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| 1 | Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection显示文摘AIM: To compare the efficacy and safety of sedation protocols for endoscopic submucosal dissection(ESD) between dexmedetomidine-remifentanil and propofolremifentanil.METHODS: Fifty-nine patients scheduled for ESD were randomly allocated into a dexmedetomidineremifentanil(DR) group or a propofol-remifentanil(PR) group. To control patient anxiety, dexmedetomidine or propofol was infused to maintain a score of 4-5 on the Modified Observer's Assessment of Alertness/Sedation scale. Remifentanil was infused continuously at a rate of 6 μg/kg per hour in both groups. The ease of advancing the scope into the throat, gastric motility grading, and satisfaction of the endoscopist and patient were assessed. Hemodynamic variables and hypoxemic events were compared to evaluate patient safety.RESULTS: Demographic data were comparable between the groups. The hemodynamic variables and pulse oximetry values were stable during the procedure in both groups despite a lower heart rate in the DR group. No oxygen desaturation events occurred in either group. Although advancing the scope into the throat was easier in the PR group('very easy' 24.1% vs 56.7%, P = 0.010), gastric motility was moresuppressed in the DR group('no + mild' 96.6% vs 73.3%, P = 0.013). The endoscopists felt that the procedure was more favorable in the DR group('very good + good' 100% vs 86.7%, P = 0.042), whereas patient satisfaction scores were comparable between the groups. En bloc resection was performed 100% of the time in both groups, and the complete resection rate was 94.4% in the DR group and 100% in the PR group(P = 0.477). CONCLUSION: The efficacy and safety of dexmedetomidine and remifentanil were comparable to propofol and remifentanil during ESD. However, the endoscopists favored dexmedetomidine perhaps due to lower gastric motility. | Namo Kim Young-Chul Yoo Sang Kil Lee Hyunzu Kim Hyang Mi Ju Kyeong Tae Min | 2015 | World Journal of Gastroenterology2015，21，12： | 25 |
| 2 | Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease显示文摘AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and CD.METHODS: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic biopsies.Microscopic features of ITB and CD were reviewed,and eight pathologic parameters were evaluated.Nine cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,respectively.PCR assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy specimens.RESULTS: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with CD.The sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,respectively.The PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy specimens.Among the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combination of histologic fi ndings and TB-PCR testing led to an increase of diagnostic sensitivity and the increase (from 47.3% to 58.2) was statistically signifi cant with kit (P = 0.000).CONCLUSION: The TB-PCR test combined with histopathologic factors appears to be a helpful technique in formulating the differential diagnosis of ITB and CD in endoscopic biopsy samples. | Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee Young Han Young Chae Chu Kye Sook Kwon Eun Joo Kim | 2010 | World Journal of Gastroenterology2010，16，20： | 20 |
| 3 | Aerobic exercise improves gastrointestinal motility in psychiatric inpatients显示文摘AIM:To evaluate the benefit of aerobic exercise on colonic transit time(CTT)for psychiatric inpatients in a closed ward.METHODS:Sixty consecutive adult inpatients of the Somang Hospital Psychiatry Unit(Eumsung-gun,South Korea),without CTT-related diseases or drug therapies,were recruited for study from March to June of 2012.Upon enrollment,the patients were randomly assigned to partake in a 12-wk instructor-led group aerobic exercise program(exercise group;n=30)or to maintain their ordinary daily activities(control group;n=30).The exercise program was structured as 10 min warm-up(stretching),40 min exercise,and 10 min cool-down(stretching)for three days each week.The exercise sessions consisted of walking only in week one and aerobics from weeks two to 12,with increasing intensity(50%heart rate reserve(HRR)for weeks one to four,60%HRR for weeks five to eight,and 70%HRR for weeks nine to 12).CTT was measured before(baseline)and after(week 12)the exercise program,in duplicate(on days four and seven),using abdominal radiography and the multiple radio-opaque marker technique.Changes in the exercising patients’CTT and weight-,cardiovascular-and fitness-related parameters were statistically assessed.RESULTS:The study dropout rate was 30.0%,with 23patients in the exercise group and 19 patients in the control group completing the study.At week 12,the exercise group showed decreases in body weight(mean±SE)baseline:69.4±2.8 vs study-end:67.6±2.7;P<0.635)and body mass index(BMI)(25.2±1.1 vs24.9±0.8;P<0.810),but the extent of change was not significantly different from that experienced by the control group(body weight:68.8±4.0 vs 68.8±3.9;BMI:24.3±1.1 vs 24.4±1.2).However,the exercise group showed significant improvements in leg muscle strength(baseline:41.7±4.3 vs study-end:64.1±5.0;P<0.001),cardio-respiratory endurance(120.5±4.5vs 105.4±2.8;P<0.004),and leg muscle elasticity and power output(21.5±2.6 vs 30.6±2.8;P<0.001).The exercise group showed an exercise-induced reduction in total CTT(baseline:54.2±8.0 vs 30.3±6.1),which was significantly different from that experienced by the control group over the 12-wk period(48.6±9.3vs 48.3±12.3;P=0.027);however,the exercise-induced decreases in CTT involving the three colonic segments examined(right,left and recto-sigmoid)showed no significant differences from the control group.CONCLUSION:A 12-wk aerobic exercise program can benefit psychiatric inpatients by increasing intestinal motility,possibly decreasing risk of metabolic-and cardiovascular-related disease. | Yeon Soo Kim Bong Kil Song Ji Sun Oh Seung Seok Woo | 2014 | World Journal of Gastroenterology2014，20，30： | 19 |
| 4 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 5 | Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection显示文摘AIM:To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection(ESD)outcome.METHODS:From January 2008 to December 2010,ESD of 1443 gastric tumors was performed.En bloc resection rate,complete resection rate,procedure time and complication rate were analyzed according to the tumor location.RESULTS:The rates of en bloc resection and complete resection were 91%(1318/1443)and 89%(1287/1443),respectively.The post-ESD bleeding rate was 4.3%,and perforation rate was 2.7%.Tumors located in the upper third of the stomach were associated with a longer procedure time and significantly higher rates of incomplete resection,piecemeal resection,and perforation than tumors below the upper third of the stomach.Posterior wall lesions had significantly longer procedure times and higher rates of incomplete resection and piecemeal resection than lesions in other locations.In multivariate analysis,posterior wall lesions and upper third lesions were significantly associated with incomplete resection and perforation,respectively.In post-ESD bleeding analysis,location was not a significant related factor.CONCLUSION:More advanced endoscopic techniques are required during ESD for lesions located in the upper third or posterior wall of the stomach to decrease complications and improve therapeutic outcomes. | Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk Lee Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jun Chul Park | 2014 | World Journal of Gastroenterology2014，20，26： | 10 |
| 6 | Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: Do we have enough data to support this?显示文摘Although endoscopic submucosal dissection(ESD)is now accepted for treatment of early gastric cancers(EGC)with negligible risk of lymph node(LN)metastasis,ESD for intramucosal undifferentiated type EGC without ulceration and with diameter≤2 cm is regarded as an investigational treatment according to the Japanese gastric cancer treatment guidelines.This consideration was largely based on the analysis of surgically resected EGCs that contained undifferentiated type EGCs;however,results from several institutes showed some discrepancies in sample size and incidence of LN metastasis.Recently,some reports about the safety and efficacy of ESD for undifferentiated type EGC meeting the expanded criteria have been published.Nonetheless,only limited data are available regarding long-term outcomes of ESD for EGC with undifferentiated histology so far.At the same time,endoscopists cannot ignore the patients’desire to guarantee quality of life after the relatively non-invasive endoscopic treatment when compared to conventional surgery.To satisfy the needs of patients and provide solid evidence to support ESD for undifferentiated EGC,we need more delicate tools to predict undetected LN metastasis and more data that can reveal predictive factors for LN metastasis. | Choong Nam Shim Sang Kil Lee | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 7 | High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer显示文摘AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric cancer.METHODS:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric cancer.Of these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 preoperatively.For this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as controls.Statistically significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS software.RESULTS:The baseline characteristics showed some differences between the two groups with regard to histology.Overall survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate analysis.Also,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate analysis.Additionally,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)analyses.CONCLUSION:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer. | A Ra Choi Jun Chul Park Jie-Hyun Kim Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jae Bock Chung | 2013 | World Journal of Gastroenterology2013，19，32： | 8 |
| 8 | Single port laparoscopic right hemicolectomy with D3 dissection for advanced colon cancer显示文摘We report the first case of single port laparoscopic right hemicolectomy for advanced colon cancer.An abdominal 3 cm length incision was made via the umbilicus.A small wound retractor and a surgical glove were used as a single port.All soft tissue anterior to the superior mesenteric vein was completely removed and D3 lymph node dissection was achieved.The total operative time was 180 min with minimal blood loss (<50 mL).The size of the tumor was 5 cm×3 cm and its tumor stage was T3N0.Sixty-nine lymph nodes were harvested and none were positive.We believe that single port surgery for colon cancer is a feasible and safe procedure with surgical results comparable to conventional laparoscopic procedures. | Sung Il Choi Kil Yeon Lee Sun Jin Park Suk-Hwan Lee | 2010 | World Journal of Gastroenterology2010，16，2： | 8 |
| 9 | Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket显示文摘Mechanical lithotripsy(ML) is usually considered as a standard treatment option for large bile duct stones.However,it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the stone.However,there is no established endoscopic extraction method for such giant stone removal.We describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket.A 78-year-old woman had suffered from upper abdominal pain for 20 d.Contrast-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct(CBD).Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large balloon.An attempt to capture the stone using a standard lithotripsy basket failed due to the large stone size.Subsequently,we used a gastric bezoar basket to successfully capturethe stone.The stone was fragmented into small pieces and extracted.The stone was completely removed after two sessions of endoscopic retrograde cholangiopancreatography;each of which took 30 min.No complications occurred during or after the procedure.The patient was fully recovered and discharged on day 11 of hospitalization.ML using a gastric bezoar basket is a safe and effective retrieval method in select cases,and is considered as an alternative nonoperative option for the management of difficult CBD stones. | Hyun Jung Chung Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Byoung Wook Bang Kye Sook Kwon Hyung Kil Kim Yong Woon Shin Young Soo Kim | 2012 | World Journal of Gastroenterology2012，18，25： | 7 |
| 10 | Effectiveness of contrast-enhanced harmonic endoscopic ultrasound for the evaluation of solid pancreatic masses显示文摘AIM:To evaluate the usefulness of contrast-enhanced harmonic endoscopic ultrasound(CH-EUS)in differentiating between pancreatic adenocarcinomas and other pancreatic disease.METHODS:This retrospective cohort study evaluated90 patients who were seen between November 2010and May 2013.All these patients had solid pancreatic masses that had a hypoechoic appearance on EUS.All patients underwent CH-EUS to evaluate this diagnostic method’s usefulness.The mass lesions observed on CH-EUS were classified into three categories based on their echo intensity:hypoenhanced,isoenhanced,and hyperenhanced lesions.We adjusted the sensitivity and the specificity of each category for detecting malignancies.We also estimated the accuracy of CH-EUS by comparing it to a pathological diagnosis.RESULTS:Of the 90 patients,62 had a pancreatic adenocarcinoma.Fifty-seven out of 62 pancreatic adenocarcinomas showed a hypoenhanced pattern on CHEUS.The sensitivity was 92%,the specificity 68%and the accuracy approximately 82%.The area under the curve of the receiver operating characteristic analysis for CH-EUS was 0.799.There is a significant association between the hypoenhanced pattern on CH-EUS and pancreatic duct adenocarcinoma(χ2=35.264,P<0.001).In pathological examinations,the number of specimens for EUS-fine needle aspiration(EUS-FNA)was considered insufficient for diagnosis in three patients,and in two patients,the results were reported to be negative for malignancy.Pancreatic masses in all five patients revealed a hypoenhanced pattern with CH-EUS.Three patients were diagnosed with pancreatic adenocarcinoma based on the pathology results of a biopsy,and the remaining two patients were clinically diagnosed with malignancy.CONCLUSION:CH-EUS is useful for distinguishing between pancreatic adenocarcinoma and other pancreatic disease.When a pancreatic mass shows a hypoenhanced pattern on CH-EUS but involves either insufficient samples or negative results with EUS-FNA,clinicians might consider performing another pathologic diagnosis on the basis of an EUS-FNA sample or a biopsy. | Jin-Seok Park Hyung Kil Kim Byoung Wook Bang Sang Gu Kim Seok Jeong Don Haeng Lee | 2014 | World Journal of Gastroenterology2014，20，2： | 7 |
| 11 | Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein显示文摘Gynostemma(G.) pentaphyllum(Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum(GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson’s disease(PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-and 6-hydroxydopamine. PD patients exhibit multiple symptoms, so PD-related research should combine neurotoxin models with genetic models. In the present study, we investigated the ameliorative effects of GP-EX, including gypenosides, on the cell death of dopaminergic neurons in the midbrain of A53 T α-synuclein transgenic mouse models of PD(A53 T). Both GP-EX and gypenosides at 50 mg/kg per day were orally administered to the A53 T mice for 20 weeks.α-Synuclein-immunopositive cells and α-synuclein phosphorylation were increased in the midbrain of A53 T mice, which was reduced following treatment with GP-EX. Treatment with GP-EX modulated the reduced phosphorylation of tyrosine hydroxylase, extracellular signal-regulated kinase(ERK1/2), Bcl-2-associated death promoter(Bad) at Ser112, and c-Jun N-terminal kinase(JNK1/2) due to α-synuclein overexpression. In the A53 T group, GP-EX treatment prolonged the latency of the step-through passive avoidance test and shortened the transfer latency of the elevated plus maze test. Gypenosides treatment exhibited the effects and efficacy similar to those of GP-EX. Taken together, GP-EX, including gypenosides, has ameliorative effects on dopaminergic neuronal cell death due to the overexpression of α-synuclein by modulating ERK1/2, Bad at Ser112, and JNK1/2 signaling in the midbrain of A53 T mouse model of PD. Further studies are needed to investigate GP-EX as a treatment for neurodegenerative synucleinopathies, including PD. This study was approved by the Animal Ethics Committee of Chungbuk National University(approval No. CBNUA-956-16-01) on September 21, 2016. | Hyun Jin Park Ting Ting Zhao Seung Hwan Kim Chong Kil Lee Bang Yeon Hwang Kyung Eun Lee Myung Koo Lee | 2020 | Neural Regeneration Research2020，15，2： | 5 |
| 12 | Combined exercise improves gastrointestinal motility in psychiatric in patients显示文摘AIM To examine the effect of combined exercise on colonic transit time(CTT) in admitted psychiatric patients. METHODS Over a 6-mo period, consecutive in patients with mental illness were recruited from the Somang Hospital Psychiatry Unit. A combined exercise program that included 60 min per day of exercise 3 d per week for 12 wk was performed. Physical fitness and CTT of the patients were measured twice before and twice after the exercise program. CTT was measured using a multiple marker technique with a radio-opaque marker. Changes in the exercising patients' CTT and weight-,cardiovascular-and fitness-related parameters were statistically assessed.RESULTS After the 12-wk combined exercise intervention, decreased intestinal transit time was observed in all CTTs of the exercise group, including the right CTT(exercise: 15.6 ± 15.2 vs 9.2 ± 11.9, control: 13.1 ± 10.4 vs 10.9 ± 18.7), left CTT(exercise: 19.7 ± 23.5 vs 10.4 ± 13.2, control: 19.2 ± 19.0 vs 16.9 ± 19.8), recto-sigmoid CTT(exercise: 14.3 ± 16.7 vs 6.7 ± 7.9, control: 15.0 ± 14.4 vs 19.3 ± 30.3), and total colonic transit time(TCTT)(exercise: 50.2 ± 38.1 vs 27.1 ± 28.0, control: 47.4 ± 34.6 vs 47.3 ± 47.3). After the 12-wk combined exercise period, TCTT was significantly shortened in the exercise group compared with that in the control group. In addition to eating habits, water intake, and fiber intake, the increased physical activity level as a result of the 12-wk combined exercise program reduced the CTT. | Bong Kil Song Yeon Soo Kim Hee Soo Kim Jung-Woo Oh On Lee Joon-Sik Kim | 2018 | World Journal of Clinical Cases2018，6，8： | 5 |
| 13 | Supplementation of different fat sources affects growth performance and carcass composition of finishing pigs显示文摘Background: There are various fat sources with different energy values and fatty acid compositions that may affect growth performance and carcass composition of grow-finishing pigs. A higher net energy was recently reported in choice white grease compared with soybean oil. Therefore, two experiments were conducted to determine whether practical responses confirm that difference between choice white grease and soybean oil, and to extend the observations to other fat sources.Results: In Exp. 1, pigs fed fats had lower(P < 0.05) average daily feed intake in phase II and overall period,greater(P < 0.05) gain:feed in phase I, phase II, and overall period than pigs fed the control diet. Pigs fed fats tended(P = 0.057) to have thicker backfat depth at the last rib than those fed control. Pigs fed 6% fats had greater(P < 0.01) gain:feed in phase II and overall period than pigs fed 3% fats. During phase I, pigs fed choice white grease grew faster(P < 0.05) than pigs fed soybean oil. In Exp. 2, pigs fed dietary fats(soybean oil, choice white grease, animal-vegetable blend, palm oil, or tallow) had greater(P < 0.01) gain:feed in each phase and overall period, greater(P < 0.01) average daily gain in phase I, but lower(P < 0.01) average daily feed intake in phase II an overall than pigs fed the control diets. The choice white grease also increased(P < 0.05) average daily gain during phase I compared with soybean oil. Pigs fed palm oil had thicker(P < 0.05) backfat depth at the 10 thrib than those fed soybean oil, animal-vegetable blend, or tallow.Conclusions: Inclusion of 6% dietary fat improved feed efficiency of finishing pigs, while different fats produced different practical results that may be consistent with their different energy values. Results from the early stage indicate that dietary fats with relatively more saturated fatty acids may provide greater energy than those with relatively more unsaturated fatty acids for growing pigs. | Yanhong Liu Dong Yong Kil Victor G.Perez-Mendoza Minho Song James E.Pettigrew | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 5 |
| 14 | Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes显示文摘Melatonin plays a critical role in regulating photoperiodic signals and has recently been shown to decrease immunosenescence with age.In this study,we examined whether melatonin activates T lymphocytes as major adaptive immune cells in in vitro and in vivo models.Splenocytes,CD4^+,and nave CD4 T lymphocytes were isolated from the spleen of BALB/c mice and the cell population patterns and mRNA profiles associated with T cell activation(CD28 and p21) and the melatonin receptor(MT1A and MT1B) were assessed.The T cell activationrelated proteins Ki67 and Bcl2 were also evaluated to confirm the relationship between gene and protein levels.Our data clearly revealed that CD28,p21,MT1 A,and MT1 B mRNA were highly expressed in the presence of melatonin.Co-culture of CD4^+ T lymphocyte and peritoneal macrophage 7 days after melatonin administration to young and aged mice significantly increased APRIL mRNA,suggesting induction or maintenance of T lymphocyte responses.We also found that the intracellular amount of Ki67 and Bcl2 proteins were significantly upregulated in aged CD4^+ T lymphocytes,suggesting enhancing T cell proliferation and ling-term maintenance of memory T cells.Taken together,we conclude that melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices in association with T lymphocytes and may be an attractive pharmacological candidate for aged and immunocompromised individuals. | Yeong-Min Yoo Su Kil Jang Gwang-Hoon Kim Jung-Youl Park Seong-Soo Joo | 2016 | The Journal of Biomedical Research2016，30，4： | 3 |
| 15 | Fatty acid methyl ester profiles and nutritive values of 20 marine microalgae in Korea显示文摘Objecive:To screen the fatty acid(FA) composition of 20 marine microalgae species,including seven Diophyceae,six Bacillariophyeae four Chlorophyceae,two Haptophyceae and one Raphidophyceae species.Methods:Microalgal cells cultured at the Korea Institute of Ocean Science & Technology were harvested during the late exponential growth phase and the FA composition analyzed.Results:The FA composition of microalgae was speciesspecific.For example,seven different species of Dinophyceae were composed primarily of C14:0,C16:0.C18:0.C20:4n-6.C20:5n-3 and C22:6n-3.while C14:0.C16:0,C16:1.C18:0.C20:5n-3 and C22:6n-3 were abundant FAs in six species of Bacillariophyceae.In addition,four Chlurophyceae,two Haptopkyeeae and one Raphidophyceae species all contained a high degree of C16:1 n-7[(9.2R-34.91)%and(34.48-35.04)%].C14:0[(13.34-25.96)%]and[(26.69-Z8.24)%],and C16:0[(5.89-29.15)%]and[(5.70-16.81)%].Several factors contribute to the nutritional value of microalgae.including the polyunsaturated FA content and n-3 to n-6 FA ratio,which could be used to assess the nutritional quality of microalgae.Conclusions:This study is the first comprehensive assessment of the FA composition and nutritional value of microalgae species in South Korea,and identifies the potential utility of FAs as species-specific biomarkers. | Sung-Suk Suh So Jung Kim Jinik Hwang Mirye Park Taek-Kyun Lee Eui-Joon Kil Sukchan Lee | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，3： | 3 |
| 16 | 水性轮转凹印油墨在PET和BOPP基材上印刷的对比研究显示文摘采用凹印机(最大速度500m/min)在PET(聚对苯二甲酸乙二醇酯)和BOPP(双向拉伸聚丙烯)承印物上进行印刷试验,以研究高速凹版印刷下油墨的转移情况和印刷适性。将水性油墨用酒精稀释后,在特定的印刷速度、印刷压力和网穴尺寸等多种印刷设备条件下对柔性承印物进行印刷。采用光学显微镜、UV可见光谱仪和原子力显微镜(AFM)测量印刷图像和油墨转移率。通过对界面张力、黏度以及油墨与承印物之间润湿角的测量与评价,定量分析它们对印刷特性的影响。实验结果表明,影响印刷特性的最重要的因素是油墨黏度、表面张力和界面张力。稀释后的油墨在PET和BOPP薄膜上的铺展系数都小于零,也就是说油墨难以在二者上顺利铺展,因此,扩散可能是由于剪切力导致油墨流动。显微镜或光谱仪测量表明,在各种试验印刷设备条件下,印刷速度不会对PET薄膜上印刷图像的均匀性和色度产生很大影响,而BOPP薄膜上的图像质量则在很大程度上依赖于转速。两者存在差异的主要原因在于BOPP薄膜多孔表面的毛细管堵塞导致油墨的铺展能力降低。此外,网穴尺寸(网点百分比)增大导致色度增大,其原因在于油墨和承印物间的接触面积变大。尤其对于BOPP薄膜来说,其印刷图像的色度会随着网点百分比的增大而线性增大。应该指出,在相同的稀释条件和设备条件下,较之PET薄膜来说,BOPP薄膜上的印刷图像的色度与墨层厚度远远高于PET薄膜。BOPP与PET薄膜在油墨转移率上的较大差异也许可以在一定程度上解释两者在界面张力上的差异,以及BOPP承印物上的吸收现象。 | Jang-Woo Lee Kwang Kil Mun Young Tai Yoo | 2009 | 中国印刷与包装研究2009，1，1： | 3 |
| 17 | Active changes of lignification-related enzymes in pepper response to Glomus intraradices and/or Phytophthora capsici显示文摘The activities of enzymes responsible for lignification in pepper, pre-inoculation with arbuscular mycorrhizal (AM) fungus of Glomus intraradices and/or infection with pathogenic strain of Phytophthora capsici, and the biological control effect of G. intraradices on Phytophthora blight in pepper were investigated. The experiment was carried out with four treatments: (1) plants pre-inoculated with G. intraradices (Gi), (2) plants pre-inoculated with G. intraradices and then infected with P. capsici (Gi+Pc), (3) plants infected with P. capsici (Pc), and (4) plants without any of the two microorganisms (C). Mycorrhizal coloni-zation rate was reduced by about 10% in pathogen challenged plants. Root mortality caused by infection of P. capsici was com-pletely eliminated by pre-inoculation with antagonistic G. intraradices. On the ninth day after pathogen infection, Peroxidase (POD) activity increased by 116.9% in Pc-treated roots but by only 21.2% in Gi+Pc-treated roots, compared with the control, respectively. Polyphenol oxidase (PPO) and Phenylalanine ammonia-lyase (PAL) activities gradually increased during the first 3 d and dramatically decreased in Pc-treated roots but slightly decreased in Gi+Pc-treated roots, respectively. On the ninth day after pathogen infection, PPO and PAL decreased by 62.8% and 73.9% in Pc-treated roots but by only 19.8% and 19.5% in Gi+Pc-treated roots, compared with the control, respectively. Three major POD isozymes (45 000, 53 000 and 114 000) were present in Pc-treated roots, while two major bands (53 000 and 114 000) and one minor band (45 000) were present in spectra of Gi+Pc-treated roots, the 45 000 POD isozyme was significantly suppressed by G. intraradices, suggesting that the 45 000 POD isozyme was induced by the pathogen infection but not induced by the antagonistic G. intraradices. A 60 000 PPO isozyme was induced in Pc-treated roots but not induced in Gi+Pc-treated roots. All these results showed the inoculation of antagonistic G. intraradices alleviates root mortality, activates changes of lignification-related enzymes and induces some of the isozymes in pepper plants infected by P. capsici. The results suggested that G. intraradices is a potentially effective protection agent against P. capsici. | 郑虎哲 崔春兰 张玉廷 王丹 荆宇 KIM Kil Yong | 2005 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2005，6，8： | 2 |
| 18 | Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma显示文摘 | Ho Lee Kyung Ryoul Kim Sang Jae Noh Ho Sung Park Keun Sang Kwon Byung-Hyun Park Sung Hoo Jung Hyun Jo Youn Byoung Kil Lee Myoung Ja Chung Dai Ha Koh Woo Sung Moon Kyu Yun Jang | 2011 | Human Pathology2011，，2： | 2 |
| 19 | Fast global kernel fuzzy c-means clustering algorithm for consonant/vowel segmentation of speech signal显示文摘We propose a novel clustering algorithm using fast global kernel fuzzy c-means-F(FGKFCM-F), where F refers to kernelized feature space. This algorithm proceeds in an incremental way to derive the near-optimal solution by solving all intermediate problems using kernel-based fuzzy c-means-F(KFCM-F) as a local search procedure. Due to the incremental nature and the nonlinear properties inherited from KFCM-F, this algorithm overcomes the two shortcomings of fuzzy c-means(FCM): sen- sitivity to initialization and inability to use nonlinear separable data. An accelerating scheme is developed to reduce the compu-tational complexity without significantly affecting the solution quality. Experiments are carried out to test the proposed algorithm on a nonlinear artificial dataset and a real-world dataset of speech signals for consonant/vowel segmentation. Simulation results demonstrate the effectiveness of the proposed algorithm in improving clustering performance on both types of datasets. | Xian ZANG Felipe P. VISTA IV Kil To CHONG | 2014 | Journal of Zhejiang University-Science C(Computers and Electronics)2014，15，7： | 2 |
| 20 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
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