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1Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival.Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud 2012World Journal of Gastroenterology2012,18,5:7
2Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van 1997Cell1997,,2:6
3Size, differentiation and the performance of Dutch daily newspapers显示文摘Christophe Boone Glenn R Carroll Arjen van Witteloostuijn 2004Industrial and Corporate Change2004,13,1:1
4Comparative evaluation of building responses to an adjacent braced excavation显示文摘BOONE S J WESTLAND J NUSINK R 1999Canadian Geotechnical Journal1999,36,2:1
5Optimal procurement portfolios when using B2Bs: A model and analysis显示文摘Ganeshan R Boone T Aggarwal P 2009International Journal of Production Economics2009,118,1:1
6Temporal and Spatial Analysis of Sin Nombre Virus Quasispecies in Naturally Infected Rodents显示文摘Feuer R Boone J D Netski D 1999J Virol1999,73,11:1
7Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions显示文摘Pendle A F Clark G P Boon R 2005Mol Biol Cell2005,16,:1
8Plant and soil responses to three years of chronic nitrogen additions at the Harvardforest, Massachusetts显示文摘Aber J D Mcdowell W H Boone R 1993Ecological Applications1993,3,1:1
9Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug显示文摘De Smedt T Raedt R Vonck K Boon P 2007CNS Drug Rev2007,13,1:1
10Comparison of predicted and measured air flow patterns in a mechanically ventilated livestock building without animals 显示文摘Harral B B Boon C R 1997Journal of Agricultural Engineering Research1997,66,:1
11Repair of ruptured tendinous chords in the newborn with flail tricuspid valve and functional pulmonary atresia 显示文摘BOON R HRUDA J SCHOOF P H 2007Int J Cardiol2007,116,3:1
12Direct temperature resolved HRMS of fire-retarded polymers by in-Source PyMS on an external ion source fourier transform ion cyclotron resonance mass spectrometer显示文摘Heeren R M A De Koster C G Boon J J 1995Analytical Chemistry1995,67,21:1
13Grazing systems are a result of equilibrium and non-equilibrium dynamics显示文摘DERRY J F BOONE R B 2010Journal of Arid Environments Elsevier Ltd2010,74,2:1
14Natural disturbance and nitrogen mineralization:Wave-form dieback of mountain hemlock in the Oregon Cascades显示文摘MATSON P A BOONE R D 1984Ecology1984,65,:1
152004, Short term soil respiration and nitrogen immobilization response to nitrogen applications in control and nitrogen-enriched temperate forests显示文摘MICKSA P ABER J D BOONE R D 2004Forest Ecology and Management2004,196,:1
16Targets for molecular therapy in esophageal cell carcinoma:an immunohistochemical analysis显示文摘Boone J van Hillegersberg R Offerhaus G J 0,,06:1
17Prediction of single fetal demise after laser therapy for twin-twin transfusion syndrome 显示文摘Eschbach SJ Boons LS Woherbeek R 2016Ultrasound Obstet Gynecol2016,47,3:1
18Soil water content and temperature as independent or confounded factors controlling soil respiration in a temperate mixed hardwood forest显示文摘Davidson E A Belk & R D Boone 1998Global Change Biology1998,4,:1
19Structural characterization of lignin polymers by temperature-resolved in-source pyrolysis- mass spectrometry and Curie-point pyrolysis-gas chromatography/mass spectrometry 显示文摘Hage R R E Mulder M M Boon J J 1993Journal of Analytical and Applied Pyrolysis1993,25,:1
20Long-term impacts of agriculture on soil carbon and nitrogen in New England forests显示文摘COMPTON J E BOONE R D 2000Ecology2000,81,:1
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