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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte- endothelial adhesion and promotes neurovascular injury during septic encephalopathy显示文摘 | Huan Wang Ling-Juan Hong Ji-Yun Huang Quan Jiang Rong-Rong Tao Chao Tan Nan-Nan Lu Cheng-Kun Wang Muhammad M Ahmed Ying-Mei Lu Zhi-Rong Liu Wei-Xing Shi En-Yin Lai Christopher S Wilcox Feng Han | 2015 | Cell Research2015，25，6： | 16 |
| 3 | Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond显示文摘Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability(MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with MSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer. | Emily M Lin Jun Gong Samuel J Klempner Joseph Chao | 2018 | World Journal of Gastroenterology2018，24，25： | 10 |
| 4 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 5 | New mineralnames显示文摘 | FLEISCHER M CHAO G Y MANDARINO J A | 1979 | Am Mineral1979，64，56： | 2 |
| 6 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 7 | Influence of process loading intensity on sludge clarification and thickening characteristics显示文摘 | Chao A C Keinath T M | 1979 | Wat Res1979，13，12： | 1 |
| 8 | Observation on the breeding of brown marbled grouper,Epinephelus fuscoguttatus (Forskal)显示文摘 | Lim L C Chao T M Khoo L T | 1990 | Singapore J Prim Ind1990，18，： | 1 |
| 9 | Spontaneous ignition of pressurized releases of hydrogen and natural gas into air 显示文摘 | DRYER F L CHAOS M ZHAO Z W | 2007 | Combustion Science and Technology2007，179，4： | 1 |
| 10 | A combined method of conventional and endoscopic adenoidectomy 显示文摘 | Huang H M Chao M C Chen Y L | 1998 | Laryngoscope1998，108，7： | 1 |
| 11 | A tabu search method for the truck and trailer routing problem 显示文摘 | CHAO I M | 2002 | Computers and Operations Research2002，29，1： | 1 |
| 12 | Local recurrence of breast cancer in stereotactic core needle biopsy site: case reports and re- view of literature显示文摘 | Chao C Torosian M Boraas M | 2001 | Breast J2001，7，2： | 1 |
| 13 | Chinese purchasing managers preferences in supplier selection显示文摘 | Mummalaneni V Dubas K M Chao C | 1996 | Industrial Marketing Management1996，25，2： | 1 |
| 14 | External skeletal fixation of canine tibial osteotomies: Compression compared with no compression显示文摘 | Hart M B Wu J J Chao EYS | 1985 | J Bone Joint Surg(Am)1985，67，4： | 1 |
| 15 | 显示文摘 | Wey M Y Chao C Y Chen J C | 1998 | Journal of the Air and Waste Management Association1998，48，： | 1 |
| 16 | A young RNA polymerase Ⅱ holoenzyme contains SWI/SNF regulators involved in chromatin remodeling显示文摘 | WILSO C J CHAO D M Imbelzano A N | 1996 | Cell1996，84，： | 1 |
| 17 | On the fracture of solids characterized by one or two parameters:theory and practice显示文摘 | Chao Y J Yang S Sutton M A | 1994 | Journal of the Mechanics of Physics and Solids1994，42，： | 1 |
| 18 | Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia 显示文摘 | Chao MP Alizadeh AA Tang C Jan M Weissman-Tsukamoto R Zhao F | 2011 | Cancer Res2011，71，4： | 1 |
| 19 | Construction ofone-coincidence sequence quasi-cyclic LDPC codes oflarge girth 显示文摘 | JENFA H CHUN M H CHAO C Y | 2012 | IEEE Transactions on Information Theory2012，58，3： | 1 |
| 20 | HIV infection and the risk of cancers with and without a known infectious cause 显示文摘 | Silverberg M J Chao C Leyden WA | 2009 | AIDS2009，23，： | 1 |
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