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| 1 | Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury:A review显示文摘Matrix metalloproteinases(MMPs) are a family ofproteases using zinc-dependent catalysis to break down extracellular matrix(ECM) components, allowing cell movement and tissue reorganization. Like many other proteases, MMPs are produced as zymogens, an inactive form, which are activated after their release from cells. Hepatic ischemia/reperfusion(I/R) is associated with MMP activation and release, with profound effects on tissue integrity: their inappropriate, prolonged or excessive expression has harmful consequences for the liver. Kupffer cells and hepatic stellate cells can secrete MMPs though sinusoidal endothelial cells are a further source of MMPs. After liver transplantation, biliary complications are mainly attributable to cholangiocytes, which, compared with hepatocytes, are particularly susceptible to injury and ultimately a major cause of increased graft dysfunction and patient morbidity. This paper focuses on liver I/R injury and cholestasis and reviews factors and mechanisms involved in MMP activation together with synthetic compounds used in their regulation. In this respect, recent data have demonstrated that the role of MMPs during I/R may go beyond the mere destruction of the ECM and may be much more complex than previously thought. We thus discuss the role of MMPs as an important factor in cholestasis associated with I/R injury. | Giuseppina Palladini Andrea Ferrigno Plinio Richelmi Stefano Perlini Mariapia Vairetti | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 2 | Lobe-Specific Heterogeneity and Matrix Metalloproteinase Activation after Ischemia/Reperfusion Injury in Rat Livers显示文摘 | Giuseppina Palladini Andrea Ferrigno Vittoria Rizzo Eleonora Boncompagni Plinio Richelmi Isabel Freitas Stefano Perlini Mariapia Vairetti | 2012 | Toxicologic Pathology2012，，5： | 2 |
| 3 | Effect of pharmacologically induced mydriasis on the normal variability of retinal oscillatory potentials in man 显示文摘 | Polo A di Summa A Perlini S | 1995 | Acta Ophthalmol Scand1995，73，2： | 2 |
| 4 | Effects of chronic adenosine uptake blockade on adrenergic responsiveness and left ventricular chamber function in pressure overload hypertrophy in the rat显示文摘 | Chung ES Perlini S Aurigemma GP | 1998 | J Hypertens1998，16，121： | 1 |
| 5 | Emotional intelligence in the national hockey league显示文摘 | PERLINI A H HALVERSON T R | 2006 | Canadian Journal of Behavioral Science2006，38，2： | 1 |
| 6 | The combination of thalid- omide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL) 显示文摘 | Palladini G Perfetti V Perlini S | 2005 | Blood2005，105，7： | 1 |
| 7 | Antiadrenergic effects of adenosine in pressure overload hypertrophy显示文摘 | Chtmg ES Perlini S | 2001 | Hypertension2001，37，： | 1 |
| 8 | Sympathectomy or doxazosin ,but not propranolol,blunt myocardial interstitial fibrosis in pressure-overload hypertrophy 显示文摘 | Perlini S Palladini G Ferrero I | 2005 | Hypertension2005，46，5： | 1 |
| 9 | Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I显示文摘 | Perlini LE Botti F Fornasiero EF | 2011 | J Cell Sci2011，124，21： | 1 |
| 10 | Midwall mechanics are improved after reprcssion of hypertensive left ventricular hypertrophy and normalization of chamber geometry 显示文摘 | Perlini S Muiesan M L Guspidi G | 2001 | Circulation2001，103，： | 1 |
| 11 | From hypertension to hypertrophy to heart failure: the role of eardiotrophin-1显示文摘 | Schillaci G Pucci G Perlini S | 2013 | J Hypertens2013，31，3： | 1 |
| 12 | Adenosine A1 receptor expression during the transition from compensated pressure overload hypertrophy to heart failure显示文摘 | PERLINI S AROSIO B PARMEGGIANI L | 2007 | J Hypertens2007，25，： | 1 |
| 13 | Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the Global Cardiometabolic Risk Profile in Patients with hypertension disease survey 显示文摘 | Kjeldsen SE Naditch-Brule L Perlini S | 2008 | J Hypertens2008，26，10： | 1 |
| 14 | Blood pressure control and components of the metabolic syndrome: the GOOD survey显示文摘 | Zidek W Naditch-Burle L Perlini S | 2009 | Cardiovasc Diabetol2009，8，： | 1 |
| 15 | Lobe-Specific Heterogeneity in Asymmetric Dimethylarginine and Matrix Metalloproteinase Levels in a Rat Model of Obstructive Cholestasis显示文摘 | Andrea Ferrigno Giuseppina Palladini Alberto Bianchi Vittoria Rizzo Laura G. Di Pasqua Stefano Perlini Plinio Richelmi Mariapia Vairetti Kim Bridle | 2014 | BioMed Research International2014，，： | 1 |
| 16 | Midwall mechanics are improved after repression of hypertensive left ventricular hypertrophy and normalization of chamber geometry显示文摘 | Perlini S Muiesan M L Guspidi G | 2001 | Circulation2001，103，5： | 1 |
| 17 | Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the Global Cardiometabolic Risk Profile in Patients with hypertension disease survey 显示文摘 | Kjeldsen SE Naditch-Brule L Perlini S | 2008 | J Hypertens2008，26，10： | 1 |
| 18 | Midwall mechanics are improved after regression if hypertensive left ventricular hypertrophy and normalization of chamber geometr显示文摘 | Perlini S Muiesan ML Cuspidi C | 2001 | Circulation2001，103，： | 1 |
| 19 | 3-hydroxyacyl-coenzyme a dehydro- genase deficiency: identification of a new mutation causing hyperinsu- linemic hypoketotic hypoglycemia, altered organic acids and acylcar- nitines concentrations显示文摘 | Popa FI Perlini S Teofoli F | 2012 | J Rep Case Res Reports2012，2，： | 1 |
| 20 | Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe:the Global Cardiometabolic Risk Profile in Patients with hypertension disease survey显示文摘 | Kjeldsen SE Naditch-Brule L Perlini S | 2008 | J Hypertens2008，26，： | 1 |
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