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| 1 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 2 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 3 | Primary malignant tumor of the small intestine显示文摘 | Zhou ZW Wan DS Chen G Chen YB Pan ZZ | 1999 | World Journal of Gastroenterology1999，5，3： | 3 |
| 4 | An antagonist decoy receptor and a death domain-containing receptor for TRAIL显示文摘 | Pan G Ni G Wei YF Ni J Yu G | | 0，，： | 3 |
| 5 | An antagonist decoy receptor and a death domain-containing receptor for TRAIL 显示文摘 | Pan G Ni J Wei Y F | 1997 | Science1997，277，5327： | 2 |
| 6 | Vapor pressure measurements of dimethyl ether from 233 to 399 K 显示文摘 | Wu J T Liu Z G Pan J | 2004 | Journal of Chemical and Engineering Data2004，49，1： | 2 |
| 7 | Radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina RPC structures as integrated solar thermochemical reactor显示文摘This paper investigated radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina reticulated porous ceramic structures as integrated solar thermochemical reactor.High-flux solar radiation absorption and axial temperature distribution in the ceramic foams reactor were analyzed by adopting surface-to-surface radiation model coupled to the P1approximation for radiation heat transfer.The radiative heat transfer and thermal characteristics of different foam-type RPC structures,including SiC,CeO_2,FeAl_2O_4,NiFeAlO_4,Fe_3O_4/SiC,and NiFe_2O_4/SiC were evaluated.The mass flow rate and foam structural parameters,including the permeability,pore mean cell size,and extinction coefficients have significantly affected the axial temperature distribution,pressure drop,heat transfer,and fluid flow.Integrated porous structure to the solar receiver could maximize the incorporation of redox powder in the reacting medium,lower the pressure drop,and enhance the thermal performance of the thermochemical reacting system.SiC structure was the candidate materials in the case where more heat flux and high axial temperature distribution is needed.However,Fe-based oxide coated Al_2O_3structure could be considered regarding the heat transfer enhancement along with the catalyst activity of oxygen carriers for solar thermochemical reacting system performance. | GUENE LOUGOU Bachirou SHUAI Yong PAN RuMing CHAFFA Gédéon AHOUANNOU Clément ZHANG Hao TAN HePing | 2018 | Science China(Technological Sciences)2018，61，12： | 2 |
| 8 | The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus显示文摘 | Pan G Pei D | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 9 | The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells 显示文摘 | Campbell J J Haraldsen G Pan J | 1999 | Nature1999，400，： | 2 |
| 10 | A novel functionally graded material in the Ti-Si-C system显示文摘 | LUO Y G PAN W LI S Q WANG R G LI J Q | 2003 | Mater Sci Eng A2003，345，： | 1 |
| 11 | Improvements in sintered density and dimensional stability of powder injection-molded 316L compacts by adjusting the alloying compositions显示文摘 | Shu G J Hwang K S Pan Y T | 2006 | Acta Materialia2006，54，2006： | 1 |
| 12 | Adsorption - Dessorption of phosphate on airborne dust and riverbone particulates in east medcterranean seawater显示文摘 | G Pan M D Krom B Herut | 2002 | Environ Sci Technol2002，36，： | 1 |
| 13 | Alternative block poly- urethanes based on poly(3-hydroxybutyrate-co-4-hydroxybu- tyrate) and poly(ethylene glycol) 显示文摘 | PAN J Y LI G Y CHEN Z F | 2009 | Biomaterials2009，30，16： | 1 |
| 14 | Preliminary design for a China ITER test blanket module 显示文摘 | Feng K M Pan C H Zhang G S | 2006 | Fusion Engineering and Design2006，81，814： | 1 |
| 15 | Preparation and characterization of arnino-functionalized nano-Fe3O4 magnetic polymer adsorbents for removal of chromium(VI) ions显示文摘 | Zhao Y G Shen H Y Pan S D | 2010 | Journal of Materials Science2010，45，： | 1 |
| 16 | MicroRNAs as oncogenes and tumor suppressors显示文摘 | Zhang B Pan X Cobb G P | 2007 | Dev Biol2007，302，1： | 1 |
| 17 | Determination of Fractal Dimensions of Solid Carbons From Gas and Liquid Phase Adsorpsion Isotherms显示文摘 | Khalili N R Pan M Sandi G | 2000 | Carbon2000，38，： | 1 |
| 18 | Apoptosis and cell proliferation in the development of gastric carcinomas:associations with cmyc and p53 protein expression显示文摘 | Ishii H H Gobe G C Pan W | 2002 | J Gastroenterol Hepatol2002，17，： | 1 |
| 19 | Strategy for the treatment of acute myelogenous leukemia based on folate receptor beta-targeted liposomal doxorubicin combined with receptor induction usingall -trans retinoic acid显示文摘 | PAN X Q ZHENG X SHI G | 2002 | Blood2002，100，2： | 1 |
| 20 | The Diagnosis of Pneumonia in Renal Transplant Recipients Using Invasive and Noninvasive Procedures显示文摘 | Chang G C Wu C L Pan S H | 2004 | Chest2004，125，3： | 1 |
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