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34篇 您的检索式:作者名="C.Yang"
    题名 作者 年代 出处 被引量
1农业企业的盈余操控更为严重吗?——基于中国上市公司的实证研究显示文摘采用2007—2014年中国沪深两市A股上市公司数据,研究行业特征和盈利能力对上市公司盈余管理水平的影响,实证分析结果表明:农业上市公司较非农上市公司具有更高的应计盈余管理水平和真实盈余管理水平;上市公司的盈利能力与应计盈余管理水平正相关,而与真实盈余管理水平负相关;较高的盈利能力强化了行业特征对真实盈余管理水平的正向影响,而对应计盈余管理水平则不具有这种影响。该研究不仅证实了农业上市公司较非农上市公司实施了更为严重的盈余操控,还揭示出上市公司的盈利能力对应计盈余管理水平和真实盈余管理水平的影响存在异质性以及盈利能力对行业特征与两种盈余管理水平之间关系的调节作用也存在异质性。李宾 韩方芳 David C.YANG 2017统计与信息论坛2017,32,7:12
2Simultaneous enhancement of mechanical and shape memory properties by heat-treatment homogenization of Ti_(2)Ni precipitates in TiNi shape memory alloy fabricated by selective laser melting显示文摘The excellent shape memory and mechanical properties of Ti Ni shape memory alloys(SMAs) fabricated using selective laser melting(SLM) are highly desirable for a wide range of critical applications. In this study, we examined the simultaneous enhancement of mechanical and shape memory properties using heat-treatment homogenization of Ti_(2)Ni precipitates in a Ti_(50.6)Ni_(49.4)SMA fabricated using SLM. Specifically, because of the complete solution treatment, nanoscale spherical Ti_(2)Ni precipitates were homogeneously dispersed throughout the grain interior. Interestingly, the resultant SMA exhibited an ultrahigh tensile strength of 880 ± 13 MPa, a large elongation of 22.4 ± 0.4%, and an excellent shape memory effect, with a recovery rate of > 98% and ultrahigh recoverable strain of 5.32% after ten loading–unloading cycles. These simultaneously enhanced properties are considerably superior than those of most previously reported Ti Ni SMAs fabricated using additive manufacturing. Fundamentally, the enhancement in tensile strength is ascribed to precipitation strengthening and work hardening, and the large plasticity is mainly attributed to the homogeneous nanoscale globular Ti_(2)Ni precipitates, which effectively impeded the rapid propagation of microcracks. Furthermore, the enhanced shape memory properties are derived from the suppression of dislocation movement and formation of retained stabilized martensite by the presence of high-density dislocations, nanoscale Ti_(2)Ni precipitates, and abundant interfaces. The obtained results provide insight into the enhancement of the two types of properties in Ti Ni SMAs and will accelerate the wider application of SMAs.H.Z.Lu L.H.Liu C.Yang X.Luo C.H.Song Z.Wang J.Wang Y.D.Su Y.F.Ding L.C.Zhang Y.Y.Li 2022Journal of Materials Science & Technology2022,,6:5
3Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles.Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang 2018Acta Pharmaceutica Sinica B2018,8,6:5
4Overcoming the strength-ductility trade-off by tailoring grain-boundary metastable Si-containing phase in β-type titanium alloy显示文摘It is well accepted that grain-boundary phases in metallic alloys greatly deteriorate the mechanical properties.In our work,we report on a novel strategy to prepare high strength-ductility β-type(Ti69.71 Nb23.72Zr4.83Ta1.74)97Si3(at.%)(TNZTS) alloys by tailoring grain-boundary metastable Si-containing phase.Specifically,the thin shell-shaped metastable S1 phase surrounding the columnar β-Ti grain was intercepted successfully via nonequilibrium rapid solidification achieved by selective laser melting(SLM).Subsequently,the thin shell-shaped metastable(Ti,Nb,Zr)5 Si3(called S1) phase was transformed into globular(Ti,Nb,Zr)2 Si(called S2) phase by the solution heat treatment.Interestingly,the globular S2 phases reinforced TNZTS alloy exhibits ultrahigh yield strength of 978 MPa,ultimate strength of 1010 MPa and large elongation of 10.4 %,overcoming the strength-ductility trade-off of TNZTS alloys by various methods.Especially,the reported yield strength herein is 55 % higher than that of conventionally forged TNZT alloys.Dynamic analysis indicates the globularization process of the metastable S1 phase is controlled by the model of termination migration.The quantitative analysis on strengthening mechanism demonstrates that the increase in yield strength of the heat-treated alloys is mainly ascribed to the strengthening of the precipitated silicide and the dislocations induced by high cooling rate.The obtained results provide some basis guidelines for designing and fabricating β-titanium alloys with excellent mechanical properties,and pave the way for biomedical application of TNZTS alloy by SLM.X.Luo L.H.Liu C.Yang H.Z Lu H.W.Ma Z.Wang D.D.Li L.C.Zhang Y.Y.Li 2021Journal of Materials Science & Technology2021,,9:5
5Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases.Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang 2016Acta Pharmaceutica Sinica B2016,6,4:4
6Numerical study on static and dynamic fracture evolution around rock cavities显示文摘In this paper,a numerical code,RFPA2D(rock failure process analysis),was used to simulate the initiation and propagation of fractures around a pre-existing single cavity and multiple cavities in brittle rocks.Both static and dynamic loads were applied to the rock specimens to investigate the mechanism of fracture evolution around the cavities for different lateral pressure coefficients.In addition,characteristics of acoustic emission(AE) associated with fracture evolution were simulated.Finally,the evolution and interaction of fractures between multiple cavities were investigated with consideration of stress redistribution and transference in compressive and tensile stress fields.The numerically simulated results reproduced primary tensile,remote,and shear crack fractures,which are in agreement with the experimental results.Moreover,numerical results suggested that both compressive and tensile waves could influence the propagation of tensile cracks;in particular,the reflected tensile wave accelerated the propagation of tensile cracks.S.Y.Wang L.Sun C.Yang S.Q.Yang C.A.Tang 2013Journal of Rock Mechanics and Geotechnical Engineering2013,5,4:4
7Methods for a blind analysis of isobar data collected by the STAR collaboration显示文摘In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of nuclei.The isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr.In order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis procedure.Analysts are initially provided a'reference sample'of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run conditions.After tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking runs.For this sample,species-specific information is disguised,but individual output files contain data from a single isobar species.Only run-by-run corrections and code alteration subsequent to these corrections are allowed at this stage.Following these modifications,the'frozen'code is passed over the fully un-blind data,completing the blind analysis.As a check of the feasibility of the blind analysis procedure,analysts completed a'mock data challenge,'analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in 2018.The Au+Au data were prepared in the same manner intended for the isobar blind data.The details of the blind analysis procedure and results from the mock data challenge are presented.J.Adam L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderon de la Barca Sanchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanad M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He Y.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.Ji J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Md.Nasim K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa S.Oh V.A.Okorokov B.S.Page R.Pak A.Pandav Y.Panebratsev B.Pawlik D.Pawlowska H.Pei C.Perkins L.Pinsky R.L.Pinter J.Pluta J.Porter M.Posik N.K.Pruthi M.Przybycien J.Putschke H.Qiu A.Quintero S.K.Radhakrishnan S.Ramachandran R.L.Ray R.Reed H.G.Ritter O.V.Rogachevskiy J.L.Romero L.Ruan J.Rusnak N.R.Sahoo H.Sako S.Salur J.Sandweiss S.Sato W.B.Schmidke N.Schmitz B.R.Schweid F.Seck J.Seger M.Sergeeva R.Seto P.Seyboth N.Shah E.Shahaliev P.V.Shanmuganathan M.Shao A.I.Sheikh W.Q.Shen S.S.Shi Y.Shi Q.Y.Shou E.P.Sichtermann R.Sikora M.Simko J.Singh S.Singha N.Smirnov W.Solyst P.Sorensen H.M.Spinka B.Srivastava T.D.S.Stanislaus M.Stefaniak D.J.Stewart M.Strikhanov B.Stringfellow A.A.P.Suaide M.Sumbera B.Summa X.M.Sun X.Sun Y.Sun Y.Sun B.Surrow D.N.Svirida P.Szymanski A.H.Tang Z.Tang A.Taranenko T.Tarnowsky J.H.Thomas A.R.Timmins D.Tlusty M.Tokarev C.A.Tomkiel S.Trentalange R.E.Tribble P.Tribedy S.K.Tripathy O.D.Tsai Z.Tu T.Ullrich D.G.Underwood I.Upsal G.Van Buren J.Vanek A.N.Vasiliev I.Vassiliev F.Videbæk S.Vokal S.A.Voloshin F.Wang G.Wang J.S.Wang P.Wang Y.Wang Y.Wang Z.Wang J.C.Webb P.C.Weidenkaff L.Wen G.D.Westfall H.Wieman S.W.Wissink R.Witt Y.Wu Z.G.Xiao G.Xie W.Xie H.Xu N.Xu Q.H.Xu Y.F.Xu Y.Xu Z.Xu Z.Xu C.Yang Q.Yang S.Yang Y.Yang Z.Yang Z.Ye Z.Ye L.Yi K.Yip Y.Yu H.Zbroszczyk W.Zha C.Zhang D.Zhang S.Zhang S.Zhang X.P.Zhang Y.Zhang Y.Zhang Z.J.Zhang Z.Zhang Z.Zhang J.Zhao C.Zhong C.Zhou X.Zhu Z.Zhu M.Zurek M.Zyzak STAR Collaboration Abilene 2021Nuclear Science and Techniques2021,32,5:3
8Microstructural evolution and superelastic properties of ultrafine-graine d NiTi-base d shape memory alloy via sintering of amorphous ribbon precursor显示文摘NiTi-based shape memory alloys(SMAs)are considered as cutting-edge intelligent functional materials.However,it remains a great challenge to obtain ultrafine-grained(UFGed)bulk materials with mm-scale size as well as outstanding superelastic properties.Here,UFGed bulk Ti_(35)Zr_(15)Ni_(35)Cu_(15)NiTi-based SMA is successfully prepared via spark plasma sintering of amorphous ribbon precursor at different sintering temperatures,and microstructural evolution and superelastic properties are symmetrically investigated.It is found that its grain size ranges from UFG to micro-grain with increased sintering temperature regard-less of the predominant B2 matrix in all bulk samples.Interestingly,the orientation relationships between B2 matrix and nano-scale fcc(Ti,Zr)_(2)Ni precipitate evolve from coherent to incoherent.Consequently,the UFGed samples exhibit perfect superelasticity with the high recoverable strain of∼5.8%,the stable recov-ery rate above 99%,and the great critical stress inducing martensitic transformation higher than 1 GPa,far superior to the corresponding ones of suction-cast micro-grained TiZrNiCu SMAs.Fundamentally,the perfect superelasticity is attributed to the good resistance to dislocation slip or grain boundary slip by residual nano-scale amorphous phase or secondary phase of coherent and semi-coherent fcc(Ti,Zr)_(2)Ni precipitate.In addition,the gentle superelastic plateau is associated to the favorable transfer stress and the strong ability to accommodate dislocation movement,which is generated by the coherent interface between nano-scale fcc(Ti,Zr)_(2)Ni and UFGed B2 matrix.These results suggest that spark plasma sintering of amorphous alloy precursor is a feasible route to obtaining excellent superelasticity in NiTi-based SMAs.W.S.Cai H.Z.Lu H.Z.Li Z.Liu H.B.Ke W.H.Wang C.Yang 2023Journal of Materials Science & Technology2023,,7:2
9Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV显示文摘High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion collisions.Redistribution of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic backgrounds.We report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR experiment.The correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderón de la Barca Sánchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanád M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Nasim Md K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa S.Oh V.A.Okorokov B.S.Page R.Pak A.Pandav Y.Panebratsev B.Pawlik D.Pawlowska H.Pei C.Perkins L.Pinsky R.L.Pintér J.Pluta J.Porter M.Posik N.K.Pruthi M.Przybycien J.Putschke H.Qiu A.Quintero S.K.Radhakrishnan S.Ramachandran R.L.Ray R.Reed H.G.Ritter O.V.Rogachevskiy J.L.Romero L.Ruan J.Rusnak N.R.Sahoo H.Sako S.Salur J.Sandweiss S.Sato W.B.Schmidke N.Schmitz B.R.Schweid F.Seck J.Seger M.Sergeeva R.Seto P.Seyboth N.Shah E.Shahaliev P.V.Shanmuganathan M.Shao A.I.Sheikh F.Shen W.Q.Shen S.S.Shi Q.Y.Shou E.P.Sichtermann R.Sikora M.Simko J.Singh S.Singha N.Smirnov W.Solyst P.Sorensen H.M.Spinka B.Srivastava T.D.S.Stanislaus M.Stefaniak D.J.Stewart M.Strikhanov B.Stringfellow A.A.P.Suaide M.Sumbera B.Summa X.M.Sun X.Sun Y.Sun Y.Sun B.Surrow D.N.Svirida P.Szymanski A.H.Tang Z.Tang A.Taranenko T.Tarnowsky J.H.Thomas A.R.Timmins D.Tlusty M.Tokarev C.A.Tomkiel S.Trentalange R.E.Tribble P.Tribedy S.K.Tripathy O.D.Tsai Z.Tu T.Ullrich D.G.Underwood I.Upsal G.Van Buren J.Vanek A.N.Vasiliev I.Vassiliev F.Videbæk S.Vokal S.A.Voloshin F.Wang G.Wang J.S.Wang P.Wang Y.Wang Y.Wang Z.Wang J.C.Webb P.C.Weidenkaff L.Wen G.D.Westfall H.Wieman S.W.Wissink R.Witt Y.Wu Z.G.Xiao G.Xie W.Xie H.Xu N.Xu Q.H.Xu Y.F.Xu Y.Xu Z.Xu Z.Xu C.Yang Q.Yang S.Yang Y.Yang Z.Yang Z.Ye Z.Ye L.Yi K.Yip H.Zbroszczyk W.Zha C.Zhang D.Zhang S.Zhang S.Zhang X.P.Zhang Y.Zhang Y.Zhang Z.J.Zhang Z.Zhang Z.Zhang J.Zhao C.Zhong C.Zhou X.Zhu Z.Zhu M.Zurek M.Zyzak 2020Chinese Physics C2020,44,10:2
10Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli:further evidence that factor H regulates the classical complement pathway显示文摘Proteins of the complement system are known to interact with many charged substances.We recently characterized binding of C1q and factor H to immobilized and liposomal anionic phospholipids.Factor H inhibited C1q binding to anionic phospholipids,suggesting a role for factor H in regulating activation of the complement classical pathway by anionic phospholipids.To extend this finding,we examined interactions of C1q and factor H with lipid A,a well-characterized activator of the classical pathway.We report that C1q and factor H both bind to immobilized lipid A,lipid A liposomes and intact Escherichia coli TG1.Factor H competes with C1q for binding to these targets.Furthermore,increasing the factor H:C1q molar ratio in serum diminished C4b fixation,indicating that factor H diminishes classical pathway activation.The recombinant forms of the Cterminal,globular heads of C1q A,B and C chains bound to lipid A and E.coli in a manner qualitatively similar to native C1q,confirming that C1q interacts with these targets via its globular head region.These observations reinforce our proposal that factor H has an additional complement regulatory role of down-regulating classical pathway activation in response to certain targets.This is distinct from its role as an alternative pathway downregulator.We suggest that under physiological conditions,factor H may serve as a downregulator of bacterially-driven inflammatory responses,thereby finetuning and balancing the inflammatory response in infections with Gram-negative bacteria.Lee Aun Tan Andrew C.Yang Uday Kishore Robert B.Sim 2011Protein & Cell2011,2,4:2
11查看详情显示文摘H.Huang Q.Fu S.Zhuang Y.Liu L.Wang J.Chen D.Ma and C.Yang 0,,11:1
12Involvement of abscisic acid and ethylene in the responses of rice grains to water stress during filling显示文摘J. C.YANG J. H.ZHANG Y. X.YE Z. Q.WANG Q. S.ZHU L. J.LIU 2004Plant Cell & Environment2004,,8:1
13Evidence of a hybridization gap in ''semimetallic'' InAs/GaSb systems显示文摘M.Yang C.Yang B.Bennett B.Shanabrook 0,,24:1
14Sedimentation on a wave‐dominated, open‐coast tidal flat, south‐western Korea: summer tidal flat – winter shoreface – reply显示文摘R. W.DALRYMPLE B. C.YANG S. S.CHUN 2006Sedimentology2006,,3:1
15Characterization of immortalized mesenchymal stem cells derived from foetal porcine pancreas显示文摘H.Cao H.Zhu J.Sun Y.Pu Z.Gao C.Yang S.Peng Z.Dou J.Hua 2010Cell Proliferation2010,,1:1
16Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram‐based cardiopulmonary coupling analysis显示文摘Albert C.Yang Cheng‐HungYang Chen‐JeeHong Shih‐JenTsai Chung‐HsunKuo Chung‐KangPeng Joseph E.Mietus Ary L.Goldberger Robert J.Thomas 2011Psychophysiology2011,,2:1
17An Algorithm for Computation of 2-DEigenvalues显示文摘Y.Zou C.Yang 0,,39:1
18Factors Influencing Internet Users' Perceived Credibility of News-related Blogs in Taiwan显示文摘Kenneth C C.Yang 0,,01:1
19Empirical reassessment of stimulus poverty arguments显示文摘Legate J C.Yang 0,,:1
20Preparation of Ultra-High Performance Concrete with common technology and materials显示文摘C.Wang C.Yang F.Liu C.Wan X.Pu 0,,34:1
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