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| 1 | Hypertension and renal disease显示文摘The relationship between chronic kidney disease(CKD)and hypertension remains enigmatic and a matter of considerable clinical and academic interest with evidence indicating that hypertension is both a cause and a consequence of kidney disease[1-2]. | Huang Chunfa Louis Stokes Cleveland Veteran Affairs Medical Center Division of Nephrology,Departments of Medicine,Case Western Reserve University and Rammelkamp Center for Research and Education,MetroHealth System Campus,Cleveland,Ohio 441061 | 2011 | 中华高血压杂志2011，19，12： | 23 |
| 2 | Effects of organic acids on the leaching process of ion-adsorption type rare earth ore显示文摘To examine the activation of organic acids on the leaching process of ion-adsorption type rare earth ore(IRE-ore), the leaching behavior of rare earth(RE) and zeta potential of IRE-ore were investigated in the absence and presence of carboxylic acids. The results show that all the tested organic acids(acetic acid,malonic acid, citric acid, tartaric acid, succinic acid, and malic acid) can promote RE extraction. At relatively high concentrations of organic acids, the activation efficiency of organic acids on RE extraction is generally consistent with their complexation ability; whereas at their low concentrations, the change of zeta potential on the IRE-ore surface with organic acid concentration and p H has a close association with RE extraction, which indicates that organic acids can impact the surface electrical property of IREore via their adsorption/desorption, and thereby increase/decrease the affinity of RE ions to IRE-ore.Therefore the influence of organic acids on the IRE-ore surface electrical property also plays an important role in RE extraction in addition to their complexation with RE ions. | Li Wang Chunfa Liao Youming Yang Haibo Xu Yanfei Xiao Chunhua Yan | 2017 | Journal of Rare Earths2017，35，12： | 23 |
| 3 | MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells显示文摘MicroRNAs regulate self renewal and differentiation of cancer stem cells.There,we sought to identify the expression of miR-181b in glioma stem cells and investigate the biological effect of miR-181b on glioma stem cells in this study.MiR-181b expression was measured by real-time PCR in glioma stem cells isolated from U87 cells by FACS sorting.After miR-181b was overexpressed in U87 glioma stem cells by miR-181b lentiviral expression vector and/or treatment of temozolomide,secondary neurosphere assay,soft agar colony assay and MTT assay were performed.Compared with U87 cells,the expression of miR-181b was significantly decreased in U87 glioma stem cells.Overexpression of miR-181b decreased neurosphere formation by U87 glioma stem cells in vitro and suppressed colony formation in soft agar,and the cell growth inhibition rates increased in a time-dependent manner in U87 glioma stem cells infected with miR-181b lentivirus.Furthermore,miR-181b had a synergistic effect on temozolomide-induced inhibition of secondary neurosphere and soft agar colony,and on cell growth inhibition rates.MiR-181b functions as a tumor suppressor that suppresses proliferation and reduces chemoresistance to temozolomide in glioma stem cells. | Ping Li Xiaoming Lu Yingyi Wang Lihua Sun Chunfa Qian Wei Yan Ning Liu Yongping You Zhen Fu | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 4 | Zircon U-Pb and geochemical analyses for leucocratic intrusive rocks in pillow lavas in the Danfeng Group,north Qinling Mountains,China显示文摘Field observation showed that there are many irregular leucocratic intrusive rocks in pillow lavas in the Danfeng Group in the Xiaowangjian area, north Qinling orogenic belt. Photomicrographs indicated that the protoliths of those altered leucocratic intrusive rocks are dioritic rocks. Geochemical analyses showed that pillow lavas have a range of SiO2 from 47.35% to 51.20%, low abundance of TiO2 from 0.97% to 1.72%, and percentages of MgO (MgO#=41―49). Chondrite-normalized REE patterns of pillow lavas are even, indicative of a weak differentiation between LREE and HREE (La/YbN=1.52―0.99). N-MORB-normalized trace element abundances showed that pillow lavas are enriched in incompatible elements (e.g., K, Rb, and Ba). Leucocratic intrusive rocks in pillow lavas have a wide range of SiO2 from 53.85%―67.20%, low abundances of TiO2 from 0.51%―1.10%, and MgO (MgO#=40―51), and higher percentages of Al2O3 (13.32%―16.62%) and concentration of Sr (342-539 μg/g), ratios of Na2O/K2O (2―7) and Sr/Y (17―28). Chondrite-normalized REE patterns of leucocratic intrusive rocks showed highly differentiation between LREE and HREE (La/YbN=12.26―19.41). N-MORB-normalized trace element abundances showed that leucocratic intrusive rocks are enriched in incompatible elements (e.g., K, Rb, and Ba), and significantly depleted in HFSE (e.g., Nb, Ta, Zr and Ti), indicative of a relationship to subduction. Isotopically, leucocratic intrusive rocks have a similar εNd(t) (+7.45―+13.14) to that of MORB (+8.8―+9.7), which indicates that those leucocratic intrusive rocks sourced from depleted mantle most likely. SHRIMP U-Pb analyses for zircon showed that those leucocratic intrusive rocks were formed at 442±7 Ma, yielding an age of subduction in the early Paleozoic in the north Qinling orogenic belt. | Yan QuanRen Chen JunLu Wang ZongQi Yan Zhen Wang Tao Li QiuGen Zhang ZongQing Jiang ChunFa | 2008 | Science China Earth Sciences2008，51，2： | 14 |
| 5 | Temperature-induced deformation of CRTS II slab track and its effect on track dynamical properties显示文摘Two finite-element models of the CRTS II slab track are presented to simulate temperature-induced deformations of the concrete track slab with no deterioration or with a deteriorated cement asphalt mortar(CAM).One model,which considers the fully bonding interface between the slab and the CAM layer,could applied to a track that is in good condition;the other model uses cohesive zone elements to simulate the deteriorated CAM with some possible interfacial separation and slip.Utilizing both of the models,temperature-induced warp deformations of track under various temperature loads are investigated.The influence of temperature deformation on the dynamic properties of the track is analyzed based on the train-track coupled dynamics.Numerical results show that the deteriorated CAM layer can significantly increase temperature deformations of a CRTS II track slab,which would produce tiny rail irregularities.There are clear differences between the deformation shapes of the track slabs that have an inseparable mortar layer and those have a separable mortar layer.The track slab with a deteriorated mortar layer showed more open curl distortion than the track slab in good condition.The dynamical response index of the slab track is intensified to a certain level due to the temperature deformation;with an increase of the train speed,the track dynamical responses increased linearly.However,rail irregularities due to the temperature deformations are very tiny.Even if a track is exposed to extreme temperature loads and the mortar layer is deteriorated,temperature deformation can have a negligible effect on the track’s dynamical properties. | SONG XiaoLin ZHAO ChunFa ZHU XiaoJia | 2014 | Science China(Technological Sciences)2014，57，10： | 8 |
| 6 | Microfossils from the siltstones and muddy slates:Constraint on the age of the Taowan Group in the Northern Qinling Orogenic Belt,Central China显示文摘The age of the Taowan Group is still a hot topic in the Northern Qinling Orogenic Belt, because of limited fossil evidence from these strata and different ideals on the Cambrian fossils of the conglomerate beds and limestone blocks. Early Ordovician acritarchs, chitinozoa and scolecodonts occur in the siltstone and muddy slate beds of the Guoling, Sanchakou, Fengmaimiao and Goushenmiao Formations of the Taowan Group, indicating the age of the Taowan Group should be the Ordovician. These fossil assemblages consist of 7 genera and 13 species of acritarchs, 7 genera and 9 species of chitinozoa, and 2 genera and 2 species of scolecodonts. | WANG ZongQi GAO LianDa WANG Tao JIANG ChunFa | 2008 | Science China Earth Sciences2008，51，2： | 6 |
| 7 | Construction of brewing-wine Aspergillus oryzaepyrG- mutant bypyrG gene deletion and its application in homology transformation显示文摘 | Yu Du Guizhen Xie Chunfa Yang Baishan Fang Hongwen Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 6 |
| 8 | Cathodic reduction process of Al-Cu-Y alloy in fluoride-oxide eutectic system via molten salt electrolysis显示文摘Al-Cu-Y alloys were prepared by molten salt electrolysis in fluoride-oxide system composed of electrolyte(Na_3 AlF_6-AlF_3-LiF-MgF_2) and oxide(Al_2 O_3-CuO-Y_2 O_3). Cathodic reduction process of Al_2 O_3,CuO and Y_2 O_3 were analyzed by cyclic voltammetry and chronoamperometry. Components and phase composition of alloy samples prepared by potentiostatic electrolysis were characterized by scanning electron microscopy and energy dispersive spectroscopy. The results show that the Al-Cu-Y alloy can be prepared in the AIF_3-NaF-5 wt%LiF-5 wt%MgF2(NaF/AlF_3 = 2.2, molecular ratio) eutectic system with mixed oxide(Al_2 O_3-CuO-Y_2 O_3) through 2 h at the conditions of a temperature of 1208 K, cell voltage3.0 V, cathode current density 0.7 A/cm^2. Al(Ⅲ) and Cu(Ⅱ) ions can be reduced to zero valence Al(0) and Cu(0) directly on carbonaceous electrode surface by instantaneous nucleation, respectively, the reduction process is controlled by diffusion. The reduction potential of Y(Ⅲ) ions is close to the active ions of fluoride melts, but strengthened phase AI3 Y can be formed through electrochemical reduction and alloyed process with active Al(Ⅲ) and Cu(Ⅱ) ions, meanwhile, the Al_2 Cu and Al_3 Y phases are distributed at the grain boundary of Al matrix. | Xu Wang Chunfa Liao Yunfen Jiao Hao Tang | 2018 | Journal of Rare Earths2018，36，3： | 6 |
| 9 | Discrete element modelling of railway ballast performance considering particle shape and rolling resistance显示文摘To simulate ballast performance accurately and efficiently,the input in discrete element models should be carefully selected,including the contact model and applied particle shape.To study the effects of the contact model and applied particle shape on the ballast performance(shear strength and deformation),the direct shear test(DST)model and the large-scale process simulation test(LPST)model were developed on the basis of two types of contact models,namely the rolling resistance linear(RRL)model and the linear contact(LC)model.Particle shapes are differentiated by clumps.A clump is a sphere assembly for one ballast particle.The results show that compared with the typical LC model,the RRL method is more efficient and realistic to predict shear strength results of ballast assemblies in DSTs.In addition,the RRL contact model can also provide accurate vertical and lateral ballast deformation under the cyclic loading in LPSTs. | Yunlong Guo Chunfa Zhao Valeri Markine Can Shi Guoqing Jing Wanming Zhai | 2020 | Railway Engineering Science2020，28，4： | 4 |
| 10 | Decrease in the Ki67 index during neoadjuvant chemotherapy predicts favorable relapse-free survival in patients with locally advanced breast cancer显示文摘Objective: The purpose of this study was to explore the optimal cutoffs of the three parameters of Ki67 during NAC for predicting patient prognosis and investigate whether the optimal cutoffs of the Ki67 values were associated with relapse-free survival(RFS) or breast cancer-specific survival(BCSS).Methods: A total of 92 patients with locally advanced breast cancer(LABC), who had residual disease after NAC were retrospectively investigated.The optimal cutoff values of the Ki67 parameters were assessed by the online algorithm Cutoff Finder.Kaplan-Meier analysis, the log-rank test and Cox regression analysis were carried out to analyze survival.Results: The optimal cutoff values for the postsurgical Ki67 level and the decrease in the Ki67 level during NAC were defined as 25% and 12.5%, respectively.According to the univariate survival analysis, a higher Ki67 level in residual disease was associated with poor RFS(P = 0.004) and BCSS(P = 0.014).In addition, a Ki67 expression decrease > 12.5% during NAC was related to favorable RFS(P = 0.007), but was not related to BCSS(P = 0.452).Cox regression analysis showed that the Ki67 expression decrease(> 12.5% vs.≤ 12.5%) and histological grade(grade 3 vs.grade 1-2) were the independent factors associated with RFS(P =0.020 and P = 0.023, respectively), with HR values of 0.353(95% CI: 0.147-0.850) and 3.422(95% CI: 1.188-9.858), respectively.Conclusions: The Ki67 decrease was one of the independent factors associated with RFS in LABC patients with residual disease after receiving NAC. | Chunfa Chen Yuling Zhang Ziyi Huang Jundong Wu Wenhe Huang Guojun Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 11 | Low-density polyethylene/silica compound modified asphalts with high-temperature storage stability显示文摘 | Ouyang Chunfa Wang Shifeng Zhang Yong | 2006 | Journal of Applied Polymer Science2006，101，1： | 1 |
| 12 | Preparation and properties of styrene- butadiene- styrene copolymer/kaolinite clay compound and asphalt modified with the compound显示文摘 | Ouyang Chunfa Wang Shifeng Zhang Yong | 2005 | Polymer degradation and stability2005，87，： | 1 |
| 13 | Proof for Part of the Strla Flow Experimental Conclusion and the Improvement of Flugel Formula 显示文摘 | Zhang Chunfa Cui Yinghong Yang Wenbin Zhang Decheng Song Zhiping | 2002 | Science in china (Series E)2002，45，1： | 1 |
| 14 | Preparation and properties of styrene-butadienestyrene copolymer/kaolinite clay compound and asphalt modified with the compound显示文摘 | OUYANG CHUNFA WANG SHIFENG ZHANG YONG | 2005 | Polymer Degradation and Stability2005，87，2： | 1 |
| 15 | Preparation and properties of styrene-butadiene-styrene copolymer/kaolinite clay compound and asphalt modified with the compound显示文摘 | Ouyang Chunfa Wang Shifeng Zhang Yong | 2005 | Poly- mer Degradation and Stability2005，87，4： | 1 |
| 16 | Low-density po- lyethylene/silica compound modified asphalts with high-temper-ature storage stability显示文摘 | Ouyang Chunfa Wang Shifeng Zhang Yong | 2006 | Journal of Applied Polymer Science2006，101，7： | 1 |
| 17 | Thermo-rheological properties and storage stability of SEBS/kaolinite clay compound modified asphalts显示文摘 | Chunfa Ouyang Shifeng Wang Yong Zhang Yinxi Zhang | 2006 | European Polymer Journal2006，42，2： | 1 |
| 18 | Proof for part of the St la flow experimental conclusion and the improvement of Flügel formula显示文摘 | Chunfa Zhang Yinghong Cui Wenbin Yang Decheng Zhang Zhiping Song | | 0，，： | 1 |
| 19 | Preparation and properties of styrene–butadiene–styrene copolymer/kaolinite clay compound and asphalt modified with the compound显示文摘 | Chunfa Ouyang Shifeng Wang Yong Zhang Yinxi Zhang | 2004 | Polymer Degradation and Stability2004，，2： | 1 |
| 20 | Optimization of capacity and operation for CCHP system by genetic algorithm显示文摘 | WANG Jiangjiang JING Youyin ZHANG Chunfa | 2010 | Applied Energy2010，87，4： | 1 |
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