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	题名	作者	年代	出处	被引量
1	一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.	Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P	2014	中华神经外科疾病研究杂志2014，13，5：	6
2	Efficacy of caspofungin alone and in combination with voriconazole in guinea pig model of invasive aspergillosis显示文摘	Kirkpatrick W R Perea S Coco B J	2002	Antimicrob Agents Chemother2002，46，：	1
3	Fundus autofluorescence in patients with age-related macnlar degeneration and high risk of visual loss显示文摘	Lois N Owens SL Coco R	2002	Am J Ophthalmol2002，133，3：	1
4	High-performance liquid chromatographic determination of vancomycin in rabbit senlm, vitreous and aqueous humour after intravitreal injection of the drug显示文摘	DelNozal M J Bemal JL Pampliega A Marinero P Lopez MI Coco R	1996	J Chromatogr A1996，727，2：	1
5	Analysis of AB- CA4 in mixed Spanish families segregating different retinal dystrophies 显示文摘	Paloma E Coco R Martinez-Mir A	2002	Hum Mutat2002，20，6：	1
6	Rituximab for managing relapsing or refractory patients with idiopathic thrombotic thrombocytopenic purpura-- haemolytic uraemic syndrome 显示文摘	Caramazza D Quintini G Abbene I Coco LL Malato A Di Trapani R	2010	Blood Transfus2010，8，3：	1
7	Differences in gastric carcinoma microenvironment stratify according to EBV infec- tion intensity: implications for possible immune adjuvant the- rapy显示文摘	STRONG M J XU G R COCO J	2013	PLoS Pathogens2013，9，10：	1
8	The use of video systems to measure run-up on beaches 显示文摘	Salmon S A Bryan K R And Coco G	2007	Joumal of Coastal Research2007，150，：	1
9	Detecting nonlinearity in run-up on a natural beach 显示文摘	K R Bryan G Coco	2007	Nonlin Processes Geophys2007，14，：	1
10	Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis显示文摘	Kirkpatrick W R Perea S Coco B J	2002	Antimicrob Agents Chemother2002，46，8：	1
11	Diagnostic and prognostic advances in the immunophenotypic and genetic characterization of acute leukaemia显示文摘	Lo Coco F Foa R	1995	Eur J Haematol1995，55，1：	1
12	The value of single umbilical artery in the prediction of fetal aneuploidy : findings in 12,672 pregnant wom- en显示文摘	Granese R Coco C Jeanty P	2007	Ultrasound Q2007，23，2：	1
13	The value of single umbilical artery in the prediction of fetal aneuploidy: findings in 12, 672 pregnant women 显示文摘	Granese R Coco C Jeanty P	2007	Ultrasound Q2007，23，2：	1
14	Fibroblast growth fac-tor receptor-1is essential for in vitro cardiomyocyte development显示文摘	DELL'ERA P RONCA R COCO L	2003	Circ Res2003，93，5：	1
15	Combined effect of PLGA and curcumin on wound healing activity显示文摘	Chereddy KK Coco R Memvanga PB	2013	J Control Release2013，171，2：	1
16	Sensitivity of modelled channel network formation to environmental conditions and initial bathymetry显示文摘	Maanen B V Coco G Bryan K R	2010	EGU General Assembly2010，12，：	1
17	Fibroblast growth factor receptor- 1 is essential for in vitro cardiomyocyte development 显示文摘	Ronca R Coco L	2003	Circ Res2003，93，5：	1
18	Variability of GPS Satellite Differential Group Delay Biases显示文摘	Coco D S Coker C Dahlke S R		0，，06：	1
19	The value of single umbilical artery in the prediction of fetal aneuploidy: findings in 12,672 pregnant women显示文摘	Granese R Coco C Jeanty P	2007	Ultrasound Q2007，23，2：	1
20	Cytogenotic findings in 200 children with montal retardation and multiple congenital anomalies of unknown course显示文摘	Coco R	1982	Am J Med Genet1982，12，：	1

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