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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Changing Crohn’s disease management: Need for new goals and indices to prevent disability and improve quality of life显示文摘 | Daniel Hommes Jean-Frédéric Colombel Paul Emery Marco Greco William J. Sandborn | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 4 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 5 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 6 | Single-ineision laparoscopic ehole- cystectomy:surgery without a visible scar 显示文摘 | Tacchino R Greco F Matera D | 2009 | Surg Endosc2009，23，4： | 1 |
| 7 | Rough Set Approach to Multiple Criteria Classification with Imprecise Evaluations and Assignments显示文摘 | Krzysztof D Greco S Slowinski R | 2009 | European Journal of Operational Research2009，198，2： | 1 |
| 8 | Small cell carcinoma of the lung显示文摘 | Jonnson D H Greco F A | 1986 | Crit Rev Oncol Hematol1986，4，4： | 1 |
| 9 | Characterization of a zinc -De- pendent transcriptional activator from Arabidopsis 显示文摘 | PATER S D GRECO V PHAM K | 1996 | Nucleic Acids Re- sareh1996，24，23： | 1 |
| 10 | Is total eolectomy the right choice in intractable slow-transit constipation? 显示文摘 | Ripetti V Caputo D Greco S | 2006 | Surgery2006，140，3： | 1 |
| 11 | Extragonadal germ cell tumors and unrecognized germ cell tumors显示文摘 | Hainsworth S D Greco F A | 1992 | Semin Oncol1992，19，： | 1 |
| 12 | Ophthalmoplegia in diabetes meltitus : a retrospective study显示文摘 | Greco D Gambina F Ma~ io F | 2009 | Acta Diabeto12009，46，1： | 1 |
| 13 | Nitroglycerin induces hyperalgesia in rats a time-course study 显示文摘 | Tassorelli C Greco R Wang D | 2003 | Eur J Phar- macol2003，464，23： | 1 |
| 14 | Morphology properties relationships in binary polyamide 6/rubber blends: influence of the addition of a functionalized rubber 显示文摘 | Cimmino S D Orazio L Greco R | 1984 | Polymer Engineering and Science1984，24，1： | 1 |
| 15 | Gene expression analysis in SV-40 immortalized human corneal epithelial cells cultured with an air-liquid interface显示文摘 | Greco D Vellonen K S Turner H C | | 0，，： | 1 |
| 16 | Single-incision lavaroscopiccholecystomy:surgery wihout a visible scar显示文摘 | Tacchino R Greco F Matera D | 2009 | Surg Endosc2009，23，4： | 1 |
| 17 | Human papillomavirus 16 E5 mod-ulates the expression of host microRNAs显示文摘 | Greco D Kivi N Qian K | 2011 | PLoS One2011，6，21： | 1 |
| 18 | Plasticizer for poly(vinylchloride) from cardanol as a renewable resource material显示文摘 | Greco A Brunetti D Renna G | 2010 | Polymer Degradation and Stability2010，95，21： | 1 |
| 19 | Angioplasty increases coronary sinus F2- isoprostane formation :evidence for in vivo oxidative stress during PTCA 显示文摘 | Iuliano L Pratico D Greco C | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 20 | Altered glucose metabolism and proteolysis in pancreatic cancer cell conditioned myoblasts: searching for a gene expression pattern with a microarray analysis of 5000 skeletal muscle genes显示文摘 | Basso D Millino C Greco E | 2004 | Gut2004，53，8： | 1 |
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