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| 1 | Tibet,the Himalaya,Asian monsoons and biodiversity-In what ways are they related?显示文摘Prevailing dogma asserts that the uplift of Tibet, the onset of the Asian monsoon system and high biodiversity in southern Asia are linked, and that all occurred after 23 million years ago in the Neogene.Here, spanning the last 60 million years of Earth history, the geological, climatological and palaeontological evidence for this linkage is reviewed. The principal conclusions are that: 1) A proto-Tibetan highland existed well before the Neogene and that an Andean type topography with surface elevations of at least 4.5 km existed at the start of the Eocene, before final closure of the Tethys Ocean that separated India from Eurasia. 2) The Himalaya were formed not at the start of the India-Eurasia collision, but after much of Tibet had achieved its present elevation. The Himalaya built against a pre-existing proto-Tibetan highland and only projected above the average height of the plateau after approximately 15 Ma. 3)Monsoon climates have existed across southern Asia for the whole of the Cenozoic, and probably for a lot longer, but that they were of the kind generated by seasonal migrations of the Inter-tropical Convergence Zone. 4) The projection of the High Himalaya above the Tibetan Plateau at about 15 Ma coincides with the development of the modern South Asia Monsoon. 5) The East Asia monsoon became established in its present form about the same time as a consequence of topographic changes in northern Tibet and elsewhere in Asia, the loss of moisture sources in the Asian interior and the development of a strong winter Siberian high as global temperatures declined. 6) New radiometric dates of palaeontological finds point to southern Asia's high biodiversity originating in the Paleogene, not the Neogene. | Robert A. Spicer | 2017 | Plant Diversity2017，39，5： | 30 |
| 2 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 3 | Lake geochemistry reveals marked environmental change in Southwest China during the Mid Miocene Climatic Optimum显示文摘中间中新世的气候的最佳(MMCO;~ 15-17 ? 妈) 是标点的短期的气候的温暖的事件之一新生代长期的冷却趋势。因为有这个事件的很少的陆上的记录,大多数我们的理解来自海洋的核心。在这份报告,我们首先介绍修订标明日期的新 palaeomagnetic 数据我们的 400 ? 在 Wenshan (云南) 的 m 厚的湖的节,以前想了晚中新世。这些新数据建议老年, ca。15.2-16.5 ? 妈,与 MMCO 与一致。我们测量了 13 体积有机物上的 C (13 C 器官的碳(TOC ) ,全部的氮(TN ) 和在高度的 C/N 比率取样的 org ), 总数分辨率:(1 ) 重建在湖集水区域的 palaeoenvironmental 变化,并且(2 ) 推断为这些变化负责的机制。我们的结果证明所有四个 geochemical 参数证明一个强壮的环境变化发生在节的中间附近,立即在在 15.97 点的 C5Cn/C5Br 地磁气的颠倒和早 / 中间中新世的边界以后 ? 妈。我们建议环境移动可能由于在气候的一个变化的联合,它变得更凉爽,和在有机物在湖以内骑车的一个变化。这研究提供新卓见进 MMCO 并且证明尽管 MMCO 通常是一个温暖的事件,它也是气候的不稳定性和突然的环境变化的一倍。 | Julie Lebreton-Anberree Shihu Li Shu-Feng Li Robert A. Spicer Shi-Tao Zhang Tao Su Chenglong Deng Zhe-Kun Zhou | 2016 | Science Bulletin2016，61，11： | 8 |
| 4 | Extinct genus Lagokarpos reveals a biogeographic connection between Tibet and other regions in the Northern Hemisphere during the Paleogene显示文摘The biodiversity history on the Qinghai-Tibetan Plateau(QTP)has remained unclear for a long time.Recent paleobotanical investigations provide opportunities for revealing the phytogeographic history on the QTP in deep time and for testing phylogeographic hypotheses.Lagokarpos is an extinct genus with unknown modern affinities.It is easily distinguished by its fruits,which have two long wings and an elliptical fruit body.Previously,Lagokarpos fossils have only been found from North America and Germany,ranging from the latest Paleogene to early middle Eocene.Recently,we found fossil fruits of this genus from the Niubao Formation,near Bangoin County in the central QTP.A new species,namely Lagokarpos tibetensis H.Tang,T.Su&Z.K.Zhou sp.nov.,is described.This is the first fossil record of the genus in Asia.The occurrence of L tibetensis indicates a close floristic linkage between the QTP and other floras in the Northern Hemisphere during the Paleogene.According to the floristic assemblages,we suggest the central QTP experienced a tropical or subtropical humid climate during that period. | He Tang Jia Liu Fei-Xiang Wu Teresa Spicer Robert A.Spicer Wei-Yu-Dong Deng Cong-Li Xu Fan Zhao Jian Huang Shu-Feng Li Tao Su Zhe-Kun Zhou | 2019 | Journal of Systematics and Evolution2019，57，6： | 7 |
| 5 | Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography显示文摘Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms.However,capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo.Here we demonstrate a novel optical imaging system,dual-band dual-scan inverse spectroscopic optical coherence tomography(D2-ISOCT),that,for the first time,can simultaneously obtain the following metrics in vivo using endogenous contrast:(1)capillary-level oxygen saturation and arteriolar-level blood flow rates,oxygen delivery rates,and oxygen metabolic rates;(2)spatial characteristics of tissue structures at length scales down to 30 nm;and(3)morphological images up to 2mm in depth.To illustrate the capabilities of D2-ISOCT,we monitored alterations to capillaries and the surrounding pericapillary tissue(tissue between the capillaries)in the healing response of a mouse ear wound model.The obtained microvascular and ultrastructural metrics corroborated well with each other,showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool. | Rongrong Liu James A.Winkelmann Graham Spicer Yunxiao Zhu Aya Eid Guillermo A.Ameer Vadim Backman Ji Yi | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 6 | 累积性液体正平衡与急性呼吸窘迫综合征合并急性肾损伤患儿病死率相关显示文摘目的:急性肾损伤(acute kidney injury,AKI)和累积液体平衡(cumulative fluidbalance,CFB)升高常同时发生在ARDS患儿中,本文旨在识别其发生的危险因素并评估其与病死率的独立关系。本文假设CFB升高与炎症指标相关,CFB升高并发AKI患儿预后较其他患儿更差。设计前瞻性观察性研究,采用pRIFLE AKI分级。场所5家学术型PICUs。对象2008至2014年间符合ARDS柏林标准的260例1月至18岁患儿。干预措施无。结果PICU病死率为13%(34/260),病死患儿与存活患儿相比在ARDS第3天CFB较高(+90.1 ml/kg,IQR 26.6~161.7比+44.9 ml/ kg,IQR 10.0~111.3,P=0.008),且AKI发生率更高(50%比23%,P=0.001)。分层分析显示并发AKI患儿中,ARDS第3天CFB较高与病死率有关(病死者+111.5 ml/kg,IQR 82.6~236.8比存活者+58.5 ml/kg,IQR 0.9~176.2,P=0.041),而在不伴有AKI的ARDS患儿中无此相关性(P=0.308)。ARDS第3天并发AKI与正CFB患儿病死率相关(29.1%比10.4%,P=0.001),而在液体平衡或负平衡患儿中无此相关性(P=0.430)。ARDS第1天的血浆IL-6水平与第3天正CFB,AKI及PICU病死率相关,第1天IL-6与PICU病死率升高之间的关系由第3天正CFB和AKI部分介导(P<0.001)。结论儿童ARDS第3天正CFB与病死率相关,尤其在并发AKI患儿。血浆IL-6水平与正CFB及AKI发生相关,提示炎症可能是导致病死率增加的机制。 | Zinter MS Spicer AC Liu KD 方伯梁(译者) 钱素云(审校者) | 2019 | 中国小儿急救医学2019，26，4： | 3 |
| 7 | Worsening renal function in heart failure: The need for a consensus definition显示文摘 | Noella J. Sheerin Phillip J. Newton Peter S. Macdonald Dominic Y.C. Leung David Sibbritt Stephen Timothy Spicer Kay Johnson Henry Krum Patricia M. Davidson | 2014 | International Journal of Cardiology2014，，： | 2 |
| 8 | Correlation of terminal cell cycle arrest of skeletal muscle with induction of P21 by myoD显示文摘 | Halevy O Novitch BG Spicer DB | 1995 | Science1995，267，5200： | 2 |
| 9 | Palaeoclimate background of the diverse Eocene floras of South China显示文摘Hainan and Guangdong provinces,located in north tropical area and south subtropical area of China respectively,bear one of the highest levels of biodiversity in China.The modern floras of Hainan and Guangdong are dominated by pantropical and tropical-subtropical taxa and many of their representative families appeared as early as in the Eocene[1].The Eocene,therefore,represents a crucial stage in the formation of the extant flora.However,previously the Eocene floras and vegetation were largely studied in mid- | Jian-Hua Jin Alexei B. Herman Robert A. Spicer Tatiana M. Kodrul | 2017 | Science Bulletin2017，62，22： | 2 |
| 10 | Insulin-like growth factor-Ⅱ stimulates steroidogenesis in cultured bovine thecal cells显示文摘 | Spicer LJ Voge JL Allen DT | 2004 | Mol Cell Endocrinol2004，227，12： | 1 |
| 11 | The epithelial mucin, MUC1, of milk, mammary gland and other tissues 显示文摘 | Patton S Gendler SJ Spicer AP | 1995 | Biochim Biophys Acta1995，1241，3： | 1 |
| 12 | Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9 显示文摘 | SPICER L J AAD P Y ALLEN D T | 2008 | Biol Reprod2008，78，2： | 1 |
| 13 | Molecular phylogeny of the chipmunks inferred from mitochondrial cytochrome B and cytochrome oxidase ii gene sequences 显示文摘 | PIAGGIO A J SPICER G S | 2001 | Mol Phylogenet Evol2001，20，3： | 1 |
| 14 | Neutrophil ex- tracellular traps sequester circulating tumor cells and promote metastasis 显示文摘 | Cools-Lartigue J Spicer J McDonald B~ | 2013 | The Journal of clinical investigation2013，123，： | 1 |
| 15 | N-capping motifs promote interaction of amphipathic helical peptides with hydrophobic surfaces and drastically alter hydrophobicity values of individual amino acids显示文摘 | Spicer V Lao Y W Shamshurin D | 2014 | Anal Chem2014，86，11： | 1 |
| 16 | Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD显示文摘 | Novitch B G Spicer D B | 1995 | Science1995，267，9： | 1 |
| 17 | Correlation of terminal cell cycle arrest of skeletal muscle cell with induction of p21 by MyoD显示文摘 | Novitch BG Spicer DB | 1995 | Science1995，267，5200： | 1 |
| 18 | Irttrafamilial corre- lates of overweight and obesity in African-American and N- ative-American grandparents, parents, and children in rural Oklahoma显示文摘 | Polley DC Spicer MT Knight AP | 2005 | J Am Diet Assoc2005，105，2： | 1 |
| 19 | Radionuclide therapy of internal illness显示文摘 | Robinson RG Preston DF Spicer JA | 1984 | JAMA1984，251，10： | 1 |
| 20 | Degradations in Gbit/s DFB lasertransmission systems due to phase-to-intensity noise conversion by multiple reflectionpoints 显示文摘 | 22,GIMLETT J L YOUNG J SPICER R F | 1988 | Electronics Lett1988，24，7： | 1 |
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