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	题名	作者	年代	出处	被引量
1	Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context.	Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest	2015	World Journal of Gastroenterology2015，21，45：	33
2	Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘	José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste	2014	The Journal of Molecular Diagnostics2014，，1：	2
3	Proteomic analysis of human vitreous fluid by fluorescence based difference gel electrophoresis (DIGE):a new strategy for identifying potential candidates in the patho- genesis of proliferative diabetic retinopathy 显示文摘	Garcia-Ramirez M Canals F Hemandez C Colome N Ferrer C Carrasco E	2007	Diabetologia2007，50，6：	1
4	Positive end expiratory pressure during one - lung ventilation : selecting ideal patients and ventilator settings with the aim of improving arterial oxygenation 显示文摘	Hoftman N Canales C Leduc M	2011	Ann Card Anaesth2011，14，3：	1
5	Photic maculopathy and iris dam-age in a psychotic patient显示文摘	Ruiz-del-Rio N Moriche Carretero M Ortega Canales I RevillaAmores R Peralta Calvo JM	2006	Arch Soc Esp Oftalmol2006，81，3：	1
6	Positive end expiratory pres- sure during one-lung ventilation: selecting ideal patients and ven- tilator settings with the aim of improving arterial oxygenation显示文摘	Hoftman N Canales C Leduc M	2011	Ann Card Anaesth2011，14，3：	1
7	Effects of iron deficiency on neonatal behavior at different stages of pregnancy显示文摘	Herndndez-Martinez C Canals J Aranda N	2011	Early Hum Dev2011，87，3：	1
8	High - dose therapy and autologous stem cell transplantation in first relapse for diffuse large B cell lymphoma in the rituximab era:An analysis based on data from the European blood and marrow transplantation registry 显示文摘	Mounier N Canals C Gisselbrecht C	2012	Biol Blood Marrow Transplantat2012，18，5：	1
9	A simple evolutionary topology optimization procedure for compliant mechanism design显示文摘	Rubén Ansola Estrella Veguería Javier Canales José A. Tárrago	2007	Finite Elements in Analysis & Design2007，，1：	1
10	Positive end expiratory pressure during one-lung ventilation: selecting ideal patients and ventilator settings with the aim of improving arterial oxygenation 显示文摘	Hoftman N Canales C Leduc M	2011	Ann Card Anaesth2011，14，3：	1
11	Model-based adaptation of behavioral mismatching components显示文摘	Canal C Poizat P Salaün G	2008	IEEE Transactions on Software Engineering2008，34，4：	1
12	Composition and run-time adaptation of mismatching behavioral interfaces显示文摘	Cámara J Salaün G Canal C	2008	J UCS2008，14，13：	1
13	Proteomic analysis of human vitreous fluid by fluoresscence based difference gel electrophoresis ( DIGE ) : a new strategy for identifying potential candidates in the patho- genesis of proliferative diabetic retinopathy 显示文摘	Garcia-Ramirez M Canals F Hemdndez C Colome N Ferrer C Carrasco E	2007	Diabetologia2007，50，6：	1
14	Effect of L-alpha- glycerylphosphorylcholine on amnesia caused by scopolamine 显示文摘	Canal N Franceschi M Alberoni M	1991	Int J Clin Pharmacol Ther Toxicol1991，29，3：	1
15	Headspace single-drop microextraction for the analysis of chlorobenzenes in water samples显示文摘	Vidal L Canals A Kalogerakis N	2005	Chromatogr A2005，1089，：	1
16	Resting microglia re- act to Aβ42 fibrils but do not detect oligomers or oligomer-in- duced neuronal damage 显示文摘	Ferrera D Mazzaro N Canale C	2014	Neurobiol Aging2014，35，：	1
17	A practical two-step quantitative clinical and electrophysiological assessmentfor the diagnosis and staging of diabetic neuropathy 显示文摘	Feldman E L Stevens M J Thomas P K Brown M B Canal N Greene D A	1994	Diabetes Care1994，17，：	1
18	Effect of cytokines and chemokines on sickle neutrophil adhesion to fibronectin显示文摘	Assis A Conran N Canalli AA	2005	Acta Haematol2005，113，2：	1
19	Headspace single-drop microextraction for the analysis of chlorobenzenes in water samples显示文摘	Vidal L Canals A Kalogerakis N	2005	J Chromatogr A2005，1089，12：	1
20	Influence of corona discharge and chitosan surface treatment on dyeing properties of wool显示文摘	Ristid N Jovenad P Canal C	2010	Journal of Applied Polymer Science2010，117，5：	1

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