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| 1 | Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury:A review显示文摘Matrix metalloproteinases(MMPs) are a family ofproteases using zinc-dependent catalysis to break down extracellular matrix(ECM) components, allowing cell movement and tissue reorganization. Like many other proteases, MMPs are produced as zymogens, an inactive form, which are activated after their release from cells. Hepatic ischemia/reperfusion(I/R) is associated with MMP activation and release, with profound effects on tissue integrity: their inappropriate, prolonged or excessive expression has harmful consequences for the liver. Kupffer cells and hepatic stellate cells can secrete MMPs though sinusoidal endothelial cells are a further source of MMPs. After liver transplantation, biliary complications are mainly attributable to cholangiocytes, which, compared with hepatocytes, are particularly susceptible to injury and ultimately a major cause of increased graft dysfunction and patient morbidity. This paper focuses on liver I/R injury and cholestasis and reviews factors and mechanisms involved in MMP activation together with synthetic compounds used in their regulation. In this respect, recent data have demonstrated that the role of MMPs during I/R may go beyond the mere destruction of the ECM and may be much more complex than previously thought. We thus discuss the role of MMPs as an important factor in cholestasis associated with I/R injury. | Giuseppina Palladini Andrea Ferrigno Plinio Richelmi Stefano Perlini Mariapia Vairetti | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 2 | Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract显示文摘Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders. | Andrea Ferrigno Clarissa Berardo Laura G Di Pasqua Veronica Siciliano Plinio Richelmi Mariapia Vairetti | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 3 | Lobe-Specific Heterogeneity and Matrix Metalloproteinase Activation after Ischemia/Reperfusion Injury in Rat Livers显示文摘 | Giuseppina Palladini Andrea Ferrigno Vittoria Rizzo Eleonora Boncompagni Plinio Richelmi Isabel Freitas Stefano Perlini Mariapia Vairetti | 2012 | Toxicologic Pathology2012，，5： | 2 |
| 4 | Liver plays a central role in asymmetric dimethylargininemediated organ injury显示文摘Asymmetric-dimethylarginine(ADMA) competes with L-arginine for each of the three isoforms of nitric oxide synthase:endothelial;neuronal;inducible.ADMA is synthesized by protein methyltransferases followed by proteolytic degradation.ADMA is metabolized to citrulline and dimethylamine,by dimethylarginine dimethylaminohydrolase(DDAH) and enters cells through cationic amino-acid transporters extensively expressed in the liver.The liver plays a crucial role in ADMA metabolism by DDAH-1 and,as has been recently demonstrated,it is also responsible for ADMA biliary excretion.A correlation has been demonstrated between plasma ADMA levels and the degree of hepatic dysfunction in patients suffering from liver diseases with varying aetiologies:plasma ADMA levels are increased in patients with liver cirrhosis,alcoholic hepatitis and acute liver failure.The mechanism by which liver dysfunction results in raised ADMA concentrations is probably due to impaired activity of DDAH due to severe inflammation,oxidative stress,and direct damage to DDAH.High plasma ADMA levels are also relevant as they are associated with the onset of multiorgan failure(MOF).Increased plasma concentration of ADMA was identified as an independent risk factor for MOF in critically-ill patients causing enhanced Intensive Care Unit mortality:a significant reduction in nitric oxide synthesis,leading to malperfusion in various organs,eventually culminating in multi organs dysfunction. | Andrea Ferrigno Laura G Di Pasqua Clarissa Berardo Plinio Richelmi Mariapia Vairetti | 2015 | World Journal of Gastroenterology2015，21，17： | 2 |
| 5 | Subnormothermic machine perfusion protects against rat liver preservation injury:a comparative evaluation with conventional cold storage显示文摘 | Vairetti M Ferrigno A Rizzo V | 2007 | Transplantation Proceedings2007，，06： | 1 |
| 6 | Demonstrationof nuclear ompartmentalization of glutathione inhepatocytes显示文摘 | BELLOMO G VAIRETTI M STIVALA L | 1992 | Proceedings of national academy of science USA1992，89，： | 1 |
| 7 | Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione显示文摘 | Vairetti M Griffini P Pietrocola G | 2001 | Free Radie Biol Med2001，31，8： | 1 |
| 8 | Nicergoline reverts hal operidol-induced loss of detoxifying-enzyme activity显示文摘 | Vairetti M Ferrigno A Canonico PL | 2004 | Eur J Pharmacol2004，505，13： | 1 |
| 9 | Impaired hepatic function and central dopaminergic denervation in a rodent model of Parkinson's disease: A self-perpetuating erosstalk? 显示文摘 | Mariapia Vairetti Andrea Ferrigno Vittoria Rizzo | 2012 | Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease2012，1822，2： | 1 |
| 10 | Liver damage during ischemia/reperfusion and glutathione: implications for potential organ donors 显示文摘 | Vairetti M Ferrigno A Rizzo V | 2007 | Transplant Proc2007，39，6： | 1 |
| 11 | Liver damage during ischemia/reperfusion and glutathione inplications for potential organ donors显示文摘 | Vairetti M Ferrigno A Rizzo V | 2007 | Transplant Proc2007，39，6： | 1 |
| 12 | Subnormothermic ma- chine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? 显示文摘 | Vairetti M Ferrigno A Carlucci F | 2009 | Liver Transpl2009，15，1： | 1 |
| 13 | Subnormothermic machine perfusion protects steatotic livers against preservation injury:a potential for donor pool increase显示文摘 | Vairetti M Ferrigno A Carlucci F | | 0，，01： | 1 |
| 14 | Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? 显示文摘 | Vairetti M Ferrigno A Carlucci F | 2009 | Liver Transpl2009，15，1： | 1 |
| 15 | Lobe-Specific Heterogeneity in Asymmetric Dimethylarginine and Matrix Metalloproteinase Levels in a Rat Model of Obstructive Cholestasis显示文摘 | Andrea Ferrigno Giuseppina Palladini Alberto Bianchi Vittoria Rizzo Laura G. Di Pasqua Stefano Perlini Plinio Richelmi Mariapia Vairetti Kim Bridle | 2014 | BioMed Research International2014，，： | 1 |
| 16 | Antioxidant properties of MDL and MMDL,two nicergoline metabolites,during chronic administration of haloperidol显示文摘 | Vairetti M Battaglia A Carfagna N | 2002 | Eur J Pharmacol2002，453，1： | 1 |
| 17 | The effects of thyroid hormone modulation on rat liver injury associated with ischemia-reperfusion and cold storage显示文摘 | Imberti R Vairetti M Gualea M R | 1998 | Anesth Analg1998，86，6： | 1 |
| 18 | Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase显示文摘 | Vairetti M Ferrigno A Carlucci F | 2009 | Liver Transpl2009，15，1： | 1 |
| 19 | Troubleshooting and improving the mouse and rat isolated perfused liver preparation显示文摘 | Andrea Ferrigno Plinio Richelmi Mariapia Vairetti | 2012 | Journal of Pharmacological and Toxicological Methods2012，，： | 1 |
| 20 | Machine perfusion at 20°C reduces preservation damage to livers from non-heart beating donors显示文摘 | Andrea Ferrigno Vittoria Rizzo Eleonora Boncompagni Alberto Bianchi Enrico Gringeri Daniele Neri Plinio Richelmi Isabel Freitas Umberto Cillo Mariapia Vairetti | 2011 | Cryobiology2011，，2： | 1 |
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