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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Benign tumors of the parotid gland 显示文摘 | Pons Rocher F Lopez Molla C Ferrer Ramirez M J | 2004 | An Otorrinolaringol Ibero Am2004，31，5： | 1 |
| 3 | Pulmonary gas exchange response to oxygen breathing in acute lung injury显示文摘 | Santos C Ferrer M Roca J | 2000 | Am J Respir Crit Care Med2000，161，1： | 1 |
| 4 | Diagnosis of boron, fluofine,lead,nickel and zinc toxicity in Citrus plantations in villarreal spain 显示文摘 | AUCEJO A FERRER J GABALDON C | 1997 | Water Air Soil Pollut1997，94，： | 1 |
| 5 | How Important is Methodology for the Estimates of the Determinants of Happiness 显示文摘 | Ferrer i C Ada Pual Frijters | 2004 | Economic Journal2004，，114： | 1 |
| 6 | Hydrogen peroxide and glutathione-associated mechanisms of acclimatory stress tolerance and signaling显示文摘 | FOYER C H LOPEZ-DELGADO H FERRER M A | 1997 | Physiol Plant1997，100，： | 1 |
| 7 | lnactivation of the peroxisomal ABCD2 transporter in the mouseleads to onset ataxia involving mitochondrla,Golgi and endoplasmatic reticulum damage 显示文摘 | Ferrer I Kapihamar J Hindelang C | 2005 | Hum Mol Genet2005，14，23： | 1 |
| 8 | The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis显示文摘 | Gonzalo Asensio J Maia C Ferrer NL | 2006 | Journal of Biological Chemistry:2006，281，3： | 1 |
| 9 | Contribution of hypoxia-measuring molecular imaging techniques toradiotherapy planning and treatment 显示文摘 | Ferrer Albiach C Conde Moreno A Rodriguez Cord6n M | 2010 | Clin Transl Oncol2010，12，1： | 1 |
| 10 | Proteomic analysis of human vitreous fluid by fluorescence based difference gel electrophoresis (DIGE):a new strategy for identifying potential candidates in the patho- genesis of proliferative diabetic retinopathy 显示文摘 | Garcia-Ramirez M Canals F Hemandez C Colome N Ferrer C Carrasco E | 2007 | Diabetologia2007，50，6： | 1 |
| 11 | The effect of Ni impurities on some structural properties of pyrite thin films 显示文摘 | I J Ferrer C D L Heras C Sanchez | 1995 | Journal of Physics: Condensed Matter1995，7，10： | 1 |
| 12 | Influence of processing variables on mechanical characteristics of sunlight aged polyester-glass fiber composites 显示文摘 | SEGOVIA F FERRER C SALVADOR M D AMIGO V | 2001 | Polymer Degradation and Stability2001，71，： | 1 |
| 13 | Downregulation of Bcl-2 protein in type 1 spinal muscular atrophy motor neurons during fetal development显示文摘 | Soler-Botija C Ferrer I Alvarez JL | 2003 | J Neuropathol Exp Neurol2003，62，4： | 1 |
| 14 | Genetic and physiologic dissection of the vertebrate cardiac conduction system显示文摘 | Chi N C Shaw R M Jungblut B Huisken J Ferrer T Arnaout R | 2008 | PLoS Biol2008，6，： | 1 |
| 15 | Comparison of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma显示文摘 | Ferrer Puchol M D la Parra C Esteban E | 2011 | Radiologia2011，53，3： | 1 |
| 16 | Temperature dependence of the optical absorption edge of pyrite FeS2 thin films显示文摘 | FErrer I J Sanchez C | 1994 | Phys Condens Matter1994，6，10： | 1 |
| 17 | Robotic sigmoid vaginoplasty:a novel technique显示文摘 | KIM C CAMPBELL B FERRER F | 2008 | Urology2008，72，4： | 1 |
| 18 | Structure and functionof enzymes involved in the biosynthesis of phenylpropanoids 显示文摘 | Ferrer JL Austin MB Stewart C Noel JP | 2008 | Plant Physiol Biochem2008，46，3： | 1 |
| 19 | Im- proved finger-knuckle-print authentication based on ori- entation enhancement 显示文摘 | Morales A Travieso C M Ferrer M A | 2011 | Electronics Letters2011，47，6： | 1 |
| 20 | Farm size,land fragmentation and economic efficiency in southern rwanda显示文摘 | BIZIMANA C NIEUWOUDT W FERRER S | 2004 | Agrekon2004，43，2： | 1 |
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