastic colon cancer treated with 5 - flu- orouracil and folinic acid 显示文摘 | Castillo - Fernandez O Santibaez M Bauza A | 2010 | Arch Med Res2010，41，6： | 1 |
| 11 | Path planning for autonomous mobile robot navigation with ant colony optimization and fuzzy cost function evaluation显示文摘 | GARCIA M A P MONTIEL O CASTILLO O | 2009 | Applied Soft Computing2009，9，3： | 1 |
| 12 | Predicting eoag-ulation and syneresis parameters of milk gels when inulin is added as fat substitute using infrared light backscatter 显示文摘 | ARANGO O TRUJILLO A J CASTILLO M | 2015 | Journal of Food Engineering2015，157，： | 1 |
| 13 | Effect of boron addition on the activity and selectivity of hydrotreating CoMo/Al2O3 catalysts显示文摘 | RAM REZ J CASTILLO P CEDE O L | 1995 | Appl Catal: A1995，132，2： | 1 |
| 14 | Uses and properties of Citrus flavonoids显示文摘 | Benavente-Garcia O Castillo J Marin FR | | 0，，12： | 1 |
| 15 | Synthesis,Crystal Structrue and Magnetic Properties of a one-dimensional Polymeric Copper(II)Complex Containing an Unusual 1,1'-Bieoordinatrd OxalatoBridge显示文摘 | Castillo O Luque A Sertucha S | | 0，，06： | 1 |
| 16 | Intelligent control of an autonomous mobile robot using Type - 2 fuzzy logic 显示文摘 | ASTUDILLO L CASTILLO O MELIN P | 2006 | Engineering Letters2006，13，2： | 1 |
| 17 | Fuzzy granular gravitational clustering algorithm for multivariate data显示文摘 | SANCHEZ M A CASTILLO O CASTRO J R | 2014 | Information Sci- ences2014，279，2： | 1 |
| 18 | Crystallization kinetics and morphology of biodegrad- able of double crystalline PLLA-b-PCL Diblock Co- polymers显示文摘 | CASTILLO R V O MULLER A J RAQUEZ J M | 2010 | Macromolecules2010，43，： | 1 |
| 19 | Complications in laparoscopic nephrectomy显示文摘 | Castillo O Bejarano C Cortes O | 2006 | Actas Urol Esp2006，30，： | 1 |
| 20 | Path planning for autonomous mobile robot navigation with ant colony optimization and fuzzy cost function evaluation显示文摘 | M A P Garcia O Montiel O Castillo | 2009 | Applied Soft Computing2009，9，6： | 1 |
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