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| 1 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 2 | Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis显示文摘AIM To investigate the temporal trends in the misdiagnosis rate between Crohn's disease(CD) and intestinal tuberculosis(ITB) in South Korea. METHODS We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB(final CD group) and vice versa(final ITB group). Final diagnostic criteria for ITB and medication for CD before definite diagnosis of TB were also analyzed in final ITB group.RESULTS In total, 2760 patients were managed for CD and 772 patients for ITB between 1996 and 2014. As well, 494 of the 2760 CD patients(17.9%) were initially misdiagnosed as ITB and 83 of the 772 ITB patients(10.8%) as CD. The temporal trend in misdiagnosing CD as ITB showed a decrease(OR = 0.89, 95%CI: 0.87-0.91, P < 0.001), whereas the temporal trend in misdiagnosing ITB as CD showed an increase(OR = 1.06, 95%CI: 1.01-1.11, P = 0.013). Age at diagnosis, presenting symptoms, and proportion of patients with active/past perianal fistula and active/inactive pulmonary tuberculosis(TB) were significantly different between final CD group and final ITB group. Forty patients(48.2%) in final ITB group were diagnosed by favorable response to empirical anti-TB treatment. Seventeen patients(20.5%) in final ITB group had inappropriately received corticosteroids and/or thiopurines due to misdiagnosis as CD. However, there were no mortalities in both groups. CONCLUSION Cases of CD misdiagnosed as ITB have been decreasing, whereas cases of ITB misdiagnosed as CD have been increasing over the past two decades. | Hyungil Seo Seohyun Lee Hoonsub So Donghoi Kim Seon-Ok Kim Jae Seung Soh Jung Ho Bae Sun-Ho Lee Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Byong Duk Ye | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 3 | MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer显示文摘 | Ji Heon Noh Young Gyoon Chang Min Gyu Kim Kwang Hwa Jung Jeong Kyu Kim Hyun Jin Bae Jung Woo Eun Qingyu Shen Seung-Jin Kim So Hee Kwon Won Sang Park Jung Young Lee Suk Woo Nam | 2013 | Cancer Letters2013，，2： | 2 |
| 4 | Non-invasive assessment of hepatic steatosis: Prospective comparison of the accuracy of imaging examinations显示文摘 | Seung Soo Lee Seong Ho Park Hye Jin Kim So Yeon Kim Min-Yeong Kim Dae Yoon Kim Dong Jin Suh Kang Mo Kim Mi Hyun Bae Joo Yeon Lee Sung-Gyu Lee Eun Sil Yu | 2010 | Journal of Hepatology2010，，4： | 2 |
| 5 | Doping Effects of Mg and/or Fe Ions on Congruent LiNbO3 Single Crystal Growth 显示文摘 | Junichiro Ichikawq Kiyoshi Shimamura | 1997 | Journal of Crystal Growth1997，180，： | 1 |
| 6 | Usefulness of Liver Biopsy in Anti–Hepatitis C Virus Antibody-Positive and Hepatitis C Virus RNA-Negative Kidney Transplant Recipients显示文摘 | So Mi Kim Hyeon Woo Kim Eun-kyoung Lee Su Kil Park Duck Jong Han Soon Bae Kim | 2013 | Transplantation Journal2013，，1： | 1 |
| 7 | SPA0355 attenuates ischemia/ Reperfusion-induced liver injury in mice 显示文摘 | Bae U J Yang JD Ka SO | 2014 | Exp Mol Med2014，46，： | 1 |
| 8 | Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors 显示文摘 | KIM B M BAE S J SO S M | 2001 | Org Lett2001，3，15： | 1 |
| 9 | Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB显示文摘 | Sun Mi Kim So Yong Lee Jin Suk Cho Seung Mo Son Sang Sook Choi Yeo Pyo Yun Hwan Soo Yoo Do Young Yoon Ki-Wan Oh Sang Bae Han Jin Tae Hong | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 10 | Synthesis ofa chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors 显示文摘 | Kim BM Bae S J So SM | 2001 | OrgLett2001，3，15： | 1 |
| 11 | Kami-ondam-tang, a tradition- al herbal prescription, attenuates the prepulse inhibition defi- cits and cognitive impairments induced by MK-801 in mice 显示文摘 | Oh HK Park S J Bae SO | 2013 | J Ethnopharmacol2013，146，2： | 1 |
| 12 | Optimization of culture conditions for CO2 fixation by a chemoautotrophic microorganism, strain YN-1 using factorial design显示文摘 | Kwak KO Jung SJ Chung SY Kang CM Huh YI Bae SO | 2006 | Biochem Eng2006，31，1： | 1 |
| 13 | COP: A new corner detector显示文摘 | Sun Cheol Bae In So Kweon Choong Don Yoo | 2002 | Pattern Recognition Letters2002，23，11： | 1 |
| 14 | Carbon nanotube-based membranes: Fabrication and application to desalination显示文摘 | Ahn CH Back YB Lee CH kim SO Kim SH Lee SH Kim SH Bae SS Park JB Yoon J | 2012 | Journal of Industrial and Engineering Chemistry2012，18，： | 1 |
| 15 | Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors 显示文摘 | Kim B Moon Sung Jin Bae Soon Mog So | 2001 | Org Lett2001，3，15： | 1 |
| 16 | Wntless regulates dentin apposition and root elongation in the mandibular molar显示文摘 | Bae CH Kim TH Ko SO | 2015 | J Dent Res2015，94，3： | 1 |
| 17 | Comparative analysis of collagens extracted from different animal sources for application of cartilage tissue engineering显示文摘 | Sang-Hyug Park Tongjin Song Tae Soo Bae Gon Khang Byung Hyune Choi So Ra Park Byoung-Hyun Min | 2012 | International Journal of Precision Engineering and Manufacturing2012，，11： | 1 |
| 18 | Synthesis of a chiral azifidine derivative as a versatile intermediate for HIV protease inhibitors显示文摘 | Kim B M Bae S J So S M | 2001 | Org Lett2001，3，15： | 1 |
| 19 | Tai- loring oxidation of A1 particles morphologically con- trolled by carbon nanotubes 显示文摘 | Hye Yun Jeong Kang Pyo So Jung Jun Bae | 2013 | Energy2013，55，15： | 1 |
| 20 | Severe intestinal toxicity after stereotactic ablative radiotherapy for abdominopelvic malignancies显示文摘 | Sun Hyun Bae Mi-Sook Kim So Young Kim Won Il Jang Chul Koo Cho Hyung Jun Yoo Kum Bae Kim Dong Han Lee Chul Ju Han Ki Young Yang Sang Bum Kim | 2013 | International Journal of Colorectal Disease2013，，12： | 1 |
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