|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic显示文摘Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD. | Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader | 2014 | World Journal of Gastroenterology2014，20，34： | 36 |
| 2 | Proton pump inhibitor-associated pneumonia:Not a breath of fresh air after all?显示文摘Over the past two decades,proton pump inhibitors (PPIs)have emerged as highly effective and relatively safe agents for the treatment of a variety of gastrointestinal disorders.Unfortunately,this desirable pharmacological profile has also contributed to superfluous and widespread use in both the inpatient and outpatient settings.While generally well-tolerated,research published over the last decade has associated these agents with increased risks of Clostridium difficile disease, fractures likely due to calcium malabsorption and both community-acquired(CAP)and hospital-acquired pneumonias(HAP).The mechanism behind PPI-associated pneumonia may be multifactorial,but is thought to stem from compromising the stomach's'acid mantle'against gastric colonization of acid-labile pathogenic bacteria which then may be aspirated.A secondary postulate is that PPIs,through their inhibition of extra-gastric H+/K+ATPase enzymes,may reduce the acidity of the upper aerodigestive tract,thus resulting in increased bacterial colonization of the larynx,esophagus and lungs.To date,several retrospective case control studies have been published looking at the association between PPI use and CAP.Some studies found a temporal relationship between PPI exposure and the incidence of pneumonia,but only two could define a dose-response re-lationship.Furthermore,other studies found an inverse correlation between duration of PPI use and risk of CAP. In terms of HAP,we reviewed two retrospective cohort studies and one prospective study.One retrospective study in a medical ICU found no increased association of HAP in PPI-exposed patients compared to no acid-lowering therapy,while the other in cardiothoracic surgery patients showed a markedly increased risk compared to those receiving H2RAs.The one prospective study in ICU patients showed an increased risk of HAP with PPIs, but not with H2RAs.In conclusion,the current literature shows a slight trend toward an association between PPI use and pneumonia and an increased risk with PPIs over H2RAs,but the findings are not consistent across all studies.Larger controlled trials still need to be done to better identify the risk that PPIs impart towards patients contracting CAP or HAP.Until these are completed, we will have to continue to extrapolate across smaller controlled trials to predict the associated risks in our respective patient populations.In the interim,it appears prudent to limit the use of PPIs to situations where they are clinically indicated and,in such cases,use them at the lowest effective dose.In the case of prescribing for stress ulcer prophylaxis in ICU patients,perhaps H2RAs should be used as the preferred agents over PPIs. | Alexander L Fohl Randolph E Regal | 2011 | World Journal of Gastrointestinal Pharmacology and Therapeutics2011，2，3： | 12 |
| 3 | Videothoracoscopic management of the solitary pulmonary nodule: a single-institution study on 429 cases显示文摘 | Giuseppe Cardillo Mohamed Regal Francesco Sera Marco Di Martino Luigi Carbone Francesco Facciolo Massimo Martelli | 2003 | The Annals of Thoracic Surgery2003，，5： | 2 |
| 4 | Cockcroft-gault revisited: New de-liver-ance on recommendations for use in cirrhosis显示文摘The Cockcroft-Gault(CG) equation has become perhaps the most popular practical approach for estimating renal function among health care professionals. Despite its widespread use, clinicians often overlook not only the limitations of the original serum creatinine(SCr) based equation, but also may not appreciate the validity of the many variations used to compensate for these limitations. For cirrhotic patients in particular, the underlying pathophysiology of the disease contributes to a falsely low SCr, thereby overestimating renal function with use of the CG equation in this population. We reviewed the original CG trial from 1976 along with data surrounding clinician specific alterations to the CG equation that followed through time. These alterations included different formulas for body weight in obese patients and the 'rounding up' approach in patients with low SCr. Additionally, we described the pathophysiology and hemodynamic changes that occur in cirrhosis; and reviewed several studies that attempted to estimate renal function in this population. The evidence we reviewed regarding the most accurate manipulation of the original CG equation to estimate creatinine clearance(Cr Cl) was inconclusive. Unfortunately, the homogeneity of the patient population in the original CG trial limited its external validity. Elimination of body weight in the CG equation actually produced the estimate closest to the measure Cr Cl. Furthermore, 'rounding up' of SCr values often underestimated Cr Cl. This approach could lead to suboptimal dosing of drug therapies in patients with low SCr. In cirrhotic patients, utilization of SCr based methods overestimated true renal function by about 50% in the literature we reviewed. | Gianni B Scappaticci Randolph E Regal | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 5 | Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis显示文摘 | Li BS Regal J Soher BJ | 2003 | AJNR2003，24，： | 1 |
| 6 | Recurrences following videothoracoscopic treatment of primary spontaneous pneumothorax:the role of redo-videothoracoscopy显示文摘 | FACCIOLO F REGAL M | 2001 | Eur J Cardiothorac Surg2001，19，： | 1 |
| 7 | Creation of Ultracold Molecules from a Fermi Gas of Atoms 显示文摘 | REGAL C A TICKNOR C BOHN J L | 2003 | Nature2003，424，： | 1 |
| 8 | Recurrences following videothoracoscopic treatment of primary spontaneous pneumothorax : the role of redo-videothoracoscopy 显示文摘 | Cardillo G Facciolo F Regal M | 2001 | Eur J Cardiothorac Surg2001，19，4： | 1 |
| 9 | The frequency of 47, q-21, 47, 18, and 47, q-13 at the uppermost extremes of maternal ages: results of 56094 fetuses studied prenatally and comparisons with data on liveborns显示文摘 | Hook EB Cross PK Regal RR | 1984 | Hum Genet1984，68，： | 1 |
| 10 | Simultaneous determination of sulfonamides, penicillins and coccidiostats in pork by high-per- formance liquid chromatography - tandem mass spectrometry 显示文摘 | Nebot C Regal P Miranda J | 2012 | Journal of chromatographic science2012，50，5： | 1 |
| 11 | Determination of the hormonal growth promoter 17α-methyltestosterone in food-producing animals: Bovine hair analysis by HPLC–MS/MS显示文摘 | P. Regal C. Nebot B.I. Vázquez A. Cepeda C.A. Fente | 2009 | Meat Science2009，，1： | 1 |
| 12 | Dual target:ng of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer显示文摘 | Regales L Gong Y Shen R | 2009 | J Clin Invest2009，119，10： | 1 |
| 13 | Indications for dual anti- platelet therapy with aspirin and elopidogrel: evidence-based rec- ommendations for use 显示文摘 | Reaume KT Regal RE Dorsch MP | 2008 | Ann Pharmacother2008，42，4： | 1 |
| 14 | Indications for dual anti- platelet therapy with aspirin and clopidogrel:evidence-based recommendations for use显示文摘 | Reaume KT Regal RE Dorsch MP | 2008 | Ann Pharmacother2008，42，4： | 1 |
| 15 | Video thoracoscopic management of the solitary pulmonary nodule: a single-institution study on 429 cases 显示文摘 | Cardillo G Regal M Sera F | 2003 | Ann Thorae Surg2003，75，： | 1 |
| 16 | Vide- othoracoscopic management of the soli- tary pulmonary nodule:a singleinstitution study on 429 cases显示文摘 | Cardillo G Regal M Sera F | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 17 | Emergence of a Molecular Bose-Einstein Condensate from a Fermi gas显示文摘 | GREINER M REGAL C A JIN D S | 2003 | Nature2003，426，： | 1 |
| 18 | Emergence of a molecular Bose-Einstein condensate from a Fermi gas显示文摘 | GREINER M REGAL C A JIN D S | 2003 | Nature London2003，426，： | 1 |
| 19 | Videothoracoscopic management of the solitary pulmonary nodule : a single-institution study on 429 cases显示文摘 | Cardillo G Regal M Sera F | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 20 | Recurrences following videothoracoscopic treatment of primary spontaneous pneumothorax:the role of redo-videothoracoscopy显示文摘 | CARDILLO G FACCIOLO F REGAL M | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员