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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 3 | 8-Bromo-7-methoxychrysin-blocked STAT3/ Twist axis inhibits the sternness of cancer stem cell-like cell originated from SMMC-7721 cells显示文摘抄写 3 的信号变换器和使活跃之物(STAT3 ) 是能调整房间增长,幸存,和开发的潜伏的细胞质的 transcriptional 因素的家庭的一个成员。扭曲是 STAT3 的目标基因,这被报导了,并且发信号的 STAT3/Twist 在调整癌症进步起一个重要作用。这里,探索 8-bromo-7-methoxychrysin (BrMC ) 是否禁止肝癌症经由破坏 STAT3/Twist 发信号的像茎的房间(LCSLC ) 性质,我们在 vitro 的有教养的 SMMC-7721 房间,并且由决定形成范围的能力和迁居在球状体的 stemness 上评估了 BrMC 的效果。范围形成试金结果在 LCSLC 显示出形成范围的能力的集中依赖者减少(P < 0.05 ) 与 BrMC 的不同集中对待。愈合创伤的试金结果在与 BrMC 的不同集中对待的 LCSLC 的房间移植表明了集中依赖者衰落。另外, CD133, CD44,和 ALDH1 层次在与 BrMC 对待的 LCSLC 被减少。有 BrMC 的不同集中的治疗也减少了 p-STAT3 和 Twist1 蛋白质的表情。BrMC 的效果被合作处理实质地与 JSI-124 提高, STAT3 的一个特定的禁止者。Twist1 的宫外的表示在 LCSLC 在标记的范围形成,移植,和表示上稀释了 BrMC 的禁止的效果。然而,它不有在 LCSLC 在 p-STAT3 上影响表示。这些结果证明 BrMC 禁止 LCSLC 的 stemness 由禁止 STAT3/Twist 从 SMMC-7721 房间线发源信号轴。 | Yimin Luo Yinghong Cui Xiaocheng Cao Xiang Li A Chen Jiansong Zhang Xiangding Chen Jianguo Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 7 |
| 4 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 5 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 6 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 7 | Optimization of Preparation Process for Allylamine-bacterial Cellulose via Graft Copolymerization by Response Surface Methodology显示文摘 | LU Min A Runa GUAN Xiaohui XU Xiaohui CUI Yingshengnan GAO Tingting | 2014 | Chemical Research in Chinese Universities2014，30，3： | 4 |
| 8 | IMPACT OF DEBRIS FLOW ON RIVER CHANNEL IN THE UPPERREACHES OF THE YANGTZE RIVER显示文摘A debris flow gully is a 'sediment highway'. Debris flow carries huge amount of sediment into river in extreme short time. which reduces discharge capacity of the river and even blocks up the river and also causes river bank erosion. | Peng CUI (1 This research is a part of key project supported by National Natural Scence Foundation (basic) (project No. 49831010). 2 Institute of Mountain hazards and Environment, Dongchuan Debris Flow Study Station. Chinese Academy of Sciences. Chengdu | 1999 | International Journal of Sediment Research1999，14，2： | 3 |
| 9 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 10 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 11 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 12 | Sand dunes as potential sources of dust in northern China显示文摘While saltation bombardment of sand grains on a fine substrate can produce considerable dust, the well-sorted nature of sand dunes tends to preclude them from consideration as major dust sources. Recent research, however, has revealed that sand dunes can, in some cases, be large sources of dust. We used the PI-SWERL(Portable In-Situ Wind Erosion Laboratory) to measure in the field the potential of sand dunes and other desert landforms to emit particulate matter <10 μm(PM-10) dust in the Tengger, Ulan Buh, and Mu Us deserts of northern China. Combined with high resolution particle size measurements of the dune sand, an assessment of sand dunes as a dust source can be made. Large active transverse dunes tend to contain little to no stored PM-10, yet they produce a low dust flux. Coppice dunes stabilized by vegetation contain appreciable PM-10 and have very high dust emission potential. There is a positive correlation between the amount of PM-10 stored in a dune and its potential dust flux. Saltation liberates loose fines stored in dunes, making them very efficient dust emitters compared to landforms such as dry lake beds and washes where dust particles are unavailable for aeolian transport due to protective crusts or sediment cohesion. In cases where large dunes do not store PM-10 yet emit dust when active, two hypotheses can be considered:(1) iron-oxide grain coatings are removed during saltation, creating dust, and(2) sand grains collide during saltation, abrading grains to create dust. Observations reveal that iron oxide coatings are present on some dune sands. PI-SWERL data suggests that low dust fluxes from dunes containing no stored dust may represent an estimate for the amount of PM-10 dust produced by removal of iron oxide coatings. These results are similar to results from dunes in the United States. In addition, PI-SWERL results suggest that dust-bearing coppice dunes, which cover vast areas of China's sandy deserts, may become major sources of dust in the future if overgrazing, depletion of groundwater, or drought destabilizes the vegetation that now partially covers these dunes. | Mark R SWEENEY LU HuaYu CUI MengChun Joseph A MASON FENG Han XU ZhiWei | 2016 | Science China Earth Sciences2016，59，4： | 2 |
| 13 | Energy-efficiency of MIMO and Cooperative MIMO Techniques in Sensor Networks显示文摘 | CUI S GOLDSMITH A J BAHAI A | 2004 | IEEE Journal on Selected Areas in Communications2004，22，6： | 1 |
| 14 | Optimal linear cooperation for spectrum sensing in cognitive radio networks 显示文摘 | QUAN Z CUI SH G SAYED A H | 2008 | IEEE Selected in Signal Processing2008，2，1： | 1 |
| 15 | The dynamically coursing processes of the microstructures in the nondendritic AlSi7Mg alloy remelted in the semi-solid state 显示文摘 | Mao W M Cui C L Zhao A M | 2000 | Trans Nonferrous Met Soc China2000，10，1： | 1 |
| 16 | Enzyme-based molecular imprinting with metals显示文摘 | Cui A Singh A Kaplan DE | 2002 | Biomacromolecules2002，3，： | 1 |
| 17 | Analysis of a Mathematical Model of the Effect of Inhibitors on the Growth of Tumors显示文摘 | Cui S Friedman A | 2000 | Math Biosci2000，164，： | 1 |
| 18 | Spray forming of hypereuteetic A1-Si alloys显示文摘 | CUI C SCHULZ A SCHIMANSKI K ZOCH H W | 2009 | Journal of Materials Processing Technology2009，209，3： | 1 |
| 19 | Evaluation of three ornamental plants for phytoremediation of Pb-contamined soil显示文摘 | CUI S ZHANG T A ZHAO S L | 2013 | International Journal of Phytoremediation2013，15，4： | 1 |
| 20 | Effect of biochar amendment on yield and methane and nitrous oxide emissions from a rice paddy from Tai Lake plain, China 显示文摘 | Zhang A Cui L Pan G | 2010 | Agriculture Ecosystems and Environment2010，139，： | 1 |
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