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| 1 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | GPS/GNSSBasedTrainPositioningforSafetyCriticalApplications显示文摘 | FILIP A MOCEK H BAZANT L | 2001 | Signal+Draht2001，93，5： | 1 |
| 4 | Detailed analy-sis of expression and promoter methylation status of apop-tosis-related genes in prostate cancer 显示文摘 | Carvalho J R Filipe L Costa V L | 2010 | Apoptosis2010，15，8： | 1 |
| 5 | Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata 显示文摘 | Filip S Peter L Elena A | 2007 | J Clin Invest2007，117，1： | 1 |
| 6 | Inhibition of influenza virus production in virus-infected mice by RNA interference显示文摘 | Ge Q Filip L Bai A | 2004 | Proc Natal Acad Sci USA2004，101，23： | 1 |
| 7 | New trends in breast reconslruc- tion 显示文摘 | Fodor L Bota IO Filip CI | 2011 | Chirurgia (Bucur)2011，106，4： | 1 |
| 8 | Inhibition of influenza virus production in virus-infected mice by RNA interference显示文摘 | Filip L Bed A | 2004 | Proc Natl Acad Sci USA2004，101，23： | 1 |
| 9 | Measurement invariance of the pay satisfaction questionnaire across three countries显示文摘 | FiliP L Frederik A Miehael MH | 2007 | Educ Psychol Meas2007，67，6： | 1 |
| 10 | Effects of pH on the rates of aerobic metabolism of phospho- rus-accumulating and glycogen-accumulating organ- isms显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Water Environment Research2001，73，： | 1 |
| 11 | The antimicrobial action of low-molar-mass chitosan, chitosan derivatives and chitooligosaccharides on bifidobacteria显示文摘 | SIMUNEK J KOPPOVA I FILIP L | 2010 | Folia Microbiol2010，55，4： | 1 |
| 12 | Stoichiometry and kinetics of acetate uptake under anaerobic conditions by an enriched culture of phosphorus-accumulating organisms at different pHs显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Biotechnology Bioengineering2001，76，1： | 1 |
| 13 | Biomass co-firing potentials for electricity generation in Poland-Matching supply and co-firing opporttmities显示文摘 | Marten B Emil L Filip J | 2008 | Biomass and Bioenergy2008，32，9： | 1 |
| 14 | Phenolic compounds in seven South American Ilex species显示文摘 | López P Giberti G | 2001 | Fitoterapia2001，，72： | 1 |
| 15 | Is there a com- promise between nutrient uptake and gas exchange in the gut of Misgurnus anguillicaudatus, an intestinal air-breathing fish?显示文摘 | Goncalves A F Filipe L Cristina C | 2007 | Comparative Biochemistry and Physiology Part D: Genomics and Proteomics2007，2，34： | 1 |
| 16 | Soccer-Related Ocular Injuries显示文摘 | Capao Filipe J A Fernandes V L Barros H | 2003 | Arch Ophthahnol2003，121，1： | 1 |
| 17 | Immobilization of TiO2 nanoparticles onto paper modification through bioconjugation显示文摘 | Ye L Filipe C D M Kavoosi M | 2009 | Journal of Materials Chemistry2009，19，： | 1 |
| 18 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 19 | Flow cytometry effects on spermatogenesis显示文摘 | Oliveira H Loureiro J evaluation of lead and Filipe L | 2006 | Reproductive Toxicology2006，22，3： | 1 |
| 20 | Inhibition of influenza virus produc- tion in virus-infected mice by RNA interference 显示文摘 | GE Q FILIP L BAI A | 2004 | Proc Natal Acad Sei USA2004，101，23： | 1 |
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