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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Quantitative Study on Nonmetallic Inclusion Particles in Steels by Automatic Image Analysis With Extreme Values Method显示文摘The presence of nonmetallic inclusion particles which appear during steelmaking process is harmful to the properties of steels,which is mainly as a function of some aspects such as size,volume fraction,shape,and distribution of these particles.The automatic image analysis technique is one of the most important tools for the quantitative determination of these parameters.The classical Student approach and the Extreme Values Method(EVM) were used for the inclusion size and shape determination and the evaluation of distance between the inclusion particles.The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products.Both methods achieved results with some differences,indicating that EVM could be used as a faster and more reliable statistical methodology. | Cássio Barbosa José Brant de Campos Jneo Lopes do Nascimento Iêda Maria Vieira Caminha | 2009 | Journal of Iron and Steel Research(International)2009，16，4： | 7 |
| 3 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 4 | On the applicability of Kirchoff's law and the principle of heat balance in thermal infrared remote sensing:A non-isothermal system显示文摘This paper proposes a basic equation of thermal radiation interaction between surface objects on the basis of the principle of heat balance in the interface. The solution of this equation takes account of the contribution of sensible heat flux and latent heat flux more completely, compared with traditional solution for surface cooling and heating processes. By the aid of the experimental data conducted in the Xiaotangshan experimental site, Beijing, both the non-applicability of Kirchoff's law and the measurability of surface emissivity in a non-isothermal system have been highlighted. Two methods called ventilation and time-delay compensations have been proposed to reduce the error induced by change of surface temperatures of non-isothermal objects during the measurement of emissivity. Based on the solution of the basic equation, this paper has analyzed and pointed out the misunderstanding in comprehension and application of Kirchoff's law published in literature. | ZHANG Renhua, LI Zhaoliang, SUN Xiaomin, ZHU Zhilin & WANG Weimin Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China LSIIT (CNRS UMR7005), Bld Sebastien Brant, BP.10413, 67412 Illkirch, France | 2005 | Science China Earth Sciences2005，48，1： | 4 |
| 5 | Recent Insights Into the Genetics of Inflammatory Bowel Disease显示文摘 | Judy H. Cho Steven R. Brant | 2011 | Gastroenterology2011，，6： | 3 |
| 6 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 7 | CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement显示文摘Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)has rapidly been developed into a robust,multifunctional genome editing tool with many uses.Following the discovery of the initial CRISPR/Cas-based system,the technology has been advanced to facilitate a multitude of different functions.These include development as a base editor,prime editor,epigenetic editor,and CRISPR interference(CRISPRi)and CRISPR activator(CRISPRa)gene regulators.It can also be used for chromatin and RNA targeting and imaging.Its applications have proved revolutionary across numerous biological fields,especially in biomedical and agricultural improvement.As a diagnostic tool,CRISPR has been developed to aid the detection and screening of both human and plant diseases,and has even been applied during the current coronavirus disease 2019(COVID-19)pandemic.CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases,including cancers,and has aided drug development.In terms of agricultural breeding,precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins,starch,oil,and other functional components for crop improvement.Adding to this,CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators.Looking to the future,increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology.This review provides an in-depth overview of current CRISPR development,including the advantages and disadvantages of the technology,recent applications,and future considerations. | Chao LI Eleanor BRANT Hikmet BUDAK Baohong ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，4： | 3 |
| 8 | Concurrent measurement of (Na+,K+)-ATPase activity and lipid peroxides in rat brain following reversible global ischemia显示文摘 | William J. Goldberg Brant D. Watson Raul Busto Harry Kurchner Mercedes Santiso Myron D. Ginsberg | 1984 | Neurochemical Research1984，，12： | 2 |
| 9 | Efficacy of Transoral Fundoplication vs Omeprazole for Treatment of Regurgitation in a Randomized Controlled Trial显示文摘 | John G. Hunter Peter J. Kahrilas Reginald C.W. Bell Erik B. Wilson Karim S. Trad James P. Dolan Kyle A. Perry Brant K. Oelschlager Nathaniel J. Soper Brad E. Snyder Miguel A. Burch William Scott Melvin Kevin Reavis Daniel G. Turgeon Eric S. Hungness Brian | 2014 | Gastroenterology2014，，： | 2 |
| 10 | Effect of medical and surgical treatment of Barrett's metaplasia显示文摘Barrett’s esophagus (BE) is a change in the esophageal mucosa as a result of long-standing gastroesophageal reflux disease. The importance of BE is that it is the main risk factor for the development of esophageal adenocarcinoma, whose incidence is currently growing faster than any other cancer in the Western world. The aim of this review was to compare the common treatment modalities of BE, with the focus on proton pump inhibitors and operative fundoplication. We performed a literature search on medical and surgical treatment of BE to determine eligible studies for this review. Studies on medical and surgical treatment of BE are discussed with regard to treatment effect on progression and regression of disease. Although there is some evidence for control of reflux with either medical or surgical therapy, there is no def initive evidence that either treatment modality decreases the risk of progression to dysplasia or cancer. Even though there is a trend toward antireflux surgery being superior, there are no def initive studies to prove this. | Eelco B Wassenaar Brant K Oelschlager | 2010 | World Journal of Gastroenterology2010，16，30： | 2 |
| 11 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，： | 2 |
| 12 | Demographic Dynamics and Per Capita Environmental Impact: Using Panel Regressions and Household Decompositions to Examine Population and Transport显示文摘 | Brant Liddle | 2004 | Population and Environment2004，，1： | 2 |
| 13 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，5： | 2 |
| 14 | Treatment of Peyronie's disease with oral pentoxifylline 显示文摘 | Brant WO Dean RC Lue TF | 2006 | Nature Clin Pract Urol2006，3，： | 1 |
| 15 | 显示文摘 | Nelson J A Brant E L Wagner M J | 2003 | Chem Mater2003，15，： | 1 |
| 16 | Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation显示文摘 | Scott R. Johnstone Jeremy Ross Michael J. Rizzo Adam C. Straub Paul D. Lampe Norbert Leitinger Brant E. Isakson | 2009 | The American Journal of Pathology2009，，2： | 1 |
| 17 | Microbial community utilization of added carbon substrates in response to long-term carbon input manipulation显示文摘 | Brant J B Sulzman E W Myrold D D | 2006 | Soil Biology and Biochemistry2006，38，8： | 1 |
| 18 | Evolutionary origins,diversification,and biogeography of liver flukes(Digenea,Fasciolidae)显示文摘 | LOTFY W M BRANT S V DEJONG R J | 2008 | Am J Trop Med Hyg2008，79，2： | 1 |
| 19 | CT-angiography beibasilaris throm bosie:ersteerfahrungen显示文摘 | Brant T Jansen O | 1996 | Radiology1996，36，： | 1 |
| 20 | Hematocolpos caused by genital bullouslesions in a patient with Stevens-Johnson syndrome显示文摘 | Murphy MI Brant WE | 1998 | J ClinUltrasound1998，26，1： | 1 |
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