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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 3 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 4 | An updated overview on the development of new photosensitizers for anticancer photodynamic therapy显示文摘Photodynamic therapy(PDT), based on the photoactivation of photosensitizers(PSs), has become a well-studied therapy for cancer. Photofrin~?, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology. | Juan Zhang Chengshi Jiang Joao Paulo Figueiró Longo Ricardo Bentes Azevedo Hua Zhang Luis Alexandre Muehlmann | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 13 |
| 5 | 棉铃虫幼虫脑和咽下神经节的三维结构构建显示文摘【目的】解剖棉铃虫Helicoverpa armigera(Hübner)5龄幼虫脑和咽下神经节及其内部神经髓形态结构,并分析和构建幼虫脑和咽下神经节以及各神经髓的三维结构模型。【方法】采用免疫组织化学方法解剖脑和咽下神经节的内部神经髓结构,利用激光共聚焦显微镜获取脑和咽下神经节扫描图像,然后利用AMIRA三维图像分析软件进行图像分析,从而构建脑和咽下神经节的三维结构模型,并测量脑和咽下神经节以及内部各神经髓的体积,并分析了相对比例。【结果】棉铃虫5龄幼虫脑和咽下神经节由围咽神经索连接在一起。脑主要由前脑、中脑和后脑3部分组成。前脑内包括视叶、蕈形体和中央体等形态结构较明显的神经髓。此外,前脑还包括其他位于脑的左右两侧以及背侧和腹侧大量神经髓区域,约占脑总神经髓的59.65%。这些神经髓区域边界不明显。中脑主要包括1对触角叶;后脑位于脑的腹侧和触角叶的下方,体积较小。咽下神经节由3个神经节融合构成,从前到后分别为上颚神经节、下颚神经节和下唇神经节,由于融合的紧密程度高,3个神经节间的边界不明显。【结论】阐明了棉铃虫5龄幼虫脑和咽下神经节的神经髓形态结构,构建了脑和咽下神经节以及内部神经髓的三维结构模型。三维模型可以任意旋转,能从任何角度观察脑、咽下神经节和内部不同神经髓的结构及其它们之间的空间关系。本研究结果对研究棉铃虫脑和咽下神经节信息接收、处理及调控行为的机制奠定了解剖学基础。 | 汤清波 詹欢 Bente G.BERG 闫凤鸣 赵新成 | 2014 | 昆虫学报2014，57，5： | 9 |
| 6 | 两种民主理论的述评显示文摘尤尔根·哈贝尔斯和米歇尔·福柯二人的著作都将现代性问题中存在的一种基本的紧张关系凸显出来。这种紧张关系存在于规范与现实之间 ,存在于应当做什么与实际做什么之间。理解这一紧张关系是理解现代民主制的关键 ,是理解现代民主制是什么和能够成为什么的关键。对于巩固市民社会是否是一种使民主制更加强大的有效方法这一点 ,一直有争议。本文对哈贝马斯和福柯二人的核心思想进行了比较分析 ,因为这些思想都涉及民主和市民社会问题。更需特别明确指出 ,哈贝马斯的论谈伦理学与福柯的权力分析方法和伦理学 ,在两者对于那些对了解和引起民主社会的变迁感兴趣的人士来讲是否有帮助这方面形成了反差。 | Bent Flyvbjery 韩旭 | 2000 | 政治学研究2000，，4： | 9 |
| 7 | 放疗与替莫唑胺联合治疗胶质母细胞瘤 | Stupp R. Mason W.P. Van Den Bent M.J. 黄卫东 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 8 |
| 8 | Rice OsFLS2-Mediated Perception of Bacterial Flagellins Is Evaded by Xanthomonas oryzae pvs. oryzae and oryzicola显示文摘细菌的 flagellins 被受体 kinase FLAGELLIN SENSITIVE2 (FLS2 ) 经常认出并且在双子叶的植物激活被触发 MAMP 的免疫。然而,单子叶植物的米饭的能力理解糟糕认出关键米饭病原体和它的生物关联遗体的 flagellins。我们证明在 Arabidopsis 的宫外地表示的 OsFLS2 察觉到得到的 flg22 肽和 invitro 净化了 Acidovorax avenae (Aa ) 以一种表示水平依赖者方式的 flagellin,但是不认出净化的 flagellins 或衍生物 flg22 Xanthomonas oryzae pvs 的 Xo 肽。oryzae (Xoo ) 和 oryzicola (Xoc ) 。一致地, flg22 肽和净化的 Aa flagellin,然而并非 Xoo/Xoc flagellins,在米饭导致象防卫基因正式就职和 MAPK 激活那样的各种各样的有免疫力的回答。由米饭的 flagellin 的感觉确实导致强壮的抵抗到 Xoo 感染,在米饭的预告的处理与 Aa flagellin 离开以后,出现。OsFLS2 被发现在它的感觉特性或敏感不同于 AtFLS2 到不同 flg22 序列。另外, Xoc flagellin 的 translational 以后修正被编码 glycosyltransferase rbfC,而是这有的小效果的删除在 Xoc 活动性上改变, rpfC 变化 detectably 没在米饭上减少 Xoc 毒力。从 Xoo/Xoc 的编码 flagellin 警察的删除堵住了游泳活动性而且显著地没改变 Xoo/Xoc 毒力。当在米饭躲避古老的 flagellin 察觉系统时,这些结果建议 Xoo/Xoc 带允许活动性的 flg22 区域氨基酸变化,它为另外的细菌的病原体保留识别能力。 | Shanzhi Wang Zhe Sun Huiqin Wang Lijuan Liu Fen Lu Jun Yang Min Zhang Shiyong Zhang Zejian Guo Andrew F. Bent Wenxian Sun | 2015 | Molecular Plant2015，8，7： | 7 |
| 9 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 10 | 一个外国记者眼中的中国观赏园艺业(一)显示文摘在过去的4年里,爱德华·本特(Edward Bent)先生多次访问中国,他对国际贸易和专业化组织与中国相互交流的情况以及目前困扰中国观赏园艺业进一步发展等问题都有一定的了解。本特先生特为本刊撰写了此文。 | Edward Bent 张庆松 | 2003 | 中国花卉园艺2003，，17： | 5 |
| 11 | 恶疫霉侵染的草莓SSH文库的构建及分析显示文摘为了解草莓与恶疫霉[Phytophthora cactorum(Lebert&Cohn)J.Schrt]互作的分子机制,以感病草莓品种FDP821为材料,以接种恶疫霉的草莓冠部为处理、未接种健康生长的草莓冠部为对照,利用抑制性差减杂交技术构建恶疫霉侵染诱导的草莓差异表达的cDNA差减文库。PCR鉴定随机挑取的阳性克隆,显示插入片段大小为300~1 000bp。随机挑取109个克隆进行测序,获得92个草莓EST,分析表明来自50个草莓基因。BLASTX比对结果表明:这些草莓基因的功能涉及抗病防卫机制、抗氧化作用、物质代谢和蛋白质合成等。这为理解草莓冠腐病抗性分子机制奠定了重要的数据基础。 | 陈孝仁 王振荣 徐敬友 童蕴慧 May Bente Brurberg | 2011 | 扬州大学学报(农业与生命科学版)2011，32，4： | 4 |
| 12 | 饲料中大豆油替代鱼油对大西洋鲑肝细胞脂肪酸代谢的影响显示文摘为探讨大豆油替代鱼油对大西洋鲑(Salmo salar L.)肝细胞脂肪酸代谢的影响,本试验分别以鱼油和大豆油为脂肪源配制2种试验饲料,并分别饲喂大西洋鲑幼鲑5个月。饲养结束后,分离和培养大西洋鲑肝细胞,一方面将细胞与碳14标记油酸([1-14C]OA)共孵育,然后测定细胞和细胞内各脂质成分以及脂肪酸β-氧化产物的放射活性;另一方面提取肝细胞总RNA,采用实时荧光定量聚合酶链式反应(RT-qPCR)测定脂肪酸结合蛋白3(FABP3)、脂肪酸结合蛋白10(FABP10)、Δ5去饱和酶(D5D)、Δ6去饱和酶(D6D)及肉碱棕榈酰转移酶Ⅰ(CPT-Ⅰ)基因的相对表达量。结果表明:1)鱼油组与大豆油组肝细胞内游离脂肪酸(FFA)放射活性百分率分别为(62.7±13.0)%和(55.9±9.1)%,2组间无显著差异(P>0.05);鱼油组与大豆油组肝细胞内磷脂(PLs)放射活性百分率分别为(20.9±8.7)%和(17.9±5.4)%,2组间无显著差异(P>0.05);鱼油组肝细胞内三酰甘油(TAG)放射活性百分率为(2.0±0.9)%,显著高于大豆油组的(0.8±0.4)%(P<0.05);鱼油组与大豆油组肝细胞内β-氧化产物放射活性百分率分别为(1.0±0.3)%和(1.0±0.2)%,2组间无显著差异(P>0.05)。2)大豆油组肝细胞中FABP3、D6D、D5D基因的相对表达量均显著高于鱼油组(P<0.05),而FABP10和CPT-Ⅰ基因的相对表达量在2组间无显著差异(P>0.05)。由此可见,大豆油替代饲料中的鱼油对大西洋鲑肝细胞内FFA、PLs合成及脂肪酸β-氧化等脂肪酸代谢途径无显著影响,但显著降低了肝细胞内TAG的合成,促进了肝细胞内脂肪酸的去饱和,因此大豆油替代鱼油在一定程度上影响了肝细胞内脂肪酸代谢。 | 周继术 TORSTENSEN Bente Elisabeth STUBHAUG Ingunn 吉红 | 2013 | 动物营养学报2013，25，11： | 4 |
| 13 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 14 | Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: A randomized controlled study显示文摘AIM: To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus? liver assist system in a randomized, controlled study. METHODS: Twenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus? system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS)? (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins. RESULTS: Systemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04).CONCLUSION: Extra-corporal liver support with Prometheus is proven to be safe in patients with end- stage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group. | Thomas Dethloff Flemming Tofteng Hans-Jorgen Frederiksen Michael Hojskov Bent Adel Hansen Fin Stolze Larsen | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 15 | 饲料中植物油替代鱼油对大西洋鲑肝细胞油酸跨膜吸收的影响显示文摘以[1-14C]油酸(oleic acid;18:1n-9,OA)为指示剂,研究了不同饲料油源饲喂下大西洋鲑肝细胞膜脂肪酸组成受到改变时该细胞对OA吸收的状况,以探讨植物油(Vegetable oil,VO)替代鱼油(Fish oil,FO)对大西洋鲑肝细胞脂肪酸跨膜吸收的影响,为大西洋鲑饲料中植物油替代鱼油的可行性提供理论依据。试验先以鱼油和大豆油为油源配制两种全价配合饲料,分别饲喂大西洋鲑幼鲑5个月,使其产生不同的脂肪酸组成。在饲养结束后,分离并培养试验鱼肝细胞,将细胞与[1-14C]OA及37.5μmol/L OA(1/30,mol/mol,0.3μCi/瓶)共孵育2h,收集并测定细胞内OA放射活性,再计算细胞内OA吸收量[nmol/(h·million cells)]。同时,试验采取RT-PCR方法测定了细胞脂肪酸运送蛋白(Fatty acid transport protein,FATP)、脂肪酸移位蛋白(Fatty acid translocase,FAT/CD36)的基因表达量。结果表明,FO和VO组肝细胞对OA吸收分别为(0.924±0.258)及(0.888±0.179)nmol/(h·million cells),两组间无显著差异(P>0.05)。RT-PCR的检测结果表明,FAT/CD36和FATP基因表达量在FO与VO两组间均无显著差异(P>0.05)。结果表明,从植物油替代鱼油不影响大西洋鲑肝细胞对长链脂肪酸的跨膜吸收方面来看,大西洋鲑饲料中以植物油替代鱼油具有可行性。 | 周继术 Bente E.Torstensen Ingunn Stubhaug | 2014 | 水生生物学报2014，38，1： | 4 |
| 16 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 17 | Low-income and overweight in China:Evidence from a life-course utility model显示文摘Previous literature has demonstrated that low-income people are more likely to settle for poor health choices in developed countries. By using income as a budget constraint and signal for future wellbeing in a life-course utility model, we examine the association amongst income and overweight. The data used for this study are from the China Health and Nutrition Survey(CHNS). Estimations are conducted for overweight initiation, cessation, and participation mirroring a decision to begin and a past decision to not terminate. Our findings propose that body weight and the likelihood of overweight commencement rise with additional income but at a diminishing degree, representing a concave relation;while the likelihood of overweight discontinuance declines with additional income but at an accelerating degree, suggesting a convex relation.We presume that, as opposed to developed countries, low-income people are less inclined to be overweight in China, a country in transition. This could be explained by an income constraint for unhealthy foodstuff. Nevertheless, it will switch when income surpasses the critical threshold of the concave or inverted U-shape curve indicating that low-income people appear to receive not as much utility from future health. Specifically, this adjustment seems to occur earlier for females and inhabitants of urban areas. | REN Yan-jun Bente Castro Campos Jens-Peter Loy Stephan Brosig | 2019 | Journal of Integrative Agriculture2019，18，8： | 3 |
| 18 | The biochemistry and medical significance of the flavonoids显示文摘 | Bent H Havsteen | 2002 | Pharmacology and Therapeutics2002，，2： | 2 |
| 19 | 不同乙酸浓度的液体发酵饲料对猪生长性能的影响显示文摘已经证实饲喂液体发酵饲料(FLF)有益于猪的胃肠道健康。然而,饲喂FLF的乳猪及育成猪的生长性能变异较大,且与饲喂非FLF或干饲料相比,饲喂FLF通常会降低猪的采食量。FLF中的微生物代谢产物(乙酸)的累积,可能伴随着饲料p H的降低,最终通过破坏适口性来降低饲料的采食量。但是,这个假设目前为止还未作深入的研究,本次试验意在探查FLF中的乙酸浓度对断奶仔猪采食量的影响。试验使用3种含有不同乙酸浓度的FLF日粮(30mM、60mM及120mM)。试验分为3组,每组20只仔猪,4周龄断奶且单独饲养,断奶后采用试验日粮饲喂6周,每周检测仔猪的采食量和体重变化。试验结果显示,高乙酸浓度的FLF略微降低饲料的pH,在不影响体增重的情况下,降低仔猪的饲料采食量。看似矛盾的结果可能由于饲喂液体饲料很难准确测定仔猪干物质采食量所导致的。总之,通常FLF中的乙酸浓度并不会显著影响仔猪的生长性能。 | 张瑞霜 Nuria Canibe Anni yan Pedersen Bent Borg Jensen | 2015 | 饲料与畜牧(新饲料)2015，0，11： | 2 |
| 20 | Estimation of particle depth from two defocused images using the Fourier transform显示文摘Depth from defocus is one technology for depth estimation.We estimate particle depth information from two defocused images captured simultaneously by two coaxial cameras with different imaging distances.The images are processed with the Fourier transform to obtain the characteristic parameter(i.e.,the standard deviation of the relative blur kernel of these two defocused images).First,we theoretically analyze the functional relationship between the object depth and the standard deviation or variation of the relative blur kernel.Then,we verify the relationship experimentally.We analyze the influence of particle size,window size and image noise on the calibration curves using both numerical simulations and experiments.We obtain the depth range and accuracy of this measurement system experimentally.For the verification experiments,we use a sample of glass microbeads and the irregularly-shaped dust particles on a microscope slide.Both of these experiments present a suitable depth measurement result.Finally,we apply the measuring system to the depth estimation of drops from a small anti-fogging spray.The results show that our system and image processing algorithm are robust for different types of particles,facilitating the in-line three-dimensional positioning of particles. | Wu Zhou Xu Luo Benting Chen Yukun Zhang Xiaoshu Cai | 2020 | Particuology2020，18，2： | 2 |
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