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| 1 | Genetic epidemiology of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(C-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS. | Jasbir Makker Sridhar Chilimuri Jonathan N Bella | 2015 | World Journal of Gastroenterology2015，21，40： | 20 |
| 2 | 腔镜微创食管癌切除术的学习过程分析显示文摘目的总结腔镜微创食管癌切除术(MIE)的学习过程。方法选取同一组医生连续完成的MIE手术100例,按手术时间顺序分为3组:第1、2组各25例行胸腔镜并常规开腹手术,第3组50例行胸腹腔镜手术.分别记录手术时间、出血量、正常结构保护及并发症发生情况、术后ICU观察时间、住院时间、术后肿瘤病理及淋巴结清扫情况等临床资料,比较各组之间的差异。结果全组中96例患者顺利完成MIE,4例患者中转开胸,无中转开腹。中位手术时间310min,中位失血量200ml,中位清扫淋巴结22枚,总体并发症发生率50%。第1组与第2组比较,在保留奇静脉弓(P=0.010)、保留支气管动静脉(P=0.038)及左侧喉返神经胸段术中暴露率(P=0.048)方面的差异有统计学意义。前50例与后50例比较,在胸部手术时间(P=0.000)、失血量(P=0.025)、保留奇静脉弓(P=0.001)、保留支气管动静脉(P=0.000)、胸野淋巴结清扫(P=0.022)、左喉返神经链淋巴结清扫(P=0.000)及该神经起始部术中暴露率(P=0.002)方面的差异有统计学意义。结论MIE学习过程较长.应循序渐进。随着经验的积累和手术技巧的提升.MIE将逐渐显示其独特的优势并替代传统开胸食管癌切除术。 | 谢绚 傅剑华 王军业 张旭 罗孔嘉 杨富 Amos Ela Bella 李小海 | 2012 | 中华胃肠外科杂志2012，15，9： | 15 |
| 3 | Cytomegalovirus positive ulcerative colitis:A single center experience and literature review显示文摘AIM:To compare the clinical outcome of cytomegalovirus(CMV)-positive ulcerative colitis(UC) patients with and without antiviral therapy.METHODS:This was a retrospective case-controlled study.The database of UC patients in our institution was scanned for documented presence of CMV on colonic biopsies.Demographics,clinical data,endoscopy findings and pathology reports were extracted from the patients' charts and electronic records.When available,the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also ex-tracted.The primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the follow-up.RESULTS:Thirteen patients were included in the study,7(53.5%) of them were treated with gancyclovir and 6(46.5%) were not.Patients treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir,while none of the patients without antivirals required rescue therapy.One patient died and another patient underwent urgent colectomy during hospitalization,both of them from the gancyclovir-treatment group.For the entire follow-up time(13 ± 13 mo),a total of 3 colectomies and one death occurred,all among the antiviral-treated patients(for colectomy:3/7 vs 0/6 patients,P = 0.19;for combined adverse outcome:4/7 vs 0/6 patients,P = 0.07).In 9/13 patients,immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient only.CONCLUSION:Gancyclovir-treated patients had a more severe disease and outcome,probably unrelated to antiviral therapy.Immunohistochemistry-CMV-positive patients with mild disease may recover without antiviral therapy. | Uri Kopylov Gila Sasson Bella Geyshis Michal Tepperberg Oikawa Iris Barshack Rami Eliakim Shomron Ben-Horin | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 10 |
| 4 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 5 | Relationship between MODIS-NDVI data and wheat yield: A case study in Northern Buenos Aires province, Argentina显示文摘In countries like Argentina,whose economy depends heavily on crop production,the estimation of harvests is an elementary requirement.Besides providing objectivity,the use of remote sensing allows estimating yield in advance.Since the time of maximum leaf area in wheat corresponds with the critical period of the crop,a good relationship is expected between the Normalized Difference Vegetation Index(NDVI)and yield.The present study was carried out in the North of Buenos Aires province,Argentina.Based on the type of soil,the study area can be divided into two homogeneous subzones:a subzone with lower clay content in the southwestand a subzone with higher clay content in the northeast.Nine growing seasons(2003–2011)were studied.In the first five years,an empirical model was calibrated and validated with field-observed wheat yields and MOD13q1 product-NDVI data,whereas in the other four years,the calibrated model was applied by means of yield maps and by comparing with official yields.The MOD13q1 image corresponding to Julian day 289 showed the best fit between NDVI and yield to estimate wheat yield early.Through yield maps,better weather conditions showedhigher yields and higher soil productivity presented a greater proportion of the area occupied by higher yields.At department level,an R2 value of 0.75 was found after relating the estimation of the calibrated empirical model with official yields.The method used allows predicting wheat yield 30 days before harvest.Through yield maps,the NDVI perceived the temporal and spatial variability in the study area. | Mariano F.Lopresti Carlos M.Di Bella Américo J.Degioanni | 2015 | Information Processing in Agriculture2015，2，2： | 8 |
| 6 | 新型可回收全覆膜镍钛合金支架治疗难治性食管良性狭窄显示文摘目的探讨自行设计的新型可回收抗反流全覆膜镍钛合金支架治疗难治性食管良性狭窄的疗效。方法2009年11月至2011年5月间中山大学肿瘤防治中心胸科采用新型支架治疗难治性食管良性狭窄患者8例。在支架置入术后第1、7、30和60天以及拔除支架术后1、2、3和6个月,进行胃镜和食管吞钡检查,评价患者吞咽功能改善及并发症发生情况。结果8例患者均成功置入新型支架.术后吞咽功能较术前明显改善(P〈0.05)。经9个月的中位随访,已拔除支架6例,其吞咽功能亦较术前明显改善(P〈0.05):支架继续留置2例,其中1例支架置入术后已15个月,目前仍进普通饮食:另1例支架置入术后2个月吞咽功能较术前改善.但3个月后吞咽功能减退至术前水平。8例患者远期吞咽功能改善率为7/8。术后再狭窄1例:支架脱落2例:肉芽过度增生3例,其中支架覆膜破裂致肉芽向内生长2例。结论新型可回收全覆膜镍钛合金支架置入食管良性狭窄术后和拔除支架后吞咽功能明显改善.远期再狭窄发生率低:但支架脱落发生率仍较高.支架覆膜材料易破裂.仍需进一步改进。 | 李小海 胡祎 杨弘 Amos Ela Bella 傅剑华 | 2011 | 中华胃肠外科杂志2011，14，11： | 7 |
| 7 | Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury显示文摘在细胞死亡的生长因素,神经发展,和预防的神经生物学的进展为多孔的神经( CN )为保护、再生的 neuromodulatory 策略的发展导致了提高的临床的兴趣,当为前列腺癌症和另外的骨盆的恶意的治疗经常导致神经元损坏和性功能的削弱的损失。氮的氧化物在平滑肌的阴茎海绵体原因松驰以内免除了这些神经的轴索终板,开始象贡献维持的肿大一样的阴茎勃起的 haemodynamic 变化;CN 功能的损失在骨盆的外科以后为可勃起的机能障碍(编辑) 的开发主要负责并且为潜在的 neuroprotective 或再生策略用作主要目标。从为精选 neuromodulatory 途径的现出症状之前的潜的研究的证据被考察,包括 neurotrophins,神经胶质房间导出线的神经营养的因素(GDNF ) ,骨头 morphogenic 蛋白质, immunophilin ligands, erythropoetin (EPO ) ,和干细胞。 | Anthony J. Bella Guiting Lin Ilias Cagiannos Tom F. Lue | 2008 | Asian Journal of Andrology2008，10，1： | 5 |
| 8 | Gastric metastasis by lung small cell carcinoma显示文摘胃肠道的转移瘤是稀罕的。我们由于主要的肺癌症描述胃的转移的一个案例,由上面的胃肠的内视镜检查法(UGIE ) 揭示了。到胃的造血的转移是一个稀罕事件。到我们的知识,仅仅 55 个案例在国际文学被描述了。在这些病人,预后是很差的。我们此处由肺报导胃的转移的一个案例小房间癌,与关于这个稀罕实体的文学的评论。 | Giovanni Casella Camillo Di Bella Antonino Roberto Cambareri Carmelo Antonio Buda Gianluigi Corti Filippo Magri Stefano Crippa Vittorio Baldini | 2006 | World Journal of Gastroenterology2006，12，25： | 3 |
| 9 | 汽车环境下的电磁干扰(EMI)显示文摘0引言'电磁兼容性'对于开发未来车辆面临的一个主要的挑战已经存在了一百多年.任何电子设备都会产生电磁辐射,其中有一些是有意发生的(例如 Wi-Fi发射机的频率),而另一些则是无意的(例如车辆中各种电气元件产生的能量).它们会一起构成设备的'EMI特性';而且,电磁兼容性(EMC)就是这些电子设备与 EMI和谐共存而不会产生中断、干扰或者其他不必要及不良结果的能力. | Greg Bella Jeff Ciarlette | 2019 | 电子产品世界2019，26，7： | 3 |
| 10 | Maximum standardized uptake value on PET/CT in preoperative assessment of lymph node metastasis from thoracic esophageal squamous cell carcinoma显示文摘The presence of lymph node metastasis is an important prognostic factor for patients with esophageal cancer.Accurate assessment of lymph nodes in thoracic esophageal carcinoma is essential for selecting appropriate treatment and forecasting disease progression.Positron emission tomography combined with computed tomography(PET/CT)is becoming an important tool in the workup of esophageal carcinoma.Here,we evaluated the effectiveness of the maximum standardized uptake value(SUVmax)in assessing lymph node metastasis in esophageal squamous cell carcinoma(ESCC)prior to surgery.Fifty-nine surgical patients with pathologically confirmed thoracic ESCC were retrospectively studied.These patients underwent radical esophagectomy with pathologic evaluation of lymph nodes.They all had18F-FDG PET/CT scans in their preoperative staging procedures.None had a prior history of cancer.The pathologic status and PET/CT SUVmax of lymph nodes were collected to calculate the receiver operating characteristic(ROC)curve and to determine the best cutoff value of the PET/CT SUVmax to distinguish benign from malignant lymph nodes.Lymph node data from 27 others were used for the validation.A total of 323 lymph nodes including 39 metastatic lymph nodes were evaluated in the training cohort,and 117lymph nodes including 32 metastatic lymph nodes were evaluated in the validation cohort.The cutoff point of the SUVmax for lymph nodes was 4.1,as calculated by ROC curve(sensitivity,80%;specificity,92%;accuracy,90%).When this cutoff value was applied to the validation cohort,a sensitivity,a specificity,and an accuracy of 81%,88%,and 86%,respectively,were obtained.These results suggest that the SUVmax of lymph nodes predicts malignancy.Indeed,when an SUVmax of 4.1 was used instead of 2.5,FDG-PET/CT was more accurate in assessing nodal metastasis. | Amos JM Ela Bella Ya-Rui Zhang Wei Fan Kong-Jia Luo Tie-Hua Rong Peng Lin Hong Yang Jian-Hua Fu | 2014 | Chinese Journal of Cancer2014，33，4： | 3 |
| 11 | An innovative bio-engineering retaining structure for supporting unstable soil显示文摘The paper presents a new prefabricated bio-engineering structure for the support of unstable soil.This prefabricated structure is made of a steel frame which is completely filled with soil and a face made of tree trunks among which scions or autochthonous bushes are planted.Due to the difficulties in interpreting the complex interaction between soil and structure during the installation and lifetime,an in situ test was carried out in order to evaluate the state of stress in the steel frame and to understand the global behavior of the structure under service loads.On the basis of the obtained results,a procedure for checking the structure safety was proposed and discussed.An easy design method was developed during the research.Moreover,the use of this type of prefabricated structure shows several advantages,such as good performances in terms of stabilizing effects,and easy assembly and transport. | Gianluca Bella Monica Barbero Fabrizio Barpi Mauro Borri-Brunetto Daniele Peila | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，2： | 3 |
| 12 | Trans-Septal Catheterization in the Electrophysiology Laboratory显示文摘 | Roberto De Ponti Riccardo Cappato Antonio Curnis Paolo Della Bella Luigi Padeletti Antonio Raviele Massimo Santini Jorge A. Salerno-Uriarte | 2006 | Journal of the American College of Cardiology2006，，5： | 2 |
| 13 | Caspase-3 expression in metastatic lymph nodes of esophageal squamous cell carcinoma is prognostic of survival显示文摘AIM:To assess whether differential expression of caspase-3 in paired metastatic lymph nodes(LNs)is prognostic of survival in patients with resectable esophageal squamous cell carcinoma(ESCC).METHODS:Capases-3 expression was evaluated immunohistochemically in 122 pairs of primary ESCCs and regional metastatic LNs assembled on tissue microarrays.The impact of caspase-3 expression on survival outcomes was analyzed by the Kaplan-Meier method and Cox proportional hazards regression model.RESULTS:The level of caspase-3 expression was significantly higher in LN metastases than in primary tumors(P<0.001).Caspase-3 expression in the primary tumors was associated with longer median survival(23 mo vs21 mo,P=0.033),whereas higher expression in paired metastatic LNs was associated with shorter median survival(20 mo vs 22 mo,P=0.043).Multivariate analysis showed that both were independent prognostic factors.CONCLUSION:Caspase-3 expression in metastatic LNs may be a potential independent predictor of poorer overall survival in patients with resected ESCC and LN metastasis.Protein expression in metastatic tumors may be a biomarker prognostic of survival. | Xiu-Shen Wang Kong-Jia Luo Amos Ela Bella Shan-Shan Bu Jing Wen Shui-Shen Zhang Yi Hu | 2014 | World Journal of Gastroenterology2014，20，15： | 2 |
| 14 | Immune response to hepatitis B vaccine among patients on hemodialysis显示文摘Infection with hepatitis B virus(HBV) poses a major health threat worldwide, where the magnitude and overburden of chronic carrier state approaches 150 million chronic carriers. The prevalence of HBV is greater among dialyzed patients compared to the general population owing to their increased vulnerability to blood and its products, along with hazards posed by contaminated hemodialysis tools and devices. Anelectronic systematic search of the published literature was carried and data on the immunological riposte to hepatitis B vaccination among hemodialysis patients was extracted from relevant studies. End stage renal disease patients on hemodialysis have a lower or an absolutely negative riposte to HBV vaccine. Several means have been tried to improve this response with some success, nevertheless none have been universally adopted. Genetic investigations are foreseen to make a break through concerning HBV vaccination. | Gasim I Gasim Abdelhaleem Bella Ishag Adam | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 15 | 建筑师事务所和建筑师职责的回归显示文摘在世界各国,当谈到最值得尊敬的职业时,人们列出的顺序大多会有:医生、教师、建筑师、律师等等,表达了无论在哪一个社会,大众对这些行业的尊敬、景仰和信任。建筑师群体,在中国这样一个经济高速发展,城市迅速扩张的时代,担任了日益重要的社会角色,登上了越来越宽的舞台。 | Alfio Di Bella | 2011 | 现代装饰(家居)2011，0，3： | 2 |
| 16 | Unveiling the controversial mechanism of reversible Na storage in TiO2 nanotube arrays: Amorphous versus anatase TiO2显示文摘由于他们的固有的安全,低费用,和结构的稳定性, TiO 2 nanostructures 在钠离子电池作为阳极材料代表一种合适的选择。在最近的年里,各种各样的假设在 TiO 2 结构关于钠离子的可逆插入的实际机制被建议了,并且以前的报告在这个方面经常是争论的。有趣地,当作为文件夹测试了时 -- 并且在实验室规模钠房间进行没有添加剂的电极,非结晶、水晶(锐钛矿) 简单阳极的氧化获得的 TiO 2 nanotubular 数组展出古怪、内在地不同的电气化学的回答。在起始的电气化学的激活以后,特别地,锐钛矿 TiO 2 与更大的特定的能力显示出优秀的率能力和很稳定的长期的骑车性能,并且这样清楚地优异的回答与非结晶的对应物相比。获得更深的卓见,现在的材料被在 TiO 2 体积阶段扫描钠离子的电子显微镜学和前 situ X 光检查衍射,和插入彻底地描绘被密度系统地建模功能的理论计算。现在的结果可以贡献更系统的屏蔽途径的开发为高度有效的基于钠的精力存储系统识别合适的活跃材料。 | Federico Bella Ana B. Munoz-Garcia Giuseppina Meligrana Andrea Lamberti Matteo Destro Michele Pavone Claudio Gerbaldi | 2017 | Nano Research2017，10，8： | 2 |
| 17 | 左房内径作为中老年患者首次临床心血管事件的独立预测指标:StrongHeart研究(SHS)显示文摘Background: Echocardiographic left atrial(LA) volume has been documented to be an independent predictor of cardiovascular events. Less is known about the predictive ability of anteroposterior LA diameter, a simpler measure of LA size obtained routinely during echocardiographic evaluation. Methods: We investigated the prognostic value of LA diameter for incident cardiovascular events in 2804 American Indians free of clinical cardiovascular disease, valvular disease, and atrial fibrillation. Echocardiographic variables were obtained using standardized methods, and previously derived sex- specific partition values were used to define left ventricular(LV) hypertrophy indexed to height2.7(in meters) and LA enlargement(>4.2 cm in men, >3.8 cm in women). Cardiovascular events included nonfatal stroke, coronary heart disease, congestive heart failure, and fatal cardiovascular disease based on validated definitions. Results: During a median follow- up of 7 years, 368 events occurred. LA diameter, both as a continuous and as a categorical variable, was significantly associated with incident cardiovascular events in unadjusted analyses. In multivariable analyses that adjusted for age, sex, body mass index, hypertension, diabetes, total cholesterol- high- density lipoprotein cholesterol, smoking, renal insufficiency, LV hypertrophy, abnormal LV systolic and diastolic function, mitral annular calcification, fibrinogen, and C- reactive protein, both LA diameter(risk ratio 1.04/mm, 95% CI 1.02- 1.07, P< .002) and LA enlargement(risk ratio 1.57, 95% CI 1.17- 2.10, P=.002) remained independent predictors of first cardiovascular events. Conclusions: In this population- based cohort, LA diameter independently predicted incident cardiovascular events after adjustment for established clinical, echocardiographic, and inflammatory risk factors. This simple measure of LA dilatation can identify individuals at heightened risk who may warrant more aggressive risk factor modification. | Kizer J.R. Bella J.N. Palmieri V. 宁宁 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 2 |
| 18 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 19 | Percutaneous Left Atrial Appendage Transcatheter Occlusion to Prevent Stroke in High-Risk Patients With Atrial Fibrillation: Early Clinical Experience显示文摘 | Horst Sievert Michael D. Lesh Thomas Trepels Heyder Omran Antonio Bartorelli Paola Della Bella Toshiko Nakai Mark Reisman Carlo DiMario Peter Block Paul Kramer Dirk Fleschenberg Ulrike Krumsdorf Detlef Scherer | 2002 | Circulation: Journal of the American Heart Association2002，，16： | 2 |
| 20 | 北京二号卫星星座影像智能服务与应用显示文摘围绕北京二号卫星星座和影像智能服务平台,重点介绍北京二号卫星星座能力、数据获取和产品体系及影像智能服务平台架构与组成,实现了遥感影像、信息处理和在线应用的智能服务能力,形成卫星编目、日新图、一张图、智能处理、智能分析、增值服务等多种高效即时服务模式,并应用在国家对地观测科学数据中心商业(北京卫星)分中心云服务平台、中国-东盟卫星数据应用公共技术服务平台和区域卫星遥感综合应用服务等系统中,为各政府、行业部门和公众提供多时期、多类型、多形态、高质量、高精度、高分辨率的遥感卫星影像数据以及海量数据智能分析的服务与应用。 | 高宇 陈婷 王瑞兆 Bella Wang 何建军 | 2022 | 卫星应用2022，30，7： | 2 |
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