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| 1 | 华法林与阿司匹林在社区老年房颤人群中卒中预防作用的对比:随机对照BAFTA(Birmingham老年房颤治疗研究)试验显示文摘背景:抗凝药物降低房颤患者的卒中风险较抗血小板药物更为有效,但是在老年患者中此益处是否超过出血风险的增加尚不清楚。在老年患者中评价与阿司匹林相比华法林是否会降低大范围卒中、动脉栓塞或其他颅内出血的风险。方法:自初级医疗中心纳入973例年龄≥75岁的房颤患者,患者被随机分配接受华法林(目标INR为2~3)或阿司匹林(75mg/d)治疗。 | Mant J. Hobbs F.R. Fletcher K. 罗亮 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，12： | 19 |
| 2 | A full multigrid method for nonlinear eigenvalue problems显示文摘We introduce a type of full multigrid method for the nonlinear eigenvalue problem. The main idea is to transform the solution of the nonlinear eigenvalue problem into a series of solutions of the corresponding linear boundary value problems on the sequence of finite element spaces and nonlinear eigenvalue problems on the coarsest finite element space. The linearized boundary value problems are solved by some multigrid iterations.Besides the multigrid iteration, all other efficient iteration methods for solving boundary value problems can serve as the linear problem solver. We prove that the computational work of this new scheme is truly optimal,the same as solving the linear corresponding boundary value problem. In this case, this type of iteration scheme certainly improves the overfull efficiency of solving nonlinear eigenvalue problems. Some numerical experiments are presented to validate the efficiency of the new method. | JIA ShangHui XIE HeHu XIE ManTing XU Fei | 2016 | Science China Mathematics2016，59，10： | 7 |
| 3 | circPTPN4 regulates myogenesis via the miR-499-3p/NAMPT axis显示文摘Background:Circular RNAs(circ RNAs)are a novel class of endogenous nc RNA,which widely exist in the transcriptomes of different species and tissues.Recent studies indicate important roles for circ RNAs in the regulation of gene expression by acting as competing endogenous RNAs(ce RNAs).However,the specific role of circ RNAs in myogenesis is still poorly understood.In this study,we attempted to systematically identify the circ RNAs involved in myogenesis and analyze the biological functions of circ RNAs in chicken skeletal muscle development.Results:In total,532 circ RNAs were identified as being differentially expressed between pectoralis major(PEM)and soleus(SOL)in 7-week-old Xinghua chicken.Among them,a novel circ RNA(novel_circ_002621),generated by PTPN4 gene,was named circ PTPN4 and identified.circ PTPN4 is highly expressed in skeletal muscle,and its expression level is upregulated during myoblast differentiation.circ PTPN4 facilitates the proliferation and differentiation of myoblast.Moreover,circ PTPN4 suppresses mitochondria biogenesis and activates fast-twitch muscle phenotype.Mechanistically,circ PTPN4 can function as a ce RNA to regulate NAMPT expression by sponging mi R-499-3p,thus participating in AMPK signaling.Conclusions:circ PTPN4 functions as a ce RNA to regulate NAMPT expression by sponging mi R-499-3p,thus promoting the proliferation and differentiation of myoblast,as well as activating fast-twitch muscle phenotype. | Bolin Cai Manting Ma Zhen Zhou Shaofen Kong Jing Zhang Xiquan Zhang Qinghua Nie | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 4 |
| 4 | 中低收入国家药品定价和采购的政策选择显示文摘药品支出上涨是全球问题。为应对这一压力,多数高收入国家制定并实施了一系列的药品定价和采购政策。然而,尽管中低收入国家希望能够有效控制药品支出预算,但其药品市场不规范,并缺乏可行的药品定价或采购政策。高收入国家药品支出通常由国家或社会医疗保险机构支付,而中低收入国家大多是个人自付,这会给政策执行造成阻力。由于对药品定价和采购政策是否高效缺乏严谨的调查研究,因而一定程度上阻碍了中低收入国家政策方案的实施。本文对已发表的有关药品定价和采购政策的文章进行综述发现,许多有效的政策也伴随着各种风险。全球尚没有一种最佳的政策选择,各国应根据具体国情,多种政策结合使用。中低收入国家的实证研究尚不足,由于缺乏完善的法律体系以及未建立专门的药品采购机构,任何一种政策选择所伴随的风险在这些国家都会引起更大的争议,然而这或许是帮助其改善药品定价和采购体系的关键因素。 | TuanAnh Nguyen Rosemary Knight Elizabeth Ellen Roughead Geoffrey Brooks Andrea Mant | 2015 | 中国卫生政策研究2015，8，4： | 4 |
| 5 | 尼古丁替代疗法的戒烟治疗显示文摘 | Silagy G Lancaster T Stead L Mant D Folower G 于淑秀 孙伟 于冬梅 | 2005 | 中国循证医学杂志2005，5，7： | 3 |
| 6 | Multi-attribute group decision making method under 2-dimension uncertain linguistic variables显示文摘A method is proposed to deal with the uncertain multiple attribute group decision making problems,where 2-dimension uncertain linguistic variables(2DULVs)are used as the reliable way for the experts to express their fuzzy subjective evaluation information.Firstly,in order to measure the 2DULVs more accurately,a new method is proposed to compare two 2DULVs,called a score function,while a new function is defined to measure the distance between two 2DULVs.Secondly,two optimization models are established to determine the weight of experts and attributes based on the new distance formula and a weighted average operator is used to determine the comprehensive evaluation value of each alternative.Then,a score function is used to determine the ranking of the alternatives.Finally,the effectiveness of the proposed method is proved by an illustrated example. | JIANG Kexin ZHANG Quan YAN Manting | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 2 |
| 7 | 成人慢性心力衰竭的诊断与治疗:最新NICE指南概要显示文摘在英国有90万人患有心力衰竭(心衰)。由于缺血性心肌病(心衰患者的主要病因)预后改善和人口老龄化导致了心衰患病率的增加。心衰的两种主要类型为:左室收缩功能(LVEF)异常和LVEF正常的心衰。 | Abdallah Al- Mohammad Jonathan Mant Philippe Laramee Sharon Swain 李喆(译) 乔树宾(校) | 2010 | 英国医学杂志中文版2010，13，6： | 2 |
| 8 | Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation( the Birmingham atrial fibrillation treatment of the aged study, BAFTA) : a randomized controlled trial 显示文摘 | Mant J Hobbs FD Fletcher K | 2007 | Lancet2007，370，3： | 1 |
| 9 | Systematic renew and modelling of the investigation of acute and chronic chest pain presenting in primary care 显示文摘 | Mant J McManus R J Oakes RA | 2004 | Health Technol Assess2004，8，2： | 1 |
| 10 | Management of chronic heart failure in adults: synopsis of the NationH Institute for Health and elinieH excellence guideline 显示文摘 | Mant JA AI- Mohammad S Swain S | 2011 | Ann Intern Med2011，155，4： | 1 |
| 11 | Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: the tasmin-sr randomized clinical trial显示文摘 | McManus RJ Mant J Haque M | 2014 | JAMA2014，312，8： | 1 |
| 12 | Topology optimization approaches显示文摘 | Sigmund O Mante K | 2013 | Structural & Multidisciplinary Optimization2013，48，5： | 1 |
| 13 | Prevalence of thyroid nodules in the valley of Mexico 显示文摘 | Hurtado LL Basurto KE Mantes OE | 2011 | Cir2011，79，2： | 1 |
| 14 | Optical lightpipe as a high -band width fusion diagnostic显示文摘 | Moran M J Lerche R A G Mant | 2006 | Rev Sci Inslrum2006，77，10： | 1 |
| 15 | Short-term effects on mobility, activities of daily living and health-related quality of life of a Conductive Education programme for adults with multiple sclerosis, Parkinson's disease and stroke显示文摘 | Brittle N Brown M Mant J | 2008 | Clin Rehabil2008，22，4： | 1 |
| 16 | Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet显示文摘 | Mantes VN Subramanian S Goodspeed L | 2015 | Nutr Diabetes2015，5，： | 1 |
| 17 | Beta-synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor显示文摘 | Hashimoto M Rockenstein E Mante M | 2001 | Neuron2001，32，2： | 1 |
| 18 | The Role of Surface Functional Groups in Calcium Phosphate Nucleation on Titanium Foil:A Self-assembled Monolayer Technique显示文摘 | Liu Q Ding J Mante FK | 2002 | Biomaterials2002，23，： | 1 |
| 19 | Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension : systematic review 显示文摘 | Hodgkinson J Mant J Martin U | 2011 | BMJ2011，342，： | 1 |
| 20 | Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants显示文摘 | Crainie M Belch R Mant MJ | 1999 | Blood1999，93，5： | 1 |
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