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| 1 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 2 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 3 | The role of flagellated and ci]iated protozoa in lagoon and grass filter sewage treatment systems显示文摘 | Layhourn-Parry ] Boyall J Rogers P | 1999 | Water Research1999，33，13： | 1 |
| 4 | A lattice framework for option pricing with two state variables显示文摘 | Boyal PP | 1988 | Journal of Financial and Quantitative Analysis1988，，23： | 1 |
| 5 | Retail leasing:the determinants of shopping center rents显示文摘 | Benjamin J D Boyal G W Sirmans C F | 1990 | Journal of the American Real Estate and Urban Economics Association1990，，： | 1 |
| 6 | A lattice framework for option pricing with two state variables显示文摘 | Boyal P P | 1988 | Journal of Financial and Quanti- tative Analysis1988，23，1： | 1 |
| 7 | A lattice framework for option pricing with two state variables显示文摘 | Boyal pp | 1988 | Journal of Financial and Quantitative Analysis1988，23，： | 1 |
| 8 | Decisions and Delays Within Stroke Patients’ Route to the Hospital: A Qualitative Study显示文摘 | Ruth M. Mellor Sheila Bailey James Sheppard Peter Carr Tom Quinn Amunpreet Boyal David Sandler Don G. Sims Jonathan Mant Sheila Greenfield Richard J. McManus | 2014 | Annals of Emergency Medicine2014，，： | 1 |
| 9 | A Lattice Framework for Option Pricing with Two State Variablea显示文摘 | Boyal pp | 1988 | Journal of Financial and Quantitative Analysis1988，23，： | 1 |
| 10 | A lattice framework for option pricing with two state variables显示文摘 | Boyal P P | | 0，，： | 1 |
| 11 | Facile,asymmetric addition of acetylene to aldehydes:In situ generation of reactive zinc acetylide显示文摘 | Sasaki H Boyall D Carreira E M | 2001 | Helv Chim Acta2001，84，： | 1 |
| 12 | A lattice framework for option pricing with two state variables显示文摘 | | 1988 | Journal of Financial and Quantitative Analysis1988，23，： | 1 |
| 13 | A lattice framework for option pricing with two state variables显示文摘 | Boyal pp | 1988 | Janmal of financial and Quantitative Analysis1988，23，： | 1 |
| 14 | Retail leasing: the determinants of shopping center rents显示文摘 | Benjamin J D Boyal G W Sirmans C F | 1990 | Journal of the American real estate and urban economics association (Fall)1990，302，： | 1 |
| 15 | A lattice framework for option pricing with two state variables显示文摘 | | 1988 | Journal of Financial and Quantitative Analysis1988，，23： | 1 |
| 16 | A lattice framework for option pricing with two state variables 显示文摘 | Boyal P P | 1988 | Journal of Finacial and Quantitative A- nalysis1988，，23： | 1 |
| 17 | A lattice framework for option pricing with two state variables显示文摘 | Boyal P P | 1988 | Journal of Financial and Quantitative Analysis1988，23，： | 1 |
| 18 | The effect of temperature on the structure of mercury显示文摘 | BOYAL R N WAKCHAM H R R | 1939 | J Chem Phys1939，7，： | 1 |
| 19 | Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy显示文摘BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and posture.Disturbances in motor functions constitute the main body of CP symptoms.These symptoms surface in early childhood and patients are affected for the rest of their lives.Currently,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal spasticity.However,none of these methods can provide full symptom relief.This has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and safety.AIM To analyze the efficacy and safety of MSCT in CP patients.METHODS Our sample consists of four CP patients who cannot stand or walk without external support.All of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)instruments.We utilized the Modified Ashworth Scale(MAS)to measure spasticity.RESULTS We found significant improvements in MAS scores after the intervention on both sides.Two months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046.However,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity,and it partially improves motor functions. | Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp CanSavrunlu Erdal Karaöz | 2024 | World Journal of Clinical Cases2024，12，9： | 0 |
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