3篇
您的检索式：作者名="Emily M Lin"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond显示文摘Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability(MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with MSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer. | Emily M Lin Jun Gong Samuel J Klempner Joseph Chao | 2018 | World Journal of Gastroenterology2018，24，25： | 10 |
| 2 | Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments显示文摘野生的老鼠并且实验室老鼠的免疫系统能作为人的免疫系统的模型被利用在工业化前并且 industrial 以后社会分别地。在这研究,在野生的老鼠的淋巴细胞显型广泛地被描绘,并且结果与我们并且由其它用从实验室老鼠的各种各样的紧张导出的房间获得的那些相比。尽管没期望,规章的 T 房间的生产不在与实验室老鼠相比的野生的老鼠是显然不同的。在另一方面,在标记的表示的差别在补充规定包含了,粘附,发信号并且成熟与实验室老鼠相比在野钩子的老鼠建议增加的补充规定和减少的敏感,并且向 T 房间的成熟之间的复杂差别指。结果潜在地借卓见进过敏症和自体免疫的疾病的 industrial 以后流行病的致病。 | Ashley M Trama Zoie E Holzknecht Anitra D Thomas Kuei-Ying Su Sean M Lee Emily E Foltz Sarah E Perkins Shu S Lin William Parker | 2012 | Cellular & Molecular Immunology2012，9，2： | 0 |
| 3 | 2011年日本东北地区近海大地震最大位移区的应力状态显示文摘2011年MW9.0的日本东北地区近海大地震在日本海沟附近产生了最大超过50m的同震滑动,这可能导致该区域进入了应力近乎完全卸载的状态。为检验上述假设,我们利用综合大洋钻探计划在震后1年左右时间得到的钻孔资料,以及对震前应力状态的推断结果,确定了陆楔前缘的原地应力状态。根据孔壁崩落法对水平应力方向与应力大小的估算结果,以及在破裂向海沟轴方向传播过程中同震位移增大的现象,可推断原地水平应力在地震过程中变小了。这种应力变化显示出板块界面的前缘发生了相对自由的滑动,该结论与地震引起了断层弱化和发生了近乎全部的应力降等观测结果是吻合的。 | Weiren Lin Marianne Conin J Casey Moore Frederick M Chester Yasuyuki Nakamura James J Mori Louise Anderson Emily E Brodsky Nobuhisa Eguchi 343勘查队科技人员 冯万鹏(译) 许忠淮(校) | 2013 | 国际地震动态2013，，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员