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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Recent Advances on the Technologies to Increase Fertilizer Use Efficiency显示文摘To increase fertilizer use efficiency (FUE) and to minimize its negative impact on environment have been the focal points in the world for a long time. It is very important to increase FUE in China for its relatively low FUE and serious losses of nutrients. Recent advances of the technologies to increase FUE are reviewed in this article. These include site-specific and real-time nitrogen management, non-destructive quick test of the nitrogen status of plants, new types of slow release and controlled release fertilizers, site-specific nutrient management, and use of urease inhibitor and nitrification inhibitor to decrease nitrogen losses. Future outlook in technologies related to FUE improvement is also discussed. | YAN Xiang JIN Ji-yun HE Ping LIANG Ming-zao | 2008 | Agricultural Sciences in China2008，7，4： | 35 |
| 3 | Function of microglia and macrophages in secondary damage after spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating type of neurological trauma with limited therapeutic opportunities.The pathophysiology of SCI involves primary and secondary mechanisms of injury.Among all the secondary injury mechanisms,the inflammatory response is the major contributor and results in expansion of the lesion and further loss of neurologic function.Meanwhile,the inflammation directly and indirectly dominates the outcomes of SCI,including not only pain and motor dysfunction,but also preventingneuronal regeneration.Microglia and macrophages play very important roles in secondary injury.Microglia reside in spinal parenchyma and survey the microenvironment through the signals of injury or infection.Macrophages are derived from monocytes recruited to injured sites from the peripheral circulation.Activated resident microglia and monocyte-derived macrophages induce and magnify immune and inflammatory responses not only by means of their secretory moleculesand phagocytosis,but also through their influence on astrocytes,oligodendrocytes and demyelination.In this review,we focus on the roles of microglia and macrophages in secondary injury and how they contribute to the sequelae of SCI. | Xiang Zhou Xijing He Yi Ren | 2014 | Neural Regeneration Research2014，9，20： | 31 |
| 4 | Source apportionment and secondary organic aerosol estimation of PM_(2.5) in an urban atmosphere in China显示文摘PM2.5 is the key pollutant in atmospheric pollution in China.With new national air quality standards taking effect,PM2.5 has become a major issue for future pollution control.To effectively prevent and control PM2.5,its emission sources must be precisely and thoroughly understood.However,there are few publications reporting comprehensive and systematic results of PM2.5 source apportionment in the country.Based on PM2.5 sampling during 2009 in Shenzhen and follow-up investigation,positive matrix factorization(PMF)analysis has been carried out to understand the major sources and their temporal and spatial variations.The results show that in urban Shenzhen(University Town site),annual mean PM2.5 concentration was 42.2μg m?3,with secondary sulfate,vehicular emission,biomass burning and secondary nitrate as major sources;these contributed30.0%,26.9%,9.8%and 9.3%to total PM2.5,respectively.Other sources included high chloride,heavy oil combustion,sea salt,dust and the metallurgical industry,with contributions between 2%–4%.Spatiotemporal variations of various sources show that vehicular emission was mainly a local source,whereas secondary sulfate and biomass burning were mostly regional.Secondary nitrate had both local and regional sources.Identification of secondary organic aerosol(SOA)has always been difficult in aerosol source apportionment.In this study,the PMF model and organic carbon/elemental carbon(OC/EC)ratio method were combined to estimate SOA in PM2.5.The results show that in urban Shenzhen,annual SOA mass concentration was 7.5μg m?3,accounting for 57%of total organic matter,with precursors emitted from vehicles as the major source.This work can serve as a case study for further in-depth research on PM2.5 pollution and source apportionment in China. | HUANG XiaoFeng YUN Hui GONG ZhaoHeng LI Xiang HE LingYan ZHANG YuanHang HU Min | 2014 | Science China Earth Sciences2014，57，6： | 28 |
| 5 | Aerosol scattering coefficients and major chemical compositions of fine particles observed at a rural site in the central Pearl River Delta,South China显示文摘During November-December 2010 aerosol scattering coefficients were monitored using a single-waved (525 nm) Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle (PM 2.5) samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon (OC),elemental carbon (EC),sulfate,nitrate and ammonium.In average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% (OC),19% (SO 4 2 -),12% (NO 3 -),8.4% (NH 4+) and 3.7% (EC),to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass concentrations.Chemical extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively. | Xinming Wang Xiang Ding Xiaoxin Fu Quanfu He Shaoyi Wang Francois Bernard Xiuying Zhao Dui Wu | 2012 | Journal of Environmental Sciences2012，24，1： | 25 |
| 6 | Three-dimensional hydrodynamic and water quality model for TMDL development of Lake Fuxian,China显示文摘Lake Fuxian is the largest deep freshwater lake in China.Although its average water quality meets Class I of the China National Water Quality Standard(CNWQS),i.e.,GB3838-2002,monitoring data indicate that the water quality approaches the Class II threshold in some areas.Thus it is urgent to reduce the watershed load through the total maximum daily load(TMDL) program.A three-dimensional hydrodynamic and water quality model was developed for Lake Fuxian,simulating flow circulation and pollutant fate and transport.The model development process consists of several steps,including grid generation,initial and boundary condition configurations,and model calibration processes.The model accurately reproduced the observed water surface elevation,spatiotemporal variations in temperature,and total nitrogen(TN),total phosphorus(TP),and chemical oxygen demand(COD) concentrations,suggesting a reasonable numerical representation of the prototype system for further TMDL analyses.The TMDL was calculated using two interpretations of the water quality standards for Class I of the CNWQS based on the maximum instantaneous surface and annual average surface water concentrations.Analysis of the first scenario indicated that the TN,TP and COD loads should be reduced by 66%,68% and 57%,respectively.Water quality was the highest priority;however,local economic development and cost feasibility for load reduction can pose significant issues.In the second interpretation,the model results showed that,under the existing conditions,the average water quality meets the Class I standard and therefore load reduction is unnecessary.Future studies are needed to conduct risk and cost assessments for realistic decision-making. | Lei Zhao Xiaoling Zhang Yong Liu Bin He Xiang Zhu Rui Zou Yuanguan Zhu | 2012 | Journal of Environmental Sciences2012，24，8： | 25 |
| 7 | Cap-assisted endoscopic sclerotherapy for hemorrhoids: Methods, feasibility and efficacy显示文摘AIM: To evaluate the methodology, feasibility, safety and efficacy of a novel method called cap-assisted endoscopic sclerotherapy(CAES) for internal hemorrhoids.METHODS: A pilot study on CAES for grade Ⅰ to Ⅲ internal hemorrhoids was performed. Colon and terminal ileum examination by colonoscopy was performed for all patients before starting CAES. Polypectomy and excision of anal papilla fibroma were performed if polyps or anal papilla fibroma were found and assessed to be suitable for resection under endoscopy. CAES was performed based on the requirement of the cap, endoscope, disposable endoscopic long injection needle, enough insufflated air and sclerosing agent.RESULTS: A total of 30 patients with grade Ⅰ to Ⅲ internal hemorrhoids was included. The follow-up was more than four weeks. No bleeding was observed after CAES. One(3.33%) patient claimed mild tenesmus within four days after CAES in that an endoscopist performed this procedure for the first time. One hundred percent of patients were satisfied with this novel procedure, especially for those patients who underwent CAES in conjunction with polypectomy or excision of anal papilla fibroma.CONCLUSION: CAES as a novel endoscopic sclerotherapy should be a convenient, safe and effective flexible endoscopic therapy for internal hemorrhoids. | Ting Zhang Li-Juan Xu Jie Xiang Zhi He Zhao-Yuan Peng Guang-Ming Huang Guo-Zhong Ji Fa-Ming Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 22 |
| 8 | Effects of short-acting β-adrenergic blocker on B-type natriuretic peptide at early stage of postresuscitation in rabbits显示文摘 | LI Xiang LI Pei-jie HE Yun-fen ZENG Hong LI Zi-li ZHANG Zheng-yi CAO Wen YANG Lan | 2006 | Chinese Medical Journal2006，，10： | 21 |
| 9 | Mechanisms and assessment of water eutrophication显示文摘Water eutrophication has become a worldwide environmental problem in recent years,and understanding the mechanisms of water eutrophication will help for prevention and remediation of water eutrophication.In this paper,recent advances in current status and major mechanisms of water eutrophication,assessment and evaluation criteria,and the influencing factors were reviewed.Water eutrophication in lakes,reservoirs,estuaries and rivers is widespread all over the world and the severity is increasing,especially in the developing countries like China.The assessment of water eutrophication has been advanced from simple individual parameters like total phosphorus,total nitrogen,etc.,to comprehensive indexes like total nutrient status index.The major influencing factors on water eutrophication include nutrient enrichment,hydrodynamics,environmental factors such as temperature,salinity,carbon dioxide,element balance,etc.,and microbial and biodiversity.The occurrence of water eutrophication is actually a complex function of all the possible influencing factors.The mechanisms of algal blooming are not fully understood and need to be further investigated. | Xiao-e YANGt Xiang WU Hu-lin HAO Zhen-li HE | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，3： | 21 |
| 10 | Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model显示文摘瞄准:评估在里面 antisense oligonucleotidestargeting midkine 的 vivo antitumor 效果(MK -- 作为).Methods:一在里面在老鼠肝 orthotopically.The MK 的 situ 人 hepatocellular 癌( HCC )模型 wasestablished --作为并且5氟尿嘧啶( 5-Fu )是 administeredintravenously.The 肿瘤尺寸,血浆 alpha-fetoprotein (法新社)被肿瘤的测径器 andradiation 免疫分析 respectively.The 形态学测量被组织学的 sections.Human 的 hematoxylin-eosinstaining 评估 MK , p53 , Bax , Bc1-2 ,和 caspase-3 蛋白质内容是 detectedby 西方的 blotting.Results : MK --当显著地在剂量依赖者 manner.After 与盐的组一起在 micecompared 在 situ 人 HCC 生长禁止了有 MK 的处理--作为或 with5-Fu ,血浆法新社集中 manner.Interestingly 在一个剂量依赖者减少了, MK --作为 alsoclearly downregulated Bc1-2 的蛋白质水平,和 upregulated p53 , Bax ,并且在 thehepatocellular 癌 tissue.Conclusion 的 caspase-3 :这些结果表明了那 MK -- 这是在在老鼠的 vivo 的 effectiveantitumor antisense oligonucleotide;它的 antitumor 效果与 pro-apoptotic 蛋白质的 theincrease 被联系例如 p53, Bax,和 caspase-3,并且 theanti-apoptotic 蛋白质的减少, Bc1-2。 | Li-cheng DAI Xiang WANG Xing YAO Li-shan MIN Jin-liang PING Jian-fang HE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 20 |
| 11 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 12 | Transplanted human umbilical cord blood mononuclear cells improve left ventricular function through angiogenesis in myocardial infarction显示文摘脐的绳索血包含的背景人许多 immaturestem/progenitor 房间,它可以参予被心肌的梗塞(MI ) 损坏了的心的修理。这研究试图评估人的脐的绳索 bloodmononuclear 房间(hUCBC ) 的效果心脏的功能并且在 MI 的老鼠模型的左室的改变上的移植。45 只男 Wistar 老鼠被使随机化进三个组的方法:MI 或控制组, MI 正房间移植(n=15 ) ,和假冒的组(n=15 )(n=15 ) 。尖锐心肌的梗塞(AMI ) 被绑扎建立此后, hUCBCwere 植入进 infarcted 的边缘的区域的左前面的下降动脉心肌层。在 MI/control 组, DMEM 被注射而不是跟随一样的协议的 hUCBC。左室的功能评价被回响心动描记法和侵略血液动力学的大小执行一月柱子 MI。所有老鼠为组织学、免疫化学的考试被牺牲。结果移植了 hUCBCsurvived 并且在主机心从事了心肌的修理的进程。那左室的功能在经历了房间移植的老鼠显著地改进了的 Echocardiographydemonstrated。血液动力学的研究发现了显著地减少的左室的 end-diastolicpressure ( LVEDP )[( 21.08 ± 8.10 ) mmHg 对( 30.82 ± 9.59 ) mmHg , P <
0.05 ],+dp/dt_(最大)的增加[( 4.29 ± 1.27 ) mmHg/ms 对( 3.24 ±0 .75 ) mmHg/ms , P <
0.05 ),并且在-dp/dt_(max)[(3.71±0.79) mmHg/ms 增加对( 3.00 ± 0.49 ) mmHg/ms , P <
0.05 ]在有 hUCBC 移植的 MI 组之中什么时候与 MI/control 相比组。马森“三色的染色揭示了的 s 在左室的骨胶原密度在 MIcontrol 比那在移植组的老鼠是显著地更低的,这组织[(6.33 ± 2 .69 )% 对(11.10 ± 3 .75 )% , P <
0.01 ] 。基于α - 肌动朊染色的免疫,当时,微容器的棕土是显著地(P <
0.01 ) 在梗塞的边界增加了地点。脉管的 endothelial 生长因素(VEGF ) 的同样更高的 mRNA 表示 164 并且当时, VEGF188 与 hUCBC 移植在 MI 组在 7 天、 28 天的帖子房间移植被发现与 MI/ 控制相比组。没有免疫拒绝,移植 hUCBC 能在主人心肌层熬过,显著地改进在 AMI 以后的左室的改变并且支持在梗塞地区的 angiogenesis 的高水平的结论。所有这些因素获利地在 MI 的背景影响心脏的修理。因此人的脐的绳索血可以是潜在的来源为 AMI 的基于 forcell 的治疗。 | HU Cheng-heng WU Gui-fu WANG Xiao-qing YANG Yan-hua DU Zhi-min HE Xiao-hong XIANG Peng | 2006 | Chinese Medical Journal2006，，18： | 20 |
| 13 | Experimental investigation into stress-relief characteristics with upward large height and upward mining under hard thick roof显示文摘 | Ke Yang Xiang He Litong Dou Wenjun Liu Li Sun Haisong Ye | 2015 | International Journal of Coal Science & Technology2015，2，1： | 20 |
| 14 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 15 | Functional electrical stimulation increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of rats with stroke显示文摘 | LIU Hui-hua XIANG Yun YAN Tie-bin TAN Zhi-mei LI Sheng-huo HE Xiao-kuo | 2013 | Chinese Medical Journal2013，，12： | 19 |
| 16 | Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and Hep G2 hepatoma cells显示文摘AIM To investigate whether Dihydromyricetin(DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 expression.METHODS The correlation between Notch1 and Hes1(a Notch1 target molecule) expression in hepatoma samples was confirmed by q RT-PCR. In addition, MTT assays, flow cytometry and TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only by reduced cell proliferation but also by enhanced apoptosis in QGY7701 and Hep G2 hepatocellular carcinoma(HCC) cells. The expressions of Notch1, Hes1, Bcl-2 and Bax were determined by Western blot.RESULTS Among the tested samples(n = 64), the expression levels of Notch1(75% of patients) and Hes1(79.7% of patients) m RNA in tumor tissues were higher than in the normal liver tissues. There was a negative correlation between the expression of Notch1 and the degree of differentiation and positively correlated with the Alpha Fetal Protein concentration. The viability of HCC cells treated with DHM was significantly inhibited in a dose and time-dependent manner. Apoptosis was induced in Hep G2 and QGY7701 cell lines following 24 h of DHM treatment. After treatment with DHM, the protein expression of Notch1 was downregulated, the apoptosis-related protein Bax was upregulated and Bcl2 was downregulated. Notch1 si RNA further enhanced the anti-tumor properties of DHM. CONCLUSION Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1. | Cai-Jie Lu Yi-Feng He Wei-Zhuang Yuan Li-Jun Xiang Jian Zhang Yan-Rui Liang Juan Duan Yun-He He Ming-Yi Li | 2017 | World Journal of Gastroenterology2017，23，34： | 19 |
| 17 | Epidemiological Survey of the Prevalence of Non-fatal Injury among Children Aged 5-14 Years in China显示文摘Objective To determine the prevalence of non-fatal injuries among children aged 5-14 years in China.Methods Data of 21 973 children aged 5-14 years were extracted from the Fourth National Health Service Survey of China carried out between June 15 and July 10,2008.Injury-related indicators included:history of ever having had an injury,and injury frequency,cause,location and severity.Results The overall prevalence of non-fatal injuries among the children in the previous 12 months was 17.0 per 1000 subjects.The leading causes of non-fatal injuries were falls,animal bites,traffic accidents,falling objects and burns.The majority of children sustained only one injury.The main place of injury was at home in 40% and 54% of urban boys and girls,respectively,at school in 48% of rural boys,and at home and at school each in 33% of rural girls.Medical treatment for one day was the main option for 80% of urban boys and girls,84% of rural boys,and 72% of rural girls.Conclusion Nonfatal injuries among children aged 5-14 years are a serious public health concern in China. | HU Ming HU Guo Qing SUN Zhen Qiu HE Xiang | 2012 | Biomedical and Environmental Sciences2012，25，4： | 18 |
| 18 | Changes in visibility with PM_(2.5) composition and relative humidity at a background site in the Pearl River Delta region显示文摘In fall–winter, 2007–2013, visibility and light scattering coefficients(b sp) were measured along with PM_(2.5)mass concentrations and chemical compositions at a background site in the Pearl River Delta(PRD) region. The daily average visibility increased significantly(p < 0.01) at a rate of 1.1 km/year, yet its median stabilized at ~13 km. No haze days occurred when the 24-hr mean PM_(2.5)mass concentration was below 75 μg/m^3. By multiple linear regression on the chemical budget of particle scattering coefficient(b sp), we obtained site-specific mass scattering efficiency(MSE) values of 6.5 ± 0.2, 2.6 ± 0.3, 2.4 ± 0.7 and 7.3 ± 1.2 m2/g,respectively, for organic matter(OM), ammonium sulfate(AS), ammonium nitrate(AN) and sea salt(SS). The reconstructed light extinction coefficient(b ext) based on the Interagency Monitoring of Protected Visual Environments(IMPROVE) algorithm with our site-specific MSE revealed that OM, AS, AN, SS and light-absorbing carbon(LAC) on average contributed 45.9% ± 1.6%,25.6% ± 1.2%, 12.0% ± 0.7%, 11.2% ± 0.9% and 5.4% ± 0.3% to light extinction, respectively.Averaged b ext displayed a significant reduction rate of 14.1/Mm·year(p < 0.05); this rate would be 82% higher if it were not counteracted by increasing relative humidity(RH) and hygroscopic growth factor(f(RH)) at rates of 2.5% and 0.16/year-1(p < 0.01), respectively, during the fall–winter, 2007–2013. This growth of RH and f(RH) partly offsets the positive effects of lowered AS in improving visibility, and aggravated the negative effects of increasing AN to impair visibility. | Xiaoxin Fu Xinming Wang Qihou Hu Guanghui Li Xiang Ding Yanli Zhang Quanfu He Tengyu Liu Zhou Zhang Qingqing Yu Ruqing Shen Xinhui Bi | 2016 | Journal of Environmental Sciences2016，28，2： | 18 |
| 19 | Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma显示文摘背景酷氨酸 kinase 禁止者(TKI ) sunitinib,为变形肾的房间癌(RCC ) 的第一线治疗的首先指向的代理人,指向脉管的 endothelial 生长因素(VEGF ) 小径。如果高血压是有效预兆的 factor.Methods,这研究的目的是在对待变形清楚房间的 RCC 调查 sunitinib 的功效和安全并且证实有变形 RCC 的 36 个病人的一个总数在 2008 年 6 月和 2010 年 12 月之间被注册。在他们之中, 29 个案例是第一线治疗, 7 个案例在首要的 cytokine 或 sorafinib 治疗上的前进。所有病人的病理被证实在清楚的房间类型占优势。Sunitinib 单音治疗在每日的口头的治疗的重复 6 星期的周期被管理 4 个星期,到 2 个星期列在后面离开在 34 个病人;并且 3 个病人连续地与 37.5 mg/d 被管理直到疾病前进或不能接受的毒性发生了。全面反应率和安全被评估。我们根据中部的后续是的血压 level.Results 把病人划分了成组 A 和组 B 15 个月(10 个周期,范围 1.5-30.0 月(1-20 周期)) 。十个病人(29.4 ) 完成了部分回答(PR ) ;23 个病人(67.6 ) 表明了持续 2 个周期的稳定的疾病(SD ) 。十七个病人(50 ) 在后续期间得了进步疾病(PD ) 。中部的没有前进的幸存(PFS ) 是 15 个月(范围 3.0-28.5 ) 月。9 个病人的一个总数死了;全面幸存没被到达;死亡病人的中部的幸存时间是 13 个月(范围 7-24 ) 月。最普通的不利事件是手脚症候群(77.8 ) , thrombocytopenia (75.0 ) ,高血压(61.1 ) 和腹泻(46.0 ) 。最不利的事件由治疗打断是可逆的。22 个病人(61.1 ) 得了高血压;并且高血压与很长时间被联系到疾病前进和长全面的幸存(P=0.004, 0.000,分别地) 这研究的结果表明的 .Conclusions 功效和可管理的不利事件与变形清楚的房间 RCC 为病人在首要或第二线的治疗作为一个单个代理人 sunitinib 介绍。进一步,联系 sunitinib 的高血压可以是为在变形 RCC 的治疗功效的一个强壮的预兆的标记。 | LI Xue-song WU Xiang ZHAO Peng-ju HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian WANG Gang HE Zhi-song ZHOU Li-qun JIN Jie | 2011 | Chinese Medical Journal2011，，18： | 17 |
| 20 | Vision,application scenarios,and key technology trends for 6G mobile communications显示文摘With the global commercialization of the fifth-generation(5G)network,many countries,including China,USA,European countries,Japan,and Korea,have started exploring 6G mobile communication network,following the tradition of“planning the next while commercializing one generation”.Currently,studies on 6G networks are at the infancy stage.Research on the vision and requirements for 6G is still ongoing,and the industry is yet to clarify the key enabling technologies for 6G.However,6G will certainly build on the success of 5G.Therefore,developing high-quality 5G networks and seamlessly integrating 5G with verticals are the priorities before 2030,when 6G is projected to be commercialized.Also,global 5G standards will keep evolving to better support vertical applications.As a milestone,the Third-Generation Partnership Project(3GPP)published Release 16 in July 2020,which continuously enhanced the capabilities of mobile broadband service based on Release 15 and realized the support for low-delay and high-reliability applications,such as Internet of Vehicles and industrial Internet.Currently,3GPP is working on Releases 17 and 18,focusing on meeting the demands of medium-and high-data-rate machine communication with low-cost and high-precision positioning,which will be published in June 2022.Thus,6G networks will further expand the application fields and scope of the Internet of Things to accommodate those services and applications that are beyond the capabilities of 5G networks.Herein,we present our vision,application scenarios,and key technological trends for 6G networks.Furthermore,we propose several future research opportunities in 6G networks with regard to industrialization and standardization. | Zhiqin WANG Ying DU Kejun WEI Kaifeng HAN Xiaoyan XU Guiming WEI Wen TONG Peiying ZHU Jianglei MA Jun WANG Guangjian WANG Xueqiang YAN Jiying XIANG He HUANG Ruyue LI Xinhui WANG Yingmin WANG Shaohui SUN Shiqiang SUO Qiubin GAO Xin SU | 2022 | Science China(Information Sciences)2022，65，5： | 17 |
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