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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings显示文摘目的: 催乳激素家庭荷尔蒙包括生长荷尔蒙,胎盘的促黄体激素和催乳激素,它能调整 angiogenesis 经由没有并且前列腺素。然而,他们脉管的音调上的效果充分没被理解。这研究的目的是在老鼠上评估催乳激素家庭荷尔蒙的效果脉管的在 vitro 的音调。 | Carmen GONZALEZ Hector ROSAS-HERNANDEZ Brenda JURADO-MANZANO Manuel Alejandro RAMIREZ-LEE Samuel SALAZAR-GARClA Pedro Pablo MARTINEZ-CUEVAS Aida Jimena VELARDE-SALCEDO Humberto MORALES- LOREDO Ricardo ESPINOSA-TANGUMA Syed F ALl Rafael RUBIO | 2015 | Acta Pharmacologica Sinica2015，36，5： | 2 |
| 3 | Health Promotion in Adolescents: A Review of Pender's Health Promotion Model显示文摘 | Brenda J S Barbara V F | 2006 | Nurs Sci Q2006，19，4： | 1 |
| 4 | Barriers and motivators to blood and cord blood donations in young African - American women显示文摘 | Brenda G Andre RW Faye F | 2005 | American Journal of Hematology2005，78，： | 1 |
| 5 | Migration intentions and behavior:decision making in a rural philippine province显示文摘 | Gordon F De Jong Brenda Davis Root | 1985 | Population and environment1985，8，12： | 1 |
| 6 | 5-substituted indoles via sodium indole-2-sulfonate 显示文摘 | Henry F R Brenda J H Darryl B H | 1986 | Org prep Proced Int1986，18，7： | 1 |
| 7 | Face rec- ognition performance : role of demographic information 显示文摘 | Brenda F K Mark J B Joshua C K | 2012 | IEEE Transactions on Information Forensics and Security2012，7，6： | 1 |
| 8 | Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally显示文摘 | Brenda Valenzuela-Alcaraz Fàtima Crispi Bart Bijnens Monica Cruz-Lemini Montserrat Creus Marta Sitges Joaquim Bartrons Salvadora Civico Juan Balasch Eduard Gratacós | 2013 | Circulation2013，，13： | 1 |
| 9 | 5-substituted indoles via sodium indoline-2-sulfonate显示文摘 | Henry F R Brenda J H | 1985 | The New Journal for Organic Synthesis1985，17，6： | 1 |
| 10 | Jet entrainment rate in air curtain of open refrigerated display cases 显示文摘 | HOMAYUN K N BRENDA S H RAMIN F | 2006 | Int J of Num Methods for Heat Fluid Flow2006，16，4： | 1 |
| 11 | Use of Traceback Methods To Confirm the Source of a Multistate Escherichia coli O157:H7 Outbreak Due to In-Shell Hazelnuts显示文摘 | Miller Benjamin D Rigdon Carrie E Ball Jill Rounds Joshua M Klos Rachel F Brennan Brenda M Arends Katherine D Kennelly Patrick Hedberg Craig Smith Kirk E | 2012 | EN2012，，2： | 1 |
| 12 | Different mechanisms of resistance to bacillus thuringiensis toxins in the Indianmeal moth显示文摘 | Salvador H Brenda O Juan F | 2001 | Appl Environ Microbio2001，，67： | 1 |
| 13 | Identification of Nucleo- capsid Binding Sites within Coronavirus-Defective Genomes 显示文摘 | Raymond C Jearmie F S Brenda G H | 2000 | Virology2000，277，： | 1 |
| 14 | Choice of computed tomography, transesophageal echocardiography, magnetic resonance imaging, and aortography in acute aortic dissection: International Registry of Acute Aortic Dissection (IRAD)显示文摘 | Andrew G Moore Kim A Eagle David Bruckman Brenda S Moon Joseph F Malouf Rossella Fattori Arturo Evangelista Eric M Isselbacher Toru Suzuki Christoph A Nienaber Dan Gilon Jae K Oh | 2002 | The American Journal of Cardiology2002，，10： | 1 |
| 15 | Deriving phage-insensitive laetececei using a food-grade vector encoding phage and nisin resistanee显示文摘 | HUGHES Brenda F MCKAY Larry L | 1992 | J Dairy Sei1992，75，4： | 1 |
| 16 | Family Migration in a Developing Country 显示文摘 | Brenda Davis Root Gordon F De Jong | 1991 | Population Studies1991，45，： | 1 |
| 17 | New generation cooperatives and cooperative theory显示文摘 | Andrea H Brenda S Murray F | 1996 | Journal of Cooperatives1996，，11： | 1 |
| 18 | Effect of endotracheal suction on lung dynamics in mechanically-ventilated paediatric patients 显示文摘 | Brenda M Merle F Andrew A | 2006 | Aust J Physiother2006，52，2： | 1 |
| 19 | A prospective comparative study of the amo array zonal-progressive multifocal silicone intraocular lens and a monofocal intraocular lens 1 1 Members of the AMO Array Clinical Study Group are listed in the Appendix at the end of this article.显示文摘 | Roger F Steinert Brenda L Aker Debra J Trentacost Pamela J Smith Nicholas Tarantino | 1999 | Ophthalmology1999，，7： | 1 |
| 20 | Role of cyclic voltammetry in characterizing solids: natual and synthetic manganese oxide octahedral molecular sieves 显示文摘 | Roberto N F G Yan F S Brenda R S | 1993 | Chem Mater1993，5，10： | 1 |
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