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| 1 | MicroRNA aberrations:An emerging field for gallbladdercancer management显示文摘Gallbladder cancer(GBC) is infrequent but most lethal biliary tract malignancy characterized by an advanced stage diagnosis and poor survival rates attributed to absence of specific symptoms and effective treatment options. These necessitate development of early prognostic/predictive markers and novel therapeutic interventions. Micro RNAs(mi RNAs) are small, noncoding RNA molecules that play a key role in tumor biology by functioning like tumor suppressor- or oncogenes and their aberrant expression are associated with the pathogenesis of several neoplasms with overwhelming clinical implications. Since mi RNA signature is tissue specific, here, we focused on current data concerning the mi RNAs abberations in GBC pathogenesis. In GBC, mi RNAs with tumor suppressor activity(mi R-135-5p, mi R-335, mi R-34 a, mi R-26 a, mi R-146b-5p, Mir-218-5p, mi R-1, mi R-145, mir-130a) were found downregulated, while those with oncogenic property(mi R-20 a, mi R-182, mir-155) were upregulated. The expression profile of mi RNAs was significantly associated with GBC prognosis and prediction, and forced over-expression/ inhibition of these mi RNAs was shown to affect tumor growth and development. Further, differential expression of mi RNAs in the blood samples of GBC patients suggest mi RNAs as promising noninvasive biomarker. Thus, mi RNAs represent potential candidate for GBC management, though many hurdles need to be overcome before mi RNAs therapy can be clinically applied to GBC prevention and treatment. | Vishal Chandra Jong Joo Kim Balraj Mittal Rajani Rai | 2016 | World Journal of Gastroenterology2016，22，5： | 14 |
| 2 | Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis显示文摘 | Kshitij Srivastava Anvesha Srivastava Kiran Lata Sharma Balraj Mittal | 2011 | Mutation Research-Reviews in Mutation Research2011，，1： | 2 |
| 3 | No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort 显示文摘 | Tan LP Ng BK Balraj P | 2007 | Pathology2007，39，2： | 1 |
| 4 | Low-temperature syn- theses and characterization of novel layered tellurites, A2Mo3TeO12 ( A = NH4, Cs ), and 'zero-dimensional' tellurites, AaMo6Te2024 · 6H2O (A =Rb, K) 显示文摘 | BALRAJ V V1DYASAGAR K | 1998 | In- org Chem1998，37，19： | 1 |
| 5 | Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled trial显示文摘 | Anjali Lepcha Sophia Amalanathan Ann Mary Augustine Amit Kumar Tyagi Achamma Balraj | 2014 | European Archives of Oto-Rhino-Laryngology2014，，11： | 1 |
| 6 | MU-MIMO in LTE Systems显示文摘 | Duplicy J Badic B Balraj R | 2011 | EURASIP Journal on Wireless Communications and Networking2011，，49： | 1 |
| 7 | Neonatal screening for hearing loss:pilot study from a tertiary care centre显示文摘 | John M Balraj A Kurien M | 2009 | Indian J Otolaryngol HeadNeck Surg2009，61，1： | 1 |
| 8 | An improved threshold free algorithm for maternal and fetal hearl rate detection显示文摘 | Shashi Kala Nagarkoti Balraj Singh Kaushik BK | 2011 | IJCA Special Issue on Evolution in Networks and Computer Communications2011，，1： | 1 |
| 9 | Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis显示文摘 | Kshitij Srivastava Anvesha Srivastava Kiran Lata Sharma Balraj Mittal | 2011 | Mutation Research-Reviews in Mutation Research2011，，1： | 1 |
| 10 | Potential role of GABA A receptor subunit; GABRA6, GABRB2 and GABRR2 gene polymorphisms in epilepsy susceptibility and pharmacotherapy in North Indian population显示文摘 | Ritu Kumari Ram Lakhan J. Kalita R.K. Garg U.K. Misra Balraj Mittal | 2011 | Clinica Chimica Acta2011，，13： | 1 |
| 11 | Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy显示文摘 | B. R. Achyut Uday C. Ghoshal Nikhil Moorchung Balraj Mittal | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 1 |
| 12 | Antioxidant effects of local fruits and vegetable显示文摘 | KUPPUSAMY U R INDRAN M BALRAJ B R S | 2002 | Journal of Tropical Medicinal Plants2002，3，1： | 1 |
| 13 | Isolation and characterization of a degradation product in leflunomide and a validated selective stability-indicating HPLC-UV method for their quantification显示文摘Leflunomide(LLM) is subjected to forced degradation under conditions of hydrolysis,oxidation,dry heat,and photolysis as recommended by International Conference on Harmonization guideline Q1A(R2).In total,four degradation products(Ⅰ-Ⅳ) were formed under different conditions.Products Ⅰ,Ⅱ and Ⅳ were formed in alkaline hydrolytic,acidic hydrolytic and alkaline photolytic conditions.LLM and all degradation products were optimally resolved by gradient elution over a C18column.The major degradation product(Ⅳ) formed in hydrolytic alkaline conditions was isolated through column chromatography.Based on its 1H NMR,IR and mass spectral data,it was characterized as a British Pharmacopoeial impurity B.The HPLC method was found to be linear,accurate,precise,sensitive,specific,rugged and robust for quantification of LLM as well as product Ⅳ.Finally,the method was applied to stability testing of the commercially available LLM tablets. | Balraj Saini Gulshan Bansal | 2015 | Journal of Pharmaceutical Analysis2015，5，3： | 1 |
| 14 | Differential algorithms-as- sisted molecular modeling-based identification of mechanistic binding of ganoderic acids显示文摘 | Gill Balraj Singh Kumar Sanjeev | 2015 | Med Chem Res2015，24，9： | 1 |
| 15 | Anterior Lumbar Interbody Fusion for Treatment of Failed Back Surgery Syndrome: An Outcome Analysis显示文摘 | Neil Duggal Ignacio Mendiondo Heraldo R. Pares Balraj S. Jhawar Kaushik Das Kathy J. Kenny Curtis A. Dickman | 2004 | Neurosurgery2004，，3： | 1 |
| 16 | Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer显示文摘 | Meenu Jain Anup Raj Tilak Rohit Upadhyay Ashwani Kumar Balraj Mittal | 2008 | Toxicology and Applied Pharmacology2008，，2： | 1 |
| 17 | A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer显示文摘 | Eugene H Balraj S Massimo C | 2009 | J Surg Res2009，155，2： | 1 |
| 18 | A study of ACE and ADD 1 polymorphism in ischemic and hemorrhagic stroke显示文摘 | Jayantee Kalita Bindu I. Somarajan Bishwanath Kumar Balraj Mittal Usha K. Misra | 2010 | Clinica Chimica Acta2010，，7： | 1 |
| 19 | Incidence of Hae- mophilus influenzae type b meningitis in India显示文摘 | MINZ S BALRAJ V LALITHA M K | 2008 | Indian J Med Res2008，128，1： | 1 |
| 20 | Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma显示文摘 | Rohit Upadhyay Meenu Jain Shaleen Kumar Uday Chand Ghoshal Balraj Mittal | 2009 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2009，，1： | 1 |
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