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| 1 | Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ显示文摘蓼 multiflorum Thunb (下午) 的根在中国被使用了治疗许多疾病,例如便秘,头发和 hyperlipemia 的早 graying。最近的证据证明那位首相在人引起特质的导致药的肝损害(IDILI ) 。在这研究,我们基于 LPS 的非肝毒素的剂量在 IDILI 的一个老鼠模型调查了导致下午的肝损害的分子的基础。SD 老鼠口头上地被管理下午的 3 潜在地肝毒素的混合物:cis 芪配糖物(cis-SG, 50 mg/kg ) , trans-SG (50 mg/kg ) 或 emodin (5 mg/kg ) ,由 LPS 的注射列在后面(2.8 mg/kg, iv ) 。浆液和肝组织学被评估在 LPS 以后的 7 h 注射。在测试的 3 混合物之中, cis-SG,然而并非 emodin 或 trans-SG,当与 LPS 结合了时,在老鼠导致了严重的肝损害。在血浆的著名计算机生产厂商和在血浆和肝纸巾的煽动性的 cytokines 的层次显著地被提高。肝纸巾显示出增加的损害, hepatocyte apoptosis,和巨噬细胞渗入,并且减少房间增长。Microarray 分析揭示了在 peroxisome 之间的否定关联激活 proliferator 的受体 --(PPAR-) 并且 LPS/cis-SG-induced 肝损害。Immunohistochemical 染色和 RT-PCR 结果进一步证实 cis-SG 显著地在 LPS/cis-SG-treated 老鼠的肝纸巾禁止了 PPAR- 小径的激活。有 PPAR- 收缩筋 pioglitazone 的预告的处理(500 g/kg, ig ) 颠倒的 LPS/cis-SG-induced 肝损害,它与禁止原子因素 kappa B (NF-B ) 被联系小径。这些数据证明 cis 芪配糖物导致免疫学的通过在 IDILI 的一个老鼠模型压制 PPAR- 的特质的 hepatotoxicity。 | Ya-kun MENG Chun-yu LI Rui-yu LI Lan-zhi HE He-rong CUI Ping YIN Cong-en ZHANG Peng-yan LI Xiu-xiu SANG Ya WANG Ming NIU Ya-ming ZHANG Yu-ming GUO Rong SUN Jia-bo WANG Zhao-fang BAI Xiao-he XIAO | 2017 | Acta Pharmacologica Sinica2017，38，10： | 30 |
| 2 | The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin显示文摘Emodin(1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field. | CUI Ya CHEN Liu-Jing HUANG Tu YING Jian-Qiong LI Juan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 23 |
| 3 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 4 | Late Pleistocene glaciation of the Hulifang Massif of Gongwang mountains in Yunnan Province显示文摘Late Pleistocene glaciation was restricted to only a few high mountains in eastern China. The Gongwang mountainsconstitute one ofthe typicalplacesonce glaciated.Geomorphic mapping of the area and the TL dating provides evidence for at least four distinct glaciations. YJT-I glacial advance occurred about100 ka BP and two TL absolute ages(101,100 ±7780 a BP;104,000±8300 a BP)indicate thisadvance happened during the Penultimale Glaciation.The early stage glacialadvance (YJT-II advance) during the last glaciation occurred about 40,920±3400 a BP. The last glacial maximum advance (YJT-IIIadvance)about18-25 ka BP,which sustained by two TL ages(18,230 ± 1420 a BP;25,420 ±2110 a BP).The Penultimale and the early stage glaciationswere more extensive and the lastglacialmaximum (LGM )and the late-glacialperiod (YJT-IV advance,10 ka BP) were progressively less extensive. Correlated with the other mountains in eastern China, these glacial advances in the Gongwang mountains justlike the advances in the western partsuch as Diancang mountains,Yulong mountains ofYunnan Province and the glacierseries are more complete than the adjacent mid-latitude regions such as Taibai mountain and Taiwan mountains and are roughly representativeofclimatechangesduring thelastglacialcyclein Yunnan Province. | ZHANG Wei CUI Zhijiu FENG Jinliag YI Chaolu YA NG Jianqiang | 2005 | Journal of Geographical Sciences2005，15，4： | 13 |
| 5 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 6 | Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia显示文摘We established a diagnostic model to predict acute Mycoplasma pneumoniae(M.pneumonia)infection in elderly Community-acquired pneumonia(CAP)patients.We divided 456 patients into acute and non-acute M.pneumoniae infection groups.Binary logistic regression and receiver operating characteristic(ROC)curves were used to establish a predictive model.The following independent factors were identified:age≥70 years;serum c TNT level≥0.05 ng/m L;lobar consolidation;mediastinal lymphadenopathy;and antibody titer in the acute phase≥1:40.The area under the ROC curve of the model was 0.923 and a score of≥7score predicted acute M.pneumoniae infection in elderly patients with CAP.The predictive model developed in this study has high diagnostic accuracy for the identification of elderly acute M.pneumoniae infection. | XiAO Hong Li XIN De Li WANG Yan CUI Li Jian LIU Xiao Ya LIU Song SONG Li Hong LIU Chun Ling YIN Cheng Hong | 2017 | Biomedical and Environmental Sciences2017，30，7： | 6 |
| 7 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 8 | Semi-analytical and computational investigation of different dust loading structures affecting the performance of a fibrous air filter显示文摘In this study, a semi-analytical model was developed to illustrate the relationship between filtration performance(filtration efficiency and pressure drop) and dust loading under two different particle deposit structures based on theoretical analysis and computational fluid dynamic(CFD) technology. Under the compact deposit structure, within the practical parameter ranges(fiber diameter, air velocity, dust loading mass), a slight efficiency enhancement(?10%) occurred at the most penetration particle size(MPPS)and pressure drop increased significantly(?100%) in response to the solidity increase from 5% to 15%.However, under the dendritic particle deposit structure, both filtration efficiency(?40%) and pressure drop(?600%) increased significantly with the same solidity increase due to the larger air velocity and swerve change between fibers. | Bin Xu Ya Wu Pengyi Cui | 2014 | Particuology2014，12，2： | 5 |
| 9 | Thioredoxin-Interacting Protein(TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes显示文摘Patients with diabetes mellitus have a higher risk of developing Parkinson’s disease(PD). However, the molecular links between PD and diabetes remain unclear.In this study, we investigated the roles of thioredoxininteracting protein(TXNIP) in Parkin/PINK1-mediated mitophagy in dopaminergic(DA) cells under high-glucose(HG) conditions. In streptozotocin-induced diabetic mice,TXNIP was upregulated and autophagy was inhibited in the midbrain, while the loss of DA neurons was accelerated by hyperglycemia. In cultured PC12 cells under HG, TXNIP expression was upregulated and the intracellular reactive oxygen species(ROS) levels increased, leading to cell death. Autophagic flux was further blocked and PINK1 expression was decreased under HG conditions. Parkin expression in the mitochondrial fraction and carbonyl cyanide 3-chlorophenylhydrazone(CCCP)-induced co-localization of COX IV(marker for mitochondria) and LAMP1(marker for lysosomes) were also significantly decreased by HG. Overexpression of TXNIP was sufficient to decrease the expression of both PINK1 and Parkin in PC12 cells, while knockdown of the expression of TXNIP by si RNA decreased intracellular ROS and attenuated cellular injury under HG. Moreover, inhibition of TXNIP improved the CCCP-induced co-localization of COX IV and LAMP1 in PC12 cells under HG. Together, these results suggest that TXNIP regulates Parkin/PINK1-mediated mitophagy under HG conditions, and targeting TXNIP may be a promising therapeutic strategy for reducing the risk of PD under hyperglycemic conditions. | Cun-Jin Su Zhu Shen Ru-Xiao Cui Ya Huang De-Lai Xu Feng-Lun Zhao Jie Pan Ai-Ming Shi Tong Liu Yun-Li Yu | 2020 | Neuroscience Bulletin2020，36，4： | 5 |
| 10 | Intelligent metasurface imager and recognizer显示文摘There is an increasing need to remotely monitor people in daily life using radio-frequency probe signals.However,conventional systems can hardly be deployed in real-world settings since they typically require objects to either deliberately cooperate or carry a wireless active device or identification tag.To accomplish complicated successive tasks using a single device in real time,we propose the simultaneous use of a smart metasurface imager and recognizer,empowered by a network of artificial neural networks(ANNs)for adaptively controlling data flow.Here,three ANNs are employed in an integrated hierarchy,transforming measured microwave data into images of the whole human body,classifying specifically designated spots(hand and chest)within the whole image,and recognizing human hand signs instantly at a Wi-Fi frequency of 2.4 GHz.Instantaneous in situ full-scene imaging and adaptive recognition of hand signs and vital signs of multiple non-cooperative people were experimentally demonstrated.We also show that the proposed intelligent metasurface system works well even when it is passively excited by stray Wi-Fi signals that ubiquitously exist in our daily lives.The reported strategy could open up a new avenue for future smart cities,smart homes,human-device interaction interfaces,health monitoring,and safety screening free of visual privacy issues. | Lianlin Li Ya Shuang Qian Ma Haoyang Li Hanting Zhao Menglin Wei Che Liu Chenglong Hao Cheng-Wei Qiu Tie Jun Cui | 2019 | Light(Science & Applications)2019，8，1： | 5 |
| 11 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 12 | Synthesis of methyl methacrylate star-branched polymer with divinylbenzene as a linking agent via controlled/living photopolymerization显示文摘HTEMPO-functionalized central cores were formed with divinylbenzene in ''core first'' method,and the four or five arms star polymers were built via controlled/living free radical photopolymerization.The four arms star polymers were also prepared with controlled/living free radical photopolymerization in ''arm first'' method.The resulting polymers had been confirmed by GPC and 1 H NMR.It showed that the star polymers had low polydispersities and molecular weight(M n) with the 85,000-560,000 g/mol range. | Yan Yan Cui Ya E Ren Xiao Xuan Liu | 2012 | Chinese Chemical Letters2012，23，8： | 3 |
| 13 | An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall显示文摘A total of 26 leptospirosis cases occurred in the outbreak,of whom six died after hospitalization.All26 patients were clinically diagnosed as leptospirosis.Microscopic agglutination test(MAT)revealed that13 of 26 patients were affected with laboratory confirmed leptospirosis.Furthermore,MAT data suggested that serogroup Icterohaemorrhagiae were the main pathogens responsible for this outbreak.And the rainfall data suggested that the increased rainfall might be responsible for the leptospirosis outbreak in Lezhi County.This outbreak has reminded us that leptospirosis should not be neglected,especially during flood season,although its incidence rate is low. | WANG Ya Lin QIN Jin Hong ZHANG Cui Cai GUO Xiao Kui JIANG Xiu Gao HE Ping | 2014 | Biomedical and Environmental Sciences2014，27，1： | 3 |
| 14 | Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration显示文摘Dental caries is one of the most prevalent human diseases resulting from tooth demineralization caused by acid production of bacteria plaque.It remains challenges for current practice to specifically identify,intervene and interrupt the development of caries while restoring defects.In this study,inspired by natural dental plaque,a stimuli-responsive multidrug delivery system(PMs@NaF-SAP)has been developed to prevent tooth decay and promote enamel restoration.Classic spherical core-shell structures of micelles dual-loaded with antibacterial and restorative agents are self-assembled into bacteria-responsive multidrug delivery system based on the pH-cleavable boronate ester bond,followed by conjugation with salivary-acquired peptide(SAP)to endow the nanoparticle with strong adhesion to tooth enamel.The constructed PMs@NaF-SAP specifically adheres to tooth,identifies cariogenic conditions and intelligently releases drugs at acidic pH,thereby providing antibacterial adhesion and cariogenic biofilm resistance,and restoring the microarchitecture and mechanical properties of demineralized teeth.Topical treatment with PMs@NaF-SAP effectively diminishes the onset and severity of caries without impacting oral microbiota diversity or surrounding mucosal tissues.These findings demonstrate this novel nanotherapy has potential as a promising biomedical application for caries prevention and tooth defect restoration while resisting biofilm-associated diseases in a controlled manner activated by pathological bacteria. | Yue Xu Yuan You Luyao Yi Xiaoyi Wu Yaning Zhao Jian Yu He Liu Ya Shen Jingmei Guo Cui Huang | 2023 | Bioactive Materials2023，，2： | 3 |
| 15 | A metasurface-based light-to-microwave transmitter for hybrid wireless communications显示文摘Signal conversion plays an important role in many applications such as communication,sensing,and imaging.Realizing signal conversion between optical and microwave frequencies is a crucial step to construct hybrid communication systems that combine both optical and microwave wireless technologies to achieve better features,which are highly desirable in the future wireless communications.However,such a signal conversion process typically requires a complicated relay to perform multiple operations,which will consume additional hardware/time/energy resources.Here,we report a light-to-microwave transmitter based on the time-varying and programmable metasurface integrated with a high-speed photoelectric detection circuit into a hybrid.Such a transmitter can convert a light intensity signal to two microwave binary frequency shift keying signals by using the dispersion characteristics of the metasurface to implement the frequency division multiplexing.To illustrate the metasurface-based transmitter,a hybrid wireless communication system that allows dual-channel data transmissions in a light-to-microwave link is demonstrated,and the experimental results show that two different videos can be transmitted and received simultaneously and independently.Our metasurface-enabled signal conversion solution may enrich the functionalities of metasurfaces,and could also stimulate new information-oriented applications. | Xin Ge Zhang Ya Lun Sun Bingcheng Zhu Wei Xiang Jiang Qian Yu Han Wei Tian Cheng-Wei Qiu Zaichen Zhang Tie Jun Cui | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 16 | Low Phase Angle Predicts Poor Survival in Patients with Hepatocellular Carcinoma:A Retrospective Study显示文摘Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis. | Jin Yu Shi Guang Yang Bo Liu Xiao Shang Guo Zhen Cui Jia Xin Huang Wan Ting Wang Ke Yu Chen Nan Ya Wang | 2022 | Journal of Nutritional Oncology2022，7，2： | 2 |
| 17 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 18 | One-bit quantization is good for programmable coding metasurfaces显示文摘The information-carrying programmable metasurfaces have found widespread applications in communication, sensing, and other related areas. However, there is a fundamental but unresolved problem,i.e., the rigorous understanding of the quantization of metasurface coding. Here, we theoretically investigate the performance difference between one-bit and continuous information-encoding metasurfaces. To this end,we derive analytical representations of system responses in various cases(single-input single-output, singleinput multiple-output, and multiple-input multiple-output). We analyze the impact of one-bit coding(in contrast to continuous coding) in terms of the resulting channel cross-talk and reduction of information capacity in various representative scenarios from wireless communication and holography. Our main finding indicates that the one-bit coding yields a satisfactory performance in most practical scenarios;we also show that in many cases there are smart ways to mildly relax optimization constraints in order to reduce the performance gap between the one-bit and continuous coding. We expect that our results can provide theoretical guidance for a large variety of metasurface-assisted information systems for electromagnetic waves and other wave phenomena. | Ya SHUANG Hanting ZHAO Menglin WEI Qiang CHENG Shi JIN Tiejun CUI Philipp DEL HOUGNE Lianlin LI | 2022 | Science China(Information Sciences)2022，65，7： | 2 |
| 19 | A functional hyperbranched binder enabling ultra-stable sulfur cathode for high-performance lithium-sulfur battery显示文摘Binders are of vital importance in stabilizing the cathodes to enhance the cycling stability of lithiumsulfur(Li-S) batteries. However, conventional binders are typically confronted with the drawback of inability for adsorbing lithium polysulfide(Li PS), thus resulting in severe active material losing and rapid capacity fading. Herein, a novel water-soluble hyperbranched poly(amidoamine)(HPAA) binder with controllable hyperbranched molecular structure and abundant amino end groups for Li-S battery is designed and fabricated, which can improve efficient adsorption for Li PS and stability of the sulfur cathodes. Besides, the strong intermolecular hydrogen bonds in HPAA binder can contribute to the structural stability of S cathode and integration of the conductive paths. Therefore, the Li-S battery with this functional binder exhibits excellent cycle performance with a capacity retention of 91% after 200 cycles at 0.1 C.Even at a high sulfur loading of 5.3 mg cm-2, a specific capacity of 601 mA h g-1 can also be achieved.Density functional theory(DFT) calculation further demonstrates that the enhanced electrochemical stability derives from the high binding energy between amino groups and LiP S and the wide electrochemical window(6.87 e V) of HPAA molecule. Based on the above all, this functional polymer will lighten a new species of binders for eco-friendly sulfur cathodes and significantly promote the practical applications of high-performance Li-S batteries. | Xiang Luo Xianbo Lu Xiaodong Chen Ya Chen Chunyang Yu Dawei Su Guoxiu Wang Lifeng Cui | 2020 | Journal of Energy Chemistry2020，29，11： | 2 |
| 20 | Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells显示文摘iptakalim (Ipt ) 和 natakalim (Nat ) 激活 SUR2B/Kir6.1 隧道,一种 ATP 敏感的钾隧道(KATP ) 子类型,与高选择。在这研究,我们在老鼠对导致 isoproterenol 的长期的心失败(ISO-CHF ) 调查了 Ipt 和 Nat 的治疗学的效果,并且在 endothelial 房间通过 SUR2B/Kir6.1 隧道的激活表明了一条新治疗学的途径到 CHF 的处理。在 ISO-CHF 老鼠, Nat 的口头的管理(1, 3, 9 mg ‰洠汯? | Shang WANG Chao-liang LONG Jun CHEN Wen-yu CUI Ya n-fang ZHANG Hao ZHANG Hai WANG | 2017 | Acta Pharmacologica Sinica2017，38，1： | 2 |
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