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| 1 | Neoadjuvant-intensified treatment for rectal cancer:Time to change?显示文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control. | Daniela Musio Francesca De Felice Nadia Bulzonetti Roberta Guarnaccia Rossella Caiazzo Caterina Bangrazi Nicola Raffetto Vincenzo Tombolini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 2 | A Novel Gaussian Extrapolation Approach for 2D Gel Electrophoresis Saturated Protein Spots显示文摘Analysis of images obtained from two-dimensional gel electrophoresis (2D-GE) is a topic of utmost importance in bioinformatics research, since commercial and academic software available currently has proven to be neither completely effective nor fully automatic, often requiring manual revision and refinement of computer generated matches. In this work, we present an effective technique for the detection and the reconstruction of over-saturated protein spots. Firstly, the algorithm reveals overexposed areas, where spots may be truncated, and plateau regions caused by smeared and overlapping spots. Next, it reconstructs the correct distribution of pixel values in these overexposed areas and plateau regions, using a two-dimensional least-squares fitting based on a generalized Gaussian distribution. Pixel correction in saturated and smeared spots allows more accurate quantification, providing more reliable image analysis results. The method is validated for processing highly exposed 2D-GE images, comparing reconstructed spots with the corresponding non-saturated image, demonstrating that the algorithm enables correct spot quantification. | Massimo Natale Alfonso Caiazzo Enrico M. Bucci Elisa Ficarra | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 3 | Chemoradiation as definitive treatment for primary squamous cell cancer of the rectum显示文摘In this report,we present a case of advanced squamous cell cancer located in the rectum of a 78-year-old woman treated with chemoradiation with curative intent.The patient showed a complete clinical response to chemoradiation;multiple biopsies were performed at the site of the previous mass 5 mo after the end of treatment and histological examination showed no residual tumour in the specimens.Surgical intervention was avoided and the patient was free of disease 12 mo after the diagnosis of cancer.Primary chemoradiation should be considered as the treatment of choice for this rare malignancy. | Eva Iannacone Francesco Dionisi Daniela Musio Rossella Caiazzo Nicola Raffetto Enzo Banelli | 2010 | World Journal of Radiology2010，2，8： | 2 |
| 4 | An unusual case of fatty liver in a patient with desmoid tumor显示文摘A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis. | Francesca De Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini | 2012 | World Journal of Gastroenterology2012，18，24： | 2 |
| 5 | Interleukin-17A exacerbates ferric chloride-induced arterial thrombosis in rat carotid artery 显示文摘 | Maione F Parisi A Caiazzo E | 2014 | Int J Inflam2014，2014，24： | 1 |
| 6 | Introducing array comparative genomic hybridization into routine prenatal diagnosis practice: a prospective study on over 1000 consecutive clinical cases显示文摘 | Fiorentino F Caiazzo F Napolitano S | 2011 | Prenat Diagn2011，13，： | 1 |
| 7 | Chronic post-thyroidectomy pain:incidence,typology,and risk factors显示文摘 | Wattier JM Caiazzo R Andrieu G | 2016 | Anaesth Crit Care Pain M ed2016，35，3： | 1 |
| 8 | Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease显示文摘 | Philippe Mathurin Antoine Hollebecque Laurent Arnalsteen David Buob Emmanuelle Leteurtre Robert Caiazzo Marie Pigeyre Hélène Verkindt Sébastien Dharancy Alexandre Louvet Monique Romon Fran?ois Pattou | 2009 | Gastroenterology2009，，2： | 1 |
| 9 | Advantages of QBI in TBSS analyses显示文摘 | Corbo D Caiazzo G Trojsi F | 2014 | Magn Reson Imaging2014，32，： | 1 |
| 10 | Control of Rhi-zoctonia solani in a tobacco - float system using low rates of iprodione - and iprodione - resistant strains of Gliocla- dium roseum 显示文摘 | Tarantino P Caiazzo R Carella A | 2007 | Crop Protection2007，26，： | 1 |
| 11 | Manufac- turing of porous biomaterials for dental implant ap- plications through selective laser melting 显示文摘 | Cardaropoli F Alfieri V Caiazzo F | 2012 | Adv Mater Res2012，6，535537： | 1 |
| 12 | Bdnf gene is a down- stream target of Nurrl transcription factor in rat midbrain neurons in vitro 显示文摘 | Volpicelli F Caiazzo M Greco D | 2007 | J Neurochem2007，102，： | 1 |
| 13 | Distributed corpus callosum in- volvement in amyotrophic lateral sclerosis: a deterministic tractog- raphy study using q-ball imaging显示文摘 | Caiazzo G Corbo D Trojsi F | 2014 | J Neurol2014，261，： | 1 |
| 14 | Direct generation of functional dopaminergic neurons frommouse and human fibro- blasts 显示文摘 | Caiazzo M Dell'Anno MT Dvoretskova E | 2011 | Nature2011，476，7359： | 1 |
| 15 | An experimental investigation on seawater SO2 scrubbing for marine application显示文摘 | Caiazzo G Langella G Miccio F | 2013 | Environmental Progress & Sustainable Energy2013，32，4： | 1 |
| 16 | One-leg stand ing balance and functional status in an elderly communitydwelling population in northeast Italy显示文摘 | Drusini AG Eleazer GP Caiazzo M | 2002 | Aging Clin Exp Res2002，14，： | 1 |
| 17 | Seawater scrubbing desulfurization:A model for SO2 absorption in fall-down droplets显示文摘 | Caiazzo G di Nardo A Langella G | 2012 | Environmental Progress & Sustainable Energy2012，31，2： | 1 |
| 18 | Ti6Al4V sheets lap and butt joints carded out by CO2 laser: mechanical and morphological characterization显示文摘 | CAIAZZO F CURCIO F DARRELIO G MEMOLA C M F | 2004 | Journal of Materials Processing Technology2004，149，13： | 1 |
| 19 | Obstructing colon cancerwhat's the surgical strategy 显示文摘 | Caiazzo P Dipalma R Pesce O | 2004 | Ann Itak Chit2004，75，4： | 1 |
| 20 | Rhodium-cata- lyzed hydroformylation of 4-vinylpyridine: 4-ethylpyridine formation via an unusual cleavage of the Rh-C bond by the enolie form of the oxo product 显示文摘 | Lazzaroni R Settambolo R Caiazzo A | 2002 | Organometallics2002，21，： | 1 |
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