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| 1 | Clinical practice guideline on bladder cancer(PartⅡ)显示文摘Bladder cancer(BC)is an increasingly common malignancy in China,with an incidence rate of 5.80 per 100000 in 2015,making it the thirteenth most common cancer in the country.This trend underscores the urgent need for standardized diagnosis and treatment protocols.In terms of treatment,approaches for bladder cancer vary based on the cancer's stage and pathology,as well as the patient's overall health.Notably,non-muscleinvasive BC(NMIBC)confined to the mucosa(Ta)and lamina propria(T1)without invading the muscle represents about 75%of all BC cases.Succeeding the first part of the guideline,this part of the clinical practice guideline focuses on NMIBC.It details risk classifications and treatment options,including both surgical procedures and posttransurethral resection of the bladder tumor intravesical instillations.Special attention is given to the treatment strategies for carcinoma in situ.The guideline also covers the recommended follow-up procedures for patients with NMIBC,underscoring the need for thorough and continuous care management. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，3： | 0 |
| 2 | Development of a high-power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia显示文摘This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations. | Liyue Mu Xiang Zhu Bing Yang Lin Yang Xiaofeng Xu Yongwei Zhao Dalin He | 2023 | UroPrecision2023，1，3： | 0 |
| 3 | Precise review of a male's infertility assessment from a men's health specialist prospective显示文摘Infertility is a pervasive issue affecting a considerable proportion of couples in their reproductive years,with a projected 10%-15% prevalence.It is characterized by the incapability to achieve conception following a year of consistent,unprotected intercourse,and its far-reaching consequences can take a profound emotional,psychological,and social toll on couples,inducing feelings of melancholy,exasperation,and anxiety.The appraisal of infertile couples'cases is a multifaceted and daunting process,necessitating a holistic understanding of the intricate underlying factors contributing to their infertility.Consequently,an individualized evaluation should be conducted,considering diverse parameters,such as the couple's medical history,age,infertility duration,and other relevant criteria.This paper will provide an in-depth overview of the current approaches utilized in the evaluation of men with infertility,including the commonly employed diagnostic tools and procedures.Enhancing our comprehension of infertility assessment and management holds the promise of helping couples achieve their ultimate desire of conceiving and enriching their overall quality of life. | Kareim Khalafalla Laila Ammar Run Wang | 2023 | UroPrecision2023，1，3： | 0 |
| 4 | Current and emerging tissue-based molecular biomarkers for prostate cancer management:A narrative review显示文摘Prostate cancer is a heterogeneous disease process with a wide spectrum of clinicopathologic variables that impact diagnosis,risk stratification,and management.To improve diagnostic accuracy and to better inform clinical decision making,the development of molecular biomarkers has undergone considerable discovery and clinical validation in the past decade.Prostate cancer is no longer seen as a single disease entity but one with considerable heterogeneity existing between tumors and between patients.Biomarkers now allow for more personalized and precision-based approaches to management that otherwise would have depended on applying clinical algorithms alone.The aim of this review is to discuss and evaluate prostate cancer tissue-based biomarkers that have been developed to aid diagnosis,improve risk stratification,and management. | Jas Singh | 2023 | UroPrecision2023，1，3： | 0 |
| 5 | Clinical practice guideline on bladder cancer(Part Ⅲ)显示文摘Bladder cancer(BC)has become a significantly prevalent disease in China,with an incidence rate of 5.80 per 100000 in 2015,ranking it as the thirteenth most common type of cancer within the nation.This illness presents a serious public health concern,highlighting the imperative need to unify the standards for diagnosis and treatment to improve patient outcomes.The section of the clinical practice guideline in question is dedicated to addressing muscle-invasive bladder cancer(MIBC)and metastatic BC.The primary treatment strategies for MIBC are well-defined:preoperative(neoadjuvant)chemotherapy combined with radical cystectomy stands as the conventional treatment protocol.For patients with locally advanced MIBC,integrating systemic and local therapies is advocated to enhance treatment effectiveness.In cases of metastatic BC,the focus shifts to systemic treatment supplemented by supportive care measures.The guideline also succinctly presents the pros and cons of various urinary diversion surgeries,which are critical considerations following radical cystectomy.It provides an in-depth exploration of the treatment modalities for metastatic urothelial carcinoma of the bladder.Additionally,this part delves into the integrated approach to treatment and the use of radiotherapy in bladder preservation for localized disease.Moreover,it offers a concise overview of the classification,diagnosis,and therapeutic approaches for nonurothelial carcinoma of the bladder.Lastly,this part emphasizes the importance of recommended posttreatment follow-up for MIBC patients to ensure comprehensive and ongoing care management. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，4： | 0 |
| 6 | Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome:An exploratory bibliometric analysis and literature review of preclinical studies显示文摘Background:As one of the most common diseases in urology,a large number of preclinical studies have been accumulated to explore the etiological mechanism and potential intervention of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS).Methods:In this study,we systematically evaluated the current status of preclinical research on CP/CPPS through bibliometrics analysis using VOSviewer and Citespace.Characteristics of publication such as year,country/region,institution,author,journal,citation,and keywords were analyzed.Based on the bibliometrics analysis results of keywords,we summarized the possible mechanisms and promising treatments for CP/CPPS narratively.Results:According to the results of this study,the most common mechanisms involved in CP/CPPS were as follows:Disturbed immune and inflammation mediators,immune cell dysfunction,oxidative stress,dysregulated signaling pathways,apoptosis,gut microbiota,and testosterone metabolism.Traditional Chinese Medicine and extracorporeal shock wave therapy have important potential in the treatment of CP/CPPS.Conclusion:Further translational studies targeting the above mechanisms and validating the objective efficacy of potential treatments indicated by preclinical studies in clinical patients are needed in the future. | Yongfeng Lao Xin Guan Jian Wang Yanan Bai Zewen Li Zhiping Wang Zhilong Dong | 2023 | UroPrecision2023，1，4： | 0 |
| 7 | Age is not a number when it comes to penile prosthesis surgery:A case series and mini literature review显示文摘Backgound:Given the overall aging of the population,erectile dysfunction(ED)has become an increasingly relevant issue.When elective surgery is offered,the patient's age is often noted as a potential limiting factor.The aim of this study is to investigate the safety of implanting penile prostheses(PPs)in men 90 years and older,and report the potential complications associated with this population.Methods:The database was screened between the years 2003 and 2023 to identify patients at least 90 years and older who underwent implantation of PP by a single surgeon at MD Anderson Cancer Center and Memorial Hermann Texas Medical Center.We collected demographic information,their anesthesia perioperative assessment,surgical procedure details,and postoperative pathway.Results:Between 2003 and 2023,2000 men underwent PP surgery.Three patients were 90 years or older at the time of PP surgeries.All surgeries were performed without intraoperative or postoperative complications.Following the surgery,patients were monitored,and the patients with implantations demonstrated the ability to use the device and reported satisfaction.Conclusion:This case series demonstrates that implantation of PP is a safe and effective treatment for elderly men with ED.Maintaining a satisfactory sexual life in this age group is vital and achievable through inflatable PP insertion.There are several factors that must be considered prior to operating on an older patient.However,with proper patient selection and preoperative optimization,this operation can be effectively performed in these patients. | Hannah Slovacek Kareim Khalafalla Run Wang | 2023 | UroPrecision2023，1，4： | 0 |
| 8 | Early drainage removal in the management of lymphatic leakage after robotic pelvic lymph node dissection显示文摘Background:Radical prostatectomy(RP)and radical cystectomy(RC)with concurrent pelvic lymph node dissection(PLND)are considered as the curative surgical treatment options for localized prostate cancer(PC)or muscle-invasive bladder cancer(BC).Regarding lymphatic leakage management after PLND,there is no standard of care,with different therapeutic approaches having been reported with varying success rates.Methods:Seventy patients underwent pelvic lymphadenectomy during robotic RP and RC with postoperative pelvic drainage volume more than 50 mL/day before the removal of drainage tube,were retrospectively evaluated in this study between August 2015 and June 2023.If the pelvic drainage volume on postoperative Day 2 was more than 50 mL/day,a drainage fluid creatinine was routinely tested to rule out urine leakage.We removed the drainage if the patient had no significant abdominal free fluid collection,no abdominal distension or pain,no fever,and no abdominal tenderness.After 1-day observation of the vital signs and abdominal symptoms,the patient was discharged and followed-up in clinic for 2 weeks after surgery.Results:Forty-one cases underwent the early drainage removal even if the pelvic drainage volume was more than 50mL/day.Among these forty-one cases,twenty-five drainage tubes were removed when drainage volume was more than 100 mL/day.All the forty-one cases with pelvic drainage volume greater than 50mL/day were successfully managed with the early drainage removal.No paracentesis or drainage placement was required.No readmission occured during the follow-up period.Conclusion:It is safe to manage the high-volume pelvic lymphatic leakage by early clamping of the drainage tube,ultrasonography assessment of no significant residual fluid in the abdominal and pelvic cavity,and then the early removal of the drainage tube. | Wei Wang Kai Zhang Hongbo Li Lihua Yuan Yan Hou Derek A.O'Reilly Gang Zhu | 2023 | UroPrecision2023，1，4： | 0 |
| 9 | UroPrecision(UP):Turn UPthevolume of precision medicine in urology显示文摘More than 100 years ago,urology was recognized as an independent specialty.It is a dynamic and rapidly evolving field that plays a critical role in the diagnosis,treatment,and management of a wide range of urologic disorders.Over the past few decades,a splendid range of diagnostic options and therapeutic strategies in urooncology,endourology,female urology,and andrology has emerged.In particular,the explosion in precision medicine in the field of urology has revolutionized the way urologic malignancies are treated,and has led research and discovery on a new journey. | Nianzeng Xing Gang Song Guiting Lin Run Wang | 2023 | UroPrecision2023，1，1： | 0 |
| 10 | Indications,strategies,and development on prostate targeted biopsy:Report of the Panjiayuan Consensus Conference 2022显示文摘Prostate biopsy is the gold standard for diagnosing prostate cancer(PCa).Prostate targeted biopsy(TB)having a higher rate of detecting clinically significant PCa(csPCa)than traditional systematic biopsy(SB)is supported by high-quality evidence.However,the TB indications and strategies are controversial.The National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences,invited a panel of recognized urology experts in PCa to address these topics at the Panjiayuan Consensus Conference 2022.The conference results on prostate TB are presented herein.The National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences identified 10 key areas of prostate biopsy:(1)selection of imaging examination;(2)indications of TB;(3)transperineal and transrectal prostate biopsy;(4)TB pathways;(5)TB and SB;(6)three techniques of TB;(7)the number of TB cores needed for one lesion;(8)core number for SB;(9)free-hand TB;(10)future development of TB/prostate diagnosis.Thus,a panel of 25 recognized urologists and 2 radiologists from China were invited to attend this conference.The panel voted anonymously on 14 predetermined questions.Voting was based on the panelists'clinical practice and opinion,rather than high-level evidence.The voting outcomes were supported by the panel unequally,and details of the voting results were reported.The voting results can help clinicians to decide on biopsy timing and proper strategies,for which guidelines are sparse.We also focused on the future development of TB and SB,such as the combined pathway of TB and SB,techniques of TB,biopsy cores,free-hand TB,and prostate-specific membrane antigen positron emission tomography/computed tomography. | Gang Song Yajian Li Huimin Hou Yichen Wang Xuejuan Wang Shaoxi Niu Xiang Tu Hongliang Shen Zhien Zhou Yinbing Wang Ruiyi Yan Ning Xu Gejun Zhang Hailong Hao Shudong Zhang Ben Liu Bin Yang Baojun Wang Haifeng Wang Haifeng Huang Qian Zhang Baijun Dong Yonghong Li Jianbin Bi Weigang Yan Hongqian Guo Yuanjie Niu Guosheng Yang Ming Liu Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，1： | 0 |
| 11 | Clinical practice guideline on bladder cancer(Part Ⅰ)显示文摘Bladder cancer represents one of the most prevalent malignant tumors affecting the urinary system.As per data disclosed by the National Cancer Registration Center of China in 2019,the incidence of bladder cancer was 5.80 per 100,000 in 2015,placing it as the thirteenth most common systemic malignancy.Bladder cancer poses a substantial threat to public health in China,underlining the critical importance of standardizing diagnosis and treatment to enhance clinical outcomes.This clinical practice guideline for bladder cancer centers on the etiologies,clinical presentations,and diagnostic procedures for suspected bladder cancer,in addition to the histopathology and staging of urothelial bladder cancer. | Xiying Dong Gang Song Kaopeng Guan Tie Wang Xiaoli Feng Yulin Liu Min Liu Zhigang Ji Xiao Li Jiongming Li Yong Zhang Fangjian Zhou Aiping Zhou Wanhai Xu Tao Xu Xianshu Gao Qing Zhai Qiang Wei Nianzeng Xing | 2023 | UroPrecision2023，1，1： | 0 |
| 12 | Application of 5G telesurgery in urology显示文摘The fifth generation of mobile communication technology(5G technology)features large system capacity,fast data transmission rate,support for large-scale device connection,low latency,and high reliability.With the development and popularization of 5G technology,it is also widely used in medicine.In recent years,5G telesurgery has been paid attention to and made continuous progress,and the research related to its combination with urology has also made significant achievements.We collect the combination of 5G technology and urology improves the uneven distribution of medical resources,provides timely,highquality remote surgical interventions for urology patients,reduces the financial burden on patients,surgical complications,and the difficulty of accessing medical care from a distance,and brings new opportunities for medical development. | Fanshuo Meng Guangdi Chu Zhao Zhang Hang Yuan Chengjun Li Haitao Niu | 2023 | UroPrecision2023，1，1： | 0 |
| 13 | Power of pee:Urine-derived stem cells in urological disorders显示文摘Given that urine-derived stem cells(USCs)originate from the urinary tract system,they hold great potential for treating urological disorders.USCs have several advantages over other types of stem cells,such as easy and noninvasive collection,and abundant supply.USCs can differentiate into different types of cells.This makes them a potential source of cells for tissue engineering and regenerative medicine in the field of urology.In animal models,USCs or USCderived exosomes regenerate damaged tissues in the treatment of various urological disorders such as urinary incontinence,bladder dysfunction,interstitial cystitis,urethra injury erectile dysfunction,and kidney injury via multiple differentiation potential,angiogenesis,anti-inflammatory,paracrine effects,and immune modulation capability.Overall,the use of USCs in urological disorders is a rapidly developing field,and ongoing research is needed to fully understand their potential applications.However,the early results are promising and suggest that USCs could become a valuable cell source for the treatment of various urological disorders in the future. | Pengfei Yu Emmanuel C.Opara Yuanyuan Zhang | 2023 | UroPrecision2023，1，1： | 0 |
| 14 | Penile mass formation after neglected penile fracture:Surgical management with pericardial graft reinforcement显示文摘Background:Penile fracture is defined as the rupture of the tunica albuginea of the corpora cavernosa while in an erect state,during mostly intercourse or masturbation.Diagnosis of such condition is mainly clinical,while on the other hand,seeking medical attention is often delayed,and treatment options depend upon the time of presentation.Methods:This case report details a patient who developed a penile cystic fibro-hematoma lesion,2 months after a neglected penile fracture.After proper assessment including detailed history,physical exam and a penile doppler ultrasound,patient was elected for surgery.Results:The patient underwent surgical removal of the mass,correction of the curvature,and reinforcement of the weakened tunica albuginea with a pericardium graft.Postoperative course was uneventful.At follow-up,he reported normal erectile function with resolved penile curvature.Conclusion:This highlights the importance of seeking prompt medical attention for suspected penile fractures to avoid potential long-term complications. | Laura Thompson Kareim Khalafalla Run Wang | 2023 | UroPrecision2023，1，1： | 0 |
| 15 | Training the scientific urologist—A future-oriented species显示文摘The history of urology can be traced back to before written records and among the discoveries of archaeologists.Bladder stones were found in Egyptian tombs,presumably 7000 years ago.The discovery of urinary stones in archaeology had been well documented and studied,and the symptoms of urinary stones had been described from a very early date.The surgical treatment of urinary stones predates other procedures by a long way. | Xiying Xiang Gang Song | 2023 | UroPrecision2023，1，1： | 0 |
| 16 | Congratulations to UroPrecision:Embark on a remarkable journey显示文摘Dear Editors,I would like to express my sincere congratulations to you on the first issue of the new journal—UroPrecision.As a urologist who dedicated most of my life to clinical and basic urology for decades of years,I am immensely proud to witness the launch of a journal that is dedicated to speeding up the growth and integration of precision medicine principles in the field of urology as well as building up the influence of important research results in the international community. | Yinglu Guo | 2023 | UroPrecision2023，1，1： | 0 |
| 17 | The launch of UroPrecision:Advancing the field of urology through the lens of precision medicine显示文摘Dear Editors,I am delighted to extend my heartfelt congratulations on the successful launch of UroPrecision.As the Current President of the Global Chinese Urological Association of the American Urological Association(AUA)and the Current President of the North American Society for the Study of Men's Health,I am delighted to witness the birth of this esteemed journal dedicated to advancing the field of urology through the lens of precision medicine. | Tom F.Lue | 2023 | UroPrecision2023，1，1： | 0 |
| 18 | Consensus on safety management of novel hormonal therapy for advanced prostate cancer显示文摘Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management. | Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu Weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang Wei Xin Wang Xinghuan Wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura Cheol Kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing | 2023 | UroPrecision2023，1，2： | 0 |
| 19 | A survey of emergency blunt urethral injury management in China:Reality versus guidelines显示文摘Background:Although urethral trauma may lead to serious consequences if mismanaged,treatment concepts are inconsistent.We designed a survey to investigate the current diagnosis and management of emergency blunt urethral trauma to aid future dissemination of relevant concepts.Methods:A 15‐item anonymous questionnaire was distributed via an online platform.It addressed items such as the cognition of how to diagnose of urethral trauma,optimal emergency management of a urethral trauma patient,and attitude towards early realignment for pelvic fracture urethral injuries.Results:Of 538 respondents,94.2%and 84.9%had received patients with straddle trauma urethral injuries or pelvic fracture urethral injuries,respectively,within the past year.In the emergency room,attempted urethral catheterization was the most selected examination method by respondents for diagnosis of both straddle injury(500/538)and pelvic fracture urethral injury(469/538).For patients with straddle injury,41.3%of respondents performed endoscopic realignment and 31.6%preferred suprapubic cystostomy.For hemodynamically stable patients with PFUI,42.2%of respondents preferred suprapubic cystostomy and 34.9%preferred endoscopic realignment.Most respondents felt favorably toward early realignment for pelvic fracture urethral injuries.After realignment,61.3%,24.5%,and 13.8%of respondents performed catheterization for 4,8,and 12 weeks,respectively.Further,54.6%of respondents believed catheter traction should be applied after realignment.Conclusion:Although the number of yearly emergency urethral trauma cases was small,the opinions and practices of most urologists were consistent with guidelines.However,the significance of retrograde urethrography was not fully understood,and some respondents had incorrect views on catheter traction after realignment. | Yubo Gu Changhao Hou Jiahao Lin Wei Yuan Zeyu Wang Xianjie Xiu Qiang Fu Lujie Song | 2023 | UroPrecision2023，1，2： | 0 |
| 20 | Complex reimplantation of an inflatable penile prosthesis with scar tissue excision and distal corporal defect repair with Tutoplast®pericardium allograft显示文摘Background:Patients with inflatable penile prostheses(IPP)may experience erosions after years of use or after indwelling Foley catheter placement.IPP erosions should be managed as an infection with the entire IPP removed.Replacing IPPs in erosion patients can be challenging due to extensive scarring development.Using proper graft materials may be necessary to close and reinforce the corporal defect after difficult corporal dilation or significant scar removal for the long‐term success of IPP reimplantation.Case Presentation:Herein we report a patient with a history of IPP placement in 2007 for erectile dysfunction and Peyronie's disease,presenting in 2018 with dysuria and a feeling of IPP displacement following Foley catheter placement for coronary artery bypass graft surgery.The left cylinder of the IPP was observed by physical examination and a defect near the fossa navicularis was discovered during office cystoscopy.A complete explantation of IPP was then performed.Reimplantation of the IPP was performed in 2021 which required excision of corporal scar tissue and repair of a left distal corporal defect using a Tutoplast®pericardium allograft.The procedure was successful with proper IPP position and good function without any penile deformity.Conclusion:The use of graft materials in the management of corporeal defects should be considered in the setting of complex IPP revision.The Tutoplast®pericardium allograft reinforcement can provide long‐term durability,flexibility,and a lower risk of infection. | Kyle A.Blum William Jones Lauren Conroy Justin Mehr Travis Green Run Wang | 2023 | UroPrecision2023，1，2： | 0 |
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