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| 1 | 豆粕和棉粕日粮中添加α-半乳糖苷酶对肉仔鸡生长性能的影响显示文摘试验研究了豆粕日粮和含5%~8%棉粕的日粮中添加α-半乳糖苷酶对肉仔鸡生长性能的影响及可能机制。试验Ⅰ为肉仔鸡饲养试验,选用1日龄AA商品代肉仔鸡公雏672只,随机分为4个处理,每个处理12个重复,每个重复14只鸡,试验期42d。结果表明:在棉粕和豆粕日粮中添加α-半乳糖苷酶对42日龄肉仔鸡体增重分别提高了4.35%和3.49%。试验Ⅱ为排空强饲代谢试验。结果显示:豆粕日粮中添加α-半乳糖苷酶增加蛋公鸡色氨酸真消化率(P<0.001),对其他氨基酸消化率无影响。添加α-半乳糖苷酶的豆粕的,真代谢能值与不添加酶的相比,提高了4.69%(0.51MJ/kg)。本研究表明,在玉米-豆粕型日粮中添加α-半乳糖苷酶,提高了色氨酸真消化率和真代谢能,有利于提高肉仔鸡生长性能。 | BUN Sidoeun 呙于明 张炳坤 袁建敏 胡骁飞 张立彬 | 2009 | 中国畜牧杂志2009，45，15： | 15 |
| 2 | Systematic review comparing endoscopic, percutaneous and surgical pancreatic pseudocyst drainage显示文摘AIM: To perform a systematic review comparing the outcomes of endoscopic, percutaneous and surgical pancreatic pseudocyst drainage.METHODS: Comparative studies published between January 1980 and May 2014 were identified on Pub Med, Embase and the Cochrane controlled trials register and assessed for suitability of inclusion. The primary outcome was the treatment success rate. Secondary outcomes included were the recurrence rates, re-interventions, length of hospital stay, adverse events and mortalities.RESULTS: Ten comparative studies were identified and 3 were randomized controlled trials. Four studies reported on the outcomes of percutaneous and surgical drainage. Based on a large-scale national study, surgical drainage appeared to reduce mortality and adverse events rate as compared to the percutaneous approach. Three studies reported on the outcomes of endoscopic ultrasound(EUS) and surgical drainage. Clinical success and adverse events rates appeared to be comparable but the EUS approach reduced hospital stay, cost and improved quality of life. Three other studies comparedEUS and esophagogastroduodenoscopy-guided drainage. Both approaches were feasible for pseudocyst drainage but the success rate of the EUS approach was better for non-bulging cyst and the approach conferred additional safety benefits.CONCLUSION: In patients with unfavorable anatomy, surgical cystojejunostomy or percutaneous drainage could be considered. Large randomized studies with current definitions of pseudocysts and longer-term follow-up are needed to assess the efficacy of the various modalities. | Anthony Yuen Bun Teoh Vinay Dhir Zhen-Dong Jin Mitsuhiro Kida Dong Wan Seo Khek Yu Ho | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，6： | 13 |
| 3 | Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer显示文摘AIM:To evaluate the depth of invasion of small,early colorectal cancers(ECCs)using conventional endoscopic features.METHODS:From January 2005 to September 2011,colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20mm underwent colonoscopy at the Yonsei University College of Medicine,Seoul,South Korea.Among them,8 patients were excluded due to incomplete medical records.Finally,a total of 64 ECCs with submucosa(SM)invasion and size less than 20 mm were included.One hundred fifty-two adenomas with size less than 20 mm were included as controls.Nine endoscopic features,including seven morphological findings(i.e.,loss of lobulation,excavation,demarcated and depressed areas,stalk swelling,fullness,fold convergence,and bleeding ulcers),pit patterns,and non-lifting signs,were evalu-ated retrospectively.All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology.RESULTS:Among the morphological findings,the size of deep submucosal cancers was bigger than that of superficial lesions(16.9 mm vs 12.3 mm,P<0.001).Also,demarcated depressed areas,stalk swelling,and fullness were more common in deep SM cancers than in superficial tumors(demarcated depressed areas:52.0%vs 15.7%,P<0.001;stalk swelling:100%vs4.2%,P<0.001;fullness:25.0%vs 0%,P=0.001).Among deep SM cancers,96%of polyps showed invasive pit patterns,whereas 19.4%of superficial tumors showed invasive pit patterns(P<0.001).A positive non-lifting sign was more common in deep SM cancers(85.0%vs 28.6%,P<0.001).Diagnostic accuracy of invasive morphology,invasive pit patterns,and nonlifting signs for deep SM cancers were 71%,82%,and75%,respectively.CONCLUSION:Conventional endoscopic findings were insufficient to discriminate small,deep SM cancers from superficial SM cancers by white light,standard colonoscopy. | Wan Park Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 4 | 不同水平有机锰(明微矿锰)对肉鸡生长、免疫力和抗氧化活性的影响显示文摘试验考察了不同剂量羟基蛋氨酸螯合锰--明微矿锰(Mintrex Mn)对0~3周龄肉鸡生长性能、免疫力以及抗氧化活性的影响。试验选用540只1日龄爱拔益加(AA)雄性肉仔鸡,随机分成5组,每组设9个重复,每个重复6只鸡。含27.86mg/kg锰的玉米-豆粕型基础日粮为负对照组,在基础日粮中添加60mg/kg硫酸锰为正对照组,添加30、60、90mg/kg有机锰为试验组,试验期为21d。结果表明,基础日粮中添加有机锰或无机锰对0~3周龄肉鸡体增重、采食量、料肉比没有显著影响,但与硫酸锰添加组相比,添加30、60、90mg/kg有机锰有提高肉鸡日增重的趋势,且随着有机锰添加量的增加肉鸡日增重也逐渐提高;饲料利用率和胫骨锰含量呈线性显著改善和增加(P≤0.05);有机锰能够显著提高0~3周龄肉鸡免疫力和抗氧化活性,添加60mg/kg、90mg/kg Mintrex Mn增加巨噬细胞吞噬指数和血清中谷胱甘肽过氧化物酶和肝脏中锰超氧化物歧化酶酶活,其效果显著高于无机硫酸锰添加组,而添加60mg/kgMintrex Mn能更好地促进肠道免疫球蛋白的分泌和降低肝脏脂质过氧化物的沉积。因此,从肉鸡的生长性能来看,添加使用有机形式的Mintrex Mn可以较好地提高肉鸡生长性能,且与无机锰添加组相比,有机锰对于促进免疫功能和抗氧化活性效果更好。 | 马娅娅 Bun Sidoeun 刘丹 呙于明 曹宏 郭福存 | 2011 | 中国家禽2011，33，13： | 9 |
| 5 | 7,8-dihydroxyflavone,a small molecular TrkB agonist,is useful for treating various BDNF-implicated human disorders显示文摘Brain-derived neurotrophic factor(BDNF)regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB.It is a potential therapeutic target in numerous neurological,mental and metabolic disorders.However,the lack of efficient means to deliver BDNF into the body imposes an insurmountable hurdle to its clinical application.To address this challenge,we initiated a cell-based drug screening to search for small molecules that act as the TrkB agonist.7,8-Dihydroxyflavone(7,8-DHF)is our first reported small molecular TrkB agonist,which has now been extensively validated in various biochemical and cellular systems.Though binding to the extracellular domain of TrkB,7,8-DHF triggers TrkB dimerization to induce the downstream signaling.Notably,7,8-DHF is orally bioactive that can penetrate the brain blood barrier(BBB)to exert its neurotrophic activities in the central nervous system.Numerous reports suggest 7,8-DHF processes promising therapeutic efficacy in various animal disease models that are related to deficient BDNF signaling.In this review,we summarize our current knowledge on the binding activity and specificity,structure-activity relationship,pharmacokinetic and metabolism,and the pre-clinical efficacy of 7,8-DHF against some human diseases. | Chaoyang Liu Chi Bun Chan Keqiang Ye | 2016 | Translational Neurodegeneration2016，5，1： | 7 |
| 6 | Malignant gastric outlet obstruction:Which is the best therapeutic option?显示文摘Malignant gastric outlet obstruction(MGOO)is a clinical condition characterized by the mechanical obstruction of the pylorus or the duodenum due to tumor compression/infiltration,with consequent reduction or impossibility of an adequate oral intake.MGOO is mainly secondary to advanced pancreatic or gastric cancers,and significantly impacts on patients’survival and quality of life.Patients suffering from this condition often present with intractable vomiting and severe malnutrition,which further compromise therapeutic chances.Currently,palliative strategies are based primarily on surgical gastrojejunostomy and endoscopic enteral stenting with self-expanding metal stents.Several studies have shown that surgical approach has the advantage of a more durable relief of symptoms and the need of fewer re-interventions,at the cost of higher procedure-related risks and longer hospital stay.On the other hand,enteral stenting provides rapid clinical improvement,but have the limit of higher stent dysfunction rate due to tumor ingrowth and a subsequent need of frequent reinterventions.Recently,a third way has come from interventional endoscopic ultrasound,through the development of endoscopic ultrasound-guided gastroenterostomy technique with lumen-apposing metal stent.This new technique may ideally encompass the minimal invasiveness of an endoscopic procedure and the long-lasting effect of the surgical gastrojejunostomy,and brought encouraging results so far,even if prospective comparative trial are still lacking.In this Review,we described technical aspects and clinical outcomes of the above-cited therapeutic approaches,and discussed the open questions about the current management of MGOO. | Edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Anthony Yuen Bun Teoh Andrea Anderloni | 2020 | World Journal of Gastroenterology2020，26，16： | 7 |
| 7 | Current developments in natural orifices transluminal endoscopic surgery:An evidence-based review显示文摘Tremendous advances have been made in recent years addressing the key obstacles to safe performance and introduction of human natural orifice transluminal endoscopic surgery (NOTES). Animal studies have focused on identifying optimal solutions to these obstacles, in particular methods of creating transluminal access,safe closure of the point of access, and development of a multitasking platform with dedicated instruments. Whether the performance data generated from these animal studies can be reproduced in humans has yet to be determined. Reports of human NOTES procedures are emerging, and the possibility of accomplishing human NOTES based on existing technology has been demonstrated. However, dedicated platforms and devices are still lacking to allow for pure NOTES procedures, and whether NOTES can deliver the postulated benef its of earlier recovery and improved cosmesis remains uncertain. | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Enders Kwok Wai Ng | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 8 | An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean显示文摘A 5.4-kDa 抗真菌的肽与对对 Mycosphaerella arachidicola (IC50= 3 M ) 的 defensins 和禁止的活动高度相应的一个 N 终端序列, Setospaeria turcica 和 Bipolaris maydis,从 Phaseolus vulgaris cv 的种子被孤立。棕色的菜豆。肽被采用必要的一个协议净化 Affi 胶化蓝胶化和单音的 S 上并且最后的吸附 Superdex 75 上的胶化过滤。对 M 的肽的抗真菌的活动。arachidicola 在 pH 范围是稳定的 312 并且在温度范围 0 桴 ?? 整浲湩污搠浯楡獮漠 ? | Yau Sang Chan Jack Ho Wong Evandro Fei Fang Wen Liang Pan Tzi Bun Ng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 6 |
| 9 | Silicon carbide resonant tuning fork for microsensing applications in high-temperature and high G-shock environments显示文摘We present the fabrication and testing of a silicon carbide(SiC)balanced mass double-ended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth.The device features a material stack that survives corrosive environments and enables high-temperature operation.To perform high-temperature testing,a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics.The tuning fork has been operated at 600 ℃ in the presence of dry steam for short durations.This tuning fork has also been tested to 64 000 G using a hard-launch,soft-catch shock implemented with a light gas gun.However,the device still has a strain sensitivity of 66 Hz/με and strain resolution of 0.045 με in a 10 kHz bandwidth.As such,this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges,accelerometers,gyroscopes,and pressure transducers.Given the adaptable fabrication process flow,this device could be useful to micro-electro-mechanical systems(MEMS) designers creating sensors for a variety of different applications. | David R Myers Kan Bun Cheng Babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu B J Wijesundara Albert P Pisano | 2012 | Engineering Sciences2012，10，5： | 6 |
| 10 | Difficulties and outcomes in starting endoscopic submucosal dissection显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu Simon Kin Hung Wong Joseph Jao Yiu Sung James Yun Wong Lau Enders Kwok Wai Ng | 2010 | Surgical Endoscopy2010，，5： | 3 |
| 11 | 2种棉籽蛋白粉代谢能和氨基酸消化率的评定显示文摘通过强饲法测定2种棉籽蛋白粉A和B的代谢能和氨基酸消化率及α-半乳糖苷酶对棉籽蛋白粉代谢能的影响。试验1,选择48只体质量约2.5kg的海兰褐父母代种公鸡,分为6个处理组,每处理组8只鸡,用于测定2种棉籽蛋白的代谢能和氨基酸消化率。试验2,选择24只海兰褐父母代种公鸡,分为3个处理组,每处理组8只鸡,分别测定棉籽蛋白粉B、棉籽蛋白粉B+α-半乳糖苷酶和内源代谢能。结果表明,棉籽蛋白粉A的表观代谢能和真代谢能分别是8.83和9.92MJ/kg;棉籽蛋白粉B的表观代谢能和真代谢能分别是9.10和10.19MJ/kg。除了含硫氨基酸,棉籽蛋白粉B的各氨基酸含量均高于棉籽蛋白粉A。棉籽蛋白粉A的蛋氨酸和胱氨酸真消化率分别为86.63%和84.56%,棉籽蛋白粉B的蛋氨酸和胱氨酸真消化率分别为75.72%和82.88%。棉籽蛋白粉B的氨基酸消化率略低于棉籽蛋白粉A。α-半乳糖苷酶对棉籽蛋白粉的代谢能测定值无明显影响。 | 张天国 Bun Sidoeun 袁建敏 呙于明 | 2008 | 饲料研究2008，31，8： | 3 |
| 12 | Current status and future applications of contrast-enhanced endoscopic ultrasonography显示文摘Endoscopic ultrasonography(EUS) is currently an in-tegral investigation of many gastrointestinal disorders.It has been shown to have a higher efficacy thanconventional computed tomography in detection andcharacterization of small lesions especially in the pan-creas. Much effort has been put to further improvethe sensitivity, specificity and overall accuracy of EUS.One of the major advances is the utilization of contrastagents for better delineation of the vascularity and tis-sue perfusion of the target lesion. This article describesthe basic principles of ultrasound contrast agents andthe different modalities used in contrast-enhanced EUS(CE-EUS) including contrast-enhanced Doppler EUS(CED-EUS) and contrast-enhanced harmonic EUS(CEH-EUS). In addition, the current applications of contrastenhanced EUS in different gastrointestinal conditionswere discussed. Furthermore, the future developmentof hybrid approaches combining CE-EUS with other im-aging modalities and the potential therapeutic aspectof using it as a vector for drug delivery were also dis-cussed. | Hon Chi Yip Anthony Yuen Bun Teoh Charing Ching Ning Chong James Yun Wong Lau | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 3 |
| 13 | Predictors for difficult cecal insertion in colonoscopy: The impact of obesity indices显示文摘AIM To identify the factors influencing cecal insertion time(CIT) and to evaluate the effect of obesity indices on CIT. METHODS We retrospectively reviewed the data for participants who received both colonoscopy and abdominal computed tomography(CT) from February 2008 to May 2008 as part of a comprehensive health screening program. Age, gender, obesity indices [body mass index(BMI), waist-to-hip circumference ratio(WHR), waist circumference(WC), visceral adipose tissue(VAT)volume and subcutaneous adipose tissue(SAT) volume on abdominal CT], history of prior abdominal surgery, constipation, experience of the colonoscopist, quality of bowel preparation, diverticulosis and time required to reach the cecum were analyzed. CIT was categorized as longer than 10 min(prolonged CIT) and shorter than or equal to 10 min, and then the factors that required a CIT longer than 10 min were examined.RESULTS A total of 1678 participants were enrolled. The mean age was 50.42 ± 9.931 years and 60.3% were men. The mean BMI, WHR, WC, VAT volume and SAT volume were 23.92 ± 2.964 kg/m2, 0.90 ± 0.076, 86.95 ± 8.030 cm, 905.29 ± 475.220 cm3 and 1707.72 ± 576.550 cm3, respectively. The number of patients who underwent abdominal surgery was 268(16.0%). Colonoscopy was performed by an attending physician alone in 61.9% of cases and with the involvement of a fellow in 38.1% of cases. The median CIT was 7 min(range 2-56 min, IQR 5-10 min), and mean CIT was 8.58 ± 5.291 min. Being female, BMI, VAT volume and involvement of fellow were significantly associated with a prolonged CIT in univariable analysis. In multivariable analysis, being female(OR = 1.29, P = 0.047), lower BMI(< 23 kg/m2)(OR = 1.62, P = 0.004) or higher BMI(≥ 25 kg/m2)(OR = 1.80, P < 0.001), low VAT volume(< 500 cm3)(OR = 1.50, P = 0.013) and fellow involvement(OR = 1.73, P < 0.001) were significant predictors of prolonged CIT. In subgroup analyses for gender, lower BMI or higher BMI and fellow involvement were predictors for prolonged CIT in both genders. However, low VAT volume was associated with prolonged CIT in only women(OR = 1.54, P = 0.034).CONCLUSION Being female, having a lower or higher BMI than the normal range, a low VAT volume, and fellow involvement were predictors of a longer CIT. | Soo Yun Moon Byung Chang Kim Dae Kyung Sohn Kyung Su Han Bun Kim Chang Won Hong Bum Joon Park Kum Hei Ryu Ji Hyung Nam | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 14 | Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours显示文摘 | Jaihwan Kim Woo Jin Lee Sang Hyub Lee Kyoung Bun Lee Ji Kon Ryu Yong-Tae Kim Sun-Whe Kim Yong Bum Yoon Jin Hyeok Hwang Ho-Seong Han Sang Myung Woo Sang Jae Park | 2011 | Digestive and Liver Disease2011，，12： | 3 |
| 15 | Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression显示文摘 | Chi Han Li Feiyue Xu Sheungching Chow Lu Feng Deling Yin Tzi Bun Ng Yangchao Chen | 2014 | European Journal of Cancer2014，，15： | 2 |
| 16 | 羟基蛋氨酸螯合锰在肉仔鸡日粮中的应用效果显示文摘选用270只‘爱拔益加’(AA)雄性肉仔鸡,随机分成5组,每组设9个重复,每个重复6只鸡,分别饲喂玉米-豆粕基础日粮、60mg/kg硫酸锰日粮、基础日粮分别添加30、60、90mg/kg羟基蛋氨酸螯合锰日粮(试验组),试验期分为前期(0~3周)和后期(4~6周),研究了不同剂量羟基蛋氨酸鳌合锰对0~6周龄肉仔鸡生长性能、免疫力以及抗氧化能力的影响.结果表明:基础日粮中添加有机锰能够提高肉仔鸡饲料利用率,增强机体免疫力和抗氧化能力;日粮中有机锰水平与饲料利用率、胫骨锰含量、腹腔巨噬细胞吞噬指数和肝脏Mn-SOD酶活性呈一次线性关系,与新城疫抗体滴度呈二次曲线关系. | 马娅娅 Bun Sidoeun 刘丹 呙于明 曹宏 郭福存 郝正里 年芳 Mercedes V A | 2011 | 甘肃农业大学学报2011，46，4： | 2 |
| 17 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 18 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 19 | Die Endogene Tagesrhythmik Als Grundlage Der Photoperiodischen Reaction显示文摘 | BUNNING E | 1936 | Ber Dtsch Bot Ges1936，54，： | 1 |
| 20 | The effects of eliminating the chain extender and varying the grating periodicity on the morphology of holographically written bragg gratings显示文摘 | Bunning T J Natarajan L V Tondiglia V P | 1996 | SPIE1996，2651，： | 1 |
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