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| 1 | Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas显示文摘In this review we focus on lymphoepitheliomalike hepatocellular carcinomas(LEL-HCC) and lymphoepithelioma-like cholangiocarcinomas(LEL-ICC). Despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune systemand neoplastic cells. Approximately half of LELHCC arise in the context of chronic hepatitis C virus(HCV) infection and have been described both in Eastern and Western patients. By contrast, LEL-ICC is associated in almost all cases with Epstein-Barr virus(EBV) infection and exhibits the same epidemiological features of EBV related malignancies. Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both LEL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival. How this behavior is related to distinct genetic alterations and tumor microenvironment is unclear. The pathophysiological mechanisms of lymphoid infiltrations seem to be different among the two groups of tumors. In fact, LEL-HCC frequently arises in the context of inflammatory changes driven by HCV infection, and has been recognized as a variant of classical hepatocellular carcinoma. At variance, lymphocyte recruitment of LEL-ICC is similar to that described in nasopharyngeal carcinoma and gastric LEL, and possibly depends on the expression pattern of latent EBV infection. | Antonio Solinas Diego F Calvisi | 2015 | World Journal of Gastroenterology2015，21，12： | 9 |
| 2 | Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC显示文摘 | Diego F. Calvisi Sara Ladu Alexis Gorden Miriam Farina Elizabeth A. Conner Ju–Seog Lee Valentina M. Factor Snorri S. Thorgeirsson | 2006 | Gastroenterology2006，，4： | 3 |
| 3 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 4 | Mechanistic and prognostic significance of aherrant methylation in the molecular pathogenesis of hmnan hepatocellular earcinoma 显示文摘 | Calvisi DF Ladu S Gorden A | 2007 | J Clin Invest2007，117，9： | 1 |
| 5 | Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis显示文摘 | Rosa M. Pascale Maria M. Simile Maria R. De Miglio Maria R. Muroni Diego F. Calvisi Giuseppina Asara Daniela Casabona Maddalena Frau Maria A. Seddaiu Francesco Feo | 2002 | Hepatology2002，，6： | 1 |
| 6 | Activation oil v-Myb a- vian myeloblastosis viral oncogene homolog-like2 (MYBL2)- LIN9 complex contributes to human hepatoearcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53显示文摘 | Calvisi DF Simile MM Ladu S | 2011 | Hepatology2011，53，4： | 1 |
| 7 | Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis 显示文摘 | Calvisi DF Simile MM Ladu S | 2007 | lnt J Cancer2007，121，11： | 1 |
| 8 | Ubiquitous activation of Ras and Jak/Stat pathways in human HCC 显示文摘 | Calvisi DF Ladu S Gorden A | 2006 | Gastroenterology2006，130，4： | 1 |
| 9 | Forkhead box M1B is a determi- nant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 显示文摘 | Calvisi DF Pinna F Ladu S | 2009 | Gut2009，58，5： | 1 |
| 10 | Ubiquitous activation of Ras and Jak/Stat pathways in human HCC显示文摘 | Calvisi D F Ladu S Gorden A | 2006 | Gastroenterology2006，130，4： | 1 |
| 11 | Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital显示文摘 | Calvisi DF Ladu S Factor VM | 2004 | Carcinogenesis2004，25，6： | 1 |
| 12 | Reversal of liver fibrosis in arylhydrocarbon receptor null mice by dietary vitamin A depletion显示文摘 | CALVISI DF ELIZONDO G | 2004 | Hepatology2004，39，1： | 1 |
| 13 | Effects of anterior cruciate ligament injury on postural control and muscle activity of head,neck and trunk muscles显示文摘 | Tecco S Salini V Calvisi V | 2006 | J Oral Rehabil2006，33，8： | 1 |
| 14 | Thymoma viral oneogene homolog/mammalian target of rapamycin activation induces a mod- ule of metabolic changes contributing to growth in insulin - induced hepatocarcinogenesis显示文摘 | Evert M Calvisi DF Evert K | 2012 | Hepatology2012，55，5： | 1 |
| 15 | Arthroscopic all-inside suture of symptomatic Baker's cysts: a technical option for surgical treatment in adults 显示文摘 | Calvisi V Lupparelli S Giuliani P | 2007 | Knee Surg Sports Tra2007，15，： | 1 |
| 16 | Forkhead box M1B is a determi- nant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 显示文摘 | Calvisi DF Pinna F Ladu S | 2009 | Gut2009，55，5： | 1 |
| 17 | Ubiquitous activation of Ras and Jak/Stat pathways in human HCC 显示文摘 | Calvisi D F Ladu S Gorden A | 2006 | Gastroenterology2006，130，4： | 1 |
| 18 | Dual-specificity phosphatase-1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocelular carcinoma显示文摘 | CALVISI D F PINNA F MELONI F | 2008 | Cancer Res2008，68，11： | 1 |
| 19 | Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice 显示文摘 | Novoselov SV Calvisi DF Labunskyy VM | 2005 | Oncogene2005，24，54： | 1 |
| 20 | Forkhead box M1B is a de- terminant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC 显示文摘 | Calvisi DF Pinna F Ladu S | 2009 | Gut2009，58，： | 1 |
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