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| 1 | MiR-20b targets AKT3 and modulates vascular endothelial growth factor-mediated changes in diabetic retinopathy显示文摘糖尿病的 retinopathy (医生) 是新发作的盲目的领先的原因。在糖尿病的 retinopathy 的 microRNAs 的角色大部分是未知的。这研究的目的是在 miR-20b 的特兰斯费克蒂恩博士调查 miR-20b 的角色在高度模仿对待的葡萄糖( HG )人的网膜的 endothelial 房间( HREC )增加了 miR-20b 表示并且减少 VEGF mRNA 的表示水平,当在控制 HREC 的 miR-20b 禁止者的 transfection 随 VEGF mRNA 的相应增加减少了 miR-20b 表达式时。在 vitro,功能的试金证明 miR-20b 的 transfection 在 HREC 在 transendothelial 渗透和试管形成模仿阻止的导致 HG 的增加。miR-20b 禁止者的 Transfection 或 VEGF 的处理在控制 HREC 增加了 transendothelial 渗透和试管形成。酶报导试金证明 AKT3 是 miR-20b 的一个目标。miR-20b 的 Transfection 模仿阻止了没有改变 AKT 的另外的 isoforms 的蛋白质层次, HG 导致的 AKT3 的起来规定,并且 AKT3 的 silencing 象 transendothelial 的阻止的导致 HG 的增加一样引起了 VEGF mRNA 和蛋白质层次的减少渗透和试管形成。最后,我们证明 miR-20b 在糖尿病的老鼠在视网膜和网膜的 endothelial 房间是下面调整的,与 VEGF 和 AKT3 的一条相关起来规定。miR-20b 的 Intravitreal 注射显著地在糖尿病的老鼠模仿增加了 miR-20b 表示并且减少在视网膜纸巾的 AKT3 和 VEGF 的表示层次,和在糖尿病的老鼠的 AKT3 siRNA 的 intravitreal 交货显著地减少了 AKT3 和 VEGF 的表情。一起, miR-20b 为在 HREC 和老鼠的调停 VEGF 的变化的规定是重要的在 hyperglycemic 条件下面的网膜的纸巾可能经由指向 AKT3。 | Bo Qin Jinwen Liu Shenwen Liu Baijun Li Jing Ren | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 10 |
| 2 | Nonreciprocal unconventional photon blockade in a spinning optomechanical system显示文摘We propose how to achieve quantum nonreciprocity via unconventional photon blockade(UPB) in a compound device consisting of an optical harmonic resonator and a spinning optomechanical resonator. We show that, even with very weak single-photon nonlinearity, nonreciprocal UPB can emerge in this system, i.e., strong photon antibunching can emerge only by driving the device from one side but not from the other side. This nonreciprocity results from the Fizeau drag, leading to different splitting of the resonance frequencies for the optical counter-circulating modes. Such quantum nonreciprocal devices can be particularly useful in achieving backaction-free quantum sensing or chiral photonic communications. | BAIJUN LI RAN HUANG XUNWEI XU ADAM MIRANOWICZ HUI JING | 2019 | Photonics Research2019，7，6： | 9 |
| 3 | Clinical observations on the treatment of infantile hemangiomas with topical imiquimod 5% cream显示文摘Objective:To observe the efficacy and safety of topical imiquimod 5% cream in the treatment of uncomplicated infantile hemangiomas (IHs). Methods:A total of 68 IHs were treated with topical imiquimod 5% cream. Among them,36 were superficial,22 were mixed,and 10 were deep. The size of IHs ranged from 1.0 cm × 1.5 cm to an area of a whole forearm. All the hemangiomas were in a proliferative stage. Imiquimod was applied 3 times weekly in 44 patients and 5 times weekly in 24 patients for up to 36 weeks. Results:All superficial IHs improved,and 18 achieved complete clinical resolution,10 had excellent improvement,5 showed moderate improvements,and 3 patients displayed minimal improvement. Two mixed IHs showed excellent improvement,3 showed moderate improvement and 5 mani-fested minimal improvements. The remaining 12 mixed IHs and all deep IHs did not respond to the therapy. The total incidence of local adverse events was 58.82%(40/68),which included erythema or edema,local itching,incrustation or peeling,erosion or ulceration,although most of these were mild to moderate reactions and did not affect the treatment. Scarring occurred in 2 mixed IHs. No systemic side effects developed. Conclusion:Imiquimod 5% cream may be a safe and effective alternative for the treatment of superficial IHs and some mixed IHs in which the superficial component predominates. An appropriate treatment duration for proliferative IHs treated with this therapy may be 24 weeks. Some local adverse events,such as crusting and erosion with possible scarring potential may occur and should be addressed by prompt,but temporary,discontinuation of the imiquimod. Topical imiquimod 5% cream can be prudently used in the treatment of IHs larger than 5.0 cm×5.0 cm in newborns and infants less than 6 months of age. To our knowledge,this is the largest IH group treated with imiquimod that has been reported in the literature to date. | Zhengtuan Guo Guowei Li Quan Xu Ya Gaox Peng Li Xiansheng Zhang Yitao Duan Xinkui Guo Baijun Zheng | 2009 | Journal of Nanjing Medical University2009，23，3： | 3 |
| 4 | Moisture Absorption and Mechanical Properties of Chemically Modified Linen/Polypropylene Composites显示文摘 | HU Qiuxue LI Li YAN Wenling ZHAO Qi ZHANG Niaona ZHANG Yumei DONG Jinbiao LIU Baijun HU Wei | 2017 | Chemical Research in Chinese Universities2017，33，6： | 1 |
| 5 | Bright Blue Light-emitting Diodes Based on a Novel Fluorescent Dye Containing Heterocyclic Groups显示文摘Novel molecular material, 1-benzotlliazoly-3 -phenyl --pyrazoline (BTPP) was found to function as bright blue light emitting dye in organic electroluminescent device, and its optical and electric characteristics were investigated. This heterocyclic compound exhibited good characteristics of blue photoluminescence and electroluminescence, which had the emission peak at 450 nm. The single layer light-emitting devices using BTPP as light-emitting material dispersed in poly(N- vinylcarbazole) (PVK) and double layer ones using PBD as hole block layer above the light-emitting layer were fabricated using conventional spin-casting and vaccum vapour deposition methods. The introduction of PBD has enhanced electron injection and luminance efficiency, compared with the single layer LEDs. | XIE Zhiyuan HUANG Jingsong CHEN Baijun HOU Jingying LIU Shiyong (National Lab. of Integrated Optoelectron., Jinn University, Changchun 130023, CHN ) LI Dongfeng (Dept.of Light Chem.and Text.Eng.,Jilin Institute of Technology,Changchun 130012,CHN) | 1998 | Semiconductor Photonics and Technology1998，4，2： | 1 |
| 6 | Mixed solvothermal synthesis and X-ray characterization of a layered copper coordination polymer, Cu(H 2 O)(1,3-BDC)<ce:hsp sp='0.12'/>·<ce:hsp sp='0.12'/>H 2 O (BDC=benzenedicarboxylate)显示文摘 | Lu Gao Baijun Zhao Guanghua Li Zhan Shi Shouhua Feng | 2003 | Inorganic Chemistry Communications2003，，9： | 1 |
| 7 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong Mimi Guan Meifei Lu Zhifeng Huang Hongchang Gao Xiaokun Li | 2011 | Diabetes Research and Clinical Practice2011，，： | 1 |
| 8 | miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2显示文摘Wilms tumor is a rare kidney malignancy primarily developed in children.Treatment for Wilms tumor includes surgery,radiotherapy,and chemotherapy.Recent studies have demonstrated that microRNAs(miRNAs)play important roles in regulating Wilms tumor development.In this study,we aimed to elucidate the expression and function of miR-378c in Wilms tumor.Quantitative real-time PCR(qRT-PCR)results showed that miR-378c was downregulated in Wilms tumor tissues and cell lines.Functionally,further CCK-8,would healing,and transwell assays revealed that overexpression of miR-378c impaired Wilms tumor cell growth and metastasis in vitro.In addition,xenograft assay showed that miR-378c overexpression inhibited Wilms tumor development in vivo.Mechanistically,luciferase reporter assay confirmed that miR-378c directly targets CAMKK2 in Wilms tumor.qRT-PCR and western blot assays demonstrated that CAMKK2 was highly expressed in Wilms tumor tissues and cell lines.Rescue experiments were performed to further evaluate the functional relationship between miR-378c and CAMKK2.Overexpression of miR-378c suppressed Wilms tumor cell metastasis via negatively regulating CAMKK2 expression.Consistently,inhibition of miR-378c enhanced Wilms tumor cell malignancy behavior via augmenting CAMKK2 expression,which could be abrogated by CAMKK2 knockdown.In summary,our findings suggest that miR-378c inhibits the development and metastasis of Wilms tumor via negatively regulating CAMKK2 expression,which could be utilized to develop new therapy strategy. | Qiang Yu Baijun Zheng Xiang Ji Peng Li Zhengtuan Guo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 1 |
| 9 | Comparison of human post-embryonic, multipotent stem cells derived from various tissues显示文摘 | Baijun Fang Ning Li Yongping Song Quande Lin Robert Chunhua Zhao | 2009 | Biotechnology Letters2009，，7： | 1 |
| 10 | Carbonization fabrication of a piezoresistive sensor with improved sensitivity via Ni decoration of carbonized cotton fibers显示文摘The development of wearable electronics urgently requires the cost-effective and scalable fabrication of high-performance pressure sensors.This work aims to develop a simple carbonization strategy to facilitate sensor sensitivity by decorating discrete nickel nanoparticles on carbonized cotton fibers(CCFs).The increased air gap between the fibers at the unloading state,as well as the enlargement of the deformation distance and the contact area between the conductive materials at the loading state,contribute to a more significant resistance change.Therefore,the sensitivity of the piezoresistive sensor is improved more than 5 times within 1 N by introducing Ni nanoparticles,and it is characterized by a rapid response(~160 ms)and recovery(~100 ms),wide detection range(~20 N/~130 kPa),and good durability(~4000 cycles).The flexible sensor has been successfully demonstrated to monitor human movements,physical stimuli,and pressure distribution.Furthermore,the proposed device can control temperature accurately as a uniform and large-scale heater.This work reveals that the Ni@CCFs-based sensor is prospective in wearable electronics,artificial intelligence,health monitoring,medical diagnosis and treatment. | HE Xiang WANG FengMing LIANG YiYing WU JiaWei LIANG JiongHong SHEN GengZhe LI BaiJun SU DaoJian ZHANG Chi SONG WeiDong HE Xin | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 11 | Devitrification-induced an Ultrahigh Strength Al-based Composite Maintaining Ductility显示文摘A new Al-based composite consisting of submicron-sized α-Al matrix embedded with precipitated intermetallic phases was developed by controlling the devitrification process of an Al-Ni-Y-Co-La amorphous alloy.Such a homogeneous composite structure presented an ultrahigh strength of about 1.34 GPa and a large compressive plastic strain up to 22%.The unique mechanical properties during compression are mainly attributed to the dislocation slip deformation of ductile a-AI matrix and the shear-induced refinement of strengthening intermetallic phases. | Dong Kan Xiaopeng Li Baijun Yang Hongwang Yang Jianqiang Wang | 2015 | Journal of Materials Science & Technology2015，31，5： | 0 |
| 12 | Indications,strategies,and development on prostate targeted biopsy:Report of the Panjiayuan Consensus Conference 2022显示文摘Prostate biopsy is the gold standard for diagnosing prostate cancer(PCa).Prostate targeted biopsy(TB)having a higher rate of detecting clinically significant PCa(csPCa)than traditional systematic biopsy(SB)is supported by high-quality evidence.However,the TB indications and strategies are controversial.The National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences,invited a panel of recognized urology experts in PCa to address these topics at the Panjiayuan Consensus Conference 2022.The conference results on prostate TB are presented herein.The National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences identified 10 key areas of prostate biopsy:(1)selection of imaging examination;(2)indications of TB;(3)transperineal and transrectal prostate biopsy;(4)TB pathways;(5)TB and SB;(6)three techniques of TB;(7)the number of TB cores needed for one lesion;(8)core number for SB;(9)free-hand TB;(10)future development of TB/prostate diagnosis.Thus,a panel of 25 recognized urologists and 2 radiologists from China were invited to attend this conference.The panel voted anonymously on 14 predetermined questions.Voting was based on the panelists'clinical practice and opinion,rather than high-level evidence.The voting outcomes were supported by the panel unequally,and details of the voting results were reported.The voting results can help clinicians to decide on biopsy timing and proper strategies,for which guidelines are sparse.We also focused on the future development of TB and SB,such as the combined pathway of TB and SB,techniques of TB,biopsy cores,free-hand TB,and prostate-specific membrane antigen positron emission tomography/computed tomography. | Gang Song Yajian Li Huimin Hou Yichen Wang Xuejuan Wang Shaoxi Niu Xiang Tu Hongliang Shen Zhien Zhou Yinbing Wang Ruiyi Yan Ning Xu Gejun Zhang Hailong Hao Shudong Zhang Ben Liu Bin Yang Baojun Wang Haifeng Wang Haifeng Huang Qian Zhang Baijun Dong Yonghong Li Jianbin Bi Weigang Yan Hongqian Guo Yuanjie Niu Guosheng Yang Ming Liu Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，1： | 0 |
| 13 | The biogenesis and secretion of exosomes and multivesicular bodies(MVBs):Intercellular shuttles and implications in human diseases显示文摘Exosomes carry and transmit signaling molecules used for intercellular communication.The generation and secretion of exosomes is a multistep interlocking process that allows simultaneous control of multiple regulatory sites.Protein molecules,mainly RAB GTPases,cytoskeletal proteins and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor(SNARE),are specifically regulated in response to pathological conditions such as altered cellular microenvironment,stimulation by pathogenic factors,or gene mutation.This interferes with the smooth functioning of endocytosis,translocation,degradation,docking and fusion processes,leading to changes in the secretion of exosomes.Large numbers of secreted exosomes are disseminated by the flow of body fluids and absorbed by the recipient cells.By transmitting characteristic functional proteins and genetic information produced under disease conditions,exosomes can change the physiological state of the recipient cells and their microenvironment.The microenvironment,in turn,affects the occurrence and development of disease.Therefore,this review will discuss the mechanism by which exosome secretion is regulated in cells following the formation of mature secretory multivesicular bodies(MVBs).The overall aim is to find ways to eliminate disease-derived exosomes at their source,thereby providing an important new basis for the clinical treatment of disease. | Minxue Xu Jie Ji Dandan Jin Yue Wu Tong Wu Renjie Lin Shengze Zhu Feng Jiang Yifei Ji Baijun Bao Mei Li Weisong Xu Mingbing Xiao | 2023 | Genes & Diseases2023，10，5： | 0 |
| 14 | Optomechanical Schrödinger cat states in a cavity Bose-Einstein condensate显示文摘Schrödinger cat states,consisting of superpositions of macroscopically distinct states,provide key resources for a large number of emerging quantum technologies in quantum information processing.Here we propose how to generate and manipulate mechanical and optical Schrödinger cat states with distinguishable superposition components by exploiting the unique properties of cavity optomechanical systems based on Bose-Einstein condensate.Specifically,we show that in comparison with its solid-state counterparts,almost a 3 order of magnitude enhancement in the size of the mechanical Schrödinger cat state could be achieved,characterizing a much smaller overlap between its two superposed coherent-state components.By exploiting this generated cat state,we further show how to engineer the quadrature squeezing of the mechanical mode.Besides,we also provide an efficient method to create multicomponent optical Schrödinger cat states in our proposed scheme.Our work opens up a new way to achieve nonclassical states of massive objects,facilitating the development of fault-tolerant quantum processors and sensors. | Baijun Li Wei Qin Ya-Feng Jiao Cui-Lu Zhai Xun-Wei Xu Le-Man Kuang Hui Jing | 2023 | Fundamental Research2023，3，1： | 0 |
| 15 | Highly stable capacitive tactile sensors with tunable sensitivity facilitated by electrostatic interaction of layered double hydroxide,MXene,and Ag NWs显示文摘A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic interaction.This flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of pressure.The sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric layer.An optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 kPa.The strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading cycles.Furthermore,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli. | SHEN GengZhe HUANG WeiQing LI HaiFeng WANG FengMing SU DaoJian LI BaiJun ZHANG BoLun LIANG Ping ZHANG Chi XIN Yue HE Xin | 2023 | Science China(Technological Sciences)2023，66，11： | 0 |
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