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| 1 | Neoadjuvant treatment of esophageal cancer显示文摘The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease. | Nicholas P Campbell Victoria M Villaflor | 2010 | World Journal of Gastroenterology2010,16,30: | 16 |
| 2 | 我国农村居民的红细胞脂肪酸、血浆脂质与心血管疾病显示文摘对我国49个县的心血管疾病(CVD,包括冠心病、高血压心脏病和脑卒中)死亡率和4900例35~64岁成年男女的膳食进行了调查,并测定了血浆脂质[总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和甘油三酸酯(TG)]的含量,结果指出:1.和西方国家人群比较,我国农民血浆TC、TG、HDL-C和依此计算而得的LDL-C水平较低,而HDL-C/TC比值较高,CVD死亡率也较西方国家的为低。2.在TC、LDL-C与CVD死亡率之间无相关,但在红细胞油酸水平与CVD死亡率间有显著负相关。3.红细胞油酸水平与血浆TC含量间无相关,而与红细胞花生四烯酸水平呈显著负相关。指出油酸对CVD死亡率的影响有可能是通过另一条途径,即减低血小板的聚集作用。4.我国的CVD死亡率呈现明显的地区性分布,即南方低于北方。其分布与红细胞油酸含量,及大米摄取量的地区性分布呈明显的负关系。5.为解释CVD死亡率与红细胞油酸的负关系,本文提出了油酸可能置换了血小板膜磷脂中多不饱和脂肪酸的设想,但对大米保护CVD的作用则尚需有更多的调查和研究数据才能确证之。 | 范文洵 Parker R Parpia B 屈荫生 Cassano P Crawford M Leyton J 田巧珍 黎均耀 陈君石 Campbell C | 1992 | 营养学报1992,14,1: | 15 |
| 3 | 红细胞增多症/红细胞增多的诊断、检查和治疗指南显示文摘 | 潘玲丽 高举 McMullin M F Bareford D Campbell P | 2006 | 国际输血及血液学杂志2006,29,1: | 9 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997,,2: | 6 |
| 5 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014,20,33: | 2 |
| 6 | Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes显示文摘 | Campbell KN Raij L Mundel P | | Curr Diabetes Rev0,,: | 2 |
| 7 | QT dispersion: an indication of arrhythmia risk in patients with long QT intervals显示文摘 | DAY C P MCCOMB L M Campbell RWF | 1990 | Br Heart J1990,63,: | 1 |
| 8 | Mechanisms of Disease: the Myeloprolife Rative Disorders显示文摘 | Campbell P J Green A R | 2006 | N Engl J Med2006,355,: | 1 |
| 9 | Sequential extraction procedure for the speciation of parficuinte trace metals显示文摘 | TESSIER A CAMPBELL P G C BLSSOM M | 1979 | Anal Chem1979,51,7: | 1 |
| 10 | Social resources and socioeconomic status 显示文摘 | Campbell K E Marsden P V Hurlbert J S | 1986 | Social Networks1986,,8: | 1 |
| 11 | Investigation into refractories as crucible and mould materials for melting and casting γ-TiAl alloys 显示文摘 | KUANG J P HARDING R A CAMPBELL J | 2000 | Mater Sci Technol2000,16,9: | 1 |
| 12 | Sequential extraction procedure for the speciation of particulate trace metals 显示文摘 | TESSIER A CAMPBELL P G C BISSON M | 1979 | Anal Chem1979,51,7: | 1 |
| 13 | Suppression subtractive hy+bridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996,93,12: | 1 |
| 14 | Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases显示文摘 | Jawahar A Shaya M Campbell P | 2005 | Surg Neurol2005,64,3: | 1 |
| 15 | Sequential extraction procedure for the sspeciation of particulate trace elements显示文摘 | Tessier A Campbell P G C | 1997 | Anal Cbem1997,51,: | 1 |
| 16 | The wetlands of lakes pontchartrain and maurepas: past, present and future 显示文摘 | KEDDY P A CAMPBELL D MCFALLS T | 2007 | Environmental Reviews2007,15,1: | 1 |
| 17 | Suppression subtractive hybridization:a method for generating differentially regulated or tissue specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996,93,12: | 1 |
| 18 | Preliminary evi-dence that chronic confinement stress reduces the quality of gametes produced by brown and rainbow trout显示文摘 | Campbell P M Pottinger T G Sumpter J P | 1994 | Aqua-culture1994,120,15: | 1 |
| 19 | Decreased accumulation of glutelin types in rice grains constitutively expressing a sunflower seed albumin gene 显示文摘 | Islam N Upadhyaya N M Campbell P M | 2005 | Phytochemistry2005,66,21: | 1 |
| 20 | Sequential extraction procedure for the speciation of particulate trace metals显示文摘 | TESSIER A CAMPBELL P G C BLSSON M | 1979 | Analytical Chemistry1979,51,7: | 1 |