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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 3 | Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer显示文摘背景人参皂甙 Rg3,从人参孤立的主要部件,禁止某些瘤生长和 angiogenesis。低剂量化疗和 antiangiogenesis 禁止者的联合比常规治疗更有效地压制试验性的瘤的生长。卵巢的癌症上的这联合的效果尚待被评估。因此,我们在人的卵巢的 cancer.Methods 的生长和 angiogenesis 上调查了人参皂甙 Rg3 和 cyclophosphamide (CTX ) 的协同 28 只女 athymic 老鼠随机被划分成 4 组 7:人参皂甙 Rg3, CTX,人参皂甙 Rg3 和 CTX 联合和控制,在与卵巢的癌症房间(SKOV-3 ) 被移植以后。老鼠为 SKOV-3cells 的 10 天后面的接种被给人参皂甙 Rg3 和 CTX 的 intraperitoneal 注射。老鼠的生活天的生活质量和数字被记录。瘤的尺寸,瘤禁止的率,生活延伸率,增殖的房间原子抗原标记索引( PCNALI ),脉管的 endothelial 房间生长因素( VEGF )和瘤纸巾的 microvessel 密度( MVD )的表示是在人参皂甙的鼠标的 estimated.Results 生活质量 Rg3 和联合治疗组更好并且比控制长生活天数。每个对待的组的平均的瘤重量是不到控制,在对待的组之中没有重要差别。对待的组的 PCNALI 比控制低。在对待的组的 MVD 价值和 VEGF 表示比控制显著地低, MVD 人参皂甙 Rg3 和联合治疗组珍视显著地比 CTX group.Conclusions 人参皂甙 Rg3 的低当独自使用了或与 CTX 结合了时,禁止了卵巢的癌症的生长和 angiogenesis。人参皂甙 Rg3 和 CTX 联合互相增强了 antitumour 效果并且与瘤改进了生活质量和老鼠的幸存时间。 | XU Tian-min XIN Ying CUI Man-hua JIANG Xin GU Li-ping | 2007 | Chinese Medical Journal2007，，7： | 59 |
| 4 | A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1显示文摘 | Huiming Sheng | 2008 | Cell Research2008，18，8： | 55 |
| 5 | Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis显示文摘背景人参皂甙是从人参提取的主要部件,并且人参皂甙 Rg3 是最重要的部分之一。人参皂甙 Rg3 被发现了禁止几种肿瘤生长和转移。现在的学习被承担在人的卵巢的癌症转移和试验性的肺转移卵巢的癌症 SKOV-3 建模的可能的 mechanism.Methods 上调查人参皂甙 Rg3 的效果,导致肿瘤的 angiogenesis 的试金被用来在肿瘤转移和 angiogenesis 上观察 Rg3 的禁止的效果。在 vitro 的 SKOV-3 房间的侵略能力上的 Rg3 的效果被 Boyden 房间检测,并且染色的 immunofluorescence 被用来认出矩阵 metalloproteinase 的表示( MMP-9 ) 9 卵巢的癌症在在试验性的肺转移的 SKOV-3 cells.Results 当模特儿,在肺和向在每个人参皂甙 Rg3 组的肿瘤团面向的容器的肿瘤殖民地的数字,比控制的低组。在有人参皂甙 Rg3.Conclusions 人参皂甙 Rg3 的治疗能显著地禁止卵巢的癌症的转移以后,侵略能力和 SKOV-3 房间的 MMP-9 表示显著地减少了。禁止的效果部分由于导致肿瘤的 angiogenesis 的抑制和侵略能力和 SKOV-3 房间的 MMP-9 表示的减少。 | XU Tian-min CUI Man-hua XIN Ying GU Li-ping JIANG Xin SU Man-man WANG Ding-ding WANG Wen-jia | 2008 | Chinese Medical Journal2008，，15： | 35 |
| 6 | 教育认知诊断测验与认知模型一致性的评估显示文摘构建正确的认知模型是成功进行认知诊断的关键之一,如果认知诊断测验不能完整准确地代表这个认知模型,这个测验的效度就存在问题。属性及其层级可以表示一个认知模型。在认知模型正确基础上,给出了一个计量公式以衡量认知诊断测验能够多大程度上代表认知模型;对于不止包含一个知识状态的等价类及其形成原因进行了分析,对Cui等人的属性层级相合性指标(HCI)提出修改建议,以更好地探查数据与专家给出的认知模型的一致性。 | 丁树良 毛萌萌 汪文义 罗芬 CUI Ying | 2012 | 心理学报2012，44，11： | 34 |
| 7 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 8 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 9 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 10 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 11 | Spectral CT imaging as a new quantitative tool? Assessment of perfusion defects of pulmonary parenchyma in patients with lung cancer显示文摘Objective:This study investigated the capability of dual-energy spectral computed tomography(CT)to quantitatively evaluate lung perfusion defects that are induced by central lung cancer.Methods:Thirty-two patients with central lung cancer underwent CT angiography using spectral imaging.A univariate general linear model was conducted to analyze the variance of iodine concentration/CT value with three factors of lung fields.A paired t-test was used to compare iodine concentrations and CT values between the distal end of lung cancer and the corresponding area in the contralateral normal lung.Results:Iodine concentrations increased progressively in the far,intermediate and near ground sides in the normal lung fields at 0.60±0.28,0.93±0.27 and 1.25±0.38 mg/mL,respectively(P<0.001).The same trend was observed for the CT values[–(840.64±49.08),–(812.66±50.85)and–(760.83±89.17)HU,P<0.001].The iodine concentration(0.70±0.42 mg/mL)of the lung field in the distal end of lung cancer was significantly lower than the corresponding area in the contralateral normal lung(1.19±0.62 mg/mL)(t=–7.23,P<0.001).However,the CT value of lung field in the distal end of lung cancer was significantly higher than the corresponding area in the contralateral normal lung[–(765.29±93.34)HU vs.–(800.07±76.18)HU,t=3.564,P=0.001].Conclusions:Spectral CT imaging based on the spectral differentiation of iodine is feasible and can quantitatively evaluate pulmonary perfusion and identify perfusion defects that are induced by central lung cancer.Spectral CT seems to be a promising technique for the simultaneous evaluation of both morphological and functional lung information. | Ying-Shi Sun Xiao-Yan Zhang Yong Cui Lei Tang Xiao-Ting Li Ying Chen Xiao-Peng Zhang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 23 |
| 12 | The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin显示文摘Emodin(1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field. | CUI Ya CHEN Liu-Jing HUANG Tu YING Jian-Qiong LI Juan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 23 |
| 13 | Kinetic Adsorption of Ammonium Nitrogen by Substrate Materials for Constructed Wetlands显示文摘Constructed wetlands (CWs) are engineered systems that utilize natural systems including wetland vegetations,soils,and their associated microbial assemblages to assist in treating wastewater.The kinetic adsorption of ammonium nitrogen (NH4+-N) by CW substrate materials such as blast furnace slag (BFS),zeolite,ceramsite,vermiculite,gravel,paddy soil,red soil,and turf,was investigated using batch experiments and kinetic adsorption isotherms.Both Freundlich and Langmuir isotherms could adequately predict the NH4+-N adsorption process.The maximum adsorption capacities of NH4+-N,estimated from the Langmuir isotherm,ranked as:zeolite (33 333.33 mg kg-1) > turf (29 274.01 mg kg-1) > BFS (5 000 mg kg-1) > vermiculite (3 333.33 mg kg-1) > gravel (769.23 mg kg-1) > paddy soil (588.24 mg kg-1) > red soil (555.56 mg kg-1) > ceramsite (107.53 mg kg-1).Some properties of the substrate materials,including bulk density,specific gravity,hydraulic conductivity,uniformity coefficient (K60),curvature coefficient (Cc),organic matter,pH,exchangeable (or active) Cu,Fe,Zn and Mn,total Cu,and Fe,Mn,Zn,Cd,Pb and Ca,had negative correlations with NH4+-N adsorption.Other properties of the substrate materials like particle diameter values of D10,D30 and D60 (the diameters of particle sizes of a substrate material at which 10%,30% and 60%,respectively,of the particles pass through the sieve based on the accumulative frequency),cation exchange capacity (CEC),exchangeable (or active) Ca and Mg,and total K and Mg had positive correlations with NH4+-N adsorption.In addition,active K and Na as well as the total Na had significant positive correlations with NH4+-N adsorption.This information would be useful for selection of suitable substrate materials for CWs. | ZHU Wen-Ling CUI Li-Hua OUYANG Ying LONG Cui-Fen TANG Xiao-Dan | 2011 | Pedosphere2011，21，4： | 21 |
| 14 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 15 | New alkylamides from pericarps of Zanthoxylum bungeanum显示文摘二新不饱和的 alkylamides (2E,7E,9E )-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide (1 ) 并且(2E,6E,8E ) 和六已知的混合物(38 ) 的 -N-(2-hydroxy-2-methylpropyl)-10-oxo-2,6,8-decatrienamide (2 ) 从 Zanthoxylum bungeanum 的果皮被孤立。他们的结构根据广泛的分光镜的分析被阐明,包括 MS,红外, 1D 和 2D NMR 实验。 | Shuai Huang Lei Zhao Xian Li Zhou Mei Ying Cui Juan Wang Jie Weng | 2012 | Chinese Chemical Letters2012，23，11： | 21 |
| 16 | Certificateless Public Key Encryption with Keyword Search显示文摘Public Key Encryption with Keyword Search(PEKS),an indispensable part of searchable encryption,is stock-intrade for both protecting data and providing operability of encrypted data.So far most of PEKS schemes have been established on Identity-Based Cryptography(IBC) with key escrow problem inherently.Such problem severely restricts the promotion of IBC-based Public Key Infrastructure including PEKS component.Hence,Certificateless Public Key Cryptography(CLPKC) is efficient to remove such problem.CLPKC is introduced into PEKS,and a general model of Certificate/ess PEKS(CLPEKS) is formalized.In addition,a practical CLPEKS scheme is constructed with security and efficiency analyses.The proposal is secure channel free,and semantically secure against adaptive chosen keyword attack and keyword guessing attack.To illustrate the superiority,massive experiments are conducted on Enron Email dataset which is famous in information retrieval field.Compared with existed constructions,CLPEKS improves the efficiency in theory and removes the key escrow problem. | PENG Yanguo CUI Jiangtao PENG Changgen YING Zuobin | 2014 | China Communications2014，11，11： | 21 |
| 17 | Water quality forecast through application of BP neural network at Yuqiao reservoir显示文摘This paper deals with the study of a water quality forecast model through application of BP neural network technique and GUI (Graphical User Interfaces) function of MATLAB at Yuqiao reservoir in Tianjin. To overcome the shortcomings of traditional BP algorithm as being slow to converge and easy to reach extreme minimum value,the model adopts LM (Leven-berg-Marquardt) algorithm to achieve a higher speed and a lower error rate. When factors affecting the study object are identified,the reservoir's 2005 measured values are used as sample data to test the model. The number of neurons and the type of transfer functions in the hidden layer of the neural network are changed from time to time to achieve the best forecast results. Through simulation testing the model shows high efficiency in forecasting the water quality of the reservoir. | ZHAO Ying NAN Jun CUI Fu-yi GUO Liang | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，9： | 20 |
| 18 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 19 | Mechanism-based anti-anxiety effects of polysaccharides extracted from Shudihuang (Radix Rehmanniae Preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins显示文摘OBJECTIVE: To investigate mechanism-based anti-anxiety effects of Shudihuang (Radix Rehmanniae Preparata) polysaccharides (RRPPs) through two-dimensional electrophoresis (2-DE) analysis with mass spectrometry (MS) of hippocampus proteins in rats treated with monosodium L-glutamate (MSG).METHODS: MSG (4 g/kg) or normal saline (NS) was injected subcutaneously into infant male rats on days 2, 4, 6, 8, 10 after birth. MSG-treated rats at 8 weeks old were given NS, diazepam, or RRPPs daily for seven consecutive days by intragastric administration, while NS-treated rats given the same volume of NS. Elevated plus maze (EPM) and light/ dark transition (LDT) tests were used to observe anti-anxiety effects of RRPPs at 1 h after the last administration. After EPM and LDT tests, hippocampus tissues were excised on ice rapidly from the brains of rats. Thereafter, 2-DE and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) were used for detecting differential proteins in hippocampus of rats so as to explore the potential mechanisms. RESULTS: RRPPs (200, 400 mg/kg) could significantly inhibit MSG-induced decrease of time and entries percentages in open zones in EPM test and numbers of light-dark transition in LDT test. Further analysis of 2-DE and MALDI-TOF/MS indicated that β-synuclein, protein DJ-1, peroxiredoxin-2, peroxiredoxin-6, dimethylarginine dimethylaminohydrolase 1 (DDAH-1) and iron-sulfur proteins were all found to be down-regulated significantly in MSG-treated rats, while such down-regulation was significantly inhibited after treatment with RRPPs. CONCLUSION: RRPPs showed anti-anxiety effects and potential mechanisms might be related to inhibiting MSG-induced down-regulation of β-synuclein, DJ-1, peroxiredoxin-2, peroxiredoxin-6, DDAH-1 and iron-sulfur proteins in hippocampus of rats. | Ying Cui Chunlei Rong Junming Wang Can Cui Li Wang Zhiyi Feng Jing Feng Bing Niu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 19 |
| 20 | Exosome-mediated transfer of miR-1290 promotes cell proliferation and invasion in gastric cancer via NKD1显示文摘Currently, exosomes rich in RNAs and proteins are regarded as vital mediators of intercellular communication. Here, we aimed to explore the effects of exosomal miR-1290 in gastric cancer (GC) and understand its mechanism of action on GC progression. We first isolated exosomes from serum samples of GC patients and healthy people and characterized them by transmission electron microscopy. Then, we examined the expression level of miR-1290 contained in the exosomes by quantitative reverse-transcription polymerase chain reaction and found that exosomal miR-1290 was overexpressed in GC patients and cell lines. Promotion of proliferation, migration, and invasiveness of GC cells was noted after they were incubated with the isolated miR-1290-rich exosomes compared with incubation with a negative control. Furthermore, we predicted that naked cuticle homolog 1 (NKD1) mRNA is a direct target of miR-1290 and confirmed their interaction by a dual luciferase reporter assay. NKD1 overexpression attenuated the stimulatory effects of miR-1290 on GC cells. Collectively, our results suggest that exosomal miR-1290 enhances GC cell proliferation and invasion by targeting NKD1 mRNA and downregulating NKD1 expression. A better understanding of this process may facilitate the development of novel therapeutic agents for GC. | Jiying Huang Manru Shen Meizhu Yan Ying Cui Zhenjun Gao Xin Meng | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 19 |
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