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| 1 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 2 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 3 | Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults显示文摘Background The incidence of diastolic heart failure has increased over time.The evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care patients.This study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive care.Data sources We searched data from PubMed/Medline.Thirty-two studies were included.Four pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late diastole.The evolution of diastolic function differs between adults and children.Unlike in adults,decreased compliance occurs at the same time as delayed relaxation in children.Diastolic function can be evaluated by Doppler echo-cardiography.The echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation time.Ventricular compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein flow.In adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic support.Conclusion Clinical studies would allow some of these parameters to be validated for use in children in intensive care. | Morgan Recher Astrid Botte Jerome Soquet Jean-Benoit Baudelet François Godart Stephane Leteurtre | 2021 | World Journal of Pediatrics2021，17，1： | 2 |
| 4 | Microcystic transitional cell carcinoma; a report of 2 cases arising in the renal pelvis显示文摘 | Leroy X Leteurtre E De La Taille A | 2002 | Arch Pathol Lab Med2002，126，7： | 1 |
| 5 | Differences in organ dysfunctions between neonates and older children: a prospec- tive, observational, multicenter study 显示文摘 | Bestati N Leteurtre S Duhamel A | 2010 | Crit Care2010，14，6： | 1 |
| 6 | Can generic paediatfic mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials? 显示文摘 | Leteurtre S Leclerc F Wirth J | 2004 | Crit Care2004，8，4： | 1 |
| 7 | Saintopin,a dual inhibitor of DNA topoisomerases I and II,as a probe for drug-enzymeinteractions显示文摘 | LETEURTRE FUJIMORI TANIZAWA | 1994 | J Biol Chem1994，269，28： | 1 |
| 8 | E-cadherin and β-catenin mRNA levels throughout colon cancer progression显示文摘 | TRUANT S C GOUYER V P LETEURTRE E A | 2008 | J Surg Res2008，150，2： | 1 |
| 9 | Saintopin, a dual inhibitor of DNA topoisomerases Ⅰ and Ⅱ, as a probe for drug-enzyme interactions显示文摘 | Leteurtre F Fujimori A Tanizawa A | 1994 | J Biol Chem1994，269，28： | 1 |
| 10 | Can generic scores(Pediatric Risk of Mortality and Pediatric Index of Mortality) replace specific scores in predicting the outcome of presumed meningococcal septic shock in children? 显示文摘 | Leteurtre S Leclerc F Martinot A | 2001 | Crit Care Med2001，29，6： | 1 |
| 11 | Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children显示文摘 | LECLERC F LETEURTRE S DUHAMEL A | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 12 | Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis显示文摘 | Augusto D Leteurtre E De La Taille A | 2002 | Appl Immunohistochem Mol Morphol2002，10，： | 1 |
| 13 | Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease显示文摘 | Philippe Mathurin Antoine Hollebecque Laurent Arnalsteen David Buob Emmanuelle Leteurtre Robert Caiazzo Marie Pigeyre Hélène Verkindt Sébastien Dharancy Alexandre Louvet Monique Romon Fran?ois Pattou | 2009 | Gastroenterology2009，，2： | 1 |
| 14 | Morphologic subtyping of papillary renal cell carcinoma: correlation with prognosis and differential expression of MUC1 between the two subtypes显示文摘 | Lerox X Zini L Leteurtre E | 2002 | Mod Pathol2002，15，11： | 1 |
| 15 | E-Cadherin and β-Catenin mRNA Levels Throughout Colon Cancer Progression显示文摘 | Stéphanie C. Truant Valérie P. Gouyer Emmanuelle A. Leteurtre Farid Zerimech Guillemette M. Huet Fran?ois-René R. Pruvot | 2008 | Journal of Surgical Research2008，，2： | 1 |
| 16 | CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma 显示文摘 | Leroy X Augusto D Leteurtre E | 2002 | J Histochem Cytochem2002，50，2： | 1 |
| 17 | Inhibitors of human immunodeficiency virus integrase 显示文摘 | Fesen M R Kohn K W Leteurtre F | 1993 | Proc Natl Acad Sci USA1993，90，6： | 1 |
| 18 | E-Cadherin and beta- Catenin mRNA Levels Throughout Colon Cancer Progression 显示文摘 | Truant SC Gouyer VP Leteurtre EA | 2008 | J Surg Res2008，150，2： | 1 |
| 19 | International com- parison of the performance of the paediatric index of mortality (PIM) 2 score in two national data sets 显示文摘 | Leteurtre S Grandbastien B Leclerc F | 2012 | Intensive Care Med2012，38，8： | 1 |
| 20 | E-cadherin and beta- catenin mRNA levels throughout colon cancer progression 显示文摘 | Truant SC Gouyer VP Leteurtre EA | 2008 | The Journal of surgical research2008，150，2： | 1 |
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