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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Polyphenols-gut microbiota interplay and brain neuromodulation显示文摘Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can modulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could contribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration. | Stefania Filosa Francesco Di Meo Stefania Crispi | 2018 | Neural Regeneration Research2018，13，12： | 5 |
| 3 | Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses显示文摘 | Fatima Crispi Edgar Hernandez-Andrade Maurice M.A.L. Pelsers Walter Plasencia Jesus Andres Benavides-Serralde Elisenda Eixarch Ferdinand Le Noble Asif Ahmed Jan F.C. Glatz Kypros H. Nicolaides Eduard Gratacos | 2008 | American Journal of Obstetrics and Gynecology2008，，3： | 1 |
| 4 | Gestational age-and estimated fetal weight-adjusted reference ranges for myocardial tissue Doppler indices at 24-41 weeks'gestation显示文摘 | Comas M Crispi F Gómez O | 2011 | Ultrasound Obstet Gynecol2011，37，1： | 1 |
| 5 | Maternal subclinical vascular changes in fetal growth restriction with and without pre‐eclampsia显示文摘 | I. Stergiotou B. Bijnens M. Cruz‐Lemini F. Figueras E. Gratacos F. Crispi | 2015 | Ultrasound Obstet Gynecol2015，，： | 1 |
| 6 | Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally显示文摘 | Brenda Valenzuela-Alcaraz Fàtima Crispi Bart Bijnens Monica Cruz-Lemini Montserrat Creus Marta Sitges Joaquim Bartrons Salvadora Civico Juan Balasch Eduard Gratacós | 2013 | Circulation2013，，13： | 1 |
| 7 | Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses显示文摘 | Hernandez-Andrade E F Crispi | 2009 | Ultrasound Obstet Gynecol2009，34，4： | 1 |
| 8 | Placental angiogenic growth fac- tors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction 显示文摘 | Crispi F Dominguez C Llurba E | 2006 | Am J Obstet Gynecol2006，195，： | 1 |
| 9 | Cytoskeletal Changes in the Hippocampus Following Restraint Stress:Role of Serotonin and Microtubules显示文摘 | Bianchi M Heidbreder C Crispi F | 2003 | Synapse2003，49，3： | 1 |
| 10 | Predictive value of angiogenic factors and uterine artery Doppler for early-versus lateonset pre-eclampsia and intrauterine growth restriction显示文摘 | Crispi F Llurba E Dominguez C | | 0，，03： | 1 |
| 11 | Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction显示文摘 | Crispi F Dominguez C Llurba E | 2006 | Am J Obstet Gynecol2006，，： | 1 |
| 12 | Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses显示文摘 | Crispi F Hernandez-Andrade E Pelsers MM | 2008 | Am J Obstet Gyneco12008，199，3： | 1 |
| 13 | The contribution of attachment to burden in adult children of institutionalized parents with dementia显示文摘 | Crispi EL Schiafino K Berman WH | | 0，，： | 1 |
| 14 | Assessment of fetal cardiac function using tissue Doppler techniques显示文摘 | Comas M Crispi F | 2012 | Fetal Diagnosis and Therapy2012，32，1： | 1 |
| 15 | Predictive value of angiogenie factors and uterine artery Doppler for early-versus late-onset preeclampsia and intrauterine growth restriction 显示文摘 | Crispi F Llurba E Dominguez C | 2008 | Ultrasound Obstet Gynecol2008，31，： | 1 |
| 16 | Update on the Pathophysi- ological Implications and Clinical Role of Angiogenic Fac- tors in Pregnancy显示文摘 | Llurba E Crispi F Verlohren S | 2015 | Fetal Diagn Ther2015，，2： | 1 |
| 17 | Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction显示文摘 | Fàtima Crispi Carmen Domínguez Elisa Llurba Pilar Martín-Gallán Luís Cabero Eduard Gratacós | 2006 | American Journal of Obstetrics and Gynecology2006，，： | 1 |
| 18 | Assessment of fetal cardiac function using tissue Doppler techniques 显示文摘 | Comas M Crispi F | 2012 | Fetal Diagn Ther2012，32，12： | 1 |
| 19 | Endometriosis of the round ligament of the uterus显示文摘 | Crispi C P de Souza C A Oliveira M A | 2012 | J Minim Invasive Gynecol2012，19，1： | 1 |
| 20 | Predictive value of angiogenic factors and uterine artery Doppler for early versuslate-onset pre-eclampsia and intrauterine growth restriction 显示文摘 | Crispi F Llurba E Dominguez C | 2008 | Ultrasound Obstet Gynecol2008，31，3： | 1 |
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