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79篇 您的检索式:作者名="COCO P"
    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers 显示文摘Brunetto MR Oliveri F Colombatto P Moriconi F Ciccorossi P Coco B Romagnoli V Cherubini B Moscato G Maina AM Cavallone D Bonino F 2010Gastroenterology2010,139,2:1
3Acute promyelocytic leukemia: recent advances in diagnosis and manage- ment显示文摘LO COCO F AMMATUNA E MONTESINOS P 2008Semin Oncol2008,35,4:1
4Determination of lead(Ⅱ) and cadmium( Ⅱ ) in hard and soft wheat by derivative potentiometric stripping analysis显示文摘Lo Coco F Monotti P Fieechi V etal 2004Analytica Chimica Acta2004,9,:1
5High-performance liquid chromatographic determination of vancomycin in rabbit senlm, vitreous and aqueous humour after intravitreal injection of the drug显示文摘DelNozal M J Bemal JL Pampliega A Marinero P Lopez MI Coco R 1996J Chromatogr A1996,727,2:1
6Volatile composition of Baga red wine: assessment of the identification of the would-be impact odoumnts显示文摘ROCHA S M RODRIGUES F COCO P 2004Analytica Chimica Acta2004,513,1:1
7Conservative Surgery for early cancer of the distal rectum 显示文摘COCO C MAGISTRELLIP P GRANONEP P 1992Dis Coco Rectum1992,35,02:1
8Transcribed-Ultra conserver region expression is associated with outcome in high-risk neuroblastoma显示文摘Scaruffi P Stigliani S Coco S 2009BMC Cancer2009,9,:1
9Intrinsic radiosensitivity and chromosome aberration analysis using fluorescence in situ hybridization incells of two human tumor cell lines显示文摘 Coco Martin J Legal JD 1994Radiat Res1994,138,1:1
10Growth factor engineering by degenerate homoduplex gene family recombination显示文摘Coco W M Encell L P Levinson W E 2002Nat Biotechnol2002,20,:1
11An isol aled echogenic heart focus is not indication for amnioeentesis in 12, 672 unselected patients显示文摘Coco C Jeaniy P 2004J Ultra - sound Med2004,23,7:1
12Isolated fetal pyelectasis and chromosomal abnormalities显示文摘Coco C Jeanly P 2005Am J Obstet Gynecol2005,193,31:1
13Phase IL open-lahel study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate显示文摘Joensuu H De Braud F Coco P 2008Annals of Oneology2008,19,1:1
14Determination of lead ( I1 ) and cadmium ( ]I ) in hard and soft wheat by derivative potentiometric stripping analysis 显示文摘Coco F L Monotti P Fiecchi V 2000Analyticu Chimica Acta2000,409,1:1
15Isolated fetal pyelectasis and chromosomal abnormalities显示文摘Coco C Jeanty P 2005Am J Obstet Gynecol2005,193,31:1
16An isolated echogenic heart focus is not an indication for amniocentesis in 12 672 unselected patients显示文摘Coco C Jeanty P Jeanty C 2004J Ultrasound Med2004,23,4:1
17Phase IT ,open label study of PTK787/ZK222584 for the treatment of metastatic gastroOintestinaIstromal tumors resistant to imatinib mesylate 显示文摘Joensuu H De Braud F Coco P 2008Ann Oncol2008,19,1:1
18Combined modality therapy in low risk (T2N0) rectal cancer显示文摘Coco C Magistrelli P Netri G 1995Rays1995,20,2:1
19Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos(t)ide analogues during lamivudine treatment显示文摘Moriconi F Colombatto P Coco B 2007Antimicrob Chemother2007,60,2:1
20Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos (t) ide analogues during lamivudine treatment 显示文摘MORICONI F COLOMBATrO P COCO B 2007J Antimicrob Chemother2007,60,2:1
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