|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Fish bioaccumula-tion and biomarkers in environmental risk assessment : A review显示文摘 | Vander Oost R Beyer J Vermeulen N P E | 2003 | Environmental Toxicology and Pharmacology2003，13，2： | 1 |
| 3 | The effects of intra-arterial vasodilators on radial artery size and spasm:implications for contemporary use of trans-radial access for coronary angiography and percutaneous coronary intervention显示文摘 | Boyer N Beyer A McH ugh T | 2013 | Cardiovasc Revasc Med2013，14，6： | 1 |
| 4 | Fish bioaccumulation andbiomarkers in environmental risk assessment:a review显示文摘 | Oost R Beyer J Vermeulen N P E | 2003 | Environmental Toxicology and Pharmacology2003，13，2： | 1 |
| 5 | Fish bioaccumulation and biomarkers in environmental risk assessment: a review 显示文摘 | VANDEROOST R BEYER J VERMEULEN N P | 2003 | Environmental Toxicology and Pharmacology2003，13，2： | 1 |
| 6 | Fish bioaccu- mulation and biomarkers in environmental risk assess- ment: A review 显示文摘 | Van der Oost R Beyer J Vermeulen N P | 2003 | Environ Toxicol Phar2003，13，： | 1 |
| 7 | Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis显示文摘 | Siawaya J F D Beyers N Helden P V | 2009 | Clin Exp Immunol2009，156，1： | 1 |
| 8 | Mesenchymal stem cells: isolation, in vitro expansion and characterization 显示文摘 | Beyer Nardi N da Silva Meirelles L | 2006 | Handb Exp Pharmacol2006，，174： | 1 |
| 9 | Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma显示文摘 | Jocelyn H. Wright Melissa M. Johnson Masami Shimizu‐Albergine Renay L. Bauer Brian J. Hayes James Surapisitchat Kelly L. Hudkins Kimberly J. Riehle Simon C. Johnson Matthew M. Yeh Theodor K. Bammler Richard P. Beyer Debra G. Gilbertson Charles E. Alpers N | 2014 | Int. J. Cancer2014，，4： | 1 |
| 10 | Mesenchymal stem cells: isolation, in vitro expansion and characterization 显示文摘 | Beyer Nardi N da Silva Meirelles L | 2006 | Handb Exp Pharmacol2006，，174： | 1 |
| 11 | One-dimensional arrangements of matal nanoclustets 显示文摘 | Wyrwa D Beyer N Schmid G | 2002 | Nano Letters2002，2，： | 1 |
| 12 | Validation of the Falls Efficacy Scale and Falls Efficacy Scale International in geriatric patients with and without cognitive impairment : results of self - report and interview - based questionnaires 显示文摘 | Hauer K Yardley L Beyer N | 2009 | Gerontology2009，56，2： | 1 |
| 13 | Mesenchymal stem cells: isola- tion, in vitro expansion and characterization 显示文摘 | Beyer Nardi N da Silva Meirelles L | 2006 | Handb Exp Pharma- col2006，174，： | 1 |
| 14 | Genetic susceptibility to tuberculosisi in Africans:a genome-wide scan显示文摘 | Bellamy R Beyers N McAdam K P | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 15 | 显示文摘 | Beyer IW Kaimali R Demeester-Mirkine N | 1998 | Thyroid1998，8，11： | 1 |
| 16 | Fish bioaeeumalation and biomarkers in environmental risk assessment: A review显示文摘 | van der Oost R Beyer J Vermeulen N P | 2003 | Environmental Toxicology and Pharmacology2003，13，2： | 1 |
| 17 | Oligonucletide(GTG)5 as a marker for strain identification in Mycobacterium tuberculosis显示文摘 | Wiid I J F Werely C Beyers N | 1994 | J Clin Microbiol1994，32，： | 1 |
| 18 | Estimates of soil ingestion by wildlife 显示文摘 | Beyer W N Connor E E Gerould S | 1994 | Journal of WildlifeManagement1994，58，2： | 1 |
| 19 | Sediment ingestion of two sympatric shorebird species 显示文摘 | Hui C A Beyer W N | 1998 | Science of the TotalEnvironment1998，224，13： | 1 |
| 20 | Fish bioac- cumulation and biomarkers in environmental risk as- sessment: A review 显示文摘 | van der Oost R Beyer J Vermeulen N P E | 2003 | Environmental Toxicology andPharmacology2003，13，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员