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| 1 | 膝关节骨关节炎治疗新进展显示文摘 | Prade,RF 李海峰 | 2000 | 美国医学会杂志(中文版)2000，19，2： | 63 |
| 2 | Spetzler-Martin IV~V级脑动静脉畸形的治疗选择分析显示文摘 | Han PP Ponce FA Spetzler RF 李林 | 2003 | 中国微侵袭神经外科杂志2003，8，4： | 57 |
| 3 | 中国成人硒需要量研究显示文摘目的探讨使人体血浆硒蛋白P(SEPP1)达到饱和的硒摄入量,以评估硒需要量,为膳食硒参考摄入量DRIs的修订提供参考。方法对98名低硒健康受试者(体重平均58kg)进行为期40w的双盲补硒实验。随机分为七组,补硒(以硒蛋氨酸形式)剂量分别为0、21、35、55、79、102和125μg/d。定期检测血浆中谷胱甘肽过氧化物酶(GPX3)活性、SEPP1含量和硒含量等硒状态功能指标。选择剂量响应曲线的饱和平台起始点的相应摄入量作为该指标的需要量。结果在实验40w时,使血浆SEPP1含量达到饱和的硒摄入量为49μg/d;使血浆GPX3活性达到饱和的硒摄入量为35μg/d;血浆硒不能达到饱和平台,故不能用来作为评价硒需要量的指标。结论就当前人体实验而言,血浆SEPP1含量是反映硒营养状态和测定硒需要量的最佳指标。所以,满足SEPP1合成的硒摄入量49μg/d,经体重和个体变异等因素适当调节后,可作为人体硒需要量和修订膳食硒参考摄入量DRIs的参考。 | 夏弈明 KE Hill 李平 徐家沅 周定友 RF Burk | 2011 | 营养学报2011，33，2： | 25 |
| 4 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 5 | Interleukin-1α, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer显示文摘Vascular endothelial growth factor (VEGF, namely VEGF-A) is an angiogenic polypeptide and VEGF-C is a lymphangiogenic polypeptide that has been implicated in cancer growth, invasion and metastasis. Several cytokines and growth factors play an important part in cancer progression. These cytokines and growth factors are the principal mediators of cancer cells-stromal cell interaction , which is critical for invasion of cancer cells to the surrounding tissues and metastatic dissemination to distant organs. In this study, we studied VEGF-A, C expression in cultured human pancreatic cancer cell lines and whether the presence of VEGF-A, C in the cell lines is regulated by cytokines interleukin-lct (EL-1α), and interleukin-6 (IL-6). METHODS: We used Northern blot and Western blot methods to analyze expression of the gene and protein of VEGF-A, C in all 6 tested cell lines (ASPC-1, CAPAN-1, MIA-PaCa-2, PANC-1, COLO-357 and T3M4) respectively. To analyze what is the regulator for this VEGF-A, C expression in pancreatic cancer,we used the reverse transcription -polymerase chain reaction (RT-PCR) method to analyze VEGF-A, C expression in cultured human pancreatic cancer cell lines (CAPAN-1 and COLO-357) under the stimulation with IL-1α (10μg/L) or IL-6 (100 μg/L). RESULTS:Northern blot analysis revealed the presence of the 4.1-kb VEGF-A mRNA transcript and 2.4-kb VEGF-C mRNA transcript in all 6 tested cell lines. Immunoblotting with highly specific anti-VEGF-A, anti-VEGF-C antibody revealed the presence of a molecular weight of 43-kDa VEGF-A protein and 55-kDa VEGF-C protein in all the cell lines. RT-PCR analysis revealed the levels of the VEGF-A and VEGF-C gene were 1-2 fold and a 1-fold increase in the COLO-357 cell line by stimulation with IL-la, however, no effect was found in the CAPAN-1 cell line. The levels of the VEGF-A and VEGF-C gene were 2-5 fold and a 1-fold increase in the CAPAN-1 cell line by stimulation with IL-6, but, no effect was found in the COLO-357 cell line. CONCLUSION:These findings suggested that the expression of VEGF-A, C and their regulation by IL-1α, IL-6 in pancreatic cancer contributes to the lymphatic and distant metastasis and the disease progression. | Department of Hepatobiliary Surgery (Tang RF, Zhang FR, Peng L, Wang SX, Xiao Y and Zhang M) and Department of Dermatology (Wang SX), 4th Hospital, Hebei Medical University, Shijiazhuang 050011, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 6 |
| 6 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 7 | 终末期肾病患者大血管和微血管内皮功能障碍与亚临床心功能不全的关系显示文摘终末期肾病(end-stagerenaldisease,ESRD)患者的心脏衰竭和心血管病死亡率较高,而我们对此缺乏深入透彻的了解,是否存在可变因素导致了这些高危患者发生心功能不全。为了评估血管内皮功能能否作为ESRD患者潜在的心功能不全的可变因素,研究人员应用横断面研究在一个控制良好的ESRD队列中,分析大血管和微血管功能障碍与左、右心功能不全的相关性。 | 刘莉 叶鹏 Dubin RF Guajardo I Ayer A Mills C Donovan C Beussink L Scherzer R Ganz P Shah SJ | 2016 | 中华高血压杂志2016，24，9： | 5 |
| 8 | MRI of pituitary abscess: two cases and review of the literature 显示文摘 | Wolansky LJ Gallagher JD Heary RF | 1997 | Neuroradiology1997，39，7： | 3 |
| 9 | Elastic constants of the human lens capsule 显示文摘 | Fisher RF | 1969 | J physiol1969，201，： | 2 |
| 10 | Role of CD4+ and CD8+ in murine contact sensitivity revealed by in vivo monoclonal antibody depletion显示文摘 | Gocioski BL Tigerlaar RF | 1990 | J Immunol1990，144，5： | 2 |
| 11 | 现代管理策略降低儿童、青少年和年轻成人肥厚型心肌病患者心血管病死亡率显示文摘青年时期一直被认为是肥厚型心肌病(hypertrophic cardiomyopathy,HCM)发生风险最高的时间,尤其是猝死风险。过去的20年间发现了许多可靠的识别高危患者的指标,并利用植入式心脏除颤器(implantable cardiac defibrillator,ICD)预防猝死,同时也产生了当前其他的治疗方案。 | 刘莉 叶鹏 Maron BJ Rowin EJ Casey SA Lesser JR Garberich RF McGriff DM Maron MS | 2015 | 中华高血压杂志2015，23，10： | 2 |
| 12 | The postnatal growth of the capsule in the human crystalline lens显示文摘 | Fisher RF Pettet B | 1972 | J Anat1972，112，： | 2 |
| 13 | Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer显示文摘 | Tang RF Itakura J Aikawa T | | 0，，： | 2 |
| 14 | Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer显示文摘 | Tang RF Itakura J Aikawa T | 2001 | Pancreas2001，22，3： | 2 |
| 15 | Idiopathic polypoidal choroidal vasculopathy (IPCV)显示文摘 | Yannuzzi LA Sorenson J Spaide RF | | 0，，： | 2 |
| 16 | Noninvasive detection of Helicobacterpylori infection in clinical practice: 13 C-urea breath tests显示文摘 | Klein PD Malaty HM Martin RF | 1996 | Am J Gastroenterol1996，91，： | 2 |
| 17 | Activity of thalidomide in AIDS-related Kaposi's sarcoma显示文摘 | Little RF Wyvill KM Pluda JM | | 0，，： | 2 |
| 18 | 白质内的神经递质信号显示文摘脑白质是由许多有髓鞘的轴突组成,白质和灰质共同组成中枢神经系统,白质是中枢神经系统内信息快速传递的基础。有髓神经通路主要是由少突胶质细胞、星形胶质细胞及少量的小胶质细胞和少突胶质前体细胞构成。大部分白质内的神经递质信号主要存在于神经细胞胞体外,这提示这些神经递质除了具有完成神经元与神经元之间信息传递的功能外,还有其他生理功能。白质中的神经递质信号种类很多,已经证实的有谷氨酸能、嘌呤能(ATP和腺苷)、GABA能、甘氨酸能、肾上腺素能、胆碱能、多巴胺能、血清素能等信号递质,通过与各种离子型或代谢型受体结合发挥作用。轴突和胶质细胞都可以释放神经递质,也可以表达相应的受体。白质内神经递质信号的生理功能还需进一步研究,但研究已经证实谷氨酸和ATP介导的信号可激活胶质细胞上的钙离子通道,并调节轴突的传导功能。某项研究显示,在动作电位传播的过程中,轴突释放神经递质并与胶质细胞上的受体结合,通过少突胶质细胞来调节星形胶质细胞的稳态和髓鞘形成。星形胶质细胞也释放神经递质,与轴突上的受体相结合,增强动作电位的传播,维持信号电位沿长的轴突传播。白质内神经递质种类的多样性,提示它们有多种功能,对信号的传递有重要作用。白质内的神经递质信号现象很有可能也存在于大脑皮质和灰质,在这些部位的神经递质对于大脑的高级认知功能有更重要的作用。 | Butt AM Fern RF Matute C 唐颖馨 | 2014 | 神经损伤与功能重建2014，9，6： | 2 |
| 19 | Optical dating of single and multiple grains of quartz from Jinmium rock shelter,northern Australia: Part Ⅰ, Experimental design and statistical models 显示文摘 | Galbraith RF Roberts RG Laslett GM | 1999 | Archaeometry1999，41，： | 2 |
| 20 | Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes显示文摘 | Li GR Yang B Feng J Bosch RF Carrier M Nattel S | 1999 | Am J Physiol1999，276，12： | 2 |
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