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| 1 | Potential pathophysiological role for the vitamin D deficiency in essential hypertension显示文摘Vitamin D deficiency has been indicated as a pandemicemerging public health problem. In addition to the well-known role on calcium-phosphorus homeostasis in thebone, vitamin D-mediated processes have been recentlyinvestigated on other diseases, such as infections, can-cer and cardiovascular diseases. Recently, both the dis-covery of paracrine actions of vitamin D(recognized as'local vitamin D system') and the link of vitamin D with renin-angiotensin-aldosterone system and the fibroblast growth factor 23/klotho pathways highlighted its ac-tive cardiovascular activity. Focusing on hypertension, this review summarizes the more recent experimental evidence involving the vitamin D system and deficiency in the cardiovascular pathophysiology. In particular, we updated the vascular synthesis/catabolism of vitamin D and its complex interactions between the various endocrine networks involved in the regulation of blood pressure in humans. On the other hand, the conflicting results emerged from the comparison between obser-vational and interventional studies emphasize the frag-mentary nature of our knowledge in the field of vitamin D and hypertension, strongly suggesting the need of further researches in this field. | Federico Carbone Fran?ois Mach Nicolas Vuilleumier Fabrizio Montecucco | 2014 | World Journal of Cardiology2014，6，5： | 17 |
| 2 | A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers显示文摘Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. | Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，46： | 14 |
| 3 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 4 | Analysis of a Peaked Carbon Emission Pathway in China Toward Carbon Neutrality显示文摘1.Introduction Climate change is currently the most significant untraditional challenge to human development.Most countries have reached an agreement to reduce their carbon emissions to address this challenge[1,2].As the world’s second largest economy,largest energy consumer,and largest carbon dioxide emitter,China plays an important and constructive role in global climate governance[3].Thus far,carbon dioxide emissions(referred to herein as“carbon emissions”)have peaked in over 50 countries,including the United States,whose carbon emissions peaked in 2007. | Project Team on the Strategy and Pathway for Peaked Carbon Emissions and Carbon Neutrality | 2021 | Engineering2021，7，12： | 9 |
| 5 | CUBE, a Cable-driven Device for Limb Rehabilitation显示文摘In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises. | Daniele Cafolla Matteo Russo Giuseppe Carbone | 2019 | Journal of Bionic Engineering2019，16，3： | 6 |
| 6 | Investigation of tribological performances of MCMB显示文摘Tribological properties of Meso-carbon Microbeads (MCMB) powders as a special addi-tive in pentaerythritol were investigated on an Optimal SRV tribotester at 300℃. The coarsely dis-persed lubricant system demonstrates fine lubricious effectiveness at the operation temperature.The friction coefficient dropped from 0.2 to circa 0.12 in the presence of MCMB in pentaerythritolfor the No.45 carbon steel tribomate. Raman spectroscopy analysis indicated the partial transfor-mation of MCMB into increased ordered structures that contributed to the lowering of friction. | CUI Xiaohao LI Shenghua SONG Huaihe JIN Yuansheng FU Honglan 1. National Tribology Laboratory, Tsinghua University, Beijing 100084, China 2. Institute of Carbon Fibers & Composites, Beijing University of Chemical Technology, Beijing 100029, China 3. Department of Biology, Peking University, Beijing 100871, China | 2001 | Science China Mathematics2001，44，S1： | 6 |
| 7 | Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: long-term outcomes显示文摘学习的目的是评估骨盆的地板肌肉(PFM ) 的长期的结果在有终生的早泄(PE ) 的男性的康复,用 intravaginal 射精的潜伏时间(IELT ) 和自我报告早泄诊断工具(PEDT ) 同样主要的结果。154 个参加者的一个总数回顾地在这研究被考察,与 122 完成训练协议。在基线,所有参加者有一个 IELT 60 s 和 PEDT 分数 > 11。参加者完成了 PFM 康复的一个 12 星期的节目,包括 physio-kinesiotherapy 处理, electrostimulation,和生物反馈,与每星期的三个会议,与为在每个会议完成的每个部件的 20 min。干预的有效性被在 IELT 和 PEDT 价值的几何平均数比较变化评估,从基线,在在干预期间的 3 , 6 ,和 12 个月,并且在 24 和 36 月 postintervention ,用配对的样品2尾巴t测试,包括联系了95%信心间隔。 122 个参加者完成了 PFM 康复, 111 获得了他们的射精反射的控制与 161.6 s 的吝啬的 IELT 和在干预的12星期的端点的 2.3 的 PEDT 分数,分别地,从 40.4 s 和 17.0 个分数的基线代表增加为 IELT 和 PEDT ( P < 0.0001 )。95 个参加者完成了 36 月的后续,在 24 和 36 月 postintervention 的 64% 和 56% 维持的令人满意的射精控制分别地。 | Antonio Luigi Pastore Giovanni Palleschi Andrea Fuschi Yazan AI Salhi Alessandro Zucchi Giorgio Bozzini Ester Illiano Elisabetta Costantini Antonio Carbone | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 8 | Magnetic resonance imaging after anterior cruciate ligament reconstruction:A practical guide显示文摘Anterior cruciate ligament(ACL) reconstruction is one of the most common orthopedic procedures performed worldwide. In this regard, magnetic resonance imaging(MRI) represents a useful pre-operative tool to confirm a disruption of the ACL and to assess for potential associated injuries. However, MRI is also valuable postoperatively, as it is able to identify, in a non-invasive way, a number of aspects and situations that could suggest potential problems to clinicians. Graft signal and integrity, correct tunnel placement, tunnel widening, and problems with fixation devices or the donor site could all compromise the surgical outcomes and potentially predict the failure of the ACL reconstruction. Furthermore, several anatomical features of the knee could be associated to worst outcomes or higher risk of failure. This review provides a practical guide for the clinician to evaluate the post-surgical ACL through MRI, and to analyze all the parameters and features directly or indirectly related to ACL reconstruction, in order to assess for normal or pathologic conditions. | Alberto Grassi James R Bailey Cecilia Signorelli Giuseppe Carbone Andy Tchonang Wakam Gian Andrea Lucidi Stefano Zaffagnini | 2016 | World Journal of Orthopedics2016，7，10： | 4 |
| 9 | BRCA相关蛋白1在恶性间皮瘤中的表达缺失及其在鉴别诊断中的应用价值显示文摘目的探讨BRCA相关蛋白1(BRCA assoeiated protein1,BAP1)在恶性间皮瘤、肺腺癌、肺鳞癌和癌肉瘤中表达情况及其在鉴别诊断中的作用。方法选取恶性间皮瘤22例,其中上皮样型17例,肉瘤样型2例,双相型3例。另选取侵犯胸膜的非小细胞肺癌共80例(肺腺癌40例、肺鳞癌40例)和全身各部位癌肉瘤15例作为对照。应用免疫组织化学方法检测BAP1在各组病例的表达情况,并分析各组表达差异。同时所有病例均检测了常规用于间皮瘤鉴别诊断的抗体组合,包括calretinin、wTl、细胞角蛋白5/6、D2.40、CAM5.2、癌胚抗原、甲状腺转录因子1、Napsin A、p63和p40。结果所有80例非小细胞肺癌和15例癌肉瘤均BAP1核表达阳性,而64%(14/22)恶性间皮瘤出现BAP1表达缺失,两者差异有统计学意义(P〈0.01)。间皮瘤诊断标志物组合中,增加BAP1后,诊断恶性间皮瘤的诊断正确度达93%。BAP1灶性表达表明肿瘤细胞具有多克隆性。结论BAP1核表达缺失有助于鉴别恶性间皮瘤和非小细胞肺癌。因此推荐BAP1与其他间皮瘤抗体一起应用于恶性间皮瘤的诊断,提高恶性间皮瘤的诊断准确性。 | 郭振英 孙文勇 Michele Carbone 张谷 胡锦林 苏丹 杨海宁 毛伟敏 | 2017 | 中华病理学杂志2017，46，10： | 4 |
| 10 | Microstructure of fibrils separated from polyacrylonitrile fibers by ultrasonic etching显示文摘Polyacrylonitrile (PAN) fiber is an important precursor fiber for high performance carbon fiber.The properties of the final carbon fiber depend strongly on the nature of the PAN fibers.The PAN fibrils were separated successfully from fibers by ultrasonic etching and were systematically investigated by field emission scanning electron microscopy (FESEM) and high resolution transmission electron microscopy (HRTEM).It is found that in certain ultrasonic etching conditions (at 75±2oC for 6 h with a frequency of 40 kHz) the PAN fibers are dissolved in the 95 wt.% aqueous dimethylsulphoxide (DMSO) solution;the fibrils consisting of numerous periodic lamellae with thickness of 30-45 nm and perpendicular to the fiber axis are separated in the 90 wt.% aqueous DMSO solution;and the fibrils with smooth surface exfoliated from the PAN fibers are obtained in the 70-90 wt.% aqueous DMSO solutions.Inner periodical structure of fibrils was observed in HRTEM,which indicates that there are different densities and two phases in fibrils.The PAN fibers are dissolved layer by layer with increasing ultrasonic etching time.The fiber surface experiences ultrasonic cleaning,selective etching,excessive etching and dissolution,and then the sublayer experiences the same process.There are numerous periodic lamellae in fibrils of nascent fibers.This means that the fibrils with lamellae are formed by orientation and crystallization in shearing field of spinning pipe and drawing stress field of coagulation bath. | WANG QiFen,WANG ChengGuo,YU MeiJie,MA Jie,HU XiuYing & ZHU Bo Carbon Fiber Engineering Research Center,Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education),Shandong University,Jinan 250061,China | 2010 | Science China(Technological Sciences)2010，53，6： | 3 |
| 11 | Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma:Case report with molecular analysis显示文摘Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma. | Marta Barisella Andrea Lampis Federica Perrone Antonino Carbone | 2008 | World Journal of Gastroenterology2008，14，42： | 3 |
| 12 | On the Optimal Design of Cable Driven Parallel Robot with a Prescribed Workspace for Upper Limb Rehabilitation Tasks显示文摘This paper deals with an optimization approach to design a cable driven parallel robot intended for upper limb rehabilitation tasks. The cable driven parallel robots have characteristics that make them best candidate for rehabilitation exercise purposes such as large workspace, re-configurable architecture, portability and cost effectiveness. Here, both the cable tensions that are needed to move a wristband as well as the workspace need to be carefully optimized for fulfilling the prescribed operation tasks. A specific case of study is addressed in this work by referring to LA RM wire driven exercising device (LAWEX), which is applied to upper limbs exercises. To that end, a motion capture system is used to collect quantitative data on the prescribed workspace of a human upper limb. A specific optimization problem is settled up for considering combining two optimization goals, namely, the smallest robot size reaching a prescribed workspace and the minimum cable tension distributions. A sequence of optimization steps is defined using Genetic Algorithms (GAs) applied to LAWEX robot. The proposed objective function is based on a mathematical formulation of the power of a point with respect to bounding surfaces in combination with a performance index to show the distributions of the minimum cable tensions. | Laribi Med Amine Carbone Giuseppe Zeghloul Said | 2019 | Journal of Bionic Engineering2019，16，3： | 3 |
| 13 | Cardiac damage in athlete's heart: When the “supernormal” heart fails!显示文摘Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias. Athlete's heart is a physiological condition and does not require a specific treatment. In some conditions, it is important to differentiate the physiological adaptations from pathological conditions, such as hypertrophic cardiomyopathy, arrhythmogenic dysplasia of the right ventricle, and non-compaction myocardium, for the greater risk of sudden cardiac death of these conditions. Moreover, some drugs and performance-enhancing drugs can cause structural alterations and arrhythmias, therefore, their use should be excluded. | Andreina Carbone Antonello D’Andrea Lucia Riegler Raffaella Scarafile Enrica Pezzullo Francesca Martone Raffaella America Biagio Liccardo Maurizio Galderisi Eduardo Bossone Raffaele Calabrò | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 14 | Videothoracoscopic management of the solitary pulmonary nodule: a single-institution study on 429 cases显示文摘 | Giuseppe Cardillo Mohamed Regal Francesco Sera Marco Di Martino Luigi Carbone Francesco Facciolo Massimo Martelli | 2003 | The Annals of Thoracic Surgery2003，，5： | 2 |
| 15 | Genetic structure and post-glacial expansion of Cornus florida L. (Cornaceae): integrative evidence from phyiogeography, population demographic history, and species distribution modeling显示文摘 | Ashley Call Yan-Xia Sun Yan Yu Peter B. Pearman David T. Thomas Robert N. Trigiano Ignazio Carbone Qiu-Yun (Jenny) Xiang | 2016 | Journal of Systematics and Evolution2016，54，2： | 2 |
| 16 | Design Considerations for an Underactuated Robotic Finger Mechanism显示文摘A design approach is presented in this paper for underactuation in robotic finger mechanisms. The characters of underactuated finger mechanisms are introduced as based on linkage and spring systems,The feature of self-adaptive enveloping grasp by underactuated finger mechanisms is discussed with feasible in grasping unknown objects. The design problem of robotic fingers is analyzed by looking at many aspects for an optimal functionality. Design problems and requirements for underactuated mechanisms are formulated as related to human-like robotic fingers. In particular,characteristics of finger mechanisms are analyzed and optimality criteria are summarized with the aim to formulate a general design algorithm. A general multi-objective optimization design approach is applied as based on a suitable optimization problem by using suitable expressions of optimality criteria. An example is illustrated as an improvement of finger mechanism in Laboratory of Robotics and Mechatronics (LARM) Hand. Results of design outputs and grasp simulations are reported with the aim to show the practical feasibility of the proposed concepts and computations. | YAO Shuangji CECCARELLI Marco ZHAN Qiang CARBONE Giuseppe LU Zhen | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 2 |
| 17 | Left atrial thrombosis in an anticoagulated patient after bioprosthetic valve replacement:Report of a case显示文摘We present the case of a 74 year old woman suffering from severe mitral valve incompetence and rapid atrial fibrillation. After an appropriate vitamin K antagonist(VKA) therapy, the patient underwent mitral valve replacement by bioprosthesis. Then, the patient was rehospitalized for jaundice. Suspecting hepatotoxicity, VKA was discontinued and fondaparinux was started. During this treatment, the patient developed a symptomatic atrial thrombus. After exclusion of a hepatic disease, VKA was re-established with hemodynamic and liver enzymes normalization and atrial thrombus resolution. Caution has to be used when considering fondaparinux as an alternative strategy to VKA in patients with multiple thrombotic risk factors. | Gian Marco Rosa Antonello Parodi Ulrico Dorighi Federico Carbone Franois Mach Alessandra Quercioli Fabrizio Montecucco Nicolas Vuilleumier Manrico Balbi Claudio Brunelli | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 18 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 19 | Current controversies and future perspectives on treatment of intensive care unit delirium in adults显示文摘Delirium is the most frequent manifestation of acute brain dysfunction in intensive care unit(ICU).Although antipsychotics are widely used to treat this serious complication,recent evidence has emphasized that these agents did not reduce ICU delirium(ICU-D)prevalence and did not improve survival,length of ICU or hospital stay after its occurrence.Of note,no pharmacological strategy to prevent or treat delirium has been identified,so far.In this scenario,new scientific evidences are urgently needed.Investigations on specific ICU-D subgroups,or focused on different clinical settings,and studies on medications other than antipsychotics,such as dexmedetomidine or melatonin,may represent interesting fields of research.In the meantime,because there is some evidence that ICU-D can be effectively prevented,the literature suggests strengthening all the strategies aimed at prevention through no-pharmacological approaches mostly focused on the correction of risk factors.The more appropriate strategy useful to treat established delirium remains the use of antipsychotics managed by choosing the right doses after a careful case-by-case analysis.While the evidence regarding the use of dexmedetomidine is still conflicting and sparse,this drug offers interesting perspectives for both ICU-D prevention and treatment.This paper aims to provide an overview of current pharmacological approaches of evidence-based medicine practice.The state of the art of the on-going clinical research on the topic and perspectives for future research are also addressed. | Marco Cascella Marco Fiore Sebastiano Leone Domenico Carbone Raffaela Di Napoli | 2019 | World Journal of Critical Care Medicine2019，8，3： | 2 |
| 20 | Growth and relational strategies used by the European logistics service providers: Rationale and outcomes显示文摘 | Valentina Carbone Marilyn A. Stone | 2005 | Transportation Research Part E2005，，6： | 2 |
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