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| 1 | 董事薪酬、CEO薪酬与公司业绩--合谋还是共同激励?显示文摘本文从中国沪深两市观测到的上市公司中CEO和董事薪酬的趋同现象,综合代理理论和乘员理论等多理论基础,基于薪酬激励和公司治理绩效的关系,考察了董事与CEO之间的合谋、单边激励和共同激励等复杂关系。论文采用2005-2007年度我国上市公司样本池数据,通过混合回归、固定效应回归和敏感性分析等实证检验发现,我国董事与CEO薪酬激励已初步与公司业绩挂钩,但是研究揭示CEO激励走在董事绩效激励前面,董事激励不足问题突出。进一步的研究发现上市公司中CEO薪酬与公司业绩正向相关,董事薪酬对公司业绩没有显著影响;结论认为我国上市公司中董事与CEO关系并非简单合谋或共同激励关系,而是处于CEO选择合适角色或监控得当,董事仍持代理角色,并且其战略指导要弱于监控作用的'单边激励'状况。 | 杨青 高铭 Besim Burcin Yurtoglu | 2009 | 金融研究2009,,6: | 54 |
| 2 | 中国上市公司CEO薪酬存在激励后效吗?显示文摘与以往纯粹基于代理理论研究CEO薪酬激励问题不同,本文同时考虑乘员理论和制度理论等,从多视角研究上市公司治理绩效。我们采用2005~2008年沪深上市公司面板数据,按全样本、私人与国有控股、国有控股与集体等对照组进行混合回归(Pooled Regress)分析,研究证实中国上市公司CEO薪酬激励与公司业绩显著正相关,董事会部分特征与薪酬机制设计相关;被激励后的CEO在外部治理环境监控下会进一步改善公司业绩,产生激励后效,股权集中度有正向促进作用,但董事会特征与激励后效无关。研究揭示目前董事会受制于代理问题,致力于改善CEO薪酬激励不足,公司业绩改善主要来自于政策、制度变革等外部公司治理,尤其国有控股公司制度改革效应和乘员主义突出,但董事会内部绩效治理仍较弱;这对改善中国CEO薪酬机制设计及内部治理具有积极意义。论文进一步采用固定效应回归(Fixed-effectRegress)、两阶段最小二乘回归法(Two Stage Least Squares Regress)和薪酬灵敏度分析后依然支持该结论。 | 杨青 黄彤 Steven TOMS Besim Burcin YURTOGLU | 2010 | 金融研究2010,,1: | 41 |
| 3 | 我国董事会职能探寻:战略咨询还是薪酬监控?显示文摘董事会究竟发挥何种作用一直是公司治理争议的焦点问题。本文采用董事会权能对战略咨询和监督控制的双路径结构方程模型(Structure Equation Model,SEM),提出董事会的监控作用表现为以薪酬激励监督CEO为间接手段来改善公司业绩;战略咨询则体现为董事会权能对公司业绩的直接贡献。以中国2005~2007年上市公司样本的测试结果表明:国资委、地方与中央国有控股公司等的董事会薪酬监控作用显著,表现为改善董事和CEO激励不足,'薪酬激励效应'突出,董事权力和治理效果逐年改善,但其战略咨询的治理任务有待加强;私人控股公司董事会的战略和监督二元作用初步凸显,但存在'薪酬挤出效应',公司治理状况呈弱化趋势,CEO监管与激励有待改善。 | 杨青 薛宇宁 YURTOGLU Besim Burcin | 2011 | 金融研究2011,,3: | 21 |
| 4 | Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia显示文摘AIM: To test the hypothesis that fluid resuscitation with Ringer's solution enriched with pyruvate(PR), a physiological antioxidant and energy substrate, affords protection of myocardial metabolism and electrophysiological performance superior to lactated Ringer's(LR) during hypovolemia and hindlimb ischemia-reperfusion.METHODS: Male domestic goats(25-30 kg) were exsanguinated to a mean arterial pressure of 48 ± 1 mm Hg. Right hindlimb ischemia was imposed for 90 min by applying a tourniquet and femoral crossclamp. LR or PR, infused iv, delivered 0.05 mmol/kg per minute L-lactate or pyruvate, respectively, from 30 min hindlimb ischemia until 30 min post-ischemia. Time controls(TC) underwent neither hemorrhage, hindlimb ischemia nor resuscitation. Goats were sacrificed and left ventricular myocardium biopsied at 90 min fluid resuscitation(n = 6 per group) or 3.5 h later(n = 9 LR, 10 PR, 8 TC).RESULTS: Myocardial 8-isoprostane content, phosphocreatine phosphorylation potential, creatine kinase activity, and heart rate-adjusted QT interval(QTc) vari- ability were evaluated at 90 min resuscitation and 3.5 h post-resuscitation. PR sharply lowered pro-arrhythmic QTc variability vs LR(P < 0.05); this effect persisted 3.5 h post-resuscitation. PR lowered myocardial 8-isoprostane content, a product of oxidative stress, by 39 and 37% during and 3.5 h after resuscitation, respectively, vs LR. Creatine kinase activity fell 42% post-LR vs TC(P < 0.05), but was stable post-PR(P < 0.02 vs post-LR). PR doubled phosphocreatine phosphorylation potential, a measure of ATP free energy state, vs TC and LR(P < 0.05); this energetic enhancement persisted 3.5 h post-resuscitation.CONCLUSION: By augmenting myocardial energy state and protecting creatine kinase activity, pyruvateenriched resuscitation stabilized cardiac electrical function during central hypovolemia and hindlimb ischemiareperfusion. | Hunaid A Gurji Daniel W White Besim Hoxha Jie Sun Albert H Olivencia-Yurvati Robert T Mallet | 2013 | World Journal of Critical Care Medicine2013,2,4: | 3 |
| 5 | S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission显示文摘Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstrated that recipient sphingosine kinase 1 (Sphk1), but not Sphk2, was required for optimal S1PR1-dependent donor T-cell allogeneic responses by secreting S1P. Using genetic and pharmacologic approaches, we demonstrated that inhibition of Sphk1 or S1PR1 substantially attenuated acute GVHD (aGVHD) while retaining the graft-versus-leukemia (GVL) effect. At the cellular level, the Sphk1/S1P/S1PR1 pathway differentially modulated the alloreactivity of CD4+ and CD8+ T cells;it facilitated T-cell differentiation into Th1/Th17 cells but not Tregs and promoted CD4+ T-cell infiltration into GVHD target organs but was dispensable for the CTL activity of allogeneic CD8+ T cells. At the molecular level, the Sphk1/S1P/S1PR1 pathway augmented mitochondrial fission and increased mitochondrial mass in allogeneic CD4+ but not CD8+ T cells by activating the AMPK/AKT/mTOR/Drp1 pathway, providing a mechanistic basis for GVL maintenance when S1P signaling was inhibited. For translational purposes, we detected the regulatory efficacy of pharmacologic inhibitors of Sphk1 and S1PR1 in GVHD induced by human T cells in a xenograft model. Our study provides novel mechanistic insight into how the Sphk1/S1P/S1PR1 pathway modulates T-cell alloreactivity and validates Sphk1 or S1PR1 as a therapeutic target for the prevention of GVHD and leukemia relapse. This novel strategy may be readily translated into the clinic to benefit patients with hematologic malignancies and disorders. | Linlu Tian Yongxia Wu Hee-Jin Choi Xiaohui Sui Xinlei Li M.Hanief Sofi Mohamed Faisal Kassir Xiao Chen Shikhar Mehrotra Besim Ogretmen Xue-zhong Yu | 2022 | Cellular & Molecular Immunology2022,19,11: | 2 |
| 6 | Thyroidectomy with and without drains 显示文摘 | Karayacin K Besim H Erecan F | 1997 | East African Medical Journal1997,74,7: | 1 |
| 7 | Thyroidectomy with andwithout drains显示文摘 | Karayacin K Besim H Ercan F | 1997 | East African Medical Journal1997,74,7: | 1 |
| 8 | Sphingollpids in cancer: Regulation of pathogenesis and therapy 显示文摘 | Besim Ogretmen | 2006 | Federation of European Biochemical Societies Letters2006,580,23: | 1 |
| 9 | A rare cause of intestinal obstruction: abdominal cocoon显示文摘 | Bas KK Besim H | 2011 | Am Surg2011,77,2: | 1 |
| 10 | Occult Intrabiliary Rupture of Hydatid Cysts in the Liver显示文摘 | Enver Okan Hamamci M.D. Hasan Besim M.D. Muhittin Sonisik M.D. Atila Korkmaz M.D | 2005 | World Journal of Surgery2005,,2: | 1 |
| 11 | Scolicial agents in hydatid cyst surgery显示文摘 | Karayalcin K Hamamci O | 1998 | HPB Surg1998,10,6: | 1 |
| 12 | Thyroidectomy with and without drains显示文摘 | Karayacin K Besim H Ercan F | 1997 | East Afr Med J1997,74,7: | 1 |
| 13 | Percutaneous transcatheter ethanol sclerotheraphy of postoperative pelvic lymphoceles显示文摘 | Okan Akhan Saruhan Cekirge Mustafa ?zmen Aytekin Besim | 1992 | Cardiovascular and Interventional Radiology1992,,4: | 1 |
| 14 | Hemodynamic Changes During Gaseous and Gasless Laparoscopic Cholecystectomy显示文摘 | Atila Korkmaz Muhittin Alk?? Okan Hamamc? Hasan Besim Nilüfer Erverdi | 2002 | Surgery Today2002,,8: | 1 |
| 15 | Direct Binding of Glyceraldehyde 3-Phosphate Dehydrogenase to Telomeric DNA Protects Telomeres against Chemotherapy-Induced Rapid Degradation显示文摘 | Neil A. Demarse Suriyan Ponnusamy Eleanor K. Spicer Elif Apohan John E. Baatz Besim Ogretmen Christopher Davies | 2009 | Journal of Molecular Biology2009,,: | 1 |
| 16 | Xanthogranulomatous cholecystitis: Retrospective analysis of 12 cases显示文摘 | Besim H Hamamci O | 2003 | Acta Chir Belg2003,103,3: | 1 |
| 17 | Percutaneous Treatment of Abdominal Hydatid Cysts with Hypertonic Saline and Alcohol: An Experimental Study in Sheep显示文摘 | OKAN AKHAN ALP DINCER AYTAC G?K?Z ISKENDER SAYEK SAMIM HAVLIO&OV0435 LU OSMAN ABBASO&OV0435 LU MUZAFFER ERYILMAZ AYTEKIN BESIM IZETTIN BARIS | 1993 | Investigative Radiology1993,,2: | 1 |
| 18 | A rare cause of intestinal obstruction:abdominal cocoon显示文摘 | Bas K K Besim H | | 0,,2: | 1 |
| 19 | Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance显示文摘 | Suriyan Ponnusamy Marisa Meyers-Needham Can E Senkal Sahar A Saddoughi David Sentelle Shanmugam Panneer Selvam Arelis Salas Besim Ogretmen | 2010 | Future Oncol2010,,10: | 1 |
| 20 | Use of laparoscopic splenectomy in developing countries:analysis of cost and strate-gies for reducing cost显示文摘 | Hamamci EO Besim H Bostanoglu S | 2002 | J Laparoendosc Adv surg Tech A2002,12,2: | 1 |